All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Lingyu Zhang, Danhua Wang, Yibei Dai, Xuchu Wang, Ying Cao, Weiwei Liu, Zhihua Ta. Machine Learning Reveals a Multipredictor Nomogram for Diagnosing the Alzheimer's Disease Based on Chemiluminescence Immunoassay for Total Tau in Plasma. Frontiers in aging neuroscience. vol 14. 2022-06-01. PMID:35645782. machine learning reveals a multipredictor nomogram for diagnosing the alzheimer's disease based on chemiluminescence immunoassay for total tau in plasma. 2022-06-01 2023-08-13 Not clear
Colin Groot, Sylvia Villeneuve, Ruben Smith, Oskar Hansson, Rik Ossenkoppel. Tau PET Imaging in Neurodegenerative Disorders. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 63. issue Suppl 1. 2022-06-01. PMID:35649647. the advent of pet ligands that bind tau pathology has enabled the quantification and visualization of tau pathology in aging and in alzheimer disease (ad). 2022-06-01 2023-08-13 Not clear
Maura Malpetti, Renaud La Joie, Gil D Rabinovic. Tau Beats Amyloid in Predicting Brain Atrophy in Alzheimer Disease: Implications for Prognosis and Clinical Trials. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 63. issue 6. 2022-06-01. PMID:35649659. tau beats amyloid in predicting brain atrophy in alzheimer disease: implications for prognosis and clinical trials. 2022-06-01 2023-08-13 Not clear
Xiaonan Wang, Bei Li, Xiaohong Yu, Ye Zhou, Yue Ga. The Neuroprotective Effect of GM-1 Ganglioside on the Amyloid-Beta-Induced Oxidative Stress in PC-12 Cells Mediated by Nrf-2/ARE Signaling Pathway. Neurochemical research. 2022-05-31. PMID:35635605. alzheimer's disease (ad) is characterized by the accumulation of amyloid-β (aβ) plaques, tau tangles, neuroinflammation, oxidative stress, and progressive memory deficits. 2022-05-31 2023-08-13 Not clear
Yutaka Nakagawa, Shizuo Yamad. The Relationships Among Metal Homeostasis, Mitochondria, and Locus Coeruleus in Psychiatric and Neurodegenerative Disorders: Potential Pathogenetic Mechanism and Therapeutic Implications. Cellular and molecular neurobiology. 2022-05-31. PMID:35635600. in early alzheimer's and parkinson's diseases, metal dyshomeostasis and mitochondrial dysfunction likely induce locus coeruleus hyperactivation, pathological tau or α-synuclein formation, and neurodegeneration, while reduction of glymphatic and cerebrospinal fluid flow might be responsible for β-amyloid aggregation in the olfactory regions before the onset of dementia. 2022-05-31 2023-08-13 Not clear
Ian M Henderson, Carlissa Marez, Karol Dokladny, Jane Smoake, Maria Martinez, David Johnson, George R Uh. Substrate-selective positive allosteric modulation of PTPRD's phosphatase by flavonols. Biochemical pharmacology. 2022-05-31. PMID:35636503. flavonol-mediated increases in ptprd's dephosphorylation of the gsk3 β and α kinases that hyperphosphorylate tau, the major component of ad-nfts, could help to explain recent data concerning genetic and dietary impacts on alzheimer's disease. 2022-05-31 2023-08-13 human
Bettina Sarg, Dhwani S Korde, Josef Marksteiner, Christian Humpe. Platelet TAU is Associated with Changes in Depression and Alzheimer's Disease. Frontiers in bioscience (Landmark edition). vol 27. issue 5. 2022-05-31. PMID:35638420. platelet tau is associated with changes in depression and alzheimer's disease. 2022-05-31 2023-08-13 Not clear
Atul Kumar, Shorena Janelidze, Erik Stomrud, Sebastian Palmqvist, Oskar Hansson, Niklas Mattsson-Carlgre. β-Amyloid-Dependent and -Independent Genetic Pathways Regulating CSF Tau Biomarkers in Alzheimer Disease. Neurology. 2022-05-31. PMID:35641311. β-amyloid-dependent and -independent genetic pathways regulating csf tau biomarkers in alzheimer disease. 2022-05-31 2023-08-13 Not clear
Md Ataur Rahman, M D Hasanur Rahman, A N M Mamun-Or-Rashid, Hongik Hwang, Sooyoung Chung, Bonglee Kim, Hyewhon Rhi. Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer's Disease. Biomedicines. vol 10. issue 5. 2022-05-28. PMID:35625764. alzheimer's disease (ad) is one of the most prevailing neurodegenerative diseases in the world, which is characterized by memory dysfunction and the formation of tau and amyloid β (aβ) aggregates in multiple brain regions, including the hippocampus and cortex. 2022-05-28 2023-08-13 Not clear
ShinWoo Kang, Jinho Kim, Sang-Yoon Lee, Nobuyuki Okamura, Keun-A Chan. MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6 × Tg Alzheimer's Disease Model Mice. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628296. micropet imaging assessment of brain tau and amyloid deposition in 6 × tg alzheimer's disease model mice. 2022-05-28 2023-08-13 mouse
Jon B Toledo, Hangfan Liu, Michel J Grothe, Tanweer Rashid, Lenore Launer, Leslie M Shaw, Haykel Snoussi, Susan Heckbert, Michael Weiner, John Q Trojanwoski, Sudha Seshadri, Mohamad Habe. Disentangling tau and brain atrophy cluster heterogeneity across the Alzheimer's disease continuum. Alzheimer's & dementia (New York, N. Y.). vol 8. issue 1. 2022-05-27. PMID:35619830. disentangling tau and brain atrophy cluster heterogeneity across the alzheimer's disease continuum. 2022-05-27 2023-08-13 Not clear
Zhonglei Bao, Jianghua Liu, Jin F. Comprehensive binary interaction mapping of τ phosphotyrosine sites with SH2 domains in the human genome: Implications for the rational design of self-inhibitory phosphopeptides to target τ hyperphosphorylation signaling in Alzheimer's Disease. Amino acids. 2022-05-27. PMID:35622130. human microtubule-associated protein tau (τ) is abundant in the axons of neurons where it stabilizes microtubule bundles; abnormally hyperphosphorylated τ is a hallmark of alzheimer's disease (ad) and related tauopathies. 2022-05-27 2023-08-13 human
Aurelio J Dregni, Pu Duan, Hong Xu, Lakshmi Changolkar, Nadia El Mammeri, Virginia M-Y Lee, Mei Hon. Fluent molecular mixing of Tau isoforms in Alzheimer's disease neurofibrillary tangles. Nature communications. vol 13. issue 1. 2022-05-27. PMID:35624093. fluent molecular mixing of tau isoforms in alzheimer's disease neurofibrillary tangles. 2022-05-27 2023-08-13 Not clear
Aurelio J Dregni, Pu Duan, Hong Xu, Lakshmi Changolkar, Nadia El Mammeri, Virginia M-Y Lee, Mei Hon. Fluent molecular mixing of Tau isoforms in Alzheimer's disease neurofibrillary tangles. Nature communications. vol 13. issue 1. 2022-05-27. PMID:35624093. alzheimer's disease (ad) is defined by intracellular neurofibrillary tangles formed by the microtubule-associated protein tau and extracellular plaques formed by the β-amyloid peptide. 2022-05-27 2023-08-13 Not clear
Kamalini Ranasinghe, Parul Verma, Chang Cai, Xihe Xie, Kiwamu Kudo, Xiao Gao, Hannah Lerner, Danielle Mizuiri, Amelia Strom, Leonardo Iaccarino, Renaud La Joie, Bruce L Miller, Maria Luisa Gorno-Tempini, Katherine P Rankin, William J Jagust, Keith Vossel, Gil Rabinovici, Ashish Raj, Srikantan Nagaraja. Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer's disease. eLife. vol 11. 2022-05-26. PMID:35616532. altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in alzheimer's disease. 2022-05-26 2023-08-13 Not clear
Koyo Tsujikawa, Kohei Hamanaka, Yuichi Riku, Yuki Hattori, Norikazu Hara, Yohei Iguchi, Shinsuke Ishigaki, Atsushi Hashizume, Satoko Miyatake, Satomi Mitsuhashi, Yu Miyazaki, Mayumi Kataoka, Li Jiayi, Keizo Yasui, Satoshi Kuru, Haruki Koike, Kenta Kobayashi, Naruhiko Sahara, Norio Ozaki, Mari Yoshida, Akiyoshi Kakita, Yuko Saito, Yasushi Iwasaki, Akinori Miyashita, Takeshi Iwatsubo, Takeshi Ikeuchi, Takaki Miyata, Gen Sobue, Naomichi Matsumoto, Kentaro Sahashi, Masahisa Katsun. Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology. Science advances. vol 8. issue 21. 2022-05-25. PMID:35613261. while amyloid-β lies upstream of tau pathology in alzheimer's disease, key drivers for other tauopathies, including progressive supranuclear palsy (psp), are largely unknown. 2022-05-25 2023-08-13 mouse
Daniel Gallo, Agustín Ruiz, Pascual Sánchez-Jua. Genetic architecture of primary tauopathies. Neuroscience. 2022-05-24. PMID:35609758. this is especially salient between psp and cbd, but also gwas studying the recently described part phenotype shows genetic overlap with genes that promote tau pathology and with others associated with alzheimer's disease. 2022-05-24 2023-08-13 Not clear
Alejandro Antón-Fernández, Gonzalo León-Espinosa, Javier DeFelipe, Alberto Muño. Pyramidal cell axon initial segment in Alzheimer´s disease. Scientific reports. vol 12. issue 1. 2022-05-24. PMID:35610289. in the present study, using immunocytochemistry with the at8 antibody (phospho-tau s202/t205) and 3d confocal microscopy reconstruction techniques in brain tissue from alzheimer's disease patients, we found that around half of the cortical pyramidal neurons with hyperphosphorylated tau showed changes in ais length and position in comparison with at8-negative neurons from the same cortical layers. 2022-05-24 2023-08-13 Not clear
Yuan Cheng, Jie-Ming Jian, Chen-Yang He, Jun-Rong Ren, Man-Yu Xu, Wang-Sheng Jin, Cheng-Rong Tan, Gui-Hua Zeng, Ying-Ying Shen, Dong-Wan Chen, Hui-Yun Li, Xu Yi, Yuan Zhang, Fan Zeng, Yan-Jiang Wan. The Correlations of Plasma Liver-Type Fatty Acid-Binding Protein with Amyloid-β and Tau Levels in Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-05-23. PMID:35599489. the correlations of plasma liver-type fatty acid-binding protein with amyloid-β and tau levels in patients with alzheimer's disease. 2022-05-23 2023-08-13 Not clear
Yi-Liang Tsai, Chieh-Tsung Yen, Yuh-Feng Wan. Astrocyte Dysregulation and Calcium Ion Imbalance May Link the Development of Osteoporosis and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-05-23. PMID:35599492. the typical symptoms of patients with alzheimer's disease (ad) are amyloid-β (aβ) plaques and tau hyperphosphorylation. 2022-05-23 2023-08-13 Not clear