All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Meng-Zhu Li, En-Jie Liu, Qiu-Zhi Zhou, Shi-Hong Li, Shi-Jie Liu, Hai-Tao Yu, Qi-Hang Pan, Fei Sun, Ting He, Wei-Jin Wang, Dan Ke, Yu-Qi Feng, Jun Li, Jian-Zhi Wan. Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling. Military Medical Research. vol 9. issue 1. 2022-07-07. PMID:35799293. autophagy dysfunction plays a crucial role in tau accumulation and neurodegeneration in alzheimer's disease (ad). 2022-07-07 2023-08-14 Not clear
Greet Vanderlinden, Jenny Ceccarini, Thomas Vande Casteele, Laura Michiels, Robin Lemmens, Eric Triau, Kim Serdons, Jos Tournoy, Michel Koole, Mathieu Vandenbulcke, Koen Van Laer. Spatial decrease of synaptic density in amnestic mild cognitive impairment follows the tau build-up pattern. Molecular psychiatry. 2022-07-06. PMID:35794185. next to amyloid and tau, synaptic loss is a key pathological hallmark in alzheimer's disease, closely related to cognitive dysfunction and neurodegeneration. 2022-07-06 2023-08-14 Not clear
Song Mi Han, Yu Jung Jang, Eun Young Kim, Sun Ah Par. The Change in Circadian Rhythms in P301S Transgenic Mice is Linked to Variability in Hsp70-related Tau Disaggregation. Experimental neurobiology. vol 31. issue 3. 2022-07-05. PMID:35786641. circadian disruption often involves a neurodegenerative disorder, such as alzheimer's disease or frontotemporal dementia, which are characterized by intraneuronal tau accumulations. 2022-07-05 2023-08-14 mouse
Effects of tau on Aβ-induced synaptic damage in a Drosophila model of Alzheimer's disease. Neuro endocrinology letters. vol 43. issue 2. 2022-07-05. PMID:35786817. effects of tau on aβ-induced synaptic damage in a drosophila model of alzheimer's disease. 2022-07-05 2023-08-14 drosophila_melanogaster
Shorena Janelidze, Bradley T Christian, Julie Price, Charles Laymon, Nicole Schupf, William E Klunk, Ira Lott, Wayne Silverman, H Diana Rosas, Shahid Zaman, Mark Mapstone, Florence Lai, Beau M Ances, Benjamin L Handen, Oskar Hansso. Detection of Brain Tau Pathology in Down Syndrome Using Plasma Biomarkers. JAMA neurology. 2022-07-05. PMID:35789365. novel plasma biomarkers, especially phosphorylated tau (p-tau), can detect brain tau aggregates in alzheimer disease. 2022-07-05 2023-08-14 Not clear
Yuanyuan Deng, Mian Bi, Fabien Delerue, Shelley L Forrest, Gabriella Chan, Julia van der Hoven, Annika van Hummel, Astrid F Feiten, Seojin Lee, Ivan Martinez-Valbuena, Tim Karl, Gabor G Kovacs, Grant Morahan, Yazi D Ke, Lars M Ittne. Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease. Acta neuropathologica. 2022-07-03. PMID:35780436. in alzheimer's disease (ad), where amyloid-β (aβ) and tau deposits in the brain, hyperexcitation of neuronal networks is an underlying disease mechanism, but its cause remains unclear. 2022-07-03 2023-08-14 mouse
Kiara Freitag, Nele Sterczyk, Sarah Wendlinger, Benedikt Obermayer, Julia Schulz, Vadim Farztdinov, Michael Mülleder, Markus Ralser, Judith Houtman, Lara Fleck, Caroline Braeuning, Roberto Sansevrino, Christian Hoffmann, Dragomir Milovanovic, Stephan J Sigrist, Thomas Conrad, Dieter Beule, Frank L Heppner, Marina Jendrac. Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model. Journal of neuroinflammation. vol 19. issue 1. 2022-07-02. PMID:35780157. deposition of amyloid beta (aβ) and hyperphosphorylated tau along with glial cell-mediated neuroinflammation are prominent pathogenic hallmarks of alzheimer's disease (ad). 2022-07-02 2023-08-14 mouse
Wei Qin, Fangyu Li, Longfei Jia, Qi Wang, Ying Li, Yiping Wei, Yan Li, Hongmei Jin, Jianping Ji. Phosphorylated Tau 181 Serum Levels Predict Alzheimer's Disease in the Preclinical Stage. Frontiers in aging neuroscience. vol 14. 2022-06-30. PMID:35769604. phosphorylated tau 181 serum levels predict alzheimer's disease in the preclinical stage. 2022-06-30 2023-08-14 human
Jeremy F Kellie, Bruce C V Campbell, Rosie Watson, Adrian J Praeger, Girish Nair, Anand Murugasu, Christopher C Rowe, Colin L Masters, Steven Collins, Catriona McLean, Nawaf Yass. Amyloid-β (Aβ)-Related Cerebral Amyloid Angiopathy Causing Lobar Hemorrhage Decades After Childhood Neurosurgery. Stroke. 2022-06-30. PMID:35770667. parenchymal aβ deposition, and to a lesser extent tau aggregation, similar to that seen in alzheimer disease, have also been described. 2022-06-30 2023-08-14 Not clear
Jaeyoon Chung, Anjali Das, Xinyu Sun, Débora R Sobreira, Yuk Yee Leung, Catherine Igartua, Sahar Mozaffari, Yi-Fan Chou, Sam Thiagalingam, Jesse Mez, Xiaoling Zhang, Gyungah R Jun, Thor D Stein, Brian W Kunkle, Eden R Martin, Margaret A Pericak-Vance, Richard Mayeux, Jonathan L Haines, Gerard D Schellenberg, Marcelo A Nobrega, Kathryn L Lunetta, Jayant M Pinto, Li-San Wang, Carole Ober, Lindsay A Farre. Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-06-30. PMID:35770850. variants in the tau gene (mapt) region are associated with breast cancer in women and alzheimer's disease (ad) among persons lacking apolipoprotein e ε4 (ε4-). 2022-06-30 2023-08-14 Not clear
Tejaswi Tammareddy, Walid Keyrouz, Ram D Sriram, Harish C Pant, Antonio Cardone, Jeffery B Klaud. Computational Study of the Allosteric Effects of p5 on CDK5-p25 Hyperactivity as Alternative Inhibitory Mechanisms in Neurodegeneration. The journal of physical chemistry. B. 2022-06-30. PMID:35771127. the cyclin-dependent kinase (cdk5) forms a stable complex with its activator p25, leading to the hyperphosphorylation of tau proteins and to the formation of plaques and tangles that are considered to be one of the typical causes of alzheimer's disease (ad). 2022-06-30 2023-08-14 Not clear
Amaryllis A Tsiknia, Steven D Edland, Erin E Sundermann, Emilie T Reas, James B Brewer, Douglas Galasko, Sarah J Bank. Sex differences in plasma p-tau181 associations with Alzheimer's disease biomarkers, cognitive decline, and clinical progression. Molecular psychiatry. 2022-06-29. PMID:35768637. studies have shown that women on the alzheimer's disease (ad) continuum have more pathological tau in the brain and cerebrospinal fluid (csf), than men. 2022-06-29 2023-08-14 human
Jeremy A Tanner, Leonardo Iaccarino, Lauren Edwards, Breton M Asken, Maria L Gorno-Tempini, Joel H Kramer, Julie Pham, David C Perry, Katherine Possin, Maura Malpetti, Taylor Mellinger, Bruce L Miller, Zachary Miller, Nidhi S Mundada, Howard J Rosen, David N Soleimani-Meigooni, Amelia Strom, Renaud La Joie, Gil D Rabinovic. Amyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer's disease. Brain : a journal of neurology. 2022-06-28. PMID:35762829. amyloid, tau and metabolic pet correlates of cognition in early and late-onset alzheimer's disease. 2022-06-28 2023-08-14 human
Jeremy A Tanner, Leonardo Iaccarino, Lauren Edwards, Breton M Asken, Maria L Gorno-Tempini, Joel H Kramer, Julie Pham, David C Perry, Katherine Possin, Maura Malpetti, Taylor Mellinger, Bruce L Miller, Zachary Miller, Nidhi S Mundada, Howard J Rosen, David N Soleimani-Meigooni, Amelia Strom, Renaud La Joie, Gil D Rabinovic. Amyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer's disease. Brain : a journal of neurology. 2022-06-28. PMID:35762829. in conclusion, tau and neurodegeneration, but not amyloid, were similarly associated with cognition in both early and late-onset alzheimer's disease. 2022-06-28 2023-08-14 human
Jeremy A Tanner, Leonardo Iaccarino, Lauren Edwards, Breton M Asken, Maria L Gorno-Tempini, Joel H Kramer, Julie Pham, David C Perry, Katherine Possin, Maura Malpetti, Taylor Mellinger, Bruce L Miller, Zachary Miller, Nidhi S Mundada, Howard J Rosen, David N Soleimani-Meigooni, Amelia Strom, Renaud La Joie, Gil D Rabinovic. Amyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer's disease. Brain : a journal of neurology. 2022-06-28. PMID:35762829. our findings support tau pet as a biomarker that captures both the clinical severity and molecular pathology specific to alzheimer's disease across the broad spectrum of ages and clinical phenotypes in alzheimer's disease. 2022-06-28 2023-08-14 human
Petrice M Cogswell, Heather J Wiste, Michelle M Mielke, Christopher G Schwarz, Stephen D Weigand, Val J Lowe, Terry M Therneau, David S Knopman, Jonathan Graff-Radford, Prashanthi Vemuri, Matthew L Senjem, Jeffrey L Gunter, Alicia Algeciras-Schimnich, Ronald C Petersen, Clifford R Jac. CSF phosphorylated tau as an indicator of subsequent tau accumulation. Neurobiology of aging. vol 117. 2022-06-28. PMID:35764037. we evaluated the relationship between baseline csf p-tau181 and the rate of tau pet change in the temporal meta-roi and entorhinal cortex (erc) and how it varied by amyloid level (csf aβ42 or amyloid pet) among 143 individuals from the mayo clinic study of aging and mayo alzheimer disease research center. 2022-06-28 2023-08-14 human
Shweta S Puntambekar, Miguel Moutinho, Peter Bor-Chian Lin, Vaishnavi Jadhav, Danika Tumbleson-Brink, Ananya Balaji, Martin Alvarado Benito, Guixiang Xu, Adrian Oblak, Cristian A Lasagna-Reeves, Gary E Landreth, Bruce T Lam. CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-06-28. PMID:35764973. despite its identification as a key checkpoint regulator of microglial activation in alzheimer's disease, the overarching role of cx3cr1 signaling in modulating mechanisms of aβ driven neurodegeneration, including accumulation of hyperphosphorylated tau is not well understood. 2022-06-28 2023-08-14 Not clear
Giavanna Paterno, Brach M Bell, Kimberly-Marie M Gorion, Stefan Prokop, Benoit I Giasso. Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology. Acta neuropathologica communications. vol 10. issue 1. 2022-06-28. PMID:35765058. the presence of tau inclusions in the form of neurofibrillary tangles, neuropil threads and dystrophic neurites within senile plaques are essential and defining features of alzheimer's disease. 2022-06-28 2023-08-14 human
Giavanna Paterno, Brach M Bell, Kimberly-Marie M Gorion, Stefan Prokop, Benoit I Giasso. Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology. Acta neuropathologica communications. vol 10. issue 1. 2022-06-28. PMID:35765058. the current dogma favors the notion that tau is predominantly an axonal protein, and that in alzheimer's disease there is a redistribution of tau towards the neuronal soma that is associated with the formation of pathological inclusions such as neurofibrillary tangles and neuropil threads. 2022-06-28 2023-08-14 human
Giavanna Paterno, Brach M Bell, Kimberly-Marie M Gorion, Stefan Prokop, Benoit I Giasso. Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology. Acta neuropathologica communications. vol 10. issue 1. 2022-06-28. PMID:35765058. additionally, in alzheimer's disease tau pathology is significantly more abundant in the brain cortical gray matter of affected brain regions compared to the adjacent white matter regions. 2022-06-28 2023-08-14 human