| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vali Akbari, Soheila Mohammadi, Masomeh Mehrabi, Sirous Ghobadi, Alireza Farrokhi, Reza Khodarahm. Investigation of the role of prolines 232/233 in RTPPK motif in tau protein aggregation: An in vitro study. International journal of biological macromolecules. 2022-09-01. PMID:36049563. |
disease-related tau protein in alzheimer's disease is hyperphosphorylated and aggregates into neurofibrillary tangles. |
2022-09-01 |
2023-08-14 |
Not clear |
| Rakesh Kumar Banote, Samuel Håkansson, Henrik Zetterberg, Johan Zelan. CSF biomarkers in patients with epilepsy in Alzheimer's disease: a nation-wide study. Brain communications. vol 4. issue 4. 2022-08-31. PMID:36043137. |
by cross-referencing the largest national laboratory database with swedish national patient register, we could identify csf biomarker results from 17901 alzheimer's disease patients, and compare levels of neurofilament light, glial fibrillary acidic protein, total tau, phosphorylated tau and amyloid beta 42 in patients with ( |
2022-08-31 |
2023-08-14 |
Not clear |
| Omid Vakili, Pooria Asili, Zeinab Babaei, Maryam Mirahmad, Atoosa Keshavarzmotamed, Zatollah Asemi, Alireza Maf. Circular RNAs in Alzheimer's Disease: A New Perspective of Diagnostic and Therapeutic Targets. CNS & neurological disorders drug targets. 2022-08-31. PMID:36043720. |
among various neurodegenerative diseases (nds), accumulating evidence has proposed key roles for circrnas in the pathogenesis of alzheimer's disease (ad); although the exact relationship between these rna molecules and ad progression is not clear, they have been believed to mostly act as mirna sponges or gene transcription modulators through correlating with multiple proteins, involved in the accumulation of amyloid β (aβ) peptides, as well as tau protein, as ad's pathological hallmark. |
2022-08-31 |
2023-08-14 |
Not clear |
| Cathryn McKenzie, Romola S Bucks, Michael Weinborn, Pierrick Bourgeat, Olivier Salvado, Brandon E Gavet. Tau and amyloid biomarkers modify the degree to which cognitive reserve and brain reserve predict cognitive decline. Journal of the International Neuropsychological Society : JINS. 2022-08-30. PMID:36039968. |
we sought to determine whether the influence of these protective factors on executive function (ef) and daily function decline was dependent upon alzheimer's disease (ad) pathology severity, as measured by the total tau to beta-amyloid (t-τ/aβ |
2022-08-30 |
2023-08-14 |
Not clear |
| Abris Gilvesy, Evelina Husen, Zsofia Magloczky, Orsolya Mihaly, Tibor Hortobágyi, Shigeaki Kanatani, Helmut Heinsen, Nicolas Renier, Tomas Hökfelt, Jan Mulder, Mathias Uhlen, Gabor G Kovacs, Csaba Ador. Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus-pericoerulear complex by three-dimensional imaging. Acta neuropathologica. 2022-08-30. PMID:36040521. |
tau pathology of the noradrenergic locus coeruleus (lc) is a hallmark of several age-related neurodegenerative disorders, including alzheimer's disease. |
2022-08-30 |
2023-08-14 |
human |
| Gihan P Ruwanpathirana, Robert C Williams, Colin L Masters, Christopher C Rowe, Leigh A Johnston, Catherine E Dave. Mapping the association between tau-PET and Aβ-amyloid-PET using deep learning. Scientific reports. vol 12. issue 1. 2022-08-30. PMID:36042256. |
in alzheimer's disease, the molecular pathogenesis of the extracellular aβ-amyloid (aβ) instigation of intracellular tau accumulation is poorly understood. |
2022-08-30 |
2023-08-14 |
Not clear |
| Shalini Kanagasingam, Christopher von Ruhland, Richard Welbury, Sim K Singhra. Antimicrobial, Polarizing Light, and Paired Helical Filament Properties of Fragmented Tau Peptides of Selected Putative Gingipains. Journal of Alzheimer's disease : JAD. 2022-08-29. PMID:36031895. |
hyperphosphorylation of tau and neurofibrillary tangle (nft) formation is a defining lesion of alzheimer's disease (ad) where nft distribution is related to braak stage and disease severity. |
2022-08-29 |
2023-08-14 |
Not clear |
| Qing Wang, Chunming Xi. Microglia activation linking amyloid-β drive tau spatial propagation in Alzheimer's disease. Frontiers in neuroscience. vol 16. 2022-08-29. PMID:36033617. |
microglia activation linking amyloid-β drive tau spatial propagation in alzheimer's disease. |
2022-08-29 |
2023-08-14 |
Not clear |
| Adelaide R Tousley, Pamela W L Yeh, Hermes H Ye. Precocious emergence of cognitive and synaptic dysfunction in 3xTg-AD mice exposed prenatally to ethanol. Alcohol (Fayetteville, N.Y.). 2022-08-29. PMID:36038084. |
here we exposed a mouse model of alzheimer's disease (3xtg-ad), bearing 3 dementia associated transgenes: presenilin1 (ps1m146v), human amyloid precursor protein (appswe) and human tau (taup301s), to ethanol on gestational days 13.5-16.5 using an established binge-type maternal ethanol exposure paradigm. |
2022-08-29 |
2023-08-14 |
mouse |
| A Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M Smith, Bandhan Mukherjee, Santiago A Salazar, Suho Lee, Tu Kiet T Lam, Stephen M Strittmatte. Correction: Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy. Molecular neurodegeneration. vol 17. issue 1. 2022-08-29. PMID:36038879. |
correction: alzheimer risk gene product pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy. |
2022-08-29 |
2023-08-14 |
Not clear |
| I-Fang Wang, Pei-Chuan Ho, Kuen-Jer Tsa. MicroRNAs in Learning and Memory and Their Impact on Alzheimer's Disease. Biomedicines. vol 10. issue 8. 2022-08-26. PMID:36009403. |
we also summarize extensive studies on mirnas correlated with pathogenic tau and amyloid-β that drive the processes of alzheimer's disease (ad). |
2022-08-26 |
2023-08-14 |
mouse |
| Bisan Saleh, Kolluru D Srikanth, Tal Sneh, Lambert Yue, Steven Pelech, Evan Elliott, Hava Gil-Hen. FAK-Mediated Signaling Controls Amyloid Beta Overload, Learning and Memory Deficits in a Mouse Model of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012331. |
using the 3xtg-ad mouse model, which carries three mutations associated with familial alzheimer's disease (app km670/671nl swedish, psen1 m146v, mapt p301l) and develops age-related progressive neuropathology including amyloid plaques and tau tangles, we describe here, for the first time, the in vivo role of fak in ad pathology. |
2022-08-26 |
2023-08-14 |
mouse |
| Ryszard Pluta, Sławomir Januszewski, Mirosław Jabłońsk. Acetylated Tau Protein: A New Piece in the Puzzle between Brain Ischemia and Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012440. |
acetylated tau protein: a new piece in the puzzle between brain ischemia and alzheimer's disease. |
2022-08-26 |
2023-08-14 |
Not clear |
| Carla Borràs, Aina Mercer, Sònia Sirisi, Daniel Alcolea, Joan Carles Escolà-Gil, Francisco Blanco-Vaca, Mireia Tond. HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer's Disease Pathogenesis. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012637. |
alzheimer's disease is characterized by the accumulation of extracellular amyloid beta (aβ) and abnormally hyperphosphorylated intracellular tau filaments in neurons. |
2022-08-26 |
2023-08-14 |
Not clear |
| Krzysztof Więckowski, Natalia Szałaj, Beata Gryzło, Tomasz Wichur, Izabella Góral, Emilia Sługocka, Joanna Sniecikowska, Gniewomir Latacz, Agata Siwek, Justyna Godyń, Adam Bucki, Marcin Kołaczkowski, Anna Więckowsk. Serotonin 5-HT International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012707. |
serotonin 5-ht neurodegeneration leading to alzheimer's disease results from a complex interplay of a variety of processes including misfolding and aggregation of amyloid beta and tau proteins, neuroinflammation or oxidative stress. |
2022-08-26 |
2023-08-14 |
Not clear |
| Giuseppe Di Natale, Giuseppina Sabatino, Michele Francesco Maria Sciacca, Rita Tosto, Danilo Milardi, Giuseppe Pappalard. Aβ and Tau Interact with Metal Ions, Lipid Membranes and Peptide-Based Amyloid Inhibitors: Are These Common Features Relevant in Alzheimer's Disease? Molecules (Basel, Switzerland). vol 27. issue 16. 2022-08-26. PMID:36014310. |
aβ and tau interact with metal ions, lipid membranes and peptide-based amyloid inhibitors: are these common features relevant in alzheimer's disease? |
2022-08-26 |
2023-08-14 |
Not clear |
| Maria Babu, Filippo Favretto, Marija Rankovic, Markus Zweckstette. Peptidyl Prolyl Isomerase A Modulates the Liquid-Liquid Phase Separation of Proline-Rich IDPs. Journal of the American Chemical Society. 2022-08-26. PMID:36018855. |
here, we demonstrate that the most ubiquitous peptidyl prolyl isomerase, peptidyl prolyl isomerase a (ppia), concentrates inside liquid-like droplets formed by the alzheimer's disease-associated protein tau, as well as inside rna-induced coacervates of a proline-arginine dipeptide repeat protein. |
2022-08-26 |
2023-08-14 |
Not clear |
| Seda Onder, Kevser Biberoglu, Melike Yuksel, Ozden Taca. Toluidine blue O attenuates tau phosphorylation in N2a-APPSwe cells. Chemico-biological interactions. 2022-08-26. PMID:36027949. |
alzheimer's disease (ad) is characterized by extracellular amyloid plaques composed of amyloid β peptide (aβ), intracellular neurofibrillary tangles containing hyperphosphorylated tau protein and neuronal loss. |
2022-08-26 |
2023-08-14 |
mouse |
| Victoria E Bernaud, Haidyn L Bulen, Veronica L Peña, Stephanie V Koebele, Steven N Northup-Smith, Alma A Manzo, Maria Valenzuela Sanchez, Zorana Opachich, Ashley M Ruhland, Heather A Bimonte-Nelso. Task-dependent learning and memory deficits in the TgF344-AD rat model of Alzheimer's disease: three key timepoints through middle-age in females. Scientific reports. vol 12. issue 1. 2022-08-26. PMID:36028737. |
the tgf344 rat model of alzheimer's disease (ad) provides a comprehensive neuropathology presentation, with age-dependent development of tau tangles, amyloid-beta (a[formula: see text]) plaques, neuronal loss, and increased gliosis. |
2022-08-26 |
2023-08-14 |
rat |
| Mozhgan Alipour, Mahsa Motavaf, Parviz Abdolmaleki, Alireza Zali, Farzad Ashrafi, Saeid Safari, Behnam Hajipour-Verdo. Structural Analysis and Conformational Dynamics of Short Helical Hyperphosphorylated Segments of Tau Protein (Sequence 254-290) in Alzheimer's Disease: A Molecular Dynamics Simulation Study. Frontiers in molecular biosciences. vol 9. 2022-08-25. PMID:36003083. |
structural analysis and conformational dynamics of short helical hyperphosphorylated segments of tau protein (sequence 254-290) in alzheimer's disease: a molecular dynamics simulation study. |
2022-08-25 |
2023-08-14 |
Not clear |