| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexa F Iannitelli, Michael A Kelberman, Daniel J Lustberg, Anu Korukonda, Katharine E McCann, Bernard Mulvey, Arielle Segal, L Cameron Liles, Steven A Sloan, Joseph D Dougherty, David Weinshenke. The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease. eNeuro. 2023-01-12. PMID:36635251. |
the noradrenergic locus coeruleus (lc) is among the earliest sites of tau and alpha-synuclein pathology in alzheimer's disease (ad) and parkinson's disease (pd), respectively. |
2023-01-12 |
2023-08-14 |
mouse |
| Melissa Huang, Jennifer Macdonald, Isabelle Lavenir, Renren Chen, Molly Craxton, Elizabeth Slavik-Smith, Stephen W Davies, Michel Goeder. Increase in tau pathology in P290S eNeuro. 2023-01-12. PMID:36635241. |
increase in tau pathology in p290s alzheimer's disease (ad) is characterized by the pathological assembly of aβ peptide, which deposits into extracellular plaques, and tau, which accumulates in intraneuronal inclusions. |
2023-01-12 |
2023-08-14 |
mouse |
| Daniele Trivellato, Fulvio Floriani, Carlo Giorgio Barracchia, Francesca Munari, Mariapina D'Onofrio, Michael Assfal. Site-directed double monoubiquitination of the repeat domain of the amyloid-forming protein tau impairs self-assembly and coacervation. Bioorganic chemistry. vol 132. 2023-01-11. PMID:36630781. |
in alzheimer's disease and related disorders called tauopathies, the microtubule-associated protein tau accumulates in the brain in the form of amyloid-like supramolecular filaments. |
2023-01-11 |
2023-08-14 |
Not clear |
| L Arouche-Delaperche, S Cadoni, C Joffrois, G Labernede, M Valet, Q César, J Dégardin, S Girardon, C Gabriel, S Krantic, S Picau. Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy. Acta neuropathologica communications. vol 11. issue 1. 2023-01-11. PMID:36631898. |
tauopathies, including alzheimer's disease, are characterized by retinal ganglion cell loss associated with amyloid and phosphorylated tau deposits. |
2023-01-11 |
2023-08-14 |
mouse |
| Charlotte Johansson, Steinunn Thordardottir, José Laffita-Mesa, Elena Rodriguez-Vieitez, Henrik Zetterberg, Kaj Blennow, Caroline Graf. Plasma biomarker profiles in autosomal dominant Alzheimer's disease. Brain : a journal of neurology. 2023-01-10. PMID:36626935. |
emerging plasma biomarkers of alzheimer's disease might be non-invasive tools to trace early alzheimer's disease-related abnormalities such as the accumulation of amyloid-beta peptides, neurofibrillary tau tangles, glial activation and neurodegeneration. |
2023-01-10 |
2023-08-14 |
Not clear |
| Arunkumar Subramanian, T Tamilanban, Abdulrhman Alsayari, Gobinath Ramachawolran, Ling Shing Wong, Mahendran Sekar, Siew Hua Gan, Vetriselvan Subramaniyan, Suresh V Chinni, Nur Najihah Izzati Mat Rani, Nagaraja Suryadevara, Shadma Waha. Trilateral association of autophagy, mTOR and Alzheimer's disease: Potential pathway in the development for Alzheimer's disease therapy. Frontiers in pharmacology. vol 13. 2023-01-09. PMID:36618946. |
alzheimer's disease (ad) is the chief cause of progressive dementia, and it is characterized by irreparable loss of cognitive abilities, forming senile plaques having amyloid beta (aβ) aggregates and neurofibrillary tangles with considerable amounts of tau in affected hippocampus and cortex regions of human brains. |
2023-01-09 |
2023-08-14 |
human |
| SungWoon Im, Kohei Hanaoka, Takahiro Yamada, Kazunari Ishi. Regional cerebral THK5351 accumulations correlate with neuropsychological test scores in Alzheimer continuum. Asia Oceania journal of nuclear medicine & biology. vol 11. issue 1. 2023-01-09. PMID:36619188. |
we evaluated the relationship between regional accumulations of the tau positron emission tomography (pet) tracer thk5351 and cognitive dysfunction in the alzheimer's disease (ad) continuum. |
2023-01-09 |
2023-08-14 |
Not clear |
| Xin Liu, Weiyi She, Herman H-Y Sung, Ian D Williams, Peiyuan Qia. Tau-aggregation inhibitors derived from Streptomyces tendae MCCC 1A01534 protect HT22 cells against okadaic acid-induced damage. International journal of biological macromolecules. 2023-01-09. PMID:36621732. |
alzheimer's disease (ad) is an age-related neurodegenerative disease characterized by tau aggregating into neurofibrillary tangles. |
2023-01-09 |
2023-08-14 |
Not clear |
| Guilherme G Moreira, Cláudio M Gome. Tau liquid-liquid phase separation is modulated by the Ca Journal of neurochemistry. 2023-01-09. PMID:36621842. |
tau liquid-liquid phase separation is modulated by the ca aggregation of the microtubule-associated protein tau is implicated in several neurodegenerative tauopathies including alzheimer's disease (ad). |
2023-01-09 |
2023-08-14 |
Not clear |
| Areeba Rashad, Atta Rasool, Muhammad Shaheryar, Azza Sarfraz, Zouina Sarfraz, Karla Robles-Velasco, Ivan Cherrez-Ojed. Donanemab for Alzheimer's Disease: A Systematic Review of Clinical Trials. Healthcare (Basel, Switzerland). vol 11. issue 1. 2023-01-08. PMID:36611492. |
amyloid-β (aβ) plaques and aggregated tau are two core mechanisms that contribute to the clinical deterioration of alzheimer's disease (ad). |
2023-01-08 |
2023-08-14 |
human |
| Areeba Rashad, Atta Rasool, Muhammad Shaheryar, Azza Sarfraz, Zouina Sarfraz, Karla Robles-Velasco, Ivan Cherrez-Ojed. Donanemab for Alzheimer's Disease: A Systematic Review of Clinical Trials. Healthcare (Basel, Switzerland). vol 11. issue 1. 2023-01-08. PMID:36611492. |
there was a slowing of overall tau levels accumulation as well as relatively reduced functional and cognitive decline noted on the integrated alzheimer's disease rating scale by 32% in the donanemab arm. |
2023-01-08 |
2023-08-14 |
human |
| Natalia Pieńkowska, Margaret Fahnestock, Crystal Mahadeo, Izabela Zaborniak, Paweł Chmielarz, Grzegorz Bartosz, Izabela Sadowska-Bartos. Induction of Oxidative Stress in SH-SY5Y Cells by Overexpression of hTau40 and Its Mitigation by Redox-Active Nanoparticles. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613801. |
abnormally phosphorylated tau protein is the principal component of neurofibrillary tangles, accumulating in the brain in many neurodegenerative diseases, including alzheimer's disease. |
2023-01-08 |
2023-08-14 |
human |
| Young-Kook Kim, Yoon Seok Jung, Juhyun Son. Transcriptome Profile in the Mouse Brain of Hepatic Encephalopathy and Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614117. |
alzheimer's disease (ad), the most common neurodegenerative disease, is characterized by tau hyperphosphorylation, excessive amyloid beta (aβ) accumulation, the formation of fibrillary tangles, hippocampus atrophy, and neuroinflammation. |
2023-01-08 |
2023-08-14 |
mouse |
| Junsoo Bok, Juchan Ha, Bum Ju Ahn, Yongwoo Jan. Disease-Modifying Effects of Non-Invasive Electroceuticals on β-Amyloid Plaques and Tau Tangles for Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614120. |
disease-modifying effects of non-invasive electroceuticals on β-amyloid plaques and tau tangles for alzheimer's disease. |
2023-01-08 |
2023-08-14 |
Not clear |
| Zhijun He, Huajie Zhang, Xiaoqian Li, Sixin Tu, Zi Wang, Shuangxue Han, Xiubo Du, Liming Shen, Nan Li, Qiong Li. The protective effects of Esculentoside A through AMPK in the triple transgenic mouse model of Alzheimer's disease. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 109. 2023-01-07. PMID:36610160. |
neurofibrillary tangles comprising hyperphosphorylated tau are vital factors associated with the pathogenesis of alzheimer's disease (ad). |
2023-01-07 |
2023-08-14 |
mouse |
| Jiyoen Kim, Maria de Haro, Ismael Al-Ramahi, Lorena Laura Garaicoechea, Hyun-Hwan Jeong, Jun Young Sonn, Bakhos Tadros, Zhandong Liu, Juan Botas, Huda Yahya Zoghb. Evolutionarily conserved regulators of tau identify targets for new therapies. Neuron. 2023-01-07. PMID:36610398. |
tauopathies are neurodegenerative diseases that involve the pathological accumulation of tau proteins; in this family are alzheimer disease, corticobasal degeneration, and chronic traumatic encephalopathy, among others. |
2023-01-07 |
2023-08-14 |
mouse |
| Jiyoen Kim, Maria de Haro, Ismael Al-Ramahi, Lorena Laura Garaicoechea, Hyun-Hwan Jeong, Jun Young Sonn, Bakhos Tadros, Zhandong Liu, Juan Botas, Huda Yahya Zoghb. Evolutionarily conserved regulators of tau identify targets for new therapies. Neuron. 2023-01-07. PMID:36610398. |
this study thus identifies several points of intervention to reduce tau levels and demonstrates that reduction of tau levels via regulation of this pathway is a viable therapeutic strategy for alzheimer disease and other tauopathies. |
2023-01-07 |
2023-08-14 |
mouse |
| Wang Liao, Haoyu Luo, Yuting Ruan, Yingren Mai, Chongxu Liu, Jiawei Chen, Shaoqing Yang, Aiguo Xuan, Jun Li. Identification of candidate genes associated with clinical onset of Alzheimer's disease. Frontiers in neuroscience. vol 16. 2023-01-06. PMID:36605552. |
alzheimer's disease (ad) is the most common type of dementia, with its pathology like beta-amyloid and phosphorylated tau beginning several years before the clinical onset. |
2023-01-06 |
2023-08-14 |
Not clear |
| Elizabeth Ochoa, Paulino Ramirez, Elias Gonzalez, Jasmine De Mange, William J Ray, Kevin F Bieniek, Bess Fros. Pathogenic tau-induced transposable element-derived dsRNA drives neuroinflammation. Science advances. vol 9. issue 1. 2023-01-06. PMID:36608133. |
deposition of tau protein aggregates in the brain of affected individuals is a defining feature of "tauopathies," including alzheimer's disease. |
2023-01-06 |
2023-08-14 |
mouse |
| Elizabeth Ochoa, Paulino Ramirez, Elias Gonzalez, Jasmine De Mange, William J Ray, Kevin F Bieniek, Bess Fros. Pathogenic tau-induced transposable element-derived dsRNA drives neuroinflammation. Science advances. vol 9. issue 1. 2023-01-06. PMID:36608133. |
we find that dsrna and dsrna sensing machinery are elevated in astrocytes of postmortem brain tissue from patients with alzheimer's disease and progressive supranuclear palsy and in brains of tau transgenic mice. |
2023-01-06 |
2023-08-14 |
mouse |