| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samantha K Baker, Na Wang, Guojun Bu, Chia-Chen Li. Effects of Microglia APOE Expression on Tau Pathology. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557103. |
one hallmark pathological feature of alzheimer's disease is the accumulation of hyperphosphorylated tau protein in the brain. |
2022-05-13 |
2023-08-13 |
mouse |
| Andrew N McCorkindale, Ellis Patrick, James A Duce, Boris Guennewig, Greg T Sutherlan. The Key Factors Predicting Dementia in Individuals With Alzheimer's Disease-Type Pathology. Frontiers in aging neuroscience. vol 14. 2022-05-13. PMID:35557837. |
alzheimer's disease, the most common form of dementia, is characterized by amyloid and tau pathology with amyloid accumulation thought to precipitate tau pathology, neurodegeneration, and dementia. |
2022-05-13 |
2023-08-13 |
Not clear |
| Yongle Cai, Jingliu Liu, Bin Wang, Miao Sun, Hao Yan. Microglia in the Neuroinflammatory Pathogenesis of Alzheimer's Disease and Related Therapeutic Targets. Frontiers in immunology. vol 13. 2022-05-13. PMID:35558075. |
alzheimer's disease (ad) is the most prevalent neurodegenerative disease worldwide, characterized by progressive neuron degeneration or loss due to excessive accumulation of β-amyloid (aβ) peptides, formation of neurofibrillary tangles (nfts), and hyperphosphorylated tau. |
2022-05-13 |
2023-08-13 |
Not clear |
| Mauro Montalbano, Elizabeth Jaworski, Stephanie Garcia, Anna Ellsworth, Salome McAllen, Andrew Routh, Rakez Kaye. Tau modulates mRNA transcription, alternative polyadenylation (APA) profiles of hnRNPs, chromatin remodeling and spliceosome complexes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560478. |
tau protein is a known contributor in several neurodegenerative diseases, including alzheimer 's disease (ad) and frontotemporal dementia (ftd). |
2022-05-13 |
2023-08-13 |
human |
| Avishek Roy, Binney Sharma, Jyotirmoy Banerjee, Soumya Iyenger, Suman Jai. Dual role of low frequency magnetic field on neuroinflammation induced dendritic trimming and memory impairment on rat model of sporadic Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560692. |
gliosis and dendritic loss is reported to be secondary to the amyloid beta (aß) and hyperphosphorylated tau (hp-tau) production in alzheimer's disease(ad) brain. |
2022-05-13 |
2023-08-13 |
mouse |
| Truong Thi Vu Nu, Nhu Hoa Thi Tran, Eunjoo Nam, Tan Tai Nguyen, Won Jung Yoon, Sungbo Cho, Jungsuk Kim, Keun-A Chang, Heongkyu J. Blood-based immunoassay of tau proteins for early diagnosis of Alzheimer's disease using surface plasmon resonance fiber sensors. RSC advances. vol 8. issue 14. 2022-05-11. PMID:35539129. |
blood-based immunoassay of tau proteins for early diagnosis of alzheimer's disease using surface plasmon resonance fiber sensors. |
2022-05-11 |
2023-08-13 |
human |
| Hrushikesh Dixit, C Selvaa Kumar, Debjani Dasgupta, Nikhil Gadewa. Molecular docking analysis of hyperphosphorylated tau protein with compounds derived from Bacopa monnieri and Withania somnifera. Bioinformation. vol 17. issue 9. 2022-05-11. PMID:35539884. |
tau protein, the major player in alzheimer's disease forms neurofibrillary tangles in elderly people. |
2022-05-11 |
2023-08-13 |
Not clear |
| Hrushikesh Dixit, C Selvaa Kumar, Debjani Dasgupta, Nikhil Gadewa. Molecular docking analysis of hyperphosphorylated tau protein with compounds derived from Bacopa monnieri and Withania somnifera. Bioinformation. vol 17. issue 9. 2022-05-11. PMID:35539884. |
we show that compounds such as bacopaside ii, bacopaside xii, and nicotine showed optimal binding features with the r2 repeat domain of hyperphosphorylated tau protein for further consideration in the context of alzheimer's disease (ad). |
2022-05-11 |
2023-08-13 |
Not clear |
| S Gauthier, A Boxer, D Knopman, J Sims, R Doody, P Aisen, T Iwatsubo, R Bateman, B Vella. Therapeutic Targets for Alzheimer's Disease: Amyloid Vs. Non-Amyloid. Where Does Consensus Lie Today? An CTAD Task Force Report. The journal of prevention of Alzheimer's disease. vol 9. issue 2. 2022-05-11. PMID:35542994. |
there was consensus that both amyloid and tau pathologies should be targeted in alzheimer's disease, as well as additional pathophysiological mechanisms such as neuroinflammation. |
2022-05-11 |
2023-08-13 |
Not clear |
| Przemysław R Kac, Fernando Gonzalez-Ortiz, Joel Simrén, Nele Dewit, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, Nicholas J Ashton, Thomas K Karikar. Diagnostic value of serum versus plasma phospho-tau for Alzheimer's disease. Alzheimer's research & therapy. vol 14. issue 1. 2022-05-11. PMID:35545792. |
blood phosphorylated tau (p-tau) forms are promising alzheimer's disease (ad) biomarkers, but validation in matrices other than ethylenediaminetetraacetic acid (edta) plasma is limited. |
2022-05-11 |
2023-08-13 |
human |
| Yuan Cheng, Jun-Rong Ren, Jie-Ming Jian, Chen-Yang He, Man-Yu Xu, Gui-Hua Zeng, Cheng-Rong Tan, Ying-Ying Shen, Wang-Sheng Jin, Dong-Wan Chen, Hui-Yun Li, Xu Yi, Yuan Zhang, Xian-Le Bu, Yan-Jiang Wan. Associations of plasma angiostatin and amyloid-β and tau levels in Alzheimer's disease. Translational psychiatry. vol 12. issue 1. 2022-05-10. PMID:35538065. |
associations of plasma angiostatin and amyloid-β and tau levels in alzheimer's disease. |
2022-05-10 |
2023-08-13 |
human |
| Cinzia Maschio, Ruiqing N. Amyloid and Tau Positron Emission Tomography Imaging in Alzheimer's Disease and Other Tauopathies. Frontiers in aging neuroscience. vol 14. 2022-05-09. PMID:35527737. |
amyloid and tau positron emission tomography imaging in alzheimer's disease and other tauopathies. |
2022-05-09 |
2023-08-13 |
Not clear |
| Peng Zeng, Hong-Fei Su, Chao-Yuan Ye, Shuo-Wen Qiu, Anbing Shi, Jian-Zhi Wang, Xin-Wen Zhou, Qing Tia. A Tau Pathogenesis-Based Network Pharmacology Approach for Exploring the Protections of Frontiers in pharmacology. vol 13. 2022-05-09. PMID:35529440. |
a tau pathogenesis-based network pharmacology approach for exploring the protections of alzheimer's disease (ad) is the most common cause of neurodegenerative dementia and one of the top medical concerns worldwide. |
2022-05-09 |
2023-08-13 |
Not clear |
| Dongmei Chen, Guihua Lan, Ruomeng Li, Yingxue Mei, Xindong Shui, Xi Gu, Long Wang, Tao Zhang, Chen-Ling Gan, Yongfang Xia, Li Hu, Yuan Tian, Mi Zhang, Tae Ho Le. Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer's disease. Translational neurodegeneration. vol 11. issue 1. 2022-05-08. PMID:35527277. |
intracellular accumulation of the microtubule-associated protein tau and its hyperphosphorylated forms is a key neuropathological feature of alzheimer's disease (ad). |
2022-05-08 |
2023-08-13 |
Not clear |
| Abha Dangi, Abhishek Ankur Balmik, Archana Kisan Ghorpade, Nalini Vijay Gorantla, Shweta Kishor Sonawane, Subashchandrabose Chinnathambi, Udaya Kiran Marell. Residue-based propensity of aggregation in the Tau amyloidogenic hexapeptides AcPHF6* and AcPHF6. RSC advances. vol 10. issue 46. 2022-05-06. PMID:35516938. |
in alzheimer's disease and related tauopathies, the aggregation of microtubule-associated protein, tau, into fibrils occurs |
2022-05-06 |
2023-08-13 |
Not clear |
| Amy R Nelso. Peripheral Pathways to Neurovascular Unit Dysfunction, Cognitive Impairment, and Alzheimer's Disease. Frontiers in aging neuroscience. vol 14. 2022-05-06. PMID:35517047. |
although there are nuances and details continuously being unraveled, many key players were identified in the early 1900's by dr. oskar fischer and dr. alois alzheimer, including amyloid-beta (aβ), tau, vascular abnormalities, gliosis, and a possible role of infections. |
2022-05-06 |
2023-08-13 |
Not clear |
| Patricia Yuste-Checa, Andreas Bracher, F Ulrich Hart. The chaperone Clusterin in neurodegeneration-friend or foe? BioEssays : news and reviews in molecular, cellular and developmental biology. 2022-05-06. PMID:35521968. |
aggregates of the microtubule-associated protein tau are observed in alzheimer's disease and primary tauopathies. |
2022-05-06 |
2023-08-13 |
human |
| Patricia Yuste-Checa, Andreas Bracher, F Ulrich Hart. The chaperone Clusterin in neurodegeneration-friend or foe? BioEssays : news and reviews in molecular, cellular and developmental biology. 2022-05-06. PMID:35521968. |
these findings raise the possibility of a mechanistic link between clusterin upregulation observed in alzheimer's disease and the progression of tau pathology. |
2022-05-06 |
2023-08-13 |
human |
| Gurpreet Singh, Peng Liu, Katherine R Yao, Jessica M Strasser, Chris Hlynialuk, Kailee Leinonen-Wright, Peter J Teravskis, Jessica M Choquette, Junaid Ikramuddin, Merlin Bresinsky, Kathryn M Nelson, Dezhi Liao, Karen H Ashe, Michael A Walters, Steffen Pocke. Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy. ACS chemical neuroscience. 2022-05-06. PMID:35522720. |
synaptic and cognitive deficits mediated by a severe reduction in excitatory neurotransmission caused by a disproportionate accumulation of the neuronal protein tau in dendritic spines is a fundamental mechanism that has been found repeatedly in models of tauopathies, including alzheimer's disease, lewy body dementia, frontotemporal dementia, and traumatic brain injury. |
2022-05-06 |
2023-08-13 |
Not clear |
| Charles Windon, Leonardo Iaccarino, Nidhi Mundada, Isabel Allen, Adam L Boxer, Desiree Byrd, Monica Rivera-Mindt, Gil D Rabinovic. Comparison of plasma and CSF biomarkers across ethnoracial groups in the ADNI. Alzheimer's & dementia (Amsterdam, Netherlands). vol 14. issue 1. 2022-05-05. PMID:35510092. |
ethnoracial differences in cerebrospinal fluid (csf; amyloid beta 42 [aβ42], total tau [t-tau], phosphorylated tau 181 [p-tau181], and plasma (p-tau181, neurofilament light [nfl]) biomarkers of alzheimer's disease (ad) are incompletely understood. |
2022-05-05 |
2023-08-13 |
Not clear |