| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Georgina Perez-Garcia, Mesude Bicak, Jean-Vianney Haure-Mirande, Gissel M Perez, Alena Otero-Pagan, Miguel A Gama Sosa, Rita De Gasperi, Mary Sano, Carrolee Barlow, Fred H Gage, Benjamin Readhead, Michelle E Ehrlich, Sam Gandy, Gregory A Elde. BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPT Neuroscience letters. 2023-01-19. PMID:36657633. |
bci-838, an orally active mglur2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the ps19 mapt tauopathies are a heterogeneous group of neurodegenerative disorders that are clinically and pathologically distinct from alzheimer's disease (ad) having tau inclusions in neurons and/or glia as their most prominent neuropathological feature. |
2023-01-19 |
2023-08-14 |
Not clear |
| Han Kyu Na, Han-Kyeol Kim, Hye Sun Lee, Mina Park, Jae Hoon Lee, Young Hoon Ryu, Hanna Cho, Chul Hyoung Lyo. Role of Enlarged Perivascular Space in the Temporal Lobe in Cerebral Amyloidosis. Annals of neurology. 2023-01-18. PMID:36651566. |
although growing evidence suggests that perivascular space (pvs) serves as a clearance route for amyloid and tau, the association between enlarged pvs (epvs) and alzheimer's disease are highly inconsistent across studies. |
2023-01-18 |
2023-08-14 |
Not clear |
| Anish Kapadia, Krish Billimoria, Prarthna Desai, James T Grist, Chris Heyn, Pejman Maralani, Sean Symons, Fulvio Zaccagn. Hypoperfusion Precedes Tau Deposition in the Entorhinal Cortex: A Retrospective Evaluation of ADNI-2 Data. Journal of clinical neurology (Seoul, Korea). 2023-01-17. PMID:36647226. |
tau deposition in the entorhinal cortex is the earliest pathological feature of alzheimer's disease (ad). |
2023-01-17 |
2023-08-14 |
Not clear |
| Mingxi Dang, Qian Chen, Xiaobin Zhao, Kewei Chen, Xin Li, Junying Zhang, Jie Lu, Lin Ai, Yaojing Chen, Zhanjun Zhan. Tau as a biomarker of cognitive impairment and neuropsychiatric symptom in Alzheimer's disease. Human brain mapping. vol 44. issue 2. 2023-01-17. PMID:36647262. |
tau as a biomarker of cognitive impairment and neuropsychiatric symptom in alzheimer's disease. |
2023-01-17 |
2023-08-14 |
Not clear |
| Javaria Baig, Jangampalli Adi Pradeepkiran, P Hemachandra Redd. Methods to Study Mitochondria: Techniques Used to Study the Effects of Age-Related Diseases Including Alzheimer's. Current protocols. vol 3. issue 1. 2023-01-17. PMID:36648280. |
most of these techniques have been performed in vitro (in human and mouse neuronal cell lines transfected with mutant amyloid precursor protein or tau protein cdnas) and in vivo (in brain tissues from different mouse models of alzheimer's and other neurological diseases). |
2023-01-17 |
2023-08-14 |
mouse |
| Z Qiu, H Zhang, M Xia, J Gu, K Guo, H Wang, C Mia. Programmed Death of Microglia in Alzheimer's Disease: Autophagy, Ferroptosis, and Pyroptosis. The journal of prevention of Alzheimer's disease. vol 10. issue 1. 2023-01-15. PMID:36641613. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by progressive cognitive decline, amyloid-β (aβ) plaques and the formation of neurofibrillary tangles (nfts) composed of hyperphosphorylated tau. |
2023-01-15 |
2023-08-14 |
Not clear |
| Mingming Yang, Rongrong Qi, Yuxiao Liu, Xin Shen, Yulou Zhao, Nana Jin, Ruozhen Wu, Fei Liu, Jianlan G. Casein Kinase 1δ Phosphorylates TDP-43 and Suppresses Its Function in Tau mRNA Processing. Journal of Alzheimer's disease : JAD. 2023-01-15. PMID:36641675. |
neurofibrillary tangles aggregated from anomalous hyperphosphorylated tau is a hallmark of alzheimer's disease (ad). |
2023-01-15 |
2023-08-14 |
Not clear |
| Susan Barendrecht, An Schreurs, Stefanie Geissler, Victor Sabanov, Victoria Ilse, Vera Rieckmann, Rico Eichentopf, Anja Künemund, Benjamin Hietel, Sebastian Wussow, Katrin Hoffmann, Kerstin Körber-Ferl, Ravi Pandey, Gregory W Carter, Hans-Ulrich Demuth, Max Holzer, Steffen Roßner, Stephan Schilling, Christoph Preuss, Detlef Balschun, Holger Cyni. A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice. Alzheimer's research & therapy. vol 15. issue 1. 2023-01-14. PMID:36641439. |
hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of alzheimer's disease (ad) brain. |
2023-01-14 |
2023-08-14 |
mouse |
| Sara Cazzaro, Xingyu Zhao, Victoria K Zhao, Yenna K Kim, Jung-A A Wo. Slingshot homolog-1 amplifies mitochondrial abnormalities by distinctly impairing health and clearance of mitochondria. Human molecular genetics. 2023-01-13. PMID:36637427. |
accumulating toxic protein assemblies, including aβ and tau, and dysfunctional mitochondria are associated with synaptic and neuronal loss in alzheimer's disease (ad). |
2023-01-13 |
2023-08-14 |
Not clear |
| Deonne Taylor, Andrew Kneynsberg, Marloes van Roijen, Jürgen Göt. Tyrosine phosphatase STEP Molecular brain. vol 16. issue 1. 2023-01-13. PMID:36639708. |
tyrosine phosphatase step synaptic degeneration is a precursor of synaptic and neuronal loss in neurodegenerative diseases such as alzheimer's disease (ad) and frontotemporal dementia with tau pathology (ftd-tau), a group of primary tauopathies. |
2023-01-13 |
2023-08-14 |
Not clear |
| Binita Rajbanshi, Anuj Guruacharya, James W Mandell, George S Bloo. Localization, induction, and cellular effects of tau phosphorylated at threonine 217. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-01-12. PMID:36633254. |
tau phosphorylation at t217 is a promising alzheimer's disease (ad) biomarker, but its functional consequences were unknown. |
2023-01-12 |
2023-08-14 |
Not clear |
| Kendall B E Moore, Ta-Jung Hung, Jessica S Forti. Hyperphosphorylated tau (p-tau) and drug discovery in the context of Alzheimer's disease and related tauopathies. Drug discovery today. 2023-01-12. PMID:36634842. |
hyperphosphorylated tau (p-tau) and drug discovery in the context of alzheimer's disease and related tauopathies. |
2023-01-12 |
2023-08-14 |
Not clear |
| Alexa F Iannitelli, Michael A Kelberman, Daniel J Lustberg, Anu Korukonda, Katharine E McCann, Bernard Mulvey, Arielle Segal, L Cameron Liles, Steven A Sloan, Joseph D Dougherty, David Weinshenke. The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease. eNeuro. 2023-01-12. PMID:36635251. |
the noradrenergic locus coeruleus (lc) is among the earliest sites of tau and alpha-synuclein pathology in alzheimer's disease (ad) and parkinson's disease (pd), respectively. |
2023-01-12 |
2023-08-14 |
mouse |
| Melissa Huang, Jennifer Macdonald, Isabelle Lavenir, Renren Chen, Molly Craxton, Elizabeth Slavik-Smith, Stephen W Davies, Michel Goeder. Increase in tau pathology in P290S eNeuro. 2023-01-12. PMID:36635241. |
increase in tau pathology in p290s alzheimer's disease (ad) is characterized by the pathological assembly of aβ peptide, which deposits into extracellular plaques, and tau, which accumulates in intraneuronal inclusions. |
2023-01-12 |
2023-08-14 |
mouse |
| Daniele Trivellato, Fulvio Floriani, Carlo Giorgio Barracchia, Francesca Munari, Mariapina D'Onofrio, Michael Assfal. Site-directed double monoubiquitination of the repeat domain of the amyloid-forming protein tau impairs self-assembly and coacervation. Bioorganic chemistry. vol 132. 2023-01-11. PMID:36630781. |
in alzheimer's disease and related disorders called tauopathies, the microtubule-associated protein tau accumulates in the brain in the form of amyloid-like supramolecular filaments. |
2023-01-11 |
2023-08-14 |
Not clear |
| L Arouche-Delaperche, S Cadoni, C Joffrois, G Labernede, M Valet, Q César, J Dégardin, S Girardon, C Gabriel, S Krantic, S Picau. Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy. Acta neuropathologica communications. vol 11. issue 1. 2023-01-11. PMID:36631898. |
tauopathies, including alzheimer's disease, are characterized by retinal ganglion cell loss associated with amyloid and phosphorylated tau deposits. |
2023-01-11 |
2023-08-14 |
mouse |
| Charlotte Johansson, Steinunn Thordardottir, José Laffita-Mesa, Elena Rodriguez-Vieitez, Henrik Zetterberg, Kaj Blennow, Caroline Graf. Plasma biomarker profiles in autosomal dominant Alzheimer's disease. Brain : a journal of neurology. 2023-01-10. PMID:36626935. |
emerging plasma biomarkers of alzheimer's disease might be non-invasive tools to trace early alzheimer's disease-related abnormalities such as the accumulation of amyloid-beta peptides, neurofibrillary tau tangles, glial activation and neurodegeneration. |
2023-01-10 |
2023-08-14 |
Not clear |
| Arunkumar Subramanian, T Tamilanban, Abdulrhman Alsayari, Gobinath Ramachawolran, Ling Shing Wong, Mahendran Sekar, Siew Hua Gan, Vetriselvan Subramaniyan, Suresh V Chinni, Nur Najihah Izzati Mat Rani, Nagaraja Suryadevara, Shadma Waha. Trilateral association of autophagy, mTOR and Alzheimer's disease: Potential pathway in the development for Alzheimer's disease therapy. Frontiers in pharmacology. vol 13. 2023-01-09. PMID:36618946. |
alzheimer's disease (ad) is the chief cause of progressive dementia, and it is characterized by irreparable loss of cognitive abilities, forming senile plaques having amyloid beta (aβ) aggregates and neurofibrillary tangles with considerable amounts of tau in affected hippocampus and cortex regions of human brains. |
2023-01-09 |
2023-08-14 |
human |
| SungWoon Im, Kohei Hanaoka, Takahiro Yamada, Kazunari Ishi. Regional cerebral THK5351 accumulations correlate with neuropsychological test scores in Alzheimer continuum. Asia Oceania journal of nuclear medicine & biology. vol 11. issue 1. 2023-01-09. PMID:36619188. |
we evaluated the relationship between regional accumulations of the tau positron emission tomography (pet) tracer thk5351 and cognitive dysfunction in the alzheimer's disease (ad) continuum. |
2023-01-09 |
2023-08-14 |
Not clear |
| Xin Liu, Weiyi She, Herman H-Y Sung, Ian D Williams, Peiyuan Qia. Tau-aggregation inhibitors derived from Streptomyces tendae MCCC 1A01534 protect HT22 cells against okadaic acid-induced damage. International journal of biological macromolecules. 2023-01-09. PMID:36621732. |
alzheimer's disease (ad) is an age-related neurodegenerative disease characterized by tau aggregating into neurofibrillary tangles. |
2023-01-09 |
2023-08-14 |
Not clear |