All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Han Gao, Ye Zhou, Peng-Shuai Jin, Dong-Gui Wu, Yu-Na Wang, Xi Zhao, Bei Zha. Molecular alteration of the proteasome contributes to AD-like pathology in the brain of HFD-STZ diabetic rats. Metabolic brain disease. 2022-12-29. PMID:36580191. furthermore, lactacystin were used to inhibit proteasomal activity in vivo and typical alzheimer's disease (ad)-like pathologies were detected, including amyloid-beta, tau phosphorylation, and oxidative protein changes. 2022-12-29 2023-08-14 rat
Zhi-Bo Wang, Ya-Hui Ma, Yan Sun, Lan Tan, Hui-Fu Wang, Jin-Tai Y. Interleukin-3 is associated with sTREM2 and mediates the correlation between amyloid-β and tau pathology in Alzheimer's disease. Journal of neuroinflammation. vol 19. issue 1. 2022-12-28. PMID:36578067. interleukin-3 is associated with strem2 and mediates the correlation between amyloid-β and tau pathology in alzheimer's disease. 2022-12-28 2023-08-14 mouse
Randall J Eck, Rebecca L Kow, Aristide H Black, Nicole F Liachko, Brian C Kraeme. SPOP loss of function protects against tauopathy. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 1. 2022-12-27. PMID:36574656. in the most common tauopathy, alzheimer's disease (ad), the accumulation of pathological tau strongly correlates with cognitive decline. 2022-12-27 2023-08-14 Not clear
Melissa E Murray, Christina M Moloney, Naomi Kouri, Jeremy A Syrjanen, Billie J Matchett, Darren M Rothberg, Jessica F Tranovich, Tiffany N Hicks Sirmans, Heather J Wiste, Baayla D C Boon, Aivi T Nguyen, R Ross Reichard, Dennis W Dickson, Val J Lowe, Jeffrey L Dage, Ronald C Petersen, Clifford R Jack, David S Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, Michelle M Mielk. Global neuropathologic severity of Alzheimer's disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels. Molecular neurodegeneration. vol 17. issue 1. 2022-12-27. PMID:36575455. global neuropathologic severity of alzheimer's disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels. 2022-12-27 2023-08-14 human
Melissa E Murray, Christina M Moloney, Naomi Kouri, Jeremy A Syrjanen, Billie J Matchett, Darren M Rothberg, Jessica F Tranovich, Tiffany N Hicks Sirmans, Heather J Wiste, Baayla D C Boon, Aivi T Nguyen, R Ross Reichard, Dennis W Dickson, Val J Lowe, Jeffrey L Dage, Ronald C Petersen, Clifford R Jack, David S Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, Michelle M Mielk. Global neuropathologic severity of Alzheimer's disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels. Molecular neurodegeneration. vol 17. issue 1. 2022-12-27. PMID:36575455. advances in ultrasensitive detection of phosphorylated tau (p-tau) in plasma has enabled the use of blood tests to measure alzheimer's disease (ad) biomarker changes. 2022-12-27 2023-08-14 human
Louise Bryan, Saurabh Awasthi, Yuanjie Li, Peter Niraj Nirmalraj, Sandor Balog, Jerry Yang, Michael Maye. Site-Specific C-Terminal Fluorescent Labeling of Tau Protein. ACS omega. vol 7. issue 50. 2022-12-26. PMID:36570287. formation of tau protein aggregates in neurons is a pathological hallmark of several neurodegenerative diseases, including alzheimer's disease. 2022-12-26 2023-08-14 Not clear
Youssra K Al-Hilaly, Connor Hurt, Janet E Rickard, Charles R Harrington, John M D Storey, Claude M Wischik, Louise C Serpell, Ansgar B Sieme. Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391). Frontiers in neuroscience. vol 16. 2022-12-26. PMID:36570831. aggregation of the tau protein into fibrillar cross-β aggregates is a hallmark of alzheimer's diseases (ad) and many other neurodegenerative tauopathies. 2022-12-26 2023-08-14 Not clear
Anna Rubinski, Simon Frerich, Rainer Malik, Nicolai Franzmeier, Alfredo Ramirez, Martin Dichgans, Michael Ewer. Polygenic effect on tau pathology progression in Alzheimer's disease. Annals of neurology. 2022-12-26. PMID:36571564. polygenic effect on tau pathology progression in alzheimer's disease. 2022-12-26 2023-08-14 Not clear
David Aguillon, Stephanie Langella, Yinghua Chen, Justin S Sanchez, Yi Su, Clara Vila-Castelar, Daniel Vasquez, Henrik Zetterberg, Oskar Hansson, Jeffrey L Dage, Shorena Janelidze, Kewei Chen, Joshua T Fox-Fuller, Paula Aduen, Jairo E Martinez, Gloria Garcia, Ana Baena, Claudia Guzman, Keith A Johnson, Reisa A Sperling, Kaj Blennow, Eric M Reiman, Francisco Lopera, Yakeel T Quiro. Plasma p-tau217 predicts in vivo brain pathology and cognition in autosomal dominant Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-12-26. PMID:36571821. plasma-measured tau phosphorylated at threonine 217 (p-tau217) is a potential non-invasive biomarker of alzheimer's disease (ad). 2022-12-26 2023-08-14 Not clear
George Anderso. Why Do Anti-Amyloid Beta Antibodies not work? Time to reconceptualize Dementia Pathophysiology by incorporating astrocyte melatonergic pathway desynchronization from amyloid-beta production. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). 2022-12-26. PMID:36571832. recent work has challenged the classical, long-standing conceptualization of alzheimer's disease pathophysiology as driven by amyloid-β plaques and hyperphosphorylated tau tangles, including the treatments thereby derived. 2022-12-26 2023-08-14 Not clear
Fernando Gonzalez-Ortiz, Michael Turton, Przemysław R Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas K Karikar. Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration. Brain : a journal of neurology. 2022-12-26. PMID:36572122. brain-derived tau: a novel blood-based biomarker for alzheimer's disease-type neurodegeneration. 2022-12-26 2023-08-14 human
Fernando Gonzalez-Ortiz, Michael Turton, Przemysław R Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas K Karikar. Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration. Brain : a journal of neurology. 2022-12-26. PMID:36572122. blood-based biomarkers for amyloid beta and phosphorylated tau show good diagnostic accuracies and agreements with their corresponding csf and neuroimaging biomarkers in the amyloid/tau/neurodegeneration [a/t/(n)] framework for alzheimer's disease. 2022-12-26 2023-08-14 human
Fernando Gonzalez-Ortiz, Michael Turton, Przemysław R Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas K Karikar. Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration. Brain : a journal of neurology. 2022-12-26. PMID:36572122. blood-based brain-derived tau showed equivalent diagnostic performance as csf total-tau and csf brain-derived tau to separate biomarker-positive alzheimer's disease participants from biomarker-negative controls. 2022-12-26 2023-08-14 human
Fernando Gonzalez-Ortiz, Michael Turton, Przemysław R Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas K Karikar. Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration. Brain : a journal of neurology. 2022-12-26. PMID:36572122. furthermore, plasma brain-derived tau accurately distinguished autopsy-confirmed alzheimer's disease from other neurodegenerative diseases (area under the curve = 86.4%) while neurofilament light did not (area under the curve = 54.3%). 2022-12-26 2023-08-14 human
Fernando Gonzalez-Ortiz, Michael Turton, Przemysław R Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas K Karikar. Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration. Brain : a journal of neurology. 2022-12-26. PMID:36572122. these results were further verified in two memory clinic cohorts where serum brain-derived tau differentiated alzheimer's disease from a range of other neurodegenerative disorders, including frontotemporal lobar degeneration and atypical parkinsonian disorders (area under the curve up to 99.6%). 2022-12-26 2023-08-14 human
Fernando Gonzalez-Ortiz, Michael Turton, Przemysław R Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas K Karikar. Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration. Brain : a journal of neurology. 2022-12-26. PMID:36572122. notably, plasma/serum brain-derived tau correlated with neurofilament light only in alzheimer's disease but not in the other neurodegenerative diseases. 2022-12-26 2023-08-14 human
Fernando Gonzalez-Ortiz, Michael Turton, Przemysław R Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas K Karikar. Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration. Brain : a journal of neurology. 2022-12-26. PMID:36572122. brain-derived tau is a new blood-based biomarker that outperforms plasma total-tau and, unlike neurofilament light, shows specificity to alzheimer's disease-type neurodegeneration. 2022-12-26 2023-08-14 human
Fernando Gonzalez-Ortiz, Michael Turton, Przemysław R Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas K Karikar. Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration. Brain : a journal of neurology. 2022-12-26. PMID:36572122. thus, brain-derived tau demonstrates potential to complete the at(n) scheme in blood, and will be useful to evaluate alzheimer's disease-dependent neurodegenerative processes for clinical and research purposes. 2022-12-26 2023-08-14 human
Anders Abildgaard, Tina Parkner, Cindy Soendersoe Knudsen, Hanne Gottrup, Henriette Kli. Diagnostic Cut-offs for CSF β-amyloid and Tau Proteins in a Danish Dementia Clinic. Clinica chimica acta; international journal of clinical chemistry. 2022-12-26. PMID:36572135. analysis of beta-amyloid 1-42 (aβ42), total tau (t-tau) and phosphorylated-tau 181 (p-tau) in the cerebrospinal fluid (csf) is often performed as a part of the diagnostic work-up in case of suspected alzheimer's dementia (ad). 2022-12-26 2023-08-14 Not clear
Yuek Ling Chai, Nathan Hao Ping Liang, Joyce R Chong, Narayanaswamy Venketasubramanian, Boon Yeow Tan, Saima Hilal, Christopher P Chen, Mitchell K P La. Serum Cathepsin D Is a Potential Biomarker for Alzheimer's Disease Dementia and Cognitive Decline. Journal of Alzheimer's disease : JAD. 2022-12-24. PMID:36565119. the lysosomal protease cathepsin d (catd) has been reported to be upregulated in postmortem alzheimer's disease (ad) cortex, where it colocalized with neurofibrillary tangles and correlated with levels of phosphorylated tau, suggesting pathophysiological links between catd and neurodegeneration. 2022-12-24 2023-08-14 Not clear