All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
S Tok, H Maurin, C Delay, D Crauwels, N V Manyakov, W Van Der Elst, D Moechars, W H I M Drinkenbur. Neurophysiological effects of human-derived pathological tau conformers in the APPKM670/671NL.PS1/L166P amyloid mouse model of Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-05-13. PMID:35546164. notably, while tau histopathological changes were present, a lack of overt longitudinal electrophysiological alterations was noted, particularly in app.ps1 animals that feature both pathologies after seeding, reiterating and underscoring the difficulty and complexity associated with elucidating physiologically relevant and translatable biomarkers of alzheimer's disease at the early stages of the disease. 2022-05-13 2023-08-13 mouse
Kaidi Li, Hang Qu, Mingyi Ma, Chenyu Xia, Ming Cai, Fang Han, Qing Zhang, Xinyi Gu, Qiang M. Correlation Between Brain Structure Atrophy and Plasma Amyloid-β and Phosphorylated Tau in Patients With Alzheimer's Disease and Amnestic Mild Cognitive Impairment Explored by Surface-Based Morphometry. Frontiers in aging neuroscience. vol 14. 2022-05-13. PMID:35547625. correlation between brain structure atrophy and plasma amyloid-β and phosphorylated tau in patients with alzheimer's disease and amnestic mild cognitive impairment explored by surface-based morphometry. 2022-05-13 2023-08-13 Not clear
Kaidi Li, Hang Qu, Mingyi Ma, Chenyu Xia, Ming Cai, Fang Han, Qing Zhang, Xinyi Gu, Qiang M. Correlation Between Brain Structure Atrophy and Plasma Amyloid-β and Phosphorylated Tau in Patients With Alzheimer's Disease and Amnestic Mild Cognitive Impairment Explored by Surface-Based Morphometry. Frontiers in aging neuroscience. vol 14. 2022-05-13. PMID:35547625. to investigate the changes in the cortical thickness of the region of interest (roi) and plasma aβ40, aβ42, and phosphorylated tau (p-tau) concentrations in patients with alzheimer's disease (ad) and amnestic mild cognitive impairment (amci) as the disease progressed with surface-based morphometry (sbm), to analyze the correlation between roi cortical thickness and measured plasma indexes and neuropsychological scales, and to explore the clinical value of roi cortical thickness combined with plasma aβ40, aβ42, and p-tau in the early recognition and diagnosis of ad. 2022-05-13 2023-08-13 Not clear
Esther M Blessing, Ankit Parekh, Rebecca A Betensky, James Babb, Natalie Saba, Ludovic Debure, Andrew W Varga, Indu Ayappa, David M Rapoport, Tracy A Butler, Mony J de Leon, Thomas Wisniewski, Brian J Lopresti, Ricardo S Osori. Association between lower body temperature and increased tau pathology in cognitively normal older adults. Neurobiology of disease. 2022-05-13. PMID:35550158. preclinical studies suggest body temperature (tb) and consequently brain temperature has the potential to bidirectionally interact with tau pathology in alzheimer's disease (ad). 2022-05-13 2023-08-13 human
Pieter Jelle Visser, Lianne M Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J van der Lee, Magda Tsolaki, Frans R J Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Simon Lovestone, Johannes Streffer, Stephanie J B Vos, Isabelle Bos, August B Smit, Kaj Blennow, Philip Scheltens, Charlotte E Teunissen, Lars Bertram, Henrik Zetterberg, Betty M Tijm. Correction: Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-05-13. PMID:35550177. correction: cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in alzheimer's disease. 2022-05-13 2023-08-13 Not clear
Ishani Pidara, Koyuki Yamad. The Structure of Tau Proteins and Its Role in Neurodegenerative Disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553522. while there are many tauopathies, such as frontotemporal dementia with parkinsonism-17 and pick disease, alzheimer's is one of the most prevalent and studied diseases associated with tau (gao et al., 2018). 2022-05-13 2023-08-13 Not clear
Bryson P Arnett, Tara Hawkinson, Lyndsay Young, Harrison Clarke, Michael Buoncristiani, Matthew Gentry, Ramon Su. Longitudinal profiling of the Plasma Glycome from Normal and Alzheimer's Disease individuals. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554486. alzheimer's disease (ad) is an incurable dementia known for its neurodegenerative pathologies including amyloid beta plaques, hyperphosphorylated neurofibrillary tau tangles, and brain glucose hypometabolism. 2022-05-13 2023-08-13 human
Madeline S Morrison, Hugo J Aparicio, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Thomas K Karikari, Yorghos Tripodis, Brett Martin, Joseph N Palmisano, Michael A Sugarman, Brandon Frank, Eric G Steinberg, Katherine W Turk, Andrew E Budson, Rhoda Au, Lee E Goldstein, Gyungah R Jun, Neil W Kowall, Ronald Killiany, Wei Qiao Qiu, Robert A Stern, Jesse Mez, Ann C McKee, Thor D Stein, Michael L Alosc. Antemortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy. Brain : a journal of neurology. 2022-05-13. PMID:35554506. antemortem plasma phosphorylated tau (181) predicts alzheimer's disease neuropathology and regional tau at autopsy. 2022-05-13 2023-08-13 human
Madeline S Morrison, Hugo J Aparicio, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Thomas K Karikari, Yorghos Tripodis, Brett Martin, Joseph N Palmisano, Michael A Sugarman, Brandon Frank, Eric G Steinberg, Katherine W Turk, Andrew E Budson, Rhoda Au, Lee E Goldstein, Gyungah R Jun, Neil W Kowall, Ronald Killiany, Wei Qiao Qiu, Robert A Stern, Jesse Mez, Ann C McKee, Thor D Stein, Michael L Alosc. Antemortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy. Brain : a journal of neurology. 2022-05-13. PMID:35554506. blood-based biomarkers such as tau phosphorylated at threonine 181 (phosphorylated-tau181) represent an accessible, cost-effective, and scalable approach for the in vivo detection of alzheimer's disease pathophysiology. 2022-05-13 2023-08-13 human
Mare Cudic, YashoNandini Sing. Synthesis and Conformational Analysis of APP O -Glycopeptides Bearing the Tn Antigen. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556493. alzheimer's disease (ad) is characterized by the accumulation of the neurotoxic deposits of β-amyloid peptide (aβ) within the brain along with hyperphosphorylated and cleaved forms of the microtubule-associated tau protein. 2022-05-13 2023-08-13 Not clear
Saina Prabhu, Emily Burrage, James Simpkins, Eric Kelley, Paul Chantle. Chronic Stress exacerbates Tau production in the 3xTg Alzheimer's Disease Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556967. chronic stress exacerbates tau production in the 3xtg alzheimer's disease mice. 2022-05-13 2023-08-13 mouse
Samantha K Baker, Na Wang, Guojun Bu, Chia-Chen Li. Effects of Microglia APOE Expression on Tau Pathology. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557103. one hallmark pathological feature of alzheimer's disease is the accumulation of hyperphosphorylated tau protein in the brain. 2022-05-13 2023-08-13 mouse
Andrew N McCorkindale, Ellis Patrick, James A Duce, Boris Guennewig, Greg T Sutherlan. The Key Factors Predicting Dementia in Individuals With Alzheimer's Disease-Type Pathology. Frontiers in aging neuroscience. vol 14. 2022-05-13. PMID:35557837. alzheimer's disease, the most common form of dementia, is characterized by amyloid and tau pathology with amyloid accumulation thought to precipitate tau pathology, neurodegeneration, and dementia. 2022-05-13 2023-08-13 Not clear
Yongle Cai, Jingliu Liu, Bin Wang, Miao Sun, Hao Yan. Microglia in the Neuroinflammatory Pathogenesis of Alzheimer's Disease and Related Therapeutic Targets. Frontiers in immunology. vol 13. 2022-05-13. PMID:35558075. alzheimer's disease (ad) is the most prevalent neurodegenerative disease worldwide, characterized by progressive neuron degeneration or loss due to excessive accumulation of β-amyloid (aβ) peptides, formation of neurofibrillary tangles (nfts), and hyperphosphorylated tau. 2022-05-13 2023-08-13 Not clear
Mauro Montalbano, Elizabeth Jaworski, Stephanie Garcia, Anna Ellsworth, Salome McAllen, Andrew Routh, Rakez Kaye. Tau modulates mRNA transcription, alternative polyadenylation (APA) profiles of hnRNPs, chromatin remodeling and spliceosome complexes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560478. tau protein is a known contributor in several neurodegenerative diseases, including alzheimer 's disease (ad) and frontotemporal dementia (ftd). 2022-05-13 2023-08-13 human
Avishek Roy, Binney Sharma, Jyotirmoy Banerjee, Soumya Iyenger, Suman Jai. Dual role of low frequency magnetic field on neuroinflammation induced dendritic trimming and memory impairment on rat model of sporadic Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560692. gliosis and dendritic loss is reported to be secondary to the amyloid beta (aß) and hyperphosphorylated tau (hp-tau) production in alzheimer's disease(ad) brain. 2022-05-13 2023-08-13 mouse
Truong Thi Vu Nu, Nhu Hoa Thi Tran, Eunjoo Nam, Tan Tai Nguyen, Won Jung Yoon, Sungbo Cho, Jungsuk Kim, Keun-A Chang, Heongkyu J. Blood-based immunoassay of tau proteins for early diagnosis of Alzheimer's disease using surface plasmon resonance fiber sensors. RSC advances. vol 8. issue 14. 2022-05-11. PMID:35539129. blood-based immunoassay of tau proteins for early diagnosis of alzheimer's disease using surface plasmon resonance fiber sensors. 2022-05-11 2023-08-13 human
Hrushikesh Dixit, C Selvaa Kumar, Debjani Dasgupta, Nikhil Gadewa. Molecular docking analysis of hyperphosphorylated tau protein with compounds derived from Bacopa monnieri and Withania somnifera. Bioinformation. vol 17. issue 9. 2022-05-11. PMID:35539884. tau protein, the major player in alzheimer's disease forms neurofibrillary tangles in elderly people. 2022-05-11 2023-08-13 Not clear
Hrushikesh Dixit, C Selvaa Kumar, Debjani Dasgupta, Nikhil Gadewa. Molecular docking analysis of hyperphosphorylated tau protein with compounds derived from Bacopa monnieri and Withania somnifera. Bioinformation. vol 17. issue 9. 2022-05-11. PMID:35539884. we show that compounds such as bacopaside ii, bacopaside xii, and nicotine showed optimal binding features with the r2 repeat domain of hyperphosphorylated tau protein for further consideration in the context of alzheimer's disease (ad). 2022-05-11 2023-08-13 Not clear
S Gauthier, A Boxer, D Knopman, J Sims, R Doody, P Aisen, T Iwatsubo, R Bateman, B Vella. Therapeutic Targets for Alzheimer's Disease: Amyloid Vs. Non-Amyloid. Where Does Consensus Lie Today? An CTAD Task Force Report. The journal of prevention of Alzheimer's disease. vol 9. issue 2. 2022-05-11. PMID:35542994. there was consensus that both amyloid and tau pathologies should be targeted in alzheimer's disease, as well as additional pathophysiological mechanisms such as neuroinflammation. 2022-05-11 2023-08-13 Not clear