All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Sanaz Arezoumandan, Sharon X Xie, Katheryn A Q Cousins, Dawn J Mechanic-Hamilton, Claire S Peterson, Camille Y Huang, Daniel T Ohm, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul Yushkevich, John Q Trojanowski, Edward B Lee, Murray Grossman, Jeffrey S Phillips, David J Irwi. Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer's disease. Acta neuropathologica. 2022-07-23. PMID:35871112. regional distribution and maturation of tau pathology among phenotypic variants of alzheimer's disease. 2022-07-23 2023-08-14 Not clear
Sanaz Arezoumandan, Sharon X Xie, Katheryn A Q Cousins, Dawn J Mechanic-Hamilton, Claire S Peterson, Camille Y Huang, Daniel T Ohm, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul Yushkevich, John Q Trojanowski, Edward B Lee, Murray Grossman, Jeffrey S Phillips, David J Irwi. Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer's disease. Acta neuropathologica. 2022-07-23. PMID:35871112. here, we investigated the distribution and burden of phosphorylated and c-terminally cleaved tau pathologies across hippocampal subfields and cortical regions among phenotypic variants of alzheimer's disease (ad). 2022-07-23 2023-08-14 Not clear
Tania Arora, Vikash Prashar, Randeep Singh, Tushar Singh Barwal, Harish Changotra, Arti Sharma, Jyoti Parkas. Dysregulated miRNAs in Progression and Pathogenesis of Alzheimer's Disease. Molecular neurobiology. 2022-07-22. PMID:35867206. alzheimer's disease (ad) is a progressive degeneration of neurons due to the accumulation of amyloid-β peptide (aβ) and hyper-phosphorylation of tau protein in the neuronal milieu leading to increased oxidative stress and apoptosis. 2022-07-22 2023-08-14 human
Kailin Zhuang, Xi Chen, Kaitlin E Cassady, Suzanne L Baker, William J Jagus. Metacognition, cortical thickness, and tauopathy in aging. Neurobiology of aging. vol 118. 2022-07-22. PMID:35868093. we investigated self-rating of cognitive task performance (self-appraisal) and the difference between self-rating and actual task performance (appraisal discrepancy) in cognitively healthy older adults and their relationship with cortical thickness and alzheimer's disease (ad) biomarkers, amyloid and tau. 2022-07-22 2023-08-14 human
Alexandria B Marciante, John Howard, Mia N Kelly, Juan Santiago Moreno, Latoya L Allen, Elisa J Gonzalez-Rothi, Gordon S Mitchel. Dose-dependent Phosphorylation of Endogenous Tau by Intermittent Hypoxia in Rat Brain. Journal of applied physiology (Bethesda, Md. : 1985). 2022-07-21. PMID:35861520. sleep apnea is comorbid in >50% of patients with alzheimer's disease-a progressive, neurodegenerative disease associated with brain amyloid and chronic tau dysregulation (pathology). 2022-07-21 2023-08-14 human
Kristie Stefanoska, Mehul Gajwani, Amanda R P Tan, Holly I Ahel, Prita R Asih, Alexander Volkerling, Anne Poljak, Arne Ittne. Alzheimer's disease: Ablating single master site abolishes tau hyperphosphorylation. Science advances. vol 8. issue 27. 2022-07-20. PMID:35857446. alzheimer's disease: ablating single master site abolishes tau hyperphosphorylation. 2022-07-20 2023-08-14 mouse
Kristie Stefanoska, Mehul Gajwani, Amanda R P Tan, Holly I Ahel, Prita R Asih, Alexander Volkerling, Anne Poljak, Arne Ittne. Alzheimer's disease: Ablating single master site abolishes tau hyperphosphorylation. Science advances. vol 8. issue 27. 2022-07-20. PMID:35857446. hyperphosphorylation of the neuronal tau protein is a hallmark of neurodegenerative tauopathies such as alzheimer's disease. 2022-07-20 2023-08-14 mouse
Kristie Stefanoska, Mehul Gajwani, Amanda R P Tan, Holly I Ahel, Prita R Asih, Alexander Volkerling, Anne Poljak, Arne Ittne. Alzheimer's disease: Ablating single master site abolishes tau hyperphosphorylation. Science advances. vol 8. issue 27. 2022-07-20. PMID:35857446. crispr point mutation and expression of human tau in alzheimer's mice showed that site interdependence governs physiologic and amyloid-associated multi-site phosphorylation and cognitive deficits, respectively. 2022-07-20 2023-08-14 mouse
Vanesa Carmona Mata, Joshua Goldber. Morin and isoquercitrin protect against ischemic neuronal injury by modulating signaling pathways and stimulating mitochondrial biogenesis. Nutritional neuroscience. 2022-07-20. PMID:35857717. the search for the etiology of alzheimer's disease has revealed dysregulation of amyloid protein precursors, β-secretase, mitophagy, apoptosis, and tau protein genes after ischemic brain injury. 2022-07-20 2023-08-14 Not clear
John David Eun, Heidy Jimenez, Leslie Adrien, Adam Wolin, Philippe Marambaud, Peter Davies, Jeremy L Koppe. Anesthesia promotes acute expression of genes related to Alzheimer's disease and latent tau aggregation in transgenic mouse models of tauopathy. Molecular medicine (Cambridge, Mass.). vol 28. issue 1. 2022-07-20. PMID:35858831. anesthesia promotes acute expression of genes related to alzheimer's disease and latent tau aggregation in transgenic mouse models of tauopathy. 2022-07-20 2023-08-14 mouse
John P Seiby. Alpha-synuclein PET and Parkinson's Disease Therapeutic Trials: Ever the Twain Shall Meet? Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2022-07-19. PMID:35853738. unlike alzheimer's dementia where there are pet imaging biomarkers for the two rogue proteins, beta-amyloid and tau, there's no equivalent pet tracer to interrogate distribution of a-syn in brain. 2022-07-19 2023-08-14 Not clear
Tharick A Pascoal, Mira Chamoun, Elad Lax, Hsiao-Ying Wey, Monica Shin, Kok Pin Ng, Min Su Kang, Sulantha Mathotaarachchi, Andrea L Benedet, Joseph Therriault, Firoza Z Lussier, Frederick A Schroeder, Jonathan M DuBois, Baileigh G Hightower, Tonya M Gilbert, Nicole R Zürcher, Changning Wang, Robert Hopewell, Mallar Chakravarty, Melissa Savard, Emilie Thomas, Sara Mohaddes, Sarah Farzin, Alyssa Salaciak, Stephanie Tullo, A Claudio Cuello, Jean-Paul Soucy, Gassan Massarweh, Heungsun Hwang, Eliane Kobayashi, Bradley T Hyman, Bradford C Dickerson, Marie-Christine Guiot, Moshe Szyf, Serge Gauthier, Jacob M Hooker, Pedro Rosa-Net. [ Nature communications. vol 13. issue 1. 2022-07-19. PMID:35853847. [ alzheimer's disease (ad) is characterized by the brain accumulation of amyloid-β and tau proteins. 2022-07-19 2023-08-14 human
Chuanbin Yang, Chengfu Su, Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Zhou Zhu, Sichang Yang, Benjamin Chunkit Tong, Jia Liu, Sravan G Sreenivasmurthy, Xinjie Guan, Yuxuan Kan, Aston Jiaxi Wu, Alexis Shiying Huang, Jieqiong Tan, Kingho Cheung, Juxian Song, Min L. Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy. Acta pharmaceutica Sinica. B. vol 12. issue 4. 2022-07-18. PMID:35847498. celastrol enhances transcription factor eb (tfeb)-mediated autophagy and mitigates tau pathology: implications for alzheimer's disease therapy. 2022-07-18 2023-08-14 Not clear
Chuanbin Yang, Chengfu Su, Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Zhou Zhu, Sichang Yang, Benjamin Chunkit Tong, Jia Liu, Sravan G Sreenivasmurthy, Xinjie Guan, Yuxuan Kan, Aston Jiaxi Wu, Alexis Shiying Huang, Jieqiong Tan, Kingho Cheung, Juxian Song, Min L. Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy. Acta pharmaceutica Sinica. B. vol 12. issue 4. 2022-07-18. PMID:35847498. alzheimer's disease (ad), characterized by the accumulation of protein aggregates including phosphorylated tau aggregates, is the most common neurodegenerative disorder with limited therapeutic agents. 2022-07-18 2023-08-14 Not clear
Yi-He Chen, Rong-Rong Lin, Hui-Feng Huang, Yan-Yan Xue, Qing-Qing Ta. Microglial Activation, Tau Pathology, and Neurodegeneration Biomarkers Predict Longitudinal Cognitive Decline in Alzheimer's Disease Continuum. Frontiers in aging neuroscience. vol 14. 2022-07-18. PMID:35847667. microglial activation, tau pathology, and neurodegeneration biomarkers predict longitudinal cognitive decline in alzheimer's disease continuum. 2022-07-18 2023-08-14 Not clear
Hui-Zhi Long, Zi-Wei Zhou, Yan Cheng, Hong-Yu Luo, Feng-Jiao Li, Shuo-Guo Xu, Li-Chen Ga. The Role of Microglia in Alzheimer's Disease From the Perspective of Immune Inflammation and Iron Metabolism. Frontiers in aging neuroscience. vol 14. 2022-07-18. PMID:35847685. alzheimer's disease (ad), the most common type of senile dementia, includes the complex pathogenesis of abnormal deposition of amyloid beta-protein (aβ), phosphorylated tau (p-tau) and neuroimmune inflammatory. 2022-07-18 2023-08-14 Not clear
Naomi Vlegels, Rik Ossenkoppele, Wiesje M van der Flier, Huiberdina L Koek, Yael D Reijmer, Laura Em Wisse, Geert Jan Biessel. Does Loss of Integrity of the Cingulum Bundle Link Amyloid-β Accumulation and Neurodegeneration in Alzheimer's Disease? Journal of Alzheimer's disease : JAD. 2022-07-18. PMID:35848018. alzheimer's disease is characterized by the accumulation of amyloid-β (aβ) into plaques, aggregation of tau into neurofibrillary tangles, and neurodegenerative processes including atrophy. 2022-07-18 2023-08-14 Not clear
Viet Hoang Man, Da Lin, Xibing He, Jie Gao, Junmei Wan. Joint Computational/Cell-Based Oligomerization for Screening Inhibitors of Tau Assembly: A Proof-of-Concept Study. Journal of Alzheimer's disease : JAD. 2022-07-18. PMID:35848028. tau assembly produces soluble oligomers and insoluble neurofibrillary tangles, which are neurotoxic to the brain and associated with alzheimer's and parkinson's diseases. 2022-07-18 2023-08-14 Not clear
B Souchet, M Audrain, Y Gu, M F Lindberg, N S Orefice, E Rey, N Cartier, N Janel, L Meijer, J Braudea. Cerebral Phospho-Tau Acts Synergistically with Soluble Aβ42 Leading to Mild Cognitive Impairment in AAV-AD Rats. The journal of prevention of Alzheimer's disease. vol 9. issue 3. 2022-07-16. PMID:35841249. alzheimer's disease (ad) is a continuum of events beginning with an increase in brain soluble aβ42 followed by the appearance of hyperphosphorylated tau (p-tau, asymptomatic stage). 2022-07-16 2023-08-14 rat
Siva Prasad Panda, Yogita Dhurandhar, Mehak Agrawa. The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. Mitochondrion. 2022-07-16. PMID:35842181. the epileptogenesis in patients with alzheimer's disease dementia (add) and parkinson's disease dementia (pdd) is due to involvement of amyloid plaques (aβ), phosphorylated tau (ptau), parkin, nf-kb and nlrp3 inflammasome.microglia, the prime protective and inflammatory cells in the brain exert crosstalk between mitophagy and inflammation. 2022-07-16 2023-08-14 Not clear