| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Einar M Sigurdsso. Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Status of Trials and Insights from Preclinical Studies. Journal of Alzheimer's disease : JAD. 2024-03-01. PMID:38427486. |
in alzheimer's disease, clearing pathological tau may therefore improve function later in the disease process than when removing amyloid-β. |
2024-03-01 |
2024-03-04 |
Not clear |
| Shawn C C Hsueh, Mark Nijland, Adekunle Aina, Steven S Plotki. Cyclization Scaffolding for Improved Vaccine Immunogen Stability: Application to Tau Protein in Alzheimer's Disease. Journal of chemical information and modeling. 2024-03-01. PMID:38427576. |
cyclization scaffolding for improved vaccine immunogen stability: application to tau protein in alzheimer's disease. |
2024-03-01 |
2024-03-04 |
Not clear |
| Lannah S Abasi, Nesreen Elathram, Manasi Movva, Amar Deep, Kevin D Corbett, Galia T Debelouchin. Phosphorylation regulates tau's phase separation behavior and interactions with chromatin. Communications biology. vol 7. issue 1. 2024-03-01. PMID:38429335. |
tau is a microtubule-associated protein often found in neurofibrillary tangles (nfts) in the brains of patients with alzheimer's disease. |
2024-03-01 |
2024-03-04 |
Not clear |
| Arpan Dey, Aditi Verma, Uchit Bhaskar, Bidyut Sarkar, Mamata Kallianpur, Vicky Vishvakarma, Anand Kant Das, Kanchan Garai, Odity Mukherjee, Kunihiko Ishii, Tahei Tahara, Sudipta Mait. A Toxicogenic Interaction between Intracellular Amyloid-β and Apolipoprotein-E. ACS chemical neuroscience. 2024-02-29. PMID:38421952. |
a toxicogenic interaction between intracellular amyloid-β and apolipoprotein-e. alzheimer's disease (ad) is associated with the aggregation of amyloid β (aβ) and tau proteins. |
2024-02-29 |
2024-03-03 |
rat |
| Veerle van Gils, Marianna Rizzo, Jade Côte, Wolfgang Viechtbauer, Giuseppe Fanelli, Jordi Salas-Salvadó, Theresa Wimberley, Mònica Bulló, Fernando Fernandez-Aranda, Søren Dalsgaard, Pieter Jelle Visser, Willemijn J Jansen, Stephanie J B Vo. The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: a systematic review and meta-analysis. Neuroscience and biobehavioral reviews. 2024-02-29. PMID:38423195. |
the association of glucose metabolism measures and diabetes status with alzheimer's disease biomarkers of amyloid and tau: a systematic review and meta-analysis. |
2024-02-29 |
2024-03-03 |
Not clear |
| Sujin Kim, Soo Jung Shin, Yunkwon Nam, Yong Ho Park, Byeong-Hyeon Kim, Hyun Ha Park, Vijay Kumar, Doo-Han Yoo, Yong Yook Lee, Hyang-Sook Hoe, Minho Moo. Korean red ginseng polysaccharide as a potential therapeutic agent targeting tau pathology in Alzheimer's disease. International journal of biological macromolecules. 2024-02-29. PMID:38423419. |
korean red ginseng polysaccharide as a potential therapeutic agent targeting tau pathology in alzheimer's disease. |
2024-02-29 |
2024-03-03 |
mouse |
| Sujin Kim, Soo Jung Shin, Yunkwon Nam, Yong Ho Park, Byeong-Hyeon Kim, Hyun Ha Park, Vijay Kumar, Doo-Han Yoo, Yong Yook Lee, Hyang-Sook Hoe, Minho Moo. Korean red ginseng polysaccharide as a potential therapeutic agent targeting tau pathology in Alzheimer's disease. International journal of biological macromolecules. 2024-02-29. PMID:38423419. |
tau pathology is stronger associated with cognitive decline in patients with alzheimer's disease (ad) than amyloid beta (aβ) pathology. |
2024-02-29 |
2024-03-03 |
mouse |
| Lars Tatenhorst, Fabian Maass, Hannah Paul, Vivian Dambeck, Mathias Bähr, Rosanna Dono, Paul Lingo. Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-02-29. PMID:38424123. |
initially described as supporting functionality of synapses via glutamate receptors during cns development, glypican 4 (gpc-4) also plays a role in the context of dementia via tau hyperphosphorylation in alzheimer's disease, which is also a co-pathology in parkinson's disease dementia. |
2024-02-29 |
2024-03-03 |
human |
| Liara Rizzi, Lea T Grinber. Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer's disease: implications for biomarker development and therapeutic targeting. Acta neuropathologica communications. vol 12. issue 1. 2024-02-28. PMID:38419122. |
exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in alzheimer's disease: implications for biomarker development and therapeutic targeting. |
2024-02-28 |
2024-03-02 |
Not clear |
| Nadia El Mammeri, Aurelio J Dregni, Pu Duan, Mei Hon. Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 10. 2024-02-28. PMID:38408247. |
the microtubule-associated protein tau aggregates into amyloid fibrils in alzheimer's disease and other neurodegenerative diseases. |
2024-02-28 |
2024-03-01 |
Not clear |
| Khalid Eltom, Tobias Mothes, Sylwia Libard, Martin Ingelsson, Anna Erlandsso. Astrocytic accumulation of tau fibrils isolated from Alzheimer's disease brains induces inflammation, cell-to-cell propagation and neuronal impairment. Acta neuropathologica communications. vol 12. issue 1. 2024-02-28. PMID:38409026. |
astrocytic accumulation of tau fibrils isolated from alzheimer's disease brains induces inflammation, cell-to-cell propagation and neuronal impairment. |
2024-02-28 |
2024-03-01 |
human |
| Anika Wuestefeld, Hannah Baumeister, Jenna N Adams, Robin de Flores, Carl J Hodgetts, Negar Mazloum-Farzaghi, Rosanna K Olsen, Vyash Puliyadi, Tammy T Tran, Arnold Bakker, Kelsey L Canada, Marshall A Dalton, Ana M Daugherty, Renaud La Joie, Lei Wang, Madigan L Bedard, Esther Buendia, Eunice Chung, Amanda Denning, María Del Mar Arroyo-Jiménez, Emilio Artacho-Pérula, David J Irwin, Ranjit Ittyerah, Edward B Lee, Sydney Lim, María Del Pilar Marcos-Rabal, Maria Mercedes Iñiguez de Onzoño Martin, Monica Munoz Lopez, Carlos de la Rosa Prieto, Theresa Schuck, Winifred Trotman, Alicia Vela, Paul Yushkevich, Katrin Amunts, Jean C Augustinack, Song-Lin Ding, Ricardo Insausti, Olga Kedo, David Berron, Laura E M Wiss. Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories. Hippocampus. 2024-02-28. PMID:38415962. |
the medial temporal lobe (mtl) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as alzheimer's disease neurofibrillary tau tangles. |
2024-02-28 |
2024-03-01 |
human |
| Frédéric St-Onge, Marianne Chapleau, John C S Breitner, Sylvia Villeneuve, Alexa Pichet Binett. Tau accumulation and its spatial progression across the Alzheimer's disease spectrum. Brain communications. vol 6. issue 1. 2024-02-27. PMID:38410618. |
tau accumulation and its spatial progression across the alzheimer's disease spectrum. |
2024-02-27 |
2024-03-02 |
Not clear |
| Frédéric St-Onge, Marianne Chapleau, John C S Breitner, Sylvia Villeneuve, Alexa Pichet Binett. Tau accumulation and its spatial progression across the Alzheimer's disease spectrum. Brain communications. vol 6. issue 1. 2024-02-27. PMID:38410618. |
the accumulation of tau abnormality in sporadic alzheimer's disease is believed typically to follow neuropathologically defined braak staging. |
2024-02-27 |
2024-03-02 |
Not clear |
| Koping Chang, Alexander Barrett, Khoa Pham, Juan C Troncos. Lateral geniculate body is spared of tau pathology in Pick disease. Journal of neuropathology and experimental neurology. 2024-02-27. PMID:38412343. |
the pathobiology of tau is of great importance for understanding the mechanisms of neurodegeneration in aging and age-associated disorders such as alzheimer disease (ad) and frontotemporal dementias. |
2024-02-27 |
2024-03-01 |
Not clear |
| James Naude, Meng Wang, Rebeca Leon, Eric Smith, Zahinoor Ismai. Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment. medRxiv : the preprint server for health sciences. 2024-02-26. PMID:38405711. |
phosphorylated tau (p-tau) is a hallmark biological manifestation of alzheimer disease (ad). |
2024-02-26 |
2024-02-28 |
human |
| Nuo Jia, Dhasarathan Ganesan, Hongyuan Guan, Yu Young Jeong, Sinsuk Han, Marialaina Nissenbaum, Alexander W Kusnecov, Qian Ca. Mitochondrial bioenergetics stimulates autophagy for pathological tau clearance in tauopathy neurons. bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405759. |
hyperphosphorylation and aggregation of microtubule-associated tau is a pathogenic hallmark of tauopathies and a defining feature of alzheimer's disease (ad). |
2024-02-26 |
2024-02-28 |
mouse |
| Haoshen Shi, Nazanin Mirzaei, Yosef Koronyo, Miyah R Davis, Edward Robinson, Gila M Braun, Ousman Jallow, Altan Rentsendorj, V Krishnan Ramanujan, Justyna Fert-Bober, Andrei A Kramerov, Alexander V Ljubimov, Lon S Schneider, Warren G Tourtellotte, Debra Hawes, Julie A Schneider, Keith L Black, Rakez Kayed, Maj-Linda B Selenica, Daniel C Lee, Dieu-Trang Fuchs, Maya Koronyo-Hamaou. Identification of retinal tau oligomers, citrullinated tau, and other tau isoforms in early and advanced AD and relations to disease status. bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405854. |
this study identifies and quantifies diverse pathological tau isoforms in the retina of both early and advanced-stage alzheimer's disease (ad) and determines their relationship with disease status. |
2024-02-26 |
2024-02-28 |
Not clear |
| Bang Wang, Xiaoshu Pan, I-Ting Teng, Xiaowei Li, Firas Kobeissy, Zo-Yu Wu, Jiepei Zhu, Guangzheng Cai, He Yan, Xin Yan, Mingwei Liang, Fahong Yu, Jianrong Lu, Zunyi Yang, Elisa Biondi, William Haskins, Y Charles Cao, Steven A Benner, Weihong Tan, Kevin Wan. Functional Selection of Tau Oligomerization-Inhibiting Aptamers. Angewandte Chemie (International ed. in English). 2024-02-26. PMID:38407551. |
pathological hyperphosphorylation and aggregation of microtubule-associated tau protein contribute to alzheimer's disease (ad) and other related tauopathies. |
2024-02-26 |
2024-02-28 |
Not clear |
| Abigail Alexander, Victor E Alvarez, Bertrand R Huber, Michael L Alosco, Jesse Mez, Yorghos Tripodis, Raymond Nicks, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Brett Martin, Joseph Palmisano, Lee E Goldstein, John F Crary, Christopher Nowinski, Robert C Cantu, Neil W Kowall, Robert A Stern, Ivana Delalle, Ann C McKee, Thor D Stei. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta neuropathologica. vol 147. issue 1. 2024-02-26. PMID:38407651. |
other comorbid tauopathies likely contributed in part to these differences: when cases with concurrent alzheimer dementia or frontal temporal lobar degeneration with tau pathology were excluded, differences were largely retained, but only remained significant for faq (p = 0.042), meta-cognition index t score (p = 0.014) and age of parkinsonian motor symptom onset (p = 0.046). |
2024-02-26 |
2024-02-28 |
human |