All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Ling Wu, Zerui Wang, Shradha Lad, Nailya Gilyazova, Darren T Dougharty, Madeleine Marcus, Frances Henderson, W Keith Ray, Sandra Siedlak, Jianyong Li, Richard F Helm, Xiongwei Zhu, George S Bloom, Shih-Hsiu J Wang, Wen-Quan Zou, Bin X. Selective Detection of Misfolded Tau From Postmortem Alzheimer's Disease Brains. Frontiers in aging neuroscience. vol 14. 2022-08-08. PMID:35936779. selective detection of misfolded tau from postmortem alzheimer's disease brains. 2022-08-08 2023-08-14 human
Ling Wu, Zerui Wang, Shradha Lad, Nailya Gilyazova, Darren T Dougharty, Madeleine Marcus, Frances Henderson, W Keith Ray, Sandra Siedlak, Jianyong Li, Richard F Helm, Xiongwei Zhu, George S Bloom, Shih-Hsiu J Wang, Wen-Quan Zou, Bin X. Selective Detection of Misfolded Tau From Postmortem Alzheimer's Disease Brains. Frontiers in aging neuroscience. vol 14. 2022-08-08. PMID:35936779. tau aggregates are present in multiple neurodegenerative diseases known as "tauopathies," including alzheimer's disease, pick's disease, progressive supranuclear palsy, and corticobasal degeneration. 2022-08-08 2023-08-14 human
Connor M Wander, Tamy Harumy Moraes Tsujimoto, John F Ervin, Chanung Wang, Spencer M Maranto, Vanya Bhat, Julian D Dallmeier, Shih-Hsiu Jerry Wang, Feng-Chang Lin, William K Scott, David M Holtzman, Todd J Cohe. Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease. Acta neuropathologica communications. vol 10. issue 1. 2022-08-08. PMID:35941704. corpora amylacea are associated with tau burden and cognitive status in alzheimer's disease. 2022-08-08 2023-08-14 mouse
Xiangxiang Zhu, Zilei Zhang, Xin Yang, Longkai Qi, Yinrui Guo, Xiaocui Tang, Yizhen Xie, Diling Che. Improvement of extraction from Hericium erinaceus on the gut-brain axis in AD-like mice. Brain research. 2022-08-07. PMID:35934088. in this study, results showed the extractions of hericium erinaceus can ameliorate the learning and memory abilities significantly, reduce the swelling of brain tissues, neuronal apoptosis, and down-regulate the expression of alzheimer's disease intracellular markers including tau and aβ1-42. 2022-08-07 2023-08-14 mouse
Pablo Gracia, David Polanco, Jorge Tarancón-Díez, Ilenia Serra, Maruan Bracci, Javier Oroz, Douglas V Laurents, Inés García, Nunilo Cremade. Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau. Nature communications. vol 13. issue 1. 2022-08-06. PMID:35933508. recently, tau protein, generally associated with alzheimer's disease, has been linked to αs pathology and observed to co-localize in αs-rich disease inclusions, although the molecular mechanisms for the co-aggregation of both proteins remain elusive. 2022-08-06 2023-08-14 Not clear
Assel Seitkazina, Kyu Hyeon Kim, Erin Fagan, Yoonsik Sung, Yun Kyung Kim, Sungsu Li. The Fate of Tau Aggregates Between Clearance and Transmission. Frontiers in aging neuroscience. vol 14. 2022-08-04. PMID:35923541. neuronal accumulation of mis-folded tau is the pathological hallmark of multiple neurodegenerative disorders, including alzheimer's disease. 2022-08-04 2023-08-14 Not clear
Kaylin Hwang, Rahil N Vaknalli, Kwaku Addo-Osafo, Mariane Vicente, Keith Vosse. Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms. Frontiers in aging neuroscience. vol 14. 2022-08-04. PMID:35923547. however, under pathological conditions, aggregation of hyperphosphorylated tau causes neuronal toxicity, neurodegeneration, and resulting tauopathies like alzheimer's disease (ad). 2022-08-04 2023-08-14 Not clear
Kaylin Hwang, Rahil N Vaknalli, Kwaku Addo-Osafo, Mariane Vicente, Keith Vosse. Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms. Frontiers in aging neuroscience. vol 14. 2022-08-04. PMID:35923547. suppressing tau phosphorylation decreases seizure activity in acquired epilepsy models while reducing or ablating tau attenuates network hyperexcitability in both alzheimer's and epilepsy models. 2022-08-04 2023-08-14 Not clear
Jijing Wang, Cong Guo, Zhaowei Meng, Marissa D Zwan, Xin Chen, Sven Seelow, Susanna L Lundström, Sergey Rodin, Charlotte E Teunissen, Roman A Zubare. Testing the link between isoaspartate and Alzheimer's disease etiology. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-08-04. PMID:35924765. here we strengthened the link between isoasp and alzheimer's disease (ad) by novel approaches to isoasp analysis in human serum albumin (hsa), the most abundant blood protein and a major carrier of amyloid beta (aβ) and phosphorylated tau (p-tau) in blood. 2022-08-04 2023-08-14 human
Jingqin Luo, Folasade Agboola, Elizabeth Grant, John C Morris, Colin L Masters, Marilyn S Albert, Sterling C Johnson, Eric M McDade, Anne M Fagan, Tammie L S Benzinger, Jason Hassenstab, Randall J Bateman, Richard J Perrin, Guoqiao Wang, Yan Li, Brian Gordon, Carlos Cruchaga, Gregory S Day, Johannes Levin, Jonathan Vöglein, Takeshi Ikeuchi, Kazushi Suzuki, Ricardo F Allegri, Chengjie Xion. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology. 2022-08-04. PMID:35925685. the temporal evolutions and relative orderings of alzheimer disease biomarkers, including csf amyloid-β42 (aβ42), aβ40, total tau (tau) and phosphorylated tau181 (ptau181), standardized uptake value ratio (suvr) from the molecular imaging of cerebral fibrillar amyloid-β with pet using the 11c-pittsburgh compound-b (pib), mri-based hippocampal volume and cortical thickness and cognition have been hypothesized but not yet fully tested with longitudinal data for all major biomarker modalities among cognitively normal individuals across the adult lifespan starting from 18 years. 2022-08-04 2023-08-14 human
Ansgar Opitz, Lisa-Marie Seitz, Vladimir Krystof, Fady Baselious, Max Holzer, Wolfgang Sippl, Andreas Hilgerot. Novel effective small-molecule inhibitors of protein kinases related to tau pathology in Alzheimer's disease. Future medicinal chemistry. 2022-08-03. PMID:35920260. novel effective small-molecule inhibitors of protein kinases related to tau pathology in alzheimer's disease. 2022-08-03 2023-08-14 Not clear
Christina M Moloney, Sydney A Labuzan, Julia E Crook, Habeeba Siddiqui, Monica Castanedes-Casey, Christian Lachner, Ronald C Petersen, Ranjan Duara, Neill R Graff-Radford, Dennis W Dickson, Michelle M Mielke, Melissa E Murra. Phosphorylated tau sites that are elevated in Alzheimer's disease fluid biomarkers are visualized in early neurofibrillary tangle maturity levels in the post mortem brain. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-08-03. PMID:35920592. phosphorylated tau sites that are elevated in alzheimer's disease fluid biomarkers are visualized in early neurofibrillary tangle maturity levels in the post mortem brain. 2022-08-03 2023-08-14 Not clear
Sanjib Guha, Anson Cheng, Trae Carroll, Dennisha King, Shon A Koren, Sierra Swords, Keith Nehrke, Gail V W Johnso. Selective Disruption of Drp1-Independent Mitophagy and Mitolysosome Trafficking by an Alzheimer's Disease Relevant Tau Modification in a Novel C. elegans Model. Genetics. 2022-08-02. PMID:35916724. selective disruption of drp1-independent mitophagy and mitolysosome trafficking by an alzheimer's disease relevant tau modification in a novel c. elegans model. 2022-08-02 2023-08-14 human
Sanjib Guha, Anson Cheng, Trae Carroll, Dennisha King, Shon A Koren, Sierra Swords, Keith Nehrke, Gail V W Johnso. Selective Disruption of Drp1-Independent Mitophagy and Mitolysosome Trafficking by an Alzheimer's Disease Relevant Tau Modification in a Novel C. elegans Model. Genetics. 2022-08-02. PMID:35916724. accumulation of inappropriately phosphorylated tau into neurofibrillary tangles (nft) is a defining feature of alzheimer's disease (ad), with tau pt231 being an early harbinger of tau pathology. 2022-08-02 2023-08-14 human
Cheng Ju, Yue Wang, Caixia Zang, Hui Liu, Fangyu Yuan, Jingwen Ning, Meiyu Shang, Jingwei Ma, Gen Li, Yang Yang, Xiuqi Bao, Dan Zhan. Inhibition of Dyrk1A Attenuates LPS-Induced Neuroinflammation via the TLR4/NF-κB P65 Signaling Pathway. Inflammation. 2022-08-02. PMID:35917097. in alzheimer's disease (ad), dyrk1a promotes hyperphosphorylation of tau protein and abnormal aggregation of amyloid-β protein (aβ). 2022-08-02 2023-08-14 mouse
Sophie A I Sanford, William A McEwa. Type-I Interferons in Alzheimer's Disease and Other Tauopathies. Frontiers in cellular neuroscience. vol 16. 2022-08-01. PMID:35910253. signatures of type-i ifn-driven gene expression, and type-i ifns themselves, are observed in the central nervous system during neurodegenerative diseases including alzheimer's disease and other tauopathies, the umbrella term for diseases that feature aggregation of the cytosolic protein tau. 2022-08-01 2023-08-14 Not clear
Parag Parekh, Qingshan Mu, Andrew Badachhape, Rohan Bhavane, Mayank Srivastava, Laxman Devkota, Xianwei Sun, Prajwal Bhandari, Jason L Eriksen, Eric Tanifum, Ketan Ghaghada, Ananth Annapragad. A surrogate marker for very early-stage tau pathology is detectable by molecular magnetic resonance imaging. Theranostics. vol 12. issue 12. 2022-08-01. PMID:35910789. the abnormal phosphorylation of tau is a necessary precursor to the formation of tau fibrils, a marker of alzheimer's disease. 2022-08-01 2023-08-14 Not clear
Cherie Strikwerda-Brown, Diana A Hobbs, Julie Gonneaud, Frédéric St-Onge, Alexa Pichet Binette, Hazal Ozlen, Karine Provost, Jean-Paul Soucy, Rachel F Buckley, Tammie L S Benzinger, John C Morris, Victor L Villemagne, Vincent Doré, Reisa A Sperling, Keith A Johnson, Christopher C Rowe, Brian A Gordon, Judes Poirier, John C S Breitner, Sylvia Villeneuv. Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment. JAMA neurology. 2022-07-30. PMID:35907254. association of elevated amyloid and tau positron emission tomography signal with near-term development of alzheimer disease symptoms in older adults without cognitive impairment. 2022-07-30 2023-08-14 Not clear
Laura Martínez-Drudis, Razan Sheta, Rémi Pellegrinato, Salma Loukili, Cyntia Tremblay, Frédéric Calon, Serge Rivest, Abid Oueslat. Inhibition of PLK2 activity affects APP and tau pathology and improves synaptic content in a sex-dependent manner in a 3xTg mouse model of Alzheimer's disease. Neurobiology of disease. 2022-07-29. PMID:35905928. inhibition of plk2 activity affects app and tau pathology and improves synaptic content in a sex-dependent manner in a 3xtg mouse model of alzheimer's disease. 2022-07-29 2023-08-14 mouse
Shengming Wang, Yu Fu, Takaki Miyata, Sakiko Matsumoto, Tomoyasu Shinoda, Kyoko Itoh, Akihiro Harada, Shinji Hirotsune, Mingyue Ji. Functional cooperation of α-synuclein and tau is essential for proper corticogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-07-29. PMID:35906071. alpha-synuclein (αsyn) and tau are abundant multifunctional neuronal proteins, and their intracellular deposits have been linked to many neurodegenerative diseases, including alzheimer's disease and parkinson's disease. 2022-07-29 2023-08-14 mouse