All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Xiaoying Chen, David M Holtzma. Emerging roles of innate and adaptive immunity in Alzheimer's disease. Immunity. 2022-11-09. PMID:36351425. alzheimer's disease (ad) is the most common neurodegenerative disease, with characteristic extracellular amyloid-β (aβ) deposition and intracellular accumulation of hyperphosphorylated, aggregated tau. 2022-11-09 2023-08-14 Not clear
Giovanna Viola, Carlo Giorgio Barracchia, Roberto Tira, Francesca Parolini, Giulia Leo, Massimo Bellanda, Francesca Munari, Stefano Capaldi, Mariapina D'Onofrio, Michael Assfal. New Paradigm for Nano-Bio Interactions: Multimolecular Assembly of a Prototypical Disordered Protein with Ultrasmall Nanoparticles. Nano letters. 2022-11-08. PMID:36346924. as a model system, we focused on ultrasmall gold nanoparticles (usgnps) and tau, a cytosolic idp associated with alzheimer's disease. 2022-11-08 2023-08-14 Not clear
Qiaolifan Aerqin, Zuo-Teng Wang, Kai-Min Wu, Xiao-Yu He, Qiang Dong, Jin-Tai Y. Omics-based biomarkers discovery for Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 79. issue 12. 2022-11-08. PMID:36348101. alzheimer's disease (ad) is the most common neurodegenerative disorders presenting with the pathological hallmarks of amyloid plaques and tau tangles. 2022-11-08 2023-08-14 Not clear
Jonathan Blackman, Laura Stankeviciute, Eider M Arenaza-Urquijo, Marc Suárez-Calvet, Gonzalo Sánchez-Benavides, Natalia Vilor-Tejedor, Alejandro Iranzo, José Luis Molinuevo, Juan Domingo Gispert, Elizabeth Coulthard, Oriol Grau-River. Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults. Brain communications. vol 4. issue 6. 2022-11-07. PMID:36337343. this study included 1168 adults aged over 50 years with csf core alzheimer's disease biomarkers (total tau, phosphorylated tau and amyloid-beta), cognitive performance, and sleep quality (pittsburgh sleep quality index questionnaire) data. 2022-11-07 2023-08-14 human
Yi Dong, Yuanjing Li, Keke Liu, Xiaolei Han, Rui Liu, Yifei Ren, Lin Cong, Qinghua Zhang, Tingting Hou, Lin Song, Shi Tang, Lin Shi, Yishan Luo, Grégoria Kalpouzos, Erika J Laukka, Bengt Winblad, Yongxiang Wang, Yifeng Du, Chengxuan Qi. Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-07. PMID:36341691. in the subsamples, we measured plasma amyloid beta (aβ)40, aβ42, total tau, and neurofilament light chain (nfl; n = 1054); and quantified hippocampal, entorhinal cortex, and white matter hyperintensity (wmh) volumes, and alzheimer's disease (ad)-signature cortical thickness (n = 917). 2022-11-07 2023-08-14 human
Erica Leyder, Prakul Suresh, Rachel Jun, Katherine Overbey, Tirtho Banerjee, Tatiana Melnikova, Alena Savonenk. Depression-related phenotypes at early stages of Aβ and tau accumulation in inducible Alzheimer's disease mouse model: task-oriented and concept-driven interpretations. Behavioural brain research. 2022-11-07. PMID:36343696. depression-related phenotypes at early stages of aβ and tau accumulation in inducible alzheimer's disease mouse model: task-oriented and concept-driven interpretations. 2022-11-07 2023-08-14 mouse
Steffen Pockes, Michael A Walters, Karen H Ash. Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias. Translational research : the journal of laboratory and clinical medicine. 2022-11-07. PMID:36343883. targeting caspase-2 interactions with tau in alzheimer's disease and related dementias. 2022-11-07 2023-08-14 Not clear
Steffen Pockes, Michael A Walters, Karen H Ash. Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias. Translational research : the journal of laboratory and clinical medicine. 2022-11-07. PMID:36343883. targeting amyloid-β plaques and tau tangles has failed to provide effective treatments for alzheimer's disease and related dementias (adrd). 2022-11-07 2023-08-14 Not clear
Pablo Martinez, Henika Patel, Yanwen You, Nur Jury, Abigail Perkins, Audrey Lee-Gosselin, Xavier Taylor, Yingjian You, Gonzalo Viana Di Prisco, Xiaoqing Huang, Sayan Dutta, Aruna B Wijeratne, Javier Redding-Ochoa, Syed Salman Shahid, Juan F Codocedo, Sehong Min, Gary E Landreth, Amber L Mosley, Yu-Chien Wu, David L McKinzie, Jean-Christophe Rochet, Jie Zhang, Brady K Atwood, Juan Troncoso, Cristian A Lasagna-Reeve. Bassoon contributes to tau-seed propagation and neurotoxicity. Nature neuroscience. 2022-11-07. PMID:36344699. tau aggregation is a defining histopathological feature of alzheimer's disease and other tauopathies. 2022-11-07 2023-08-14 mouse
Pablo Martinez, Henika Patel, Yanwen You, Nur Jury, Abigail Perkins, Audrey Lee-Gosselin, Xavier Taylor, Yingjian You, Gonzalo Viana Di Prisco, Xiaoqing Huang, Sayan Dutta, Aruna B Wijeratne, Javier Redding-Ochoa, Syed Salman Shahid, Juan F Codocedo, Sehong Min, Gary E Landreth, Amber L Mosley, Yu-Chien Wu, David L McKinzie, Jean-Christophe Rochet, Jie Zhang, Brady K Atwood, Juan Troncoso, Cristian A Lasagna-Reeve. Bassoon contributes to tau-seed propagation and neurotoxicity. Nature neuroscience. 2022-11-07. PMID:36344699. we identified bassoon (bsn), a presynaptic scaffolding protein, as an interactor of the tau seed isolated from a mouse model of tauopathy, and from alzheimer's disease and progressive supranuclear palsy postmortem samples. 2022-11-07 2023-08-14 mouse
Alexa Pichet Binette, Nicolai Franzmeier, Nicola Spotorno, Michael Ewers, Matthias Brendel, Davina Biel, Olof Strandberg, Shorena Janelidze, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Ruben Smith, Erik Stomrud, Rik Ossenkoppele, Oskar Hansso. Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer's disease. Nature communications. vol 13. issue 1. 2022-11-05. PMID:36333294. amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early alzheimer's disease. 2022-11-05 2023-08-14 human
Alexa Pichet Binette, Nicolai Franzmeier, Nicola Spotorno, Michael Ewers, Matthias Brendel, Davina Biel, Olof Strandberg, Shorena Janelidze, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Ruben Smith, Erik Stomrud, Rik Ossenkoppele, Oskar Hansso. Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer's disease. Nature communications. vol 13. issue 1. 2022-11-05. PMID:36333294. therefore, we set out to investigate how aβ and soluble phosphorylated tau (p-tau) relate to the accumulation of tau aggregates assessed with pet and subsequent cognitive decline across the alzheimer's disease (ad) continuum. 2022-11-05 2023-08-14 human
Gerard J Nuovo, David Suster, Dwitiya Sawant, Aditi Mishra, Jean-Jacques Michaille, Esmerina Til. The amplification of CNS damage in Alzheimer's disease due to SARS-CoV2 infection. Annals of diagnostic pathology. vol 61. 2022-11-05. PMID:36334414. immunohistochemistry analyses for hyperphosphorylated tau protein, α-synuclein, and β-amyloid-42 confirmed the diagnoses of alzheimer's disease (n = 4), and lewy body dementia (n = 1) in the covid-19 group. 2022-11-05 2023-08-14 human
Gerard J Nuovo, David Suster, Dwitiya Sawant, Aditi Mishra, Jean-Jacques Michaille, Esmerina Til. The amplification of CNS damage in Alzheimer's disease due to SARS-CoV2 infection. Annals of diagnostic pathology. vol 61. 2022-11-05. PMID:36334414. it is concluded that fatal covid-19 induces a diffuse microencephalitis and microglial activation in the brain due to endocytosis of circulating viral spike protein that amplifies pre-existing dementia in at least two ways: 1) modulates the expression of proteins that may worsen alzheimer's disease and 2) stresses the already dysfunctional neurons by causing an acute proinflammatory/hypercoagulable/hypoxic microenvironment in areas with abundant hyperphosphorylated tau protein and/or βa-42. 2022-11-05 2023-08-14 human
Edita Sarukhanyan, Thomas Dandeka. Journal of biomolecular structure & dynamics. 2022-11-04. PMID:36331069. alzheimer's disease evolves when tau proteins are abnormally phosphorylated. 2022-11-04 2023-08-14 Not clear
Tushar Dubey, Shweta Kishor Sonawane, Mk Chaitanya Mannava, Ashwini K Nangia, Madhura Chandrashekar, Subashchandrabose Chinnathamb. The inhibitory effect of Curcumin-Artemisinin co-amorphous on Tau aggregation and Tau phosphorylation. Colloids and surfaces. B, Biointerfaces. vol 221. 2022-11-04. PMID:36332313. tau neurofibrillary tangles are one of the hallmarks of alzheimer's disease. 2022-11-04 2023-08-14 Not clear
Tushar Dubey, Shweta Kishor Sonawane, Mk Chaitanya Mannava, Ashwini K Nangia, Madhura Chandrashekar, Subashchandrabose Chinnathamb. The inhibitory effect of Curcumin-Artemisinin co-amorphous on Tau aggregation and Tau phosphorylation. Colloids and surfaces. B, Biointerfaces. vol 221. 2022-11-04. PMID:36332313. thus, curcumin and cur-art co-amorphous exhibit therapeutic potential against tau protein in alzheimer's disease. 2022-11-04 2023-08-14 Not clear
Lisa Diez, Larisa E Kapinos, Roderick Y H Lim, Susanne Wegman. Analysis of Tau/Nucleoporin Interactions by Surface Plasmon Resonance Spectroscopy. Methods in molecular biology (Clifton, N.J.). vol 2551. 2022-10-31. PMID:36310199. in alzheimer's disease and other tauopathies, tau is altered into forming intracellular neurofibrillary tangles; additionally, also a mislocalization from the cytosol to the nucleus has been observed where interactions of tau with the nucleus become possible. 2022-10-31 2023-08-14 Not clear
Senthilvelrajan Kaniyappan, Varun Balaji, Yipeng Wang, Eckhard Mandelko. Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 2551. 2022-10-31. PMID:36310200. microfluidic chamber technology to study missorting and spreading of tau protein in alzheimer's disease. 2022-10-31 2023-08-14 Not clear
Senthilvelrajan Kaniyappan, Varun Balaji, Yipeng Wang, Eckhard Mandelko. Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 2551. 2022-10-31. PMID:36310200. abnormal changes in tau (e.g., aggregation, hyperphosphorylation) are hallmarks of alzheimer's disease. 2022-10-31 2023-08-14 Not clear