| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O G Steele, A C Stuart, L Minkley, K Shaw, O Bonnar, S Anderle, A C Penn, J Rusted, L Serpell, C Hall, S Kin. A multi-hit hypothesis for an APOE4-dependent pathophysiological state. The European journal of neuroscience. 2022-05-05. PMID:35510513. |
intriguingly, apoe4 has been associated with neuropathological and cognitive deficits in the absence of alzheimer's disease-related amyloid or tau pathology. |
2022-05-05 |
2023-08-13 |
Not clear |
| Swadesh Pal, Roderick Melni. Nonlocal models in the analysis of brain neurodegenerative protein dynamics with application to Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-05-05. PMID:35513401. |
in this paper, we focus on alzheimer's disease, where it is believed that the concentration changes in amyloid-beta and tau proteins play a central role in its onset and development. |
2022-05-05 |
2023-08-13 |
Not clear |
| Marangelie Criado-Marrero, Danielle M Blazier, Lauren A Gould, Niat T Gebru, Santiago Rodriguez Ospina, Debra S Armendariz, April L Darling, David Beaulieu-Abdelahad, Laura J Blai. Evidence against a contribution of the CCAAT-enhancer binding protein homologous protein (CHOP) in mediating neurotoxicity in rTg4510 mice. Scientific reports. vol 12. issue 1. 2022-05-05. PMID:35513476. |
tau accumulation and progressive loss of neurons are associated with alzheimer's disease (ad). |
2022-05-05 |
2023-08-13 |
mouse |
| Ian Fyf. Influence of amyloid-β on tau spread in Alzheimer disease explained. Nature reviews. Neurology. 2022-05-04. PMID:35508634. |
influence of amyloid-β on tau spread in alzheimer disease explained. |
2022-05-04 |
2023-08-13 |
Not clear |
| Panos Theofilas, Antonia M H Piergies, Ian Oh, Yoo Bin Lee, Song Hua Li, Felipe L Pereira, Cathrine Petersen, Alexander J Ehrenberg, Rana A Eser, Andrew J Ambrose, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Salvatore Spina, Willian W Seeley, Bruce L Miller, Michelle R Arkin, Lea T Grinber. Caspase-6-cleaved tau is relevant in Alzheimer's disease and marginal in four-repeat tauopathies: diagnostic and therapeutic implications. Neuropathology and applied neurobiology. 2022-05-04. PMID:35508761. |
caspase-6-cleaved tau is relevant in alzheimer's disease and marginal in four-repeat tauopathies: diagnostic and therapeutic implications. |
2022-05-04 |
2023-08-13 |
human |
| Panos Theofilas, Antonia M H Piergies, Ian Oh, Yoo Bin Lee, Song Hua Li, Felipe L Pereira, Cathrine Petersen, Alexander J Ehrenberg, Rana A Eser, Andrew J Ambrose, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Salvatore Spina, Willian W Seeley, Bruce L Miller, Michelle R Arkin, Lea T Grinber. Caspase-6-cleaved tau is relevant in Alzheimer's disease and marginal in four-repeat tauopathies: diagnostic and therapeutic implications. Neuropathology and applied neurobiology. 2022-05-04. PMID:35508761. |
yet, the relationship between acasp-6, different forms of tr-tau, and hyperphosphorylated tau (p-tau) accumulation in human brains with alzheimer's disease (ad) and other tauopathies remains unclear. |
2022-05-04 |
2023-08-13 |
human |
| Christopher Daniel Morrone, Aaron Yenhsin Lai, Jossana Bishay, Mary Elizabeth Hill, JoAnne McLauri. Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer's disease. Translational neurodegeneration. vol 11. issue 1. 2022-05-03. PMID:35501886. |
patient-to-patient variability in the degree to which β-amyloid, tau and neurodegeneration impact cognitive decline in alzheimer's disease (ad) complicates disease modeling and treatment. |
2022-05-03 |
2023-08-13 |
Not clear |
| A Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M Smith, Bandhan Mukherjee, Santiago A Salazar, Suho Lee, Tu Kiet T Lam, Stephen M Strittmatte. Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy. Molecular neurodegeneration. vol 17. issue 1. 2022-05-03. PMID:35501917. |
alzheimer risk gene product pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy. |
2022-05-03 |
2023-08-13 |
mouse |
| Hyun Kim, Alina Levine, Daniel Cohen, Philip Gehrman, Xi Zhu, Davangere P Devanand, Seonjoo Lee, Terry E Goldber. The Role of Amyloid, Tau, and APOE Genotype on the Relationship Between Informant-Reported Sleep Disturbance and Alzheimer's Disease Risks. Journal of Alzheimer's disease : JAD. 2022-05-02. PMID:35491776. |
the role of amyloid, tau, and apoe genotype on the relationship between informant-reported sleep disturbance and alzheimer's disease risks. |
2022-05-02 |
2023-08-13 |
Not clear |
| Christian LoBue, Brendan J Kelley, John Hart, Jessica Helphrey, Jeff Schaffert, C Munro Cullum, Matthew E Peters, Peter M Dougla. Mild Traumatic Brain Injury is Related to Elevated Cerebrospinal Fluid Tau in Alzheimer's Disease Dementia. Journal of Alzheimer's disease : JAD. 2022-05-02. PMID:35491792. |
mild traumatic brain injury is related to elevated cerebrospinal fluid tau in alzheimer's disease dementia. |
2022-05-02 |
2023-08-13 |
Not clear |
| Mingchao Shi, Fengna Chu, Feiqi Zhu, Jie Zh. Impact of Anti-amyloid-β Monoclonal Antibodies on the Pathology and Clinical Profile of Alzheimer's Disease: A Focus on Aducanumab and Lecanemab. Frontiers in aging neuroscience. vol 14. 2022-05-02. PMID:35493943. |
alzheimer's disease (ad) is the most prevalent form of age-related dementia in the world, and its main pathological features consist of amyloid-β (aβ) plaque deposits and neurofibrillary tangles formed by hyperphosphorylated tau protein. |
2022-05-02 |
2023-08-13 |
Not clear |
| Rebeca Lapresa, Jesus Agulla, Sonia Gonzalez-Guerrero, Juan P Bolaños, Angeles Almeid. Amyloid-β Induces Cdh1-Mediated Rock2 Stabilization Causing Neurodegeneration. Frontiers in pharmacology. vol 13. 2022-05-02. PMID:35496276. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by progressive cognitive decline, which is causally related to the accumulation of abnormally folded amyloid-β (aβ) peptide and hyperphosphorylated tau protein aggregates. |
2022-05-02 |
2023-08-13 |
mouse |
| Lulu Schulz, Paulino Ramirez, Adrienne Lemieux, Elias Gonzalez, Travis Thomson, Bess Fros. Tau-induced elevation of the activity-regulated cytoskeleton associated protein Arc1 causally mediates neurodegeneration in the adult Drosophila brain. Neuroscience. 2022-04-29. PMID:35487302. |
alzheimer's disease and other tauopathies are neurodegenerative disorders pathologically defined by aggregated forms of tau protein in the brain. |
2022-04-29 |
2023-08-13 |
human |
| Lulu Schulz, Paulino Ramirez, Adrienne Lemieux, Elias Gonzalez, Travis Thomson, Bess Fros. Tau-induced elevation of the activity-regulated cytoskeleton associated protein Arc1 causally mediates neurodegeneration in the adult Drosophila brain. Neuroscience. 2022-04-29. PMID:35487302. |
taken together, our results suggest that arc elevation in human alzheimer's disease is a consequence of tau pathology and is a causal factor contributing to neuronal death. |
2022-04-29 |
2023-08-13 |
human |
| Lei Liu, Yuqi Cai, Bianca M Lauro, Angela L Meunier, Jasmeer Chhatwal, Dennis J Selko. Generation and application of semi-synthetic p-Tau181 calibrator for immunoassay calibration. Biochemical and biophysical research communications. vol 611. 2022-04-28. PMID:35483223. |
evidence suggests that plasma levels of tau protein phosphorylated at specific residues such as p-t181, p-t217, and p-t231 can be used as biomarkers for alzheimer's disease (ad) diagnosis and prognosis. |
2022-04-28 |
2023-08-13 |
Not clear |
| Qiang Xie, Ming Ni, Feng Gao, Lin-Bin Dai, Xin-Yi Lv, Yi-Fan Zhang, Qin Shi, Xing-Xing Zhu, Ji-Kui Xie, Yong Shen, Shi-Cun Wan. Correlation between Cerebrospinal Fluid Core Alzheimer's Disease Biomarkers and β-Amyloid PET in Chinese Dementia Population. ACS chemical neuroscience. 2022-04-27. PMID:35476397. |
the current diagnoses of alzheimer's disease (ad) mainly rely on such measures as amyloid-β (aβ) and tau neuropathology biomarkers in vivo via cerebrospinal fluid (csf) and positron emission tomography (pet) imaging, which had been systematically studied in caucasian individuals, whereas diagnostic performances of these approaches in chinese dementia population still remain unclear. |
2022-04-27 |
2023-08-13 |
Not clear |
| Phuong H Nguyen, Philippe Derreumau. Molecular Dynamics Simulations of the Tau R3-R4 Domain Monomer in the Bulk Solution and at the Surface of a Lipid Bilayer Model. The journal of physical chemistry. B. 2022-04-27. PMID:35476504. |
the aggregation of the tau protein plays a significant role in alzheimer's disease, and the tau r3-r4 domain spanning residues 306-378 was shown to form the amyloid fibril core of a full-length tau. |
2022-04-27 |
2023-08-13 |
Not clear |
| Maryam Bazrgar, Pariya Khodabakhsh, Leila Dargahi, Fatemeh Mohagheghi, Abolhassan Ahmadian. MicroRNA modulation is a potential molecular mechanism for neuroprotective effects of intranasal insulin administration in amyloid βeta oligomer induced Alzheimer's like rat model. Experimental gerontology. 2022-04-27. PMID:35476966. |
substantial evidence indicates that imbalance in the expression of mir-132-3p, mir-181b-5p, mir-125b-5p, mir-26a-5p, mir-124-3p, mir-146a-5p, mir-29a-3p, and mir-30a-5p in the ad brain are associated with amyloid-beta (aβ) aggregation, tau pathology, neuroinflammation, and synaptic dysfunction, the major pathological hallmarks of alzheimer's disease)ad(. |
2022-04-27 |
2023-08-13 |
rat |
| Zarin Tabassum, Jui-Heng Tseng, Camryn Isemann, Xu Tian, Youjun Chen, Laura E Herring, Todd J Cohe. Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase. The Journal of biological chemistry. 2022-04-26. PMID:35469920. |
here, we describe the reciprocal regulation of a kinase, the microtubule affinity-regulating kinase 2 (mark2), and an acetyltransferase, creb-binding protein (cbp), two enzymes known to extensively modify tau proteins in the progression of alzheimer's disease (ad). |
2022-04-26 |
2023-08-13 |
Not clear |
| Jaime Ramos-Cejudo, Andrew D Johnson, Alexa Beiser, Sudha Seshadri, Joel Salinas, Jeffrey S Berger, Nathanael R Fillmore, Nhan Do, Chunlei Zheng, Zanetta Kovbasyuk, Babak A Ardekani, Pomara Nunzio, Omonigho M Bubu, Ankit Parekh, Antonio Convit, Rebecca A Betensky, Thomas M Wisniewski, Ricardo S Osori. Platelet Function Is Associated With Dementia Risk in the Framingham Heart Study. Journal of the American Heart Association. 2022-04-26. PMID:35470685. |
background vascular function is compromised in alzheimer disease (ad) years before amyloid and tau pathology are detected and a substantial body of work shows abnormal platelet activation states in patients with ad. |
2022-04-26 |
2023-08-13 |
human |