All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Gunel Ayyubov. Dysfunctional microglia and tau pathology in Alzheimer's disease. Reviews in the neurosciences. 2022-10-27. PMID:36302379. dysfunctional microglia and tau pathology in alzheimer's disease. 2022-10-27 2023-08-14 human
Pai-Yi Chiu, Fu-Chi Yang, Ming-Jang Chiu, Wei-Che Lin, Cheng-Hsien Lu, Shieh-Yueh Yan. Relevance of plasma biomarkers to pathologies in Alzheimer's disease, Parkinson's disease and frontotemporal dementia. Scientific reports. vol 12. issue 1. 2022-10-26. PMID:36289355. amyloid plaques and tau tangles are pathological hallmarks of alzheimer's disease (ad). 2022-10-26 2023-08-14 human
C M Wischik, P Bentham, S Gauthier, S Miller, K Kook, B O Schelte. Oral Tau Aggregation Inhibitor for Alzheimer's Disease: Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate. The journal of prevention of Alzheimer's disease. vol 9. issue 4. 2022-10-25. PMID:36281683. oral tau aggregation inhibitor for alzheimer's disease: design, progress and basis for selection of the 16 mg/day dose in a phase 3, randomized, placebo-controlled trial of hydromethylthionine mesylate. 2022-10-25 2023-08-14 Not clear
C M Wischik, P Bentham, S Gauthier, S Miller, K Kook, B O Schelte. Oral Tau Aggregation Inhibitor for Alzheimer's Disease: Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate. The journal of prevention of Alzheimer's disease. vol 9. issue 4. 2022-10-25. PMID:36281683. hydromethylthionine mesylate is a tau aggregation inhibitor shown to have exposure-dependent pharmacological activity on cognitive decline and brain atrophy in two completed phase 3 trials in mild/moderate alzheimer's disease (ad). 2022-10-25 2023-08-14 Not clear
Kaitlin M Stouffer, Zhenzhen Wang, Eileen Xu, Karl Lee, Paige Lee, Michael I Miller, Daniel J Twar. From Picoscale Pathology to Decascale Disease: Image Registration with a Scattering Transform and Varifolds for Manipulating Multiscale Data. Multimodal learning for clinical decision support : 11th International Workshop, ML-CDS 2021, held in conjunction with MICCAI 2021, Strasbourg, France, October 1, 2021, Proceedings. ML-CDS (Workshop) (11th : 2021 : Online). vol 13050. 2022-10-25. PMID:36283001. we use our methods to quantify microscopic tau pathology across macroscopic 3d regions of the medial temporal lobe to address a major challenge in the diagnosis of alzheimer's disease-the reliance on invasive methods to detect microscopic pathology. 2022-10-25 2023-08-14 Not clear
Tianxin Xie, Yuying Li, Chuan Tian, Chang Yuan, Bin Dai, Shubo Wang, Kaixiang Zhou, Jiaqi Liu, Hongwei Tan, Yi Liang, Jiapei Dai, Baian Chen, Mengchao Cu. Fused Cycloheptatriene-BODIPY Is a High-Performance Near-Infrared Probe to Image Tau Tangles. Journal of medicinal chemistry. 2022-10-25. PMID:36283122. neurofibrillary tangles (nfts), which are composed of abnormally hyperphosphorylated tau, are one of the main pathologic hallmarks of alzheimer's disease and other tauopathies. 2022-10-25 2023-08-14 Not clear
Javier Andrés Muñiz, Carolina Lucía Facal, Leandro Urrutia, Ramiro Clerici-Delville, Ana Damianich, Juan E Ferrario, Germán Falasco, María Elena Aval. SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy. Frontiers in bioengineering and biotechnology. vol 10. 2022-10-24. PMID:36277399. abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, such as alzheimer's disease and frontotemporal dementia. 2022-10-24 2023-08-14 human
Julia J Segura-Uribe, Paola Garcia-de la Torre, Tzayaka Castillo-Mendieta, Iván Bribiesca-Cruz, Sandra Orozco-Suárez, Marvin Soriano-Ursúa, Rodolfo Pinto-Almazán, Claudia Fuentes-Venado, Christian Guerra-Araiz. Tibolone Improves Memory and Decreases the Content of Amyloid-β Peptides and Tau Protein in the Hippocampus of a Mice Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-10-24. PMID:36278346. tibolone improves memory and decreases the content of amyloid-β peptides and tau protein in the hippocampus of a mice model of alzheimer's disease. 2022-10-24 2023-08-14 mouse
Ankur Kumar, Bhupender Nehra, Dilpreet Singh, Dileep Kuma, Pooja A Chawl. Recent advances in the development of nitrogen-containing heterocyclic Anti-Alzheimer's agents. Current topics in medicinal chemistry. 2022-10-24. PMID:36278462. alzheimer's disease is usually triggered by numerous associated factors, including depleted amount of acetylcholine (ach), excessive aggregation of β-amyloid peptide (aβ), tau hyperphosphorylation with neurofibrillary tangle formation as well as deposition of feeble plaques in a specific portion of the brain (hippocampus and cortex). 2022-10-24 2023-08-14 Not clear
E A Kovalenko, E V Makhnovich, N A Osinovskaya, A N Bogolepov. [Focused ultrasound as a non-invasive method with therapeutic potential in patients with Alzheimer's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 122. issue 10. 2022-10-24. PMID:36279227. alzheimer's disease (ad) is a common, progressive neurodegenerative disease characterized by abnormal deposition of β-amyloid (aβ) and hyperphosphorylated tau protein. 2022-10-24 2023-08-14 Not clear
Soumya Mukherjee, Celine Dubois, Keyla Perez, Shiji Varghese, Ian E Birchall, Miranda Leckey, Natalia Davydova, Catriona McLean, Rebecca M Nisbet, Blaine R Roberts, Qiao-Xin Li, Colin L Masters, Victor A Streltso. Quantitative proteomics of tau and Aβ in detergent fractions from Alzheimer's disease brains. Journal of neurochemistry. 2022-10-22. PMID:36271678. quantitative proteomics of tau and aβ in detergent fractions from alzheimer's disease brains. 2022-10-22 2023-08-14 human
Soumya Mukherjee, Celine Dubois, Keyla Perez, Shiji Varghese, Ian E Birchall, Miranda Leckey, Natalia Davydova, Catriona McLean, Rebecca M Nisbet, Blaine R Roberts, Qiao-Xin Li, Colin L Masters, Victor A Streltso. Quantitative proteomics of tau and Aβ in detergent fractions from Alzheimer's disease brains. Journal of neurochemistry. 2022-10-22. PMID:36271678. the two hallmarks of alzheimer's disease (ad) are amyloid-β (aβ) plaques and neurofibrillary tangles marked by phosphorylated tau. 2022-10-22 2023-08-14 human
Pei-Hao Chen, Sang-Yi Lin, Ying-Yi Liao, Wei-Ling Hsu, Fang-Yu Chen. Associations between blood-based biomarkers of Alzheimer's disease with cognition in motoric cognitive risk syndrome: A pilot study using plasma Aβ42 and total tau. Frontiers in aging neuroscience. vol 14. 2022-10-21. PMID:36268195. associations between blood-based biomarkers of alzheimer's disease with cognition in motoric cognitive risk syndrome: a pilot study using plasma aβ42 and total tau. 2022-10-21 2023-08-14 Not clear
Emma S Davies, Russell M Morphew, David Cutress, A Jennifer Morton, Sebastian McBrid. Characterization of microtubule-associated protein tau isoforms and Alzheimer's disease-like pathology in normal sheep (Ovis aries): relevance to their potential as a model of Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 79. issue 11. 2022-10-21. PMID:36269420. characterization of microtubule-associated protein tau isoforms and alzheimer's disease-like pathology in normal sheep (ovis aries): relevance to their potential as a model of alzheimer's disease. 2022-10-21 2023-08-14 Not clear
Emma S Davies, Russell M Morphew, David Cutress, A Jennifer Morton, Sebastian McBrid. Characterization of microtubule-associated protein tau isoforms and Alzheimer's disease-like pathology in normal sheep (Ovis aries): relevance to their potential as a model of Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 79. issue 11. 2022-10-21. PMID:36269420. we identified numerous intraneuronal aggregates of both β-amyloid and tau that are consistent with early alzheimer's disease-like pathology. 2022-10-21 2023-08-14 Not clear
Emma S Davies, Russell M Morphew, David Cutress, A Jennifer Morton, Sebastian McBrid. Characterization of microtubule-associated protein tau isoforms and Alzheimer's disease-like pathology in normal sheep (Ovis aries): relevance to their potential as a model of Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 79. issue 11. 2022-10-21. PMID:36269420. together, these data show that sheep exhibit naturally occurring β-amyloid and tau pathologies, that reflect those that occur in the early stages of alzheimer's disease. 2022-10-21 2023-08-14 Not clear
Ahmed K ElHady, Dalia S El-Gamil, Ashraf H Abadi, Mohammad Abdel-Halim, Matthias Enge. An overview of cdc2-like kinase 1 (Clk1) inhibitors and their therapeutic indications. Medicinal research reviews. 2022-10-20. PMID:36262046. in addition, clk1 was found to contribute to the progression of alzheimer's disease through causing an imbalance of tau splicing products. 2022-10-20 2023-08-14 mouse
Pinky Gehlot, Sunil Kumar, Vivek Kumar Vyas, Bhanwar Singh Choudhary, Manish Sharma, Ruchi Mali. Guanidine-based β amyloid precursor protein cleavage enzyme 1 (BACE-1) inhibitors for the Alzheimer's disease (AD): A review. Bioorganic & medicinal chemistry. vol 74. 2022-10-20. PMID:36265268. alzheimer's disease (ad) is an irreversible, progressive neurological disorder characterized by amyloid plaques, hyperphosphorylated tau protein (hyper p-tau), neuronal damage, memory loss, etc. 2022-10-20 2023-08-14 Not clear
Manasi Agrawal, Anil K Agrawa. Pathophysiological Association Between Diabetes Mellitus and Alzheimer's Disease. Cureus. vol 14. issue 9. 2022-10-19. PMID:36258952. both alzheimer's disease and dm are linked with decreased insulin secretion, reduced uptake of glucose, raised oxidative stress, angiopathy, activation of the apoptotic pathway, aging, abnormal peroxidation of lipids, increased production of advanced glycation end products and tau phosphorylation, brain atrophy, and decreased fat metabolism. 2022-10-19 2023-08-14 Not clear
Laura Gómez-Virgilio, Gabriela S Reyes-Gutiérrez, María-Del-C Silva-Lucero, Gustavo López-Toledo, María-Del-C Cárdenas-Aguay. Etiology, risk factors, treatments and current status of Alzheimer's disease in Mexico. Gaceta medica de Mexico. vol 158. issue 4. 2022-10-18. PMID:36256566. approval of this antibody as a disease-modifying treatment for alzheimer's disease opens the door to continue using this type of treatments, but with different therapeutic targets, such as, for example, tau protein. 2022-10-18 2023-08-14 human