| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anqesha Murray, Lufeng Yan, James M Gibson, Jian Liu, David Eliezer, Guy Lippens, Fuming Zhang, Robert J Linhardt, Jing Zhao, Chunyu Wan. Proline-Rich Region II (PRR2) Plays an Important Role in Tau-Glycan Interaction: An NMR Study. Biomolecules. vol 12. issue 11. 2022-11-11. PMID:36358923. |
(1) background: prion-like transcellular spreading of tau pathology in alzheimer's disease (ad) is mediated by tau binding to the cell-surface glycan heparan sulfate (hs). |
2022-11-11 |
2023-08-14 |
Not clear |
| Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Zheng-Kui Weng, Ying-Chieh Sun, Wenwei Lin, Guey-Jen Lee-Chen, Chiung-Mei Che. Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protein. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361524. |
hyperphosphorylation and aggregation of the microtubule binding protein tau is a neuropathological hallmark of alzheimer's disease/tauopathies. |
2022-11-11 |
2023-08-14 |
Not clear |
| Priyanka Rawat, Ujala Sehar, Jasbir Bisht, Ashley Selman, John Culberson, P Hemachandra Redd. Phosphorylated Tau in Alzheimer's Disease and Other Tauopathies. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361631. |
phosphorylated tau in alzheimer's disease and other tauopathies. |
2022-11-11 |
2023-08-14 |
Not clear |
| Priyanka Rawat, Ujala Sehar, Jasbir Bisht, Ashley Selman, John Culberson, P Hemachandra Redd. Phosphorylated Tau in Alzheimer's Disease and Other Tauopathies. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361631. |
tauopathies, including pick's disease, frontotemporal dementia, corticobasal degeneration, alzheimer's disease, argyrophilic grain disease, progressive supranuclear palsy, and huntington's disease, are the result of misprocessing and accumulation of tau within the neuronal and glial cells. |
2022-11-11 |
2023-08-14 |
Not clear |
| Ergina Vourkou, Vassilis Paspaliaris, Anna Bourouliti, Maria-Christina Zerva, Engie Prifti, Katerina Papanikolopoulou, Efthimios M C Skoulaki. Differential Effects of Human Tau Isoforms to Neuronal Dysfunction and Toxicity in the Drosophila CNS. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361774. |
accumulation of highly post-translationally modified tau proteins is a hallmark of neurodegenerative disorders known as tauopathies, the most common of which is alzheimer's disease. |
2022-11-11 |
2023-08-14 |
human |
| Rocio Alfaro-Ruiz, Carolina Aguado, Alejandro Martín-Belmonte, Ana Esther Moreno-Martínez, Jesús Merchán-Rubira, Félix Hernández, Jesús Ávila, Yugo Fukazawa, Rafael Lujá. Alteration in the Synaptic and Extrasynaptic Organization of AMPA Receptors in the Hippocampus of P301S Tau Transgenic Mice. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362317. |
tau pathology is a hallmark of alzheimer's disease (ad) and other tauopathies, but how pathological tau accumulation alters the glutamate receptor dynamics driving synaptic dysfunction is unclear. |
2022-11-11 |
2023-08-14 |
mouse |
| Kwan H Cheng, Angela Graf, Amber Lewis, Thuong Pham, Aakriti Achary. Exploring Membrane Binding Targets of Disordered Human Tau Aggregates on Lipid Rafts Using Multiscale Molecular Dynamics Simulations. Membranes. vol 12. issue 11. 2022-11-11. PMID:36363654. |
the self-aggregation of tau, a microtubule-binding protein, has been linked to the onset of alzheimer's disease. |
2022-11-11 |
2023-08-14 |
human |
| Kwan H Cheng, Angela Graf, Amber Lewis, Thuong Pham, Aakriti Achary. Exploring Membrane Binding Targets of Disordered Human Tau Aggregates on Lipid Rafts Using Multiscale Molecular Dynamics Simulations. Membranes. vol 12. issue 11. 2022-11-11. PMID:36363654. |
the molecular details of these specific and non-specific tau bindings to lipid rafts may provide new insights into understanding membrane-associated tauopathies leading to alzheimer's disease. |
2022-11-11 |
2023-08-14 |
human |
| Daniel A Llano, Priya Devanarayan, Viswanath Devanaraya. CSF peptides from VGF and other markers enhance prediction of MCI to AD progression using the ATN framework. Neurobiology of aging. vol 121. 2022-11-11. PMID:36368195. |
the amyloid beta, tau, neurodegenerative markers framework has been proposed to serve as a system to classify and combine biomarkers for alzheimer's disease (ad). |
2022-11-11 |
2023-08-14 |
human |
| Maud Gratuze, Johannes C M Schlachetzki, Ricardo D'Oliveira Albanus, Nimansha Jain, Brenna Novotny, Logan Brase, Lea Rodriguez, Clayton Mansel, Michal Kipnis, Sydney O'Brien, Martina P Pasillas, Choonghee Lee, Melissa Manis, Marco Colonna, Oscar Harari, Christopher K Glass, Jason D Ulrich, David M Holtzma. TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4. Neuron. 2022-11-11. PMID:36368315. |
in addition to tau and aβ pathologies, inflammation plays an important role in alzheimer's disease (ad). |
2022-11-11 |
2023-08-14 |
mouse |
| Alexandra J Weigand, Abbey M Hamlin, Jordana Breton, Alexandra L Clar. Cerebral blood flow, tau imaging, and memory associations in cognitively unimpaired older adults. Cerebral circulation - cognition and behavior. vol 3. 2022-11-10. PMID:36353072. |
cerebral blood flow (cbf) has been independently linked to cognitive impairment and traditional alzheimer's disease (ad) pathology (e.g., amyloid-beta [aβ], tau) in older adults. |
2022-11-10 |
2023-08-14 |
Not clear |
| Pulak R Manna, Arubala P Reddy, Jangampalli Adi Pradeepkiran, Sudhir Kshirsagar, P Hemachandra Redd. Regulation of retinoid mediated StAR transcription and steroidogenesis in hippocampal neuronal cells: Implications for StAR in protecting Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2022-11-10. PMID:36356843. |
loss of neuronal cells, involving accumulation of amyloid beta (aβ) and/or phosphorylated tau within the brain, is the pathological hallmark of alzheimer's disease (ad). |
2022-11-10 |
2023-08-14 |
mouse |
| Rik Ossenkoppele, Alexa Pichet Binette, Colin Groot, Ruben Smith, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Pontus Tideman, Tomas Ohlsson, Jonas Jögi, Keith Johnson, Reisa Sperling, Vincent Dore, Colin L Masters, Christopher Rowe, Denise Visser, Bart N M van Berckel, Wiesje M van der Flier, Suzanne Baker, William J Jagust, Heather J Wiste, Ronald C Petersen, Clifford R Jack, Oskar Hansso. Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline. Nature medicine. 2022-11-10. PMID:36357681. |
a major unanswered question in the dementia field is whether cognitively unimpaired individuals who harbor both alzheimer's disease neuropathological hallmarks (that is, amyloid-β plaques and tau neurofibrillary tangles) can preserve their cognition over time or are destined to decline. |
2022-11-10 |
2023-08-14 |
Not clear |
| Ling Wu, Nailya Gilyazova, John F Ervin, Shih-Hsiu J Wang, Bin X. Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation. ACS chemical neuroscience. 2022-11-09. PMID:36350059. |
tau aggregates are present in multiple neurodegenerative diseases known as "tauopathies," including alzheimer's disease (ad), pick's disease (pid), progressive supranuclear palsy (psp), and corticobasal degeneration (cbd). |
2022-11-09 |
2023-08-14 |
human |
| Xiaoying Chen, David M Holtzma. Emerging roles of innate and adaptive immunity in Alzheimer's disease. Immunity. 2022-11-09. PMID:36351425. |
alzheimer's disease (ad) is the most common neurodegenerative disease, with characteristic extracellular amyloid-β (aβ) deposition and intracellular accumulation of hyperphosphorylated, aggregated tau. |
2022-11-09 |
2023-08-14 |
Not clear |
| Giovanna Viola, Carlo Giorgio Barracchia, Roberto Tira, Francesca Parolini, Giulia Leo, Massimo Bellanda, Francesca Munari, Stefano Capaldi, Mariapina D'Onofrio, Michael Assfal. New Paradigm for Nano-Bio Interactions: Multimolecular Assembly of a Prototypical Disordered Protein with Ultrasmall Nanoparticles. Nano letters. 2022-11-08. PMID:36346924. |
as a model system, we focused on ultrasmall gold nanoparticles (usgnps) and tau, a cytosolic idp associated with alzheimer's disease. |
2022-11-08 |
2023-08-14 |
Not clear |
| Qiaolifan Aerqin, Zuo-Teng Wang, Kai-Min Wu, Xiao-Yu He, Qiang Dong, Jin-Tai Y. Omics-based biomarkers discovery for Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 79. issue 12. 2022-11-08. PMID:36348101. |
alzheimer's disease (ad) is the most common neurodegenerative disorders presenting with the pathological hallmarks of amyloid plaques and tau tangles. |
2022-11-08 |
2023-08-14 |
Not clear |
| Jonathan Blackman, Laura Stankeviciute, Eider M Arenaza-Urquijo, Marc Suárez-Calvet, Gonzalo Sánchez-Benavides, Natalia Vilor-Tejedor, Alejandro Iranzo, José Luis Molinuevo, Juan Domingo Gispert, Elizabeth Coulthard, Oriol Grau-River. Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults. Brain communications. vol 4. issue 6. 2022-11-07. PMID:36337343. |
this study included 1168 adults aged over 50 years with csf core alzheimer's disease biomarkers (total tau, phosphorylated tau and amyloid-beta), cognitive performance, and sleep quality (pittsburgh sleep quality index questionnaire) data. |
2022-11-07 |
2023-08-14 |
human |
| Yi Dong, Yuanjing Li, Keke Liu, Xiaolei Han, Rui Liu, Yifei Ren, Lin Cong, Qinghua Zhang, Tingting Hou, Lin Song, Shi Tang, Lin Shi, Yishan Luo, Grégoria Kalpouzos, Erika J Laukka, Bengt Winblad, Yongxiang Wang, Yifeng Du, Chengxuan Qi. Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-07. PMID:36341691. |
in the subsamples, we measured plasma amyloid beta (aβ)40, aβ42, total tau, and neurofilament light chain (nfl; n = 1054); and quantified hippocampal, entorhinal cortex, and white matter hyperintensity (wmh) volumes, and alzheimer's disease (ad)-signature cortical thickness (n = 917). |
2022-11-07 |
2023-08-14 |
human |
| Erica Leyder, Prakul Suresh, Rachel Jun, Katherine Overbey, Tirtho Banerjee, Tatiana Melnikova, Alena Savonenk. Depression-related phenotypes at early stages of Aβ and tau accumulation in inducible Alzheimer's disease mouse model: task-oriented and concept-driven interpretations. Behavioural brain research. 2022-11-07. PMID:36343696. |
depression-related phenotypes at early stages of aβ and tau accumulation in inducible alzheimer's disease mouse model: task-oriented and concept-driven interpretations. |
2022-11-07 |
2023-08-14 |
mouse |