| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alisa Cario, Sanjula P Wickramasinghe, Elizabeth Rhoades, Christopher L Berge. The N-terminal disease-associated R5L Tau mutation increases microtubule shrinkage rate due to disruption of microtubule-bound Tau patches. The Journal of biological chemistry. 2022-09-26. PMID:36162501. |
tau misregulation is associated with a class of neurodegenerative diseases, known as tauopathies, including progressive supranuclear palsy (psp), pick's disease, and alzheimer's disease. |
2022-09-26 |
2023-08-14 |
Not clear |
| Michael L Alosco, Yi Su, Thor D Stein, Hillary Protas, Jonathan D Cherry, Charles H Adler, Laura J Balcer, Charles Bernick, Surya Vamsi Pulukuri, Bobak Abdolmohammadi, Michael J Coleman, Joseph N Palmisano, Yorghos Tripodis, Jesse Mez, Gil D Rabinovici, Kenneth L Marek, Thomas G Beach, Keith A Johnson, Bertrand Russell Huber, Inga Koerte, Alexander P Lin, Sylvain Bouix, Jeffrey L Cummings, Martha E Shenton, Eric M Reiman, Ann C McKee, Robert A Ster. Associations between near end-of-life flortaucipir PET and postmortem CTE-related tau neuropathology in six former American football players. European journal of nuclear medicine and molecular imaging. 2022-09-24. PMID:36152064. |
flourine-18-flortaucipir tau positron emission tomography (pet) was developed for the detection for alzheimer's disease. |
2022-09-24 |
2023-08-14 |
human |
| Subhamita Maitra, Bruno Vincen. Cdk5-p25 as a key element linking amyloid and tau pathologies in Alzheimer's disease: Mechanisms and possible therapeutic interventions. Life sciences. 2022-09-24. PMID:36152679. |
cdk5-p25 as a key element linking amyloid and tau pathologies in alzheimer's disease: mechanisms and possible therapeutic interventions. |
2022-09-24 |
2023-08-14 |
human |
| Subhamita Maitra, Bruno Vincen. Cdk5-p25 as a key element linking amyloid and tau pathologies in Alzheimer's disease: Mechanisms and possible therapeutic interventions. Life sciences. 2022-09-24. PMID:36152679. |
the present review highlights the pivotal roles of the hyperactive cdk5-p25 complex activity in contributing to the development of alzheimer's disease pathogenesis, with a particular emphasis on the linking function between aβ and tau that this kinase fulfils and on the fact that cdk5-p25 is part of a deleterious feed forward loop giving rise to a molecular machinery runaway leading to ad pathogenesis. |
2022-09-24 |
2023-08-14 |
human |
| Gemma Shireby, Emma L Dempster, Stefania Policicchio, Rebecca G Smith, Ehsan Pishva, Barry Chioza, Jonathan P Davies, Joe Burrage, Katie Lunnon, Dorothea Seiler Vellame, Seth Love, Alan Thomas, Keeley Brookes, Kevin Morgan, Paul Francis, Eilis Hannon, Jonathan Mil. DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types. Nature communications. vol 13. issue 1. 2022-09-24. PMID:36153390. |
alzheimer's disease (ad) is a chronic neurodegenerative disease characterized by the progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex. |
2022-09-24 |
2023-08-14 |
Not clear |
| Anna Rubinski, Nicolai Franzmeier, Anna Dewenter, Ying Luan, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Martin Dichgans, Oskar Hansson, Michael Ewer. Higher levels of myelin are associated with higher resistance against tau pathology in Alzheimer's disease. Alzheimer's research & therapy. vol 14. issue 1. 2022-09-24. PMID:36153607. |
higher levels of myelin are associated with higher resistance against tau pathology in alzheimer's disease. |
2022-09-24 |
2023-08-14 |
human |
| Anna Rubinski, Nicolai Franzmeier, Anna Dewenter, Ying Luan, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Martin Dichgans, Oskar Hansson, Michael Ewer. Higher levels of myelin are associated with higher resistance against tau pathology in Alzheimer's disease. Alzheimer's research & therapy. vol 14. issue 1. 2022-09-24. PMID:36153607. |
in alzheimer's disease (ad), fibrillar tau initially occurs locally and progresses preferentially between closely connected regions. |
2022-09-24 |
2023-08-14 |
human |
| Anna Mikhailovna Kosyreva, Alexandra Vladislavovna Sentyabreva, Ivan Sergeevich Tsvetkov, Olga Vasilievna Makarov. Alzheimer's Disease and Inflammaging. Brain sciences. vol 12. issue 9. 2022-09-23. PMID:36138973. |
one of the factors, which might play a key role in senile plaques and tau fibrils generation due to alzheimer's disease, is inflammaging, i.e., systemic chronic low-grade age-related inflammation. |
2022-09-23 |
2023-08-14 |
Not clear |
| Si Eun Kim, Hee Jin Kim, Hyemin Jang, Michael W Weiner, Charles DeCarli, Duk L Na, Sang Won Se. Interaction between Alzheimer's Disease and Cerebral Small Vessel Disease: A Review Focused on Neuroimaging Markers. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142419. |
alzheimer's disease (ad) is characterized by the presence of β-amyloid (aβ) and tau, and subcortical vascular cognitive impairment (svci) is characterized by cerebral small vessel disease (csvd). |
2022-09-23 |
2023-08-14 |
Not clear |
| Jinho Kim, ShinWoo Kang, Keun-A Chan. Effect of cx-DHED on Abnormal Glucose Transporter Expression Induced by AD Pathologies in the 5xFAD Mouse Model. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142509. |
alzheimer's disease (ad) is a form of dementia associated with abnormal glucose metabolism resulting from amyloid-beta (aβ) plaques and intracellular neurofibrillary tau protein tangles. |
2022-09-23 |
2023-08-14 |
mouse |
| Javad Sharifi-Rad, Simona Rapposelli, Simona Sestito, Jesús Herrera-Bravo, Alejandra Arancibia-Diaz, Luis A Salazar, Balakyz Yeskaliyeva, Ahmet Beyatli, Gerardo Leyva-Gómez, Carlos González-Contreras, Eda Sönmez Gürer, Miquel Martorell, Daniela Calin. Multi-Target Mechanisms of Phytochemicals in Alzheimer's Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation. Journal of personalized medicine. vol 12. issue 9. 2022-09-23. PMID:36143299. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by a tangle-shaped accumulation of beta-amyloid peptide fragments and tau protein in brain neurons. |
2022-09-23 |
2023-08-14 |
Not clear |
| Zachary Valiukas, Ramya Ephraim, Kathy Tangalakis, Majid Davidson, Vasso Apostolopoulos, Jack Feeha. Immunotherapies for Alzheimer's Disease-A Review. Vaccines. vol 10. issue 9. 2022-09-23. PMID:36146605. |
alzheimer's disease (ad) is a chronic neurodegenerative disorder that falls under the umbrella of dementia and is characterised by the presence of highly neurotoxic amyloid-beta (aβ) plaques and neurofibrillary tangles (nfts) of tau protein within the brain. |
2022-09-23 |
2023-08-14 |
Not clear |
| Jianfeng Wu, Yi Su, Eric M Reiman, Richard J Caselli, Kewei Chen, Paul M Thompson, Junwen Wang, Yalin Wan. INVESTIGATING THE EFFECT OF TAU DEPOSITION AND APOE ON HIPPOCAMPAL MORPHOMETRY IN ALZHEIMER'S DISEASE: A FEDERATED CHOW TEST MODEL. Proceedings. IEEE International Symposium on Biomedical Imaging. vol 2022. 2022-09-23. PMID:36147309. |
investigating the effect of tau deposition and apoe on hippocampal morphometry in alzheimer's disease: a federated chow test model. |
2022-09-23 |
2023-08-14 |
Not clear |
| Gary A Rosenber. Willis Lecture: Biomarkers for Inflammatory White Matter Injury in Binswanger Disease Provide Pathways to Precision Medicine. Stroke. 2022-09-23. PMID:36148658. |
it is possible to diagnose mixed dementia before autopsy with biomarkers for vascular disease derived from diffusor tensor images on magnetic resonance imaging and alzheimer disease proteins, aβ (amyloid β), and phosphorylated tau, in cerebrospinal fluid or in brain with positron emission tomography. |
2022-09-23 |
2023-08-14 |
Not clear |
| Bangfu Zhu, Tom Parsons, Christopher Foley, Yeng Shaw, Travis Dunckley, Christopher Hulme, James J L Hodg. DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity. Scientific reports. vol 12. issue 1. 2022-09-23. PMID:36151233. |
alzheimer's disease (ad) involves pathological processing of amyloid precursor protein (app) into amyloid-β and microtubule associated protein tau (mapt) into hyperphosphorylated tau tangles leading to neurodegeneration. |
2022-09-23 |
2023-08-14 |
human |
| Mehdi Azouz, Cécile Feuillie, Michel Lafleur, Michaël Molinari, Sophie Lecomt. Interaction of Tau construct K18 with model lipid membranes. Nanoscale advances. vol 3. issue 14. 2022-09-22. PMID:36132846. |
one of the hallmarks of alzheimer's disease (ad) is the formation of neurofibrillary tangles, resulting from the aggregation of the tubulin associated unit protein (tau), which holds a vital role in maintaining neuron integrity in a healthy brain. |
2022-09-22 |
2023-08-14 |
Not clear |
| Takashi Hara, Hanae Toyama, Yumi Ohata, Takeshi Ikeuchi, Sumiko Nakamura, Toshio Joh, Ken'ichi Ohtsub. Black rice bran intake reduces phosphorylated tau levels and enhances insulin signaling in the brain of aged normal mice. Bioscience, biotechnology, and biochemistry. 2022-09-21. PMID:36130217. |
brb holds promise for preventing the formation of neurofibrillary tangles consisting of hyperphosphorylated tau, a pathological hallmark of alzheimer's disease. |
2022-09-21 |
2023-08-14 |
mouse |
| Nicola Spotorno, Olof Strandberg, Geraline Vis, Erik Stomrud, Markus Nilsson, Oskar Hansso. Measures of cortical microstructure are linked to amyloid pathology in Alzheimer's disease. Brain : a journal of neurology. 2022-09-21. PMID:36130332. |
we aimed to investigate to what extent diffusion-mri can provide sensitive markers of cortical microstructural changes and to test their associations with multiple aspects of the alzheimer's disease pathological cascade, including both aβ and tau accumulation, astrocytic activation and cognitive deficits. |
2022-09-21 |
2023-08-14 |
human |
| Anna Rosenberg, Ulf Öhlund-Wistbacka, Anette Hall, Alexandre Bonnard, Göran Hagman, Marie Rydén, Charlotta Thunborg, Fleur Wiggenraad, Anna Sandebring-Matton, Alina Solomon, Miia Kivipelt. β-Amyloid, Tau, Neurodegeneration Classification and Eligibility for Anti-amyloid Treatment in a Memory Clinic Population. Neurology. 2022-09-21. PMID:36130840. |
atn (β-amyloid, tau, neurodegeneration) system categorizes individuals based on their core alzheimer's disease (ad) biomarkers. |
2022-09-21 |
2023-08-14 |
Not clear |
| Simanta Sarani Paul, Aaron Lyons, Russell Kirchner, Michael T Woodsid. Quantifying Oligomer Populations in Real Time during Protein Aggregation Using Single-Molecule Mass Photometry. ACS nano. 2022-09-20. PMID:36126253. |
by applying the approach to tau protein, whose aggregates are linked to diseases including alzheimer's and frontotemporal dementia, we found that tau existed in an equilibrium between monomers, dimers, and trimers before aggregation was triggered. |
2022-09-20 |
2023-08-14 |
Not clear |