| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew T McKenzie, Gabriel A Marx, Daniel Koenigsberg, Mary Sawyer, Megan A Iida, Jamie M Walker, Timothy E Richardson, Gabriele Campanella, Johannes Attems, Ann C McKee, Thor D Stein, Thomas J Fuchs, Charles L White, Kurt Farrell, John F Crar. Interpretable deep learning of myelin histopathology in age-related cognitive impairment. Acta neuropathologica communications. vol 10. issue 1. 2022-09-20. PMID:36127723. |
amyloid beta (aβ) plays a major role in alzheimer's type age-related cognitive impairment, in addition to other etiopathologies such as aβ-independent hyperphosphorylated tau, cerebrovascular disease, and myelin damage, which also warrant further investigation. |
2022-09-20 |
2023-08-14 |
human |
| Cui-Cui Yang, Xiao-Yu Jia, Li Zhang, Ya-Li Li, Zhan-Jun Zhang, Lin Li, Lan Zhan. Shenqi Xingnao Granules ameliorates cognitive impairments and Alzheimer's disease-like pathologies in APP/PS1 mouse model. Chinese herbal medicines. vol 12. issue 4. 2022-09-19. PMID:36120170. |
alzheimer's disease (ad) is along with cognitive decline due to amyloid-β (aβ) plaques, tau hyperphosphorylation, and neuron loss. shenqi xingnao granules (sqxn), a traditional chinese medicine, significantly ameliorated the cognitive function and daily living abilities of patients with ad. |
2022-09-19 |
2023-08-14 |
mouse |
| Peter Bloomingdale, Daniela Bumbaca-Yadav, Jonathan Sugam, Steve Grauer, Brad Smith, Svetlana Antonenko, Michael Judo, Glareh Azadi, Ka Lai Ye. PBPK-PD modeling for the preclinical development and clinical translation of tau antibodies for Alzheimer's disease. Frontiers in pharmacology. vol 13. 2022-09-19. PMID:36120380. |
pbpk-pd modeling for the preclinical development and clinical translation of tau antibodies for alzheimer's disease. |
2022-09-19 |
2023-08-14 |
human |
| Peter Bloomingdale, Daniela Bumbaca-Yadav, Jonathan Sugam, Steve Grauer, Brad Smith, Svetlana Antonenko, Michael Judo, Glareh Azadi, Ka Lai Ye. PBPK-PD modeling for the preclinical development and clinical translation of tau antibodies for Alzheimer's disease. Frontiers in pharmacology. vol 13. 2022-09-19. PMID:36120380. |
disrupted tau proteostasis and transneuronal spread is a pathological hallmark of alzheimer's disease. |
2022-09-19 |
2023-08-14 |
human |
| Peter Bloomingdale, Daniela Bumbaca-Yadav, Jonathan Sugam, Steve Grauer, Brad Smith, Svetlana Antonenko, Michael Judo, Glareh Azadi, Ka Lai Ye. PBPK-PD modeling for the preclinical development and clinical translation of tau antibodies for Alzheimer's disease. Frontiers in pharmacology. vol 13. 2022-09-19. PMID:36120380. |
a physiologically-based pharmacokinetic-pharmacodynamic (pbpk-pd) modeling approach was employed to support the preclinical development and clinical translation of therapeutic antibodies targeting tau for the treatment of alzheimer's disease. |
2022-09-19 |
2023-08-14 |
human |
| Miho Ota, Noriko Sato, Moto Nakaya, Yoko Shigemoto, Yukio Kimura, Emiko Chiba, Yuma Yokoi, Tadashi Tsukamoto, Hiroshi Matsud. Relationships Between the Deposition of Amyloid-β and Tau Protein and Glymphatic System Activity in Alzheimer's Disease: Diffusion Tensor Image Study. Journal of Alzheimer's disease : JAD. 2022-09-19. PMID:36120782. |
relationships between the deposition of amyloid-β and tau protein and glymphatic system activity in alzheimer's disease: diffusion tensor image study. |
2022-09-19 |
2023-08-14 |
Not clear |
| Miho Ota, Noriko Sato, Moto Nakaya, Yoko Shigemoto, Yukio Kimura, Emiko Chiba, Yuma Yokoi, Tadashi Tsukamoto, Hiroshi Matsud. Relationships Between the Deposition of Amyloid-β and Tau Protein and Glymphatic System Activity in Alzheimer's Disease: Diffusion Tensor Image Study. Journal of Alzheimer's disease : JAD. 2022-09-19. PMID:36120782. |
amyloid-β (aβ) and tau protein accumulation in the brain is thought to be one of the causes of alzheimer's disease (ad). |
2022-09-19 |
2023-08-14 |
Not clear |
| Inês Baldeiras, Anuschka Silva-Spínola, Marisa Lima, Maria João Leitão, João Durães, Daniela Vieira, Miguel Tbuas-Pereira, Vitor Tedim Cruz, Raquel Rocha, Luisa Alves, Álvaro Machado, Miguel Milheiro, Beatriz Santiago, Isabel Santan. Alzheimer's Disease Diagnosis Based on the Amyloid, Tau, and Neurodegeneration Scheme (ATN) in a Real-Life Multicenter Cohort of General Neurological Centers. Journal of Alzheimer's disease : JAD. 2022-09-19. PMID:36120784. |
alzheimer's disease diagnosis based on the amyloid, tau, and neurodegeneration scheme (atn) in a real-life multicenter cohort of general neurological centers. |
2022-09-19 |
2023-08-14 |
Not clear |
| Maria Fatima Falangola, Xingju Nie, Joshua Voltin, Ralph Ward, Siddhartha Dhiman, Paul J Nietert, Jens H Jense. Brain microstructure abnormalities in the 3xTg-AD mouse - A diffusion MRI and morphology correlation study. Magnetic resonance imaging. 2022-09-18. PMID:36116712. |
the widely studied triple transgenic (3xtg-ad) mouse provides a robust model of alzheimer's disease (ad) with region dependent patterns of progressive amyloid-β (aß) and tau pathology. |
2022-09-18 |
2023-08-14 |
mouse |
| Francesca Mazzo, Ioana Butnaru, Olivera Grubisha, Elena Ficulle, Helen Sanger, Griffin Fitzgerald, Feng Pan, Francesca Pasqui, Tracey Murray, James Monn, Xia Li, Michael Hutton, Suchira Bose, Giampietro Schiavo, Emanuele She. Metabotropic glutamate receptors modulate exocytotic tau release and propagation. The Journal of pharmacology and experimental therapeutics. 2022-09-18. PMID:36116796. |
using synaptosomes purified from the brains of two transgenic mouse models overexpressing mutated human tau (tgp301s and tg4510) and brains of patients with sporadic alzheimer's disease, we showed that aggregated and hyperphosphorylated tau was both present in purified synaptosomes and released in a calcium- and snap25-dependent manner. |
2022-09-18 |
2023-08-14 |
mouse |
| Longfei Li, Jin Miao, Dandan Chu, Nana Jin, Yunn Chyn Tung, Chun-Ling Dai, Wen Hu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation. CNS neuroscience & therapeutics. 2022-09-17. PMID:36114722. |
neurofibrillary tangle (nft) of hyperphosphorylated tau is a hallmark of alzheimer's disease (ad) and related tauopathies. |
2022-09-17 |
2023-08-14 |
Not clear |
| Jason A Witek, Allen F Brooks, Peter J H Scot. Classics in Neuroimaging: Untangling the Role of Tau in Neurodegenerative Disorders Using Positron Emission Tomography. ACS chemical neuroscience. 2022-09-16. PMID:36112411. |
we also highlight development of tauvid, the first tau pet radiotracer approved by the us fda for tau imaging in adult patients with cognitive impairment who are being evaluated for alzheimer's disease. |
2022-09-16 |
2023-08-14 |
Not clear |
| Paul M Seidler, Kevin A Murray, David R Boyer, Peng Ge, Michael R Sawaya, Carolyn J Hu, Xinyi Cheng, Romany Abskharon, Hope Pan, Michael A DeTure, Christopher K Williams, Dennis W Dickson, Harry V Vinters, David S Eisenber. Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nature communications. vol 13. issue 1. 2022-09-16. PMID:36114178. |
structure-based discovery of small molecules that disaggregate alzheimer's disease tissue derived tau fibrils in vitro. |
2022-09-16 |
2023-08-14 |
Not clear |
| Paul M Seidler, Kevin A Murray, David R Boyer, Peng Ge, Michael R Sawaya, Carolyn J Hu, Xinyi Cheng, Romany Abskharon, Hope Pan, Michael A DeTure, Christopher K Williams, Dennis W Dickson, Harry V Vinters, David S Eisenber. Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nature communications. vol 13. issue 1. 2022-09-16. PMID:36114178. |
alzheimer's disease (ad) is the consequence of neuronal death and brain atrophy associated with the aggregation of protein tau into fibrils. |
2022-09-16 |
2023-08-14 |
Not clear |
| Erin E Congdon, Ruimin Pan, Yixiang Jiang, Leslie A Sandusky-Beltran, Andie Dodge, Yan Lin, Mengyu Liu, Min-Hao Kuo, Xiang-Peng Kong, Einar M Sigurdsso. Single domain antibodies targeting pathological tau protein: Influence of four IgG subclasses on efficacy and toxicity. EBioMedicine. vol 84. 2022-09-13. PMID:36099813. |
eleven tau immunoglobulin g (igg) antibodies have entered clinical trials to treat tauopathies, including alzheimer's disease, but it is unclear which igg subclass/subtype has the ideal efficacy and safety profile. |
2022-09-13 |
2023-08-14 |
Not clear |
| Morgan G Shelton, Kimberly A Kerns, Frank J Castora, Randolph A Colema. Incorporating Mitochondrial Gene Expression Changes Within a Testable Mathematical Model for Alzheimer's Disease: Stress Response Modulation Predicts Potential Therapeutic Targets. Journal of Alzheimer's disease : JAD. 2022-09-12. PMID:36093692. |
alzheimer's disease is a specific form of dementia characterized by the aggregation of amyloid-β plaques and tau tangles. |
2022-09-12 |
2023-08-14 |
Not clear |
| Sergey Shcherbinin, Cynthia D Evans, Ming Lu, Scott W Andersen, Michael J Pontecorvo, Brian A Willis, Ivelina Gueorguieva, Paula M Hauck, Dawn A Brooks, Mark A Mintun, John R Sim. Association of Amyloid Reduction After Donanemab Treatment With Tau Pathology and Clinical Outcomes: The TRAILBLAZER-ALZ Randomized Clinical Trial. JAMA neurology. 2022-09-12. PMID:36094645. |
β-amyloid plaques and neurofibrillary tau deposits biologically define alzheimer disease. |
2022-09-12 |
2023-08-14 |
Not clear |
| Masoume Alipour, Majid Tebianian, Nahid Tofigh, Reyhaneh Sadat Taheri, Sayed Alireza Mousavi, Asal Naseri, Amin Ahmadi, Nayla Munawar, Koorosh Shahpasan. Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models. Neuropeptides. vol 96. 2022-09-10. PMID:36087426. |
traumatic brain injury (tbi), characterized by acute neurological impairment, is associated with a higher incidence of neurodegenerative diseases, particularly chronic traumatic encephalopathy (cte), alzheimer's disease (ad), and parkinson's disease (pd), whose hallmarks include hyperphosphorylated tau protein. |
2022-09-10 |
2023-08-14 |
mouse |
| Rong Shi, Luyao Wang, Jiehui Jian. An unsupervised region of interest extraction model for tau PET images and its application in the diagnosis of Alzheimer's disease. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2022. 2022-09-09. PMID:36083928. |
an unsupervised region of interest extraction model for tau pet images and its application in the diagnosis of alzheimer's disease. |
2022-09-09 |
2023-08-14 |
Not clear |
| Rong Shi, Luyao Wang, Jiehui Jian. An unsupervised region of interest extraction model for tau PET images and its application in the diagnosis of Alzheimer's disease. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2022. 2022-09-09. PMID:36083928. |
recently, tau positron-emission tomography (pet) images have been widely used for the diagnosis of alzheimer's disease (ad). |
2022-09-09 |
2023-08-14 |
Not clear |