| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Steward, Davina Biel, Matthias Brendel, Anna Dewenter, Sebastian Roemer, Anna Rubinski, Ying Luan, Martin Dichgans, Michael Ewers, Nicolai Franzmeie. Functional network segregation is associated with attenuated tau spreading in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-26. PMID:36433865. |
lower network segregation is associated with accelerated cognitive decline in alzheimer's disease (ad), yet it is unclear whether less segregated brain networks facilitate connectivity-mediated tau spreading. |
2022-11-26 |
2023-08-14 |
Not clear |
| Mehboob Hoque, Arijit Samanta, Syed Sahajada Mahafujul Alam, Torki A Zughaibi, Mohammad Amjad Kamal, Shams Tabre. Nanomedicine-based immunotherapy for Alzheimer's Disease. Neuroscience and biobehavioral reviews. 2022-11-26. PMID:36435391. |
alzheimer's disease (ad) is the most prevalent neurodegenerative disease caused by the deposition of amyloid β (aβ) fibrils forming extracellular plaques and the development of neurofibrillary tangles (nft) of intracellular hyperphosphorylated tau protein. |
2022-11-26 |
2023-08-14 |
Not clear |
| Zdeněk Fiša. Linking the Amyloid, Tau, and Mitochondrial Hypotheses of Alzheimer's Disease and Identifying Promising Drug Targets. Biomolecules. vol 12. issue 11. 2022-11-24. PMID:36421690. |
linking the amyloid, tau, and mitochondrial hypotheses of alzheimer's disease and identifying promising drug targets. |
2022-11-24 |
2023-08-14 |
Not clear |
| Shuai Zhao, Ziqi Fan, Xinyi Zhang, Zheyu Li, Ting Shen, Kaicheng Li, Yaping Yan, Yunfeng Yuan, Jiali Pu, Jun Tian, Zhirong Liu, Yanxing Chen, Baorong Zhan. Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-11-24. PMID:36422837. |
accumulation of neurofibrillary tangles (nfts) composed of hyperphosphorylated tau is a histopathological hallmark of alzheimer's disease (ad) and related tauopathies. |
2022-11-24 |
2023-08-14 |
mouse |
| Gøril Rolfseng Grøntvedt, Sigrid Botne Sando, Camilla Lauridsen, Geir Bråthen, Linda R White, Øyvind Salvesen, Dag Aarsland, Erik Hessen, Tormod Fladby, Knut Waterloo, Katja Scheffle. Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden. JAMA network open. vol 5. issue 11. 2022-11-22. PMID:36413367. |
association of klotho protein levels and kl-vs heterozygosity with alzheimer disease and amyloid and tau burden. |
2022-11-22 |
2023-08-14 |
Not clear |
| Heikki Lukkarinen, Aleksi Vanninen, Ina Tesseur, Darrel Pemberton, Peter Van Der Ark, Tarja Kokkola, Sanna-Kaisa Herukka, Tuomas Rauramaa, Mikko Hiltunen, Kaj Blennow, Henrik Zetterberg, Ville Leinone. Concordance of Alzheimer's Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus. Journal of Alzheimer's disease : JAD. 2022-11-21. PMID:36404546. |
alzheimer's disease cerebrospinal fluid (csf) biomarkers amyloid-β 1-42 (aβ42), total tau (t-tau), and phosphorylated tau 181 (p-tau181) are widely used. |
2022-11-21 |
2023-08-14 |
Not clear |
| Jianhao Bai, Zhongqi Wan, Minli Wang, Xue Wu, Tianyu Wang, Yuanyuan Zhang, Yawen Xue, Hong Xu, Qing Pen. Association of cognitive function with Neurofilament light chain in the aqueous humor of human eye. Frontiers in aging neuroscience. vol 14. 2022-11-21. PMID:36408096. |
to evaluate the predictive clinical role of neurofilament light chain (nfl), amyloid-β (aβ), glial fibrillary acidic protein (gfap), and phosphorylated tau at threonine 181 (p-tau181) proteins in human aqueous humor (ah) and quantify the retinal macular microvascular parameters by optical coherence tomography angiography (octa) as early diagnostic markers of alzheimer's disease (ad). |
2022-11-21 |
2023-08-14 |
human |
| M I Holubiec, M Gellert, E M Hanschman. Redox signaling and metabolism in Alzheimer's disease. Frontiers in aging neuroscience. vol 14. 2022-11-21. PMID:36408110. |
alzheimer's disease (ad) is a neurodegenerative pathology linked to both, abnormal amyloid precursor protein (app) processing, generating aβ peptide, and tau hyperphosphorylation and aggregation. |
2022-11-21 |
2023-08-14 |
Not clear |
| Daniel Lee, Virginia M-Y Lee, Seong Kwon Hu. Manipulation of the diet-microbiota-brain axis in Alzheimer's disease. Frontiers in neuroscience. vol 16. 2022-11-21. PMID:36408394. |
several studies investigating the pathogenesis of alzheimer's disease have identified various interdependent constituents contributing to the exacerbation of the disease, including aβ plaque formation, tau protein hyperphosphorylation, neurofibrillary tangle accumulation, glial inflammation, and the eventual loss of proper neural plasticity. |
2022-11-21 |
2023-08-14 |
human |
| Sumra Malik, G A Miana, Athar Ata, Madiha Kanwal, Saima Maqsood, Imran Malik, Zartashia Kazm. Synthesis, characterization, in-silico, and pharmacological evaluation of new 2-amino-6‑trifluoromethoxy benzothiazole derivatives. Bioorganic chemistry. vol 130. 2022-11-21. PMID:36410112. |
alzheimer's disease (ad), a relentless neurodegenerative disorder, is still waiting for safer profile drugs, risk factors affecting ad's pathogenesis include aβ accumulation, tau protein hyperphosphorylation, and neuroinflammation. |
2022-11-21 |
2023-08-14 |
Not clear |
| Nastaran Karimi, Feyza Bayram Çatak, Ebru Arslan, Amene Saghazadeh, Nima Rezae. Tau immunotherapy in Alzheimer's disease and progressive supranuclear palsy. International immunopharmacology. vol 113. issue Pt B. 2022-11-21. PMID:36410182. |
tau immunotherapy in alzheimer's disease and progressive supranuclear palsy. |
2022-11-21 |
2023-08-14 |
Not clear |
| Gillian Carling, Wenjie Luo, Li Ga. Friend turned foe: TREM2 agonist in battles against tau. The Journal of experimental medicine. vol 220. issue 1. 2022-11-18. PMID:36399126. |
med.https://doi.org/10.1084/jem.20220654) find that chronic trem2 activation by al002a antibody exacerbates the seeding and spread of pathological tau, enhances the disease-associated microglial signature, and increases neurite dystrophy in 5xfad mice seeded with alzheimer's disease tau. |
2022-11-18 |
2023-08-14 |
mouse |
| Stéphanie Levert, Julie Pilliod, Étienne Aumont, Sandrine Armanville, Cyntia Tremblay, Frédéric Calon, Nicole Lecler. Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells. Molecular neurobiology. 2022-11-18. PMID:36399251. |
in alzheimer disease (ad), tau, an axonal microtubule-associated protein, becomes hyperphosphorylated, detaches from microtubules, accumulates, and self-aggregates in the somatodendritic (sd) compartment. |
2022-11-18 |
2023-08-14 |
Not clear |
| Geoffrey Pires, Beatrix Ueberheide, Thomas Wisniewski, Eleanor Drummon. Use of Affinity Purification-Mass Spectrometry to Identify Phosphorylated Tau Interactors in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 2561. 2022-11-18. PMID:36399275. |
use of affinity purification-mass spectrometry to identify phosphorylated tau interactors in alzheimer's disease. |
2022-11-18 |
2023-08-14 |
human |
| Geoffrey Pires, Beatrix Ueberheide, Thomas Wisniewski, Eleanor Drummon. Use of Affinity Purification-Mass Spectrometry to Identify Phosphorylated Tau Interactors in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 2561. 2022-11-18. PMID:36399275. |
phosphorylated tau is the main protein present in neurofibrillary tangles, the presence of which is a key neuropathological hallmark of alzheimer's disease (ad). |
2022-11-18 |
2023-08-14 |
human |
| Carlo Condello, Gregory E Merz, Atsushi Aoyagi, William F DeGrado, Stanley B Prusine. Aβ and Tau Prions Causing Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 2561. 2022-11-18. PMID:36399277. |
aβ and tau prions causing alzheimer's disease. |
2022-11-18 |
2023-08-14 |
mouse |
| Carlo Condello, Gregory E Merz, Atsushi Aoyagi, William F DeGrado, Stanley B Prusine. Aβ and Tau Prions Causing Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 2561. 2022-11-18. PMID:36399277. |
studies show that patients with alzheimer's disease (ad) have both aβ and tau prions, and thus, ad is a double-prion disease. |
2022-11-18 |
2023-08-14 |
mouse |
| Maria Rosaria Tropea, Walter Gulisano, Valeria Vacanti, Ottavio Arancio, Daniela Puzzo, Agostino Palmer. Nitric oxide/cGMP/CREB pathway and amyloid-beta crosstalk: From physiology to Alzheimer's disease. Free radical biology & medicine. 2022-11-18. PMID:36400326. |
the no/cgmp/creb signaling is downregulated during aging and neurodegenerative disorders and is affected by amyloid-β peptide (aβ) and tau protein, whose increase and deposition is considered the key pathogenic event of alzheimer's disease (ad). |
2022-11-18 |
2023-08-14 |
Not clear |
| Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Rambabu N Reddi, Ananth Kumar Kammala, Karthick Vasudevan, Sanjib Senapati, Zhou Zhu, Cheng-Fu Su, Jia Liu, Xin-Jie Guan, Ka-Kit Chua, King-Ho Cheung, Hubiao Chen, Hong-Jie Zhang, Yuan Zhang, Ju-Xian Song, Siva Sundara Kumar Durairajan, Min L. Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer's disease therapy. Frontiers in molecular biosciences. vol 9. 2022-11-17. PMID:36387280. |
bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for alzheimer's disease therapy. |
2022-11-17 |
2023-08-14 |
Not clear |
| Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Rambabu N Reddi, Ananth Kumar Kammala, Karthick Vasudevan, Sanjib Senapati, Zhou Zhu, Cheng-Fu Su, Jia Liu, Xin-Jie Guan, Ka-Kit Chua, King-Ho Cheung, Hubiao Chen, Hong-Jie Zhang, Yuan Zhang, Ju-Xian Song, Siva Sundara Kumar Durairajan, Min L. Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer's disease therapy. Frontiers in molecular biosciences. vol 9. 2022-11-17. PMID:36387280. |
emerging evidence from alzheimer's disease (ad) patients suggests that reducing tau pathology can restore cognitive and memory loss. |
2022-11-17 |
2023-08-14 |
Not clear |