| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tharick A Pascoal, Mira Chamoun, Elad Lax, Hsiao-Ying Wey, Monica Shin, Kok Pin Ng, Min Su Kang, Sulantha Mathotaarachchi, Andrea L Benedet, Joseph Therriault, Firoza Z Lussier, Frederick A Schroeder, Jonathan M DuBois, Baileigh G Hightower, Tonya M Gilbert, Nicole R Zürcher, Changning Wang, Robert Hopewell, Mallar Chakravarty, Melissa Savard, Emilie Thomas, Sara Mohaddes, Sarah Farzin, Alyssa Salaciak, Stephanie Tullo, A Claudio Cuello, Jean-Paul Soucy, Gassan Massarweh, Heungsun Hwang, Eliane Kobayashi, Bradley T Hyman, Bradford C Dickerson, Marie-Christine Guiot, Moshe Szyf, Serge Gauthier, Jacob M Hooker, Pedro Rosa-Net. [ Nature communications. vol 13. issue 1. 2022-07-19. PMID:35853847. |
[ alzheimer's disease (ad) is characterized by the brain accumulation of amyloid-β and tau proteins. |
2022-07-19 |
2023-08-14 |
human |
| Chuanbin Yang, Chengfu Su, Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Zhou Zhu, Sichang Yang, Benjamin Chunkit Tong, Jia Liu, Sravan G Sreenivasmurthy, Xinjie Guan, Yuxuan Kan, Aston Jiaxi Wu, Alexis Shiying Huang, Jieqiong Tan, Kingho Cheung, Juxian Song, Min L. Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy. Acta pharmaceutica Sinica. B. vol 12. issue 4. 2022-07-18. PMID:35847498. |
celastrol enhances transcription factor eb (tfeb)-mediated autophagy and mitigates tau pathology: implications for alzheimer's disease therapy. |
2022-07-18 |
2023-08-14 |
Not clear |
| Chuanbin Yang, Chengfu Su, Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Zhou Zhu, Sichang Yang, Benjamin Chunkit Tong, Jia Liu, Sravan G Sreenivasmurthy, Xinjie Guan, Yuxuan Kan, Aston Jiaxi Wu, Alexis Shiying Huang, Jieqiong Tan, Kingho Cheung, Juxian Song, Min L. Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy. Acta pharmaceutica Sinica. B. vol 12. issue 4. 2022-07-18. PMID:35847498. |
alzheimer's disease (ad), characterized by the accumulation of protein aggregates including phosphorylated tau aggregates, is the most common neurodegenerative disorder with limited therapeutic agents. |
2022-07-18 |
2023-08-14 |
Not clear |
| Yi-He Chen, Rong-Rong Lin, Hui-Feng Huang, Yan-Yan Xue, Qing-Qing Ta. Microglial Activation, Tau Pathology, and Neurodegeneration Biomarkers Predict Longitudinal Cognitive Decline in Alzheimer's Disease Continuum. Frontiers in aging neuroscience. vol 14. 2022-07-18. PMID:35847667. |
microglial activation, tau pathology, and neurodegeneration biomarkers predict longitudinal cognitive decline in alzheimer's disease continuum. |
2022-07-18 |
2023-08-14 |
Not clear |
| Hui-Zhi Long, Zi-Wei Zhou, Yan Cheng, Hong-Yu Luo, Feng-Jiao Li, Shuo-Guo Xu, Li-Chen Ga. The Role of Microglia in Alzheimer's Disease From the Perspective of Immune Inflammation and Iron Metabolism. Frontiers in aging neuroscience. vol 14. 2022-07-18. PMID:35847685. |
alzheimer's disease (ad), the most common type of senile dementia, includes the complex pathogenesis of abnormal deposition of amyloid beta-protein (aβ), phosphorylated tau (p-tau) and neuroimmune inflammatory. |
2022-07-18 |
2023-08-14 |
Not clear |
| Naomi Vlegels, Rik Ossenkoppele, Wiesje M van der Flier, Huiberdina L Koek, Yael D Reijmer, Laura Em Wisse, Geert Jan Biessel. Does Loss of Integrity of the Cingulum Bundle Link Amyloid-β Accumulation and Neurodegeneration in Alzheimer's Disease? Journal of Alzheimer's disease : JAD. 2022-07-18. PMID:35848018. |
alzheimer's disease is characterized by the accumulation of amyloid-β (aβ) into plaques, aggregation of tau into neurofibrillary tangles, and neurodegenerative processes including atrophy. |
2022-07-18 |
2023-08-14 |
Not clear |
| Viet Hoang Man, Da Lin, Xibing He, Jie Gao, Junmei Wan. Joint Computational/Cell-Based Oligomerization for Screening Inhibitors of Tau Assembly: A Proof-of-Concept Study. Journal of Alzheimer's disease : JAD. 2022-07-18. PMID:35848028. |
tau assembly produces soluble oligomers and insoluble neurofibrillary tangles, which are neurotoxic to the brain and associated with alzheimer's and parkinson's diseases. |
2022-07-18 |
2023-08-14 |
Not clear |
| B Souchet, M Audrain, Y Gu, M F Lindberg, N S Orefice, E Rey, N Cartier, N Janel, L Meijer, J Braudea. Cerebral Phospho-Tau Acts Synergistically with Soluble Aβ42 Leading to Mild Cognitive Impairment in AAV-AD Rats. The journal of prevention of Alzheimer's disease. vol 9. issue 3. 2022-07-16. PMID:35841249. |
alzheimer's disease (ad) is a continuum of events beginning with an increase in brain soluble aβ42 followed by the appearance of hyperphosphorylated tau (p-tau, asymptomatic stage). |
2022-07-16 |
2023-08-14 |
rat |
| Siva Prasad Panda, Yogita Dhurandhar, Mehak Agrawa. The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. Mitochondrion. 2022-07-16. PMID:35842181. |
the epileptogenesis in patients with alzheimer's disease dementia (add) and parkinson's disease dementia (pdd) is due to involvement of amyloid plaques (aβ), phosphorylated tau (ptau), parkin, nf-kb and nlrp3 inflammasome.microglia, the prime protective and inflammatory cells in the brain exert crosstalk between mitophagy and inflammation. |
2022-07-16 |
2023-08-14 |
Not clear |
| Chisato Fujisawa, Naoki Saji, Akinori Takeda, Takashi Kato, Akinori Nakamura, Keita Sakurai, Yuya Asanomi, Kouichi Ozaki, Koji Takada, Hiroyuki Umegaki, Masafumi Kuzuya, Takashi Sakura. Early-onset Alzheimer Disease Associated With Neuromyelitis Optica Spectrum Disorder. Alzheimer disease and associated disorders. 2022-07-15. PMID:35838179. |
she was diagnosed with early-onset alzheimer disease based on amyloid and tau positron emission tomography imaging biomarkers. |
2022-07-15 |
2023-08-14 |
Not clear |
| Diego Sepulveda-Falla, Justin S Sanchez, Maria Camila Almeida, Daniela Boassa, Juliana Acosta-Uribe, Clara Vila-Castelar, Liliana Ramirez-Gomez, Ana Baena, David Aguillon, Nelson David Villalba-Moreno, Jessica Lisa Littau, Andres Villegas, Thomas G Beach, Charles L White, Mark Ellisman, Susanne Krasemann, Markus Glatzel, Keith A Johnson, Reisa A Sperling, Eric M Reiman, Joseph F Arboleda-Velasquez, Kenneth S Kosik, Francisco Lopera, Yakeel T Quiro. Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia. Acta neuropathologica. 2022-07-15. PMID:35838824. |
distinct tau neuropathology and cellular profiles of an apoe3 christchurch homozygote protected against autosomal dominant alzheimer's dementia. |
2022-07-15 |
2023-08-14 |
Not clear |
| Alejandro Marmolejo-Garza, Tiago Medeiros-Furquim, Ramya Rao, Bart J L Eggen, Erik Boddeke, Amalia M Dolg. Transcriptomic and epigenomic landscapes of Alzheimer's disease evidence mitochondrial-related pathways. Biochimica et biophysica acta. Molecular cell research. 2022-07-15. PMID:35839870. |
alzheimer's disease (ad) is the main cause of dementia and it is defined by cognitive decline coupled to extracellular deposit of amyloid-beta protein and intracellular hyperphosphorylation of tau protein. |
2022-07-15 |
2023-08-14 |
Not clear |
| Vigneshwaran Namasivayam, Katja Stefan, Lukas Gorecki, Jan Korabecny, Ondrej Soukup, Patric Jan Jansson, Jens Pahnke, Sven Marcel Stefa. Physicochemistry shapes bioactivity landscape of pan-ABC transporter modulators: Anchor point for innovative Alzheimer's disease therapeutics. International journal of biological macromolecules. 2022-07-15. PMID:35839956. |
alzheimer's disease (ad) is a devastating neurological disorder characterized by the pathological accumulation of macromolecular aβ and tau leading to neuronal death. |
2022-07-15 |
2023-08-14 |
Not clear |
| Kirsten E J Wesenhagen, Betty M Tijms, Lynn Boonkamp, Patty L Hoede, Julie Goossens, Nele Dewit, Philip Scheltens, Eugeen Vanmechelen, Pieter Jelle Visser, Charlotte E Teunisse. P-tau subgroups in AD relate to distinct amyloid production and synaptic integrity profiles. Alzheimer's research & therapy. vol 14. issue 1. 2022-07-15. PMID:35841015. |
we previously identified four alzheimer's disease (ad) subgroups with increasingly higher cerebrospinal fluid (csf) levels of tau phosphorylated at threonine 181 (p-tau). |
2022-07-15 |
2023-08-14 |
Not clear |
| Paige Mumford, Justin Tosh, Silvia Anderle, Eleni Gkanatsiou Wikberg, Gloria Lau, Sue Noy, Karen Cleverley, Takashi Saito, Takaomi C Saido, Eugene Yu, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Henrik Zetterberg, Victor Tybulewicz, Elizabeth M C Fisher, Frances K Wisema. Genetic mapping of APP and amyloid-β biology modulation by trisomy 21. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-07-14. PMID:35835549. |
individuals who have down syndrome (ds) frequently develop early onset alzheimer's disease (ad), a neurodegenerative condition caused by the build-up of aggregated amyloid-β and tau proteins in the brain. |
2022-07-14 |
2023-08-14 |
Not clear |
| Van N Huynh, Sheng Wang, Xiaosen Ouyang, Willayat Y Wani, Michelle S Johnson, Balu K Chacko, Anil G Jegga, Wei-Jun Qian, John C Chatham, Victor M Darley-Usmar, Jianhua Zhan. Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases. Frontiers in aging. vol 2. 2022-07-13. PMID:35822049. |
pharmacological increase of protein o-glcnacylation by thiamet g (tg) has been shown to decrease tau phosphorylation and neurotoxicity, and proposed as a therapy in alzheimer's disease (ad). |
2022-07-13 |
2023-08-14 |
mouse |
| Ayano Ishii, Yukio Matsuba, Naomi Mihira, Naoko Kamano, Takashi Saito, Shin-Ichi Muramatsu, Makoto Yokosuka, Takaomi C Saido, Shoko Hashimot. Tau-binding protein PRMT8 facilitates vacuole degeneration in the brain. Journal of biochemistry. 2022-07-12. PMID:35818334. |
amyloid-β (aβ) and tau pathologies are important factors leading to neurodegeneration in alzheimer's disease (ad); however the molecular mechanisms that link these pathologies remain unclear. |
2022-07-12 |
2023-08-14 |
mouse |
| Grace I Hallinan, Kadir A Ozcan, Md Rejaul Hoq, Laura Cracco, Frank S Vago, Sakshibeedu R Bharath, Daoyi Li, Max Jacobsen, Emma H Doud, Amber L Mosley, Anllely Fernandez, Holly J Garringer, Wen Jiang, Bernardino Ghetti, Ruben Vida. Cryo-EM structures of prion protein filaments from Gerstmann-Sträussler-Scheinker disease. Acta neuropathologica. 2022-07-12. PMID:35819518. |
it has been shown that neurodegeneration in this disease is associated with the presence of extracellular aprp plaques and neuronal intracytoplasmic tau inclusions, that have been shown to contain paired helical filaments identical to those found in alzheimer disease. |
2022-07-12 |
2023-08-14 |
human |
| Natasha Krishnadas, Kun Huang, Stephanie A Schultz, Vincent Doré, Pierrick Bourgeat, Anita M Y Goh, Fiona Lamb, Svetlana Bozinovski, Samantha C Burnham, Joanne S Robertson, Simon M Laws, Paul Maruff, Colin L Masters, Victor L Villemagne, Christopher C Row. Visually Identified Tau 18F-MK6240 PET Patterns in Symptomatic Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-07-11. PMID:35811517. |
visually identified tau 18f-mk6240 pet patterns in symptomatic alzheimer's disease. |
2022-07-11 |
2023-08-14 |
Not clear |
| Natasha Krishnadas, Kun Huang, Stephanie A Schultz, Vincent Doré, Pierrick Bourgeat, Anita M Y Goh, Fiona Lamb, Svetlana Bozinovski, Samantha C Burnham, Joanne S Robertson, Simon M Laws, Paul Maruff, Colin L Masters, Victor L Villemagne, Christopher C Row. Visually Identified Tau 18F-MK6240 PET Patterns in Symptomatic Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-07-11. PMID:35811517. |
in alzheimer's disease, heterogeneity has been observed in the postmortem distribution of tau neurofibrillary tangles. |
2022-07-11 |
2023-08-14 |
Not clear |