| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marcela Cespedes, Kelly R Jacobs, Paul Maruff, Alan Rembach, Christopher J Fowler, Brett Trounson, Kelly K Pertile, Rebecca L Rumble, Stephanie R Rainey-Smithe, Christopher C Rowe, Victor L Villemagne, Pierrick Bourgeat, Chai K Lim, Pratishtha Chatterjee, Ralph N Martins, Arne Ittner, Colin L Masters, James D Doecke, Gilles J Guillemin, David B Lovejo. Systemic perturbations of the kynurenine pathway precede progression to dementia independently of amyloid-β. Neurobiology of disease. 2022-06-08. PMID:35675895. |
studies in alzheimer's disease (ad) patients confirm kp dyshomeostasis in plasma and cerebrospinal fluid (csf) which correlates with amyloid-β and tau pathology. |
2022-06-08 |
2023-08-14 |
human |
| Sung Hyun Tag, Baeksun Kim, Jinhee Bae, Keun-A Chang, Heh-In I. Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer's disease. Molecular brain. vol 15. issue 1. 2022-06-08. PMID:35676711. |
here, we investigated the neurobehavioral sequelae in the novel 6xtg mouse model of alzheimer's disease, which was developed by incorporating human tau containing p301l mutation in the widely used 5xfad mouse model of alzheimer's disease. |
2022-06-08 |
2023-08-14 |
mouse |
| Sung Hyun Tag, Baeksun Kim, Jinhee Bae, Keun-A Chang, Heh-In I. Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer's disease. Molecular brain. vol 15. issue 1. 2022-06-08. PMID:35676711. |
at 11-months-old, 6xtg mice displayed the core pathological processes found in alzheimer's disease, including accumulation of amyloid-β plaque, extensive neuronal loss, elevated level of astrocyte activation, and abnormal tau phosphorylation in the brain. |
2022-06-08 |
2023-08-14 |
mouse |
| Amaresh Kumar Mahakud, Jafarulla Shaikh, V V Rifa Iqbal, Abhinav Gupta, Anuj Tiwari, Mohammed Salee. Amyloids on Membrane Interfaces: Implications for Neurodegeneration. The Journal of membrane biology. 2022-06-07. PMID:35670831. |
the review focuses on the various aspects of membrane interactions of amyloids, particularly amyloid-β (aβ) peptides and tau involved in alzheimer's and α-synuclein involved in parkinson's disease. |
2022-06-07 |
2023-08-14 |
Not clear |
| Alexis Moscoso, Melissa C Wren, Tammaryn Lashley, Erik Arstad, Melissa E Murray, Nick C Fox, Kerstin Sander, Michael Schöl. Imaging tau pathology in Alzheimer's disease with positron emission tomography: lessons learned from imaging-neuropathology validation studies. Molecular neurodegeneration. vol 17. issue 1. 2022-06-06. PMID:35659709. |
imaging tau pathology in alzheimer's disease with positron emission tomography: lessons learned from imaging-neuropathology validation studies. |
2022-06-06 |
2023-08-14 |
Not clear |
| Joost M Riphagen, Roy W E van Hooren, Gunter Kenis, Frans R J Verhey, Heidi I L Jacob. Distinct Patterns Link the BDNF Val66Met Polymorphism to Alzheimer's Disease Pathology. Journal of Alzheimer's disease : JAD. 2022-06-06. PMID:35662115. |
we used cerebrospinal fluid (csf) amyloid-β (aβ)42 and phosphorylated tau (p-tau) to investigate associations with bdnf polymorphisms and modifications by apoe ɛ4 or inflammation in a memory clinic population (n = 114; subjective cognitive decline, mild cognitive impairment, alzheimer's disease). |
2022-06-06 |
2023-08-14 |
Not clear |
| Debia Wakhloo, Jane Oberhauser, Angela Madira, Sameehan Mahajan. From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer's and Parkinson's diseases. Neural regeneration research. vol 17. issue 12. 2022-06-06. PMID:35662189. |
the intracellular aggregation of hyper-phosphorylated tau and the extracellular aggregation of amyloid beta plaques form the basis of alzheimer's disease pathology. |
2022-06-06 |
2023-08-14 |
human |
| Liang Gu, Nan Cai, Meiting Li, Decheng Bi, Lijun Yao, Weishan Fang, Yan Wu, Zhangli Hu, Qiong Liu, Zhijian Lin, Jun Lu, Xu X. Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease. Frontiers in nutrition. vol 9. 2022-06-06. PMID:35662922. |
inhibitory effects of macelignan on tau phosphorylation and aβ aggregation in the cell model of alzheimer's disease. |
2022-06-06 |
2023-08-14 |
mouse |
| Boyi Zong, Fengzhi Yu, Xiaoyou Zhang, Wenrui Zhao, Peng Sun, Shichang Li, Lin L. Understanding How Physical Exercise Improves Alzheimer's Disease: Cholinergic and Monoaminergic Systems. Frontiers in aging neuroscience. vol 14. 2022-06-06. PMID:35663578. |
alzheimer's disease (ad) is an age-related neurodegenerative disorder, characterized by the accumulation of proteinaceous aggregates and neurofibrillary lesions composed of β-amyloid (aβ) peptide and hyperphosphorylated microtubule-associated protein tau, respectively. |
2022-06-06 |
2023-08-14 |
Not clear |
| Zhen Qiao, Guihong Wang, Xiaobin Zhao, Kai Wang, Di Fan, Qian Chen, Lin A. Neuropsychological Performance Is Correlated With Tau Protein Deposition and Glucose Metabolism in Patients With Alzheimer's Disease. Frontiers in aging neuroscience. vol 14. 2022-06-06. PMID:35663582. |
neuropsychological performance is correlated with tau protein deposition and glucose metabolism in patients with alzheimer's disease. |
2022-06-06 |
2023-08-14 |
Not clear |
| Zhen Qiao, Guihong Wang, Xiaobin Zhao, Kai Wang, Di Fan, Qian Chen, Lin A. Neuropsychological Performance Is Correlated With Tau Protein Deposition and Glucose Metabolism in Patients With Alzheimer's Disease. Frontiers in aging neuroscience. vol 14. 2022-06-06. PMID:35663582. |
this study characterizes glucose metabolism and tau protein deposition distribution in patients with alzheimer's disease (ad) and to evaluate the relationships between neuropsychological performance and tau protein deposition or glucose metabolism using |
2022-06-06 |
2023-08-14 |
Not clear |
| Charlotte S Bold, Danny Baltissen, Susann Ludewig, Michaela K Back, Jennifer Just, Lara Kilian, Susanne Erdinger, Marija Banicevic, Lena Rehra, Fadi Almouhanna, Martina Nigri, David P Wolfer, Roman Spilger, Karl Rohr, Oliver Kann, Christian J Buchholz, Jakob von Engelhardt, Martin Korte, Ulrike C Mülle. APPsα rescues Tau-induced synaptic pathology. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-06-06. PMID:35667850. |
alzheimer's disease (ad) is histopathologically characterized by aβ plaques and the accumulation of hyperphosphorylated tau species, the latter also constituting key hallmarks of primary tauopathies. |
2022-06-06 |
2023-08-14 |
mouse |
| Wade Self, Khader Awwad, John Paul Savaryn, Michael Schul. An immuno-enrichment free, validated quantification of tau protein in human CSF by LC-MS/MS. PloS one. vol 17. issue 6. 2022-06-02. PMID:35653415. |
we demonstrate that the fit-for-purpose validated method in alzheimer's disease csf is limited to quasi quantitative measures of tau surrogate peptides. |
2022-06-02 |
2023-08-14 |
human |
| Lara Blömeke, Marlene Pils, Victoria Kraemer-Schulien, Alexandra Dybala, Anja Schaffrath, Andreas Kulawik, Fabian Rehn, Anneliese Cousin, Volker Nischwitz, Johannes Willbold, Rebecca Zack, Thomas F Tropea, Tuyen Bujnicki, Gültekin Tamgüney, Daniel Weintraub, David Irwin, Murray Grossman, David A Wolk, John Q Trojanowski, Oliver Bannach, Alice Chen-Plotkin, Dieter Willbol. Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting. NPJ Parkinson's disease. vol 8. issue 1. 2022-06-02. PMID:35655068. |
in this work, we measured asyn and tau aggregate concentrations of 237 cerebrospinal fluid (csf) samples from five cohorts: parkinson's disease (pd), dementia with lewy bodies (dlb), alzheimer's disease (ad), progressive supranuclear palsy (psp), and a neurologically-normal control group. |
2022-06-02 |
2023-08-14 |
human |
| Rik Ossenkoppele, Rik van der Kant, Oskar Hansso. Tau biomarkers in Alzheimer's disease: towards implementation in clinical practice and trials. The Lancet. Neurology. 2022-06-01. PMID:35643092. |
tau biomarkers in alzheimer's disease: towards implementation in clinical practice and trials. |
2022-06-01 |
2023-08-13 |
human |
| Rik Ossenkoppele, Rik van der Kant, Oskar Hansso. Tau biomarkers in Alzheimer's disease: towards implementation in clinical practice and trials. The Lancet. Neurology. 2022-06-01. PMID:35643092. |
deposition of tau aggregates is a pathological hallmark of alzheimer's disease that is closely linked both spatially and temporally to emergence of neurodegeneration and manifestation of clinical symptoms. |
2022-06-01 |
2023-08-13 |
human |
| Autumn E Tucker, Coral Del Mar Alicea Pauneto, Alexandra M Barnett, Leon G Colema. Chronic Ethanol Causes Persistent Increases in Alzheimer's Tau Pathology in Female 3xTg-AD Mice: A Potential Role for Lysosomal Impairment. Frontiers in behavioral neuroscience. vol 16. 2022-06-01. PMID:35645744. |
chronic ethanol causes persistent increases in alzheimer's tau pathology in female 3xtg-ad mice: a potential role for lysosomal impairment. |
2022-06-01 |
2023-08-13 |
mouse |
| Lingyu Zhang, Danhua Wang, Yibei Dai, Xuchu Wang, Ying Cao, Weiwei Liu, Zhihua Ta. Machine Learning Reveals a Multipredictor Nomogram for Diagnosing the Alzheimer's Disease Based on Chemiluminescence Immunoassay for Total Tau in Plasma. Frontiers in aging neuroscience. vol 14. 2022-06-01. PMID:35645782. |
machine learning reveals a multipredictor nomogram for diagnosing the alzheimer's disease based on chemiluminescence immunoassay for total tau in plasma. |
2022-06-01 |
2023-08-13 |
Not clear |
| Colin Groot, Sylvia Villeneuve, Ruben Smith, Oskar Hansson, Rik Ossenkoppel. Tau PET Imaging in Neurodegenerative Disorders. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 63. issue Suppl 1. 2022-06-01. PMID:35649647. |
the advent of pet ligands that bind tau pathology has enabled the quantification and visualization of tau pathology in aging and in alzheimer disease (ad). |
2022-06-01 |
2023-08-13 |
Not clear |
| Maura Malpetti, Renaud La Joie, Gil D Rabinovic. Tau Beats Amyloid in Predicting Brain Atrophy in Alzheimer Disease: Implications for Prognosis and Clinical Trials. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 63. issue 6. 2022-06-01. PMID:35649659. |
tau beats amyloid in predicting brain atrophy in alzheimer disease: implications for prognosis and clinical trials. |
2022-06-01 |
2023-08-13 |
Not clear |