| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Javier Andrés Muñiz, Carolina Lucía Facal, Leandro Urrutia, Ramiro Clerici-Delville, Ana Damianich, Juan E Ferrario, Germán Falasco, María Elena Aval. SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy. Frontiers in bioengineering and biotechnology. vol 10. 2022-10-24. PMID:36277399. |
abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, such as alzheimer's disease and frontotemporal dementia. |
2022-10-24 |
2023-08-14 |
human |
| Julia J Segura-Uribe, Paola Garcia-de la Torre, Tzayaka Castillo-Mendieta, Iván Bribiesca-Cruz, Sandra Orozco-Suárez, Marvin Soriano-Ursúa, Rodolfo Pinto-Almazán, Claudia Fuentes-Venado, Christian Guerra-Araiz. Tibolone Improves Memory and Decreases the Content of Amyloid-β Peptides and Tau Protein in the Hippocampus of a Mice Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-10-24. PMID:36278346. |
tibolone improves memory and decreases the content of amyloid-β peptides and tau protein in the hippocampus of a mice model of alzheimer's disease. |
2022-10-24 |
2023-08-14 |
mouse |
| Ankur Kumar, Bhupender Nehra, Dilpreet Singh, Dileep Kuma, Pooja A Chawl. Recent advances in the development of nitrogen-containing heterocyclic Anti-Alzheimer's agents. Current topics in medicinal chemistry. 2022-10-24. PMID:36278462. |
alzheimer's disease is usually triggered by numerous associated factors, including depleted amount of acetylcholine (ach), excessive aggregation of β-amyloid peptide (aβ), tau hyperphosphorylation with neurofibrillary tangle formation as well as deposition of feeble plaques in a specific portion of the brain (hippocampus and cortex). |
2022-10-24 |
2023-08-14 |
Not clear |
| E A Kovalenko, E V Makhnovich, N A Osinovskaya, A N Bogolepov. [Focused ultrasound as a non-invasive method with therapeutic potential in patients with Alzheimer's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 122. issue 10. 2022-10-24. PMID:36279227. |
alzheimer's disease (ad) is a common, progressive neurodegenerative disease characterized by abnormal deposition of β-amyloid (aβ) and hyperphosphorylated tau protein. |
2022-10-24 |
2023-08-14 |
Not clear |
| Soumya Mukherjee, Celine Dubois, Keyla Perez, Shiji Varghese, Ian E Birchall, Miranda Leckey, Natalia Davydova, Catriona McLean, Rebecca M Nisbet, Blaine R Roberts, Qiao-Xin Li, Colin L Masters, Victor A Streltso. Quantitative proteomics of tau and Aβ in detergent fractions from Alzheimer's disease brains. Journal of neurochemistry. 2022-10-22. PMID:36271678. |
quantitative proteomics of tau and aβ in detergent fractions from alzheimer's disease brains. |
2022-10-22 |
2023-08-14 |
human |
| Soumya Mukherjee, Celine Dubois, Keyla Perez, Shiji Varghese, Ian E Birchall, Miranda Leckey, Natalia Davydova, Catriona McLean, Rebecca M Nisbet, Blaine R Roberts, Qiao-Xin Li, Colin L Masters, Victor A Streltso. Quantitative proteomics of tau and Aβ in detergent fractions from Alzheimer's disease brains. Journal of neurochemistry. 2022-10-22. PMID:36271678. |
the two hallmarks of alzheimer's disease (ad) are amyloid-β (aβ) plaques and neurofibrillary tangles marked by phosphorylated tau. |
2022-10-22 |
2023-08-14 |
human |
| Pei-Hao Chen, Sang-Yi Lin, Ying-Yi Liao, Wei-Ling Hsu, Fang-Yu Chen. Associations between blood-based biomarkers of Alzheimer's disease with cognition in motoric cognitive risk syndrome: A pilot study using plasma Aβ42 and total tau. Frontiers in aging neuroscience. vol 14. 2022-10-21. PMID:36268195. |
associations between blood-based biomarkers of alzheimer's disease with cognition in motoric cognitive risk syndrome: a pilot study using plasma aβ42 and total tau. |
2022-10-21 |
2023-08-14 |
Not clear |
| Emma S Davies, Russell M Morphew, David Cutress, A Jennifer Morton, Sebastian McBrid. Characterization of microtubule-associated protein tau isoforms and Alzheimer's disease-like pathology in normal sheep (Ovis aries): relevance to their potential as a model of Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 79. issue 11. 2022-10-21. PMID:36269420. |
characterization of microtubule-associated protein tau isoforms and alzheimer's disease-like pathology in normal sheep (ovis aries): relevance to their potential as a model of alzheimer's disease. |
2022-10-21 |
2023-08-14 |
Not clear |
| Emma S Davies, Russell M Morphew, David Cutress, A Jennifer Morton, Sebastian McBrid. Characterization of microtubule-associated protein tau isoforms and Alzheimer's disease-like pathology in normal sheep (Ovis aries): relevance to their potential as a model of Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 79. issue 11. 2022-10-21. PMID:36269420. |
we identified numerous intraneuronal aggregates of both β-amyloid and tau that are consistent with early alzheimer's disease-like pathology. |
2022-10-21 |
2023-08-14 |
Not clear |
| Emma S Davies, Russell M Morphew, David Cutress, A Jennifer Morton, Sebastian McBrid. Characterization of microtubule-associated protein tau isoforms and Alzheimer's disease-like pathology in normal sheep (Ovis aries): relevance to their potential as a model of Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 79. issue 11. 2022-10-21. PMID:36269420. |
together, these data show that sheep exhibit naturally occurring β-amyloid and tau pathologies, that reflect those that occur in the early stages of alzheimer's disease. |
2022-10-21 |
2023-08-14 |
Not clear |
| Ahmed K ElHady, Dalia S El-Gamil, Ashraf H Abadi, Mohammad Abdel-Halim, Matthias Enge. An overview of cdc2-like kinase 1 (Clk1) inhibitors and their therapeutic indications. Medicinal research reviews. 2022-10-20. PMID:36262046. |
in addition, clk1 was found to contribute to the progression of alzheimer's disease through causing an imbalance of tau splicing products. |
2022-10-20 |
2023-08-14 |
mouse |
| Pinky Gehlot, Sunil Kumar, Vivek Kumar Vyas, Bhanwar Singh Choudhary, Manish Sharma, Ruchi Mali. Guanidine-based β amyloid precursor protein cleavage enzyme 1 (BACE-1) inhibitors for the Alzheimer's disease (AD): A review. Bioorganic & medicinal chemistry. vol 74. 2022-10-20. PMID:36265268. |
alzheimer's disease (ad) is an irreversible, progressive neurological disorder characterized by amyloid plaques, hyperphosphorylated tau protein (hyper p-tau), neuronal damage, memory loss, etc. |
2022-10-20 |
2023-08-14 |
Not clear |
| Manasi Agrawal, Anil K Agrawa. Pathophysiological Association Between Diabetes Mellitus and Alzheimer's Disease. Cureus. vol 14. issue 9. 2022-10-19. PMID:36258952. |
both alzheimer's disease and dm are linked with decreased insulin secretion, reduced uptake of glucose, raised oxidative stress, angiopathy, activation of the apoptotic pathway, aging, abnormal peroxidation of lipids, increased production of advanced glycation end products and tau phosphorylation, brain atrophy, and decreased fat metabolism. |
2022-10-19 |
2023-08-14 |
Not clear |
| Laura Gómez-Virgilio, Gabriela S Reyes-Gutiérrez, María-Del-C Silva-Lucero, Gustavo López-Toledo, María-Del-C Cárdenas-Aguay. Etiology, risk factors, treatments and current status of Alzheimer's disease in Mexico. Gaceta medica de Mexico. vol 158. issue 4. 2022-10-18. PMID:36256566. |
approval of this antibody as a disease-modifying treatment for alzheimer's disease opens the door to continue using this type of treatments, but with different therapeutic targets, such as, for example, tau protein. |
2022-10-18 |
2023-08-14 |
human |
| Mohd Adnan, Saleha Anwar, Debarati DasGupta, Mitesh Patel, Abdelbaset Mohamed Elasbali, Hassan H Alhassan, Alaa Shafie, Arif Jamal Siddiqui, Fevzi Bardakci, Mejdi Snoussi, Md Imtaiyaz Hassa. Targeting inhibition of microtubule affinity regulating kinase 4 by Harmaline: Strategy to combat Alzheimer's disease. International journal of biological macromolecules. 2022-10-18. PMID:36257368. |
due to its direct role in the hyper-phosphorylation of tau protein, mark4 is considered as an attractive target to fight alzheimer's disease and neuroinflammation. |
2022-10-18 |
2023-08-14 |
Not clear |
| Ramón Martínez-Mármol, Christopher Small, Anmin Jiang, Tishila Palliyaguru, Tristan P Wallis, Rachel S Gormal, Jean-Baptiste Sibarita, Jürgen Götz, Frédéric A Meunie. Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates. Molecular psychiatry. 2022-10-18. PMID:36258016. |
postsynaptic enrichment of fyn underpins synaptotoxicity in dementias such as alzheimer's disease and frontotemporal lobar degeneration with tau pathology (ftld-tau). |
2022-10-18 |
2023-08-14 |
Not clear |
| Josef Marksteiner, Michaela Defrancesco, Christian Humpe. Saliva tau and phospho-tau-181 measured by Lumipulse in patients with Alzheimer's disease. Frontiers in aging neuroscience. vol 14. 2022-10-17. PMID:36247998. |
saliva tau and phospho-tau-181 measured by lumipulse in patients with alzheimer's disease. |
2022-10-17 |
2023-08-14 |
human |
| Pijush Chakraborty, Markus Zweckstette. Phase separation of the microtubule-associated protein tau. Essays in biochemistry. 2022-10-17. PMID:36251053. |
the aggregation and misfolding of the neuronal microtubule-associated protein tau is closely linked to the pathology of alzheimer's disease and several other neurodegenerative diseases. |
2022-10-17 |
2023-08-14 |
Not clear |
| Qiang Qiang, Loren Skudder-Hill, Tomoko Toyota, Wenshi Wei, Hiroaki Adach. CSF GAP-43 as a biomarker of synaptic dysfunction is associated with tau pathology in Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-10-17. PMID:36253408. |
csf gap-43 as a biomarker of synaptic dysfunction is associated with tau pathology in alzheimer's disease. |
2022-10-17 |
2023-08-14 |
human |
| b' Dietmar Rudolf Thal, Sandra O Tom\\xc3\\xa. The central role of tau in Alzheimer\'s disease: From neurofibrillary tangle maturation to the induction of cell death. Brain research bulletin. 2022-10-16. PMID:36244581.' |
the central role of tau in alzheimer's disease: from neurofibrillary tangle maturation to the induction of cell death. |
2022-10-16 |
2023-08-14 |
Not clear |