All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Wenting Hu, Zhuoqun Wang, Huiliang Zhang, Yacoubou Abdoul Razak Mahaman, Fang Huang, Dongli Meng, Ying Zhou, Shiyi Wang, Nan Jiang, Jing Xiong, Jukka Westermarck, Youming Lu, Jianzhi Wang, Xiaochuan Wang, Yangping Shentu, Rong Li. Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-03-14. PMID:35286657. in conclusion, our study uncovers a mechanism by which dna damage-induced chk1 activation promotes cip2a-mediated tau and app hyperphosphorylation and cognitive dysfunction in alzheimer's disease and highlights the therapeutic potential of chk1 inhibitors in ad. 2022-03-14 2023-08-13 mouse
Ashok Iyaswamy, Xueli Wang, Senthilkumar Krishnamoorthi, Venkatapathy Kaliamoorthy, Sravan G Sreenivasmurthy, Siva Sundara Kumar Durairajan, Ju-Xian Song, Benjamin Chun-Kit Tong, Zhou Zhu, Cheng-Fu Su, Jia Liu, King-Ho Cheung, Jia-Hong Lu, Jie-Qiong Tan, Hung Wing Li, Man Shing Wong, Min L. Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models. Redox biology. vol 51. 2022-03-14. PMID:35286997. accumulation of amyloid-β (aβ) oligomers and phosphorylated tau aggregates are crucial pathological events or factors that cause progressive neuronal loss, and cognitive impairments in alzheimer's disease (ad). 2022-03-14 2023-08-13 mouse
Frédérique K Kok, Suzanne L van Leerdam, Elizabeth C M de Lang. Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer's Disease Neuropathology. Journal of Alzheimer's disease : JAD. 2022-03-11. PMID:35275527. alzheimer's disease (ad) is the most common form of dementia and typically characterized by the accumulation amyloid-β plaques and tau tangles. 2022-03-11 2023-08-13 human
Sojung Yoon, Sung Eun Kim, Younhee Ko, Gwang Hun Jeong, Keum Hwa Lee, Jinhee Lee, Marco Solmi, Louis Jacob, Lee Smith, Andrew Stickley, Andre F Carvalho, Elena Dragioti, Andreas Kronbichler, Ai Koyanagi, Sung Hwi Hong, Trevor Thompson, Hans Oh, Gonzalo Salazar de Pablo, Joaquim Radua, Jae Il Shin, Paolo Fusar-Pol. Differential expression of MicroRNAs in Alzheimer's disease: a systematic review and meta-analysis. Molecular psychiatry. 2022-03-10. PMID:35264731. alzheimer's disease (ad) results in progressive cognitive decline owing to the accumulation of amyloid plaques and hyperphosphorylated tau. 2022-03-10 2023-08-13 Not clear
Abdeslem El Idrissi, Alejandra Del Carmen Alons. Pathological Human Tau Induces Alterations in the Brain Insulin Signaling Cascade. Frontiers in neuroscience. vol 16. 2022-03-10. PMID:35264925. we propose that the appearance of abnormal tau might potentiate the toxic environment by interfering with the insulin signaling cascade in the brain of patients with alzheimer's disease. 2022-03-10 2023-08-13 mouse
Tyler C Hammond, Xin Xing, Lucy M Yanckello, Arnold Stromberg, Ya-Hsuan Chang, Peter T Nelson, Ai-Ling Li. Human Gray and White Matter Metabolomics to Differentiate APOE and Stage Dependent Changes in Alzheimer's Disease. Journal of cellular immunology. vol 3. issue 6. 2022-03-10. PMID:35265943. alzheimer's disease (ad) is the most common form of dementia with hallmarks of β-amyloid (aβ) plaques, tau tangles, and neurodegeneration. 2022-03-10 2023-08-13 human
Kazuhiko Uchid. Waste Clearance in the Brain and Neuroinflammation: A Novel Perspective on Biomarker and Drug Target Discovery in Alzheimer's Disease. Cells. vol 11. issue 5. 2022-03-10. PMID:35269541. the pathology of alzheimer's disease is characterized by amyloid-beta and hyperphosphorylated tau, which are necessary for disease progression. 2022-03-10 2023-08-13 Not clear
Syed Jawad Ali Shah, Haiyang Zhong, Qianqian Zhang, Huanxiang Li. Deciphering the Effect of Lysine Acetylation on the Misfolding and Aggregation of Human Tau Fragment International journal of molecular sciences. vol 23. issue 5. 2022-03-10. PMID:35269542. deciphering the effect of lysine acetylation on the misfolding and aggregation of human tau fragment the formation of neurofibrillary tangles (nft) with β-sheet-rich structure caused by abnormal aggregation of misfolded microtubule-associated protein tau is a hallmark of tauopathies, including alzheimer's disease. 2022-03-10 2023-08-13 human
Zhen-Dong Sun, Jia-Xin Hu, Jia-Rui Wu, Bing Zhou, Yun-Peng Huan. Toxicities of amyloid-beta and tau protein are reciprocally enhanced in the Neural regeneration research. vol 17. issue 10. 2022-03-09. PMID:35259851. toxicities of amyloid-beta and tau protein are reciprocally enhanced in the extracellular aggregation of amyloid-beta (aβ) and intracellular tau tangles are two major pathogenic hallmarks and critical factors of alzheimer's disease. 2022-03-09 2023-08-13 drosophila_melanogaster
Zhen-Dong Sun, Jia-Xin Hu, Jia-Rui Wu, Bing Zhou, Yun-Peng Huan. Toxicities of amyloid-beta and tau protein are reciprocally enhanced in the Neural regeneration research. vol 17. issue 10. 2022-03-09. PMID:35259851. our results indicate that aβ and tau protein work synergistically to further accelerate alzheimer's disease progression and may be considered as a combined target for future development of alzheimer's disease therapeutics. 2022-03-09 2023-08-13 drosophila_melanogaster
Stéphane Epelbaum, Ninon Burgos, Michael Canney, Dawn Matthews, Marion Houot, Mathieu D Santin, Carole Desseaux, Guillaume Bouchoux, Sebastian Stroer, Cyril Martin, Marie-Odile Habert, Marcel Levy, Aicha Bah, Karine Martin, Benoît Delatour, Maximilien Riche, Bruno Dubois, Lisa Belin, Alexandre Carpentie. Pilot study of repeated blood-brain barrier disruption in patients with mild Alzheimer's disease with an implantable ultrasound device. Alzheimer's research & therapy. vol 14. issue 1. 2022-03-09. PMID:35260178. temporary disruption of the blood-brain barrier (bbb) using pulsed ultrasound leads to the clearance of both amyloid and tau from the brain, increased neurogenesis, and mitigation of cognitive decline in pre-clinical models of alzheimer's disease (ad) while also increasing bbb penetration of therapeutic antibodies. 2022-03-09 2023-08-13 Not clear
Qing Wang, Gengsheng Chen, Suzanne E Schindler, Jon Christensen, Nicole S McKay, Jingxia Liu, Sicheng Wang, Zhexian Sun, Jason Hassenstab, Yi Su, Shaney Flores, Russ Hornbeck, Lisa Cash, Carlos Cruchaga, Anne M Fagan, Zhude Tu, John C Morris, Mark A Mintun, Yong Wang, Tammie L S Benzinge. Baseline Microglial Activation Correlates With Brain Amyloidosis and Longitudinal Cognitive Decline in Alzheimer Disease. Neurology(R) neuroimmunology & neuroinflammation. vol 9. issue 3. 2022-03-09. PMID:35260470. this study aims to quantify microglial activation in individuals with alzheimer disease (ad) using the 18-kda translocator protein (tspo) pet imaging in the hippocampus and precuneus, the 2 ad-vulnerable regions, and to evaluate the association of baseline neuroinflammation with amyloidosis, tau, and longitudinal cognitive decline. 2022-03-09 2023-08-13 Not clear
Heidi G Standke, Allison Krau. Seed amplification and RT-QuIC assays to investigate protein seed structures and strains. Cell and tissue research. 2022-03-08. PMID:35258712. first shown for prp prions and prion diseases, it is now recognized that self-propagating misfolded proteins occur broadly in neurodegenerative diseases and include amyloid-β (aβ) and tau in alzheimer's disease (ad), tau in chronic traumatic encephalopathy (cte), pick's disease (pid), corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), and α-synuclein (α-syn) in parkinson's disease (pd) and lewy body dementias (lbd). 2022-03-08 2023-08-13 Not clear
Elena Tsolaki, Lajos Csincsik, Jing Xue, Imre Lengyel, Sergio Bertazz. Nuclear and cellular, micro and nano calcification in Alzheimer's disease patients and correlation to phosphorylated Tau. Acta biomaterialia. 2022-03-08. PMID:35259518. nuclear and cellular, micro and nano calcification in alzheimer's disease patients and correlation to phosphorylated tau. 2022-03-08 2023-08-13 Not clear
Johanna Andrea Gutiérrez-Vargas, John Fredy Castro-Álvarez, Jose Fernando Zapata-Berruecos, Komal Abdul-Rahim, Anibal Arteaga-Norieg. Neurodegeneration and convergent factors contributing to the deterioration of the cytoskeleton in Alzheimer's disease, cerebral ischemia and multiple sclerosis (Review). Biomedical reports. vol 16. issue 4. 2022-03-07. PMID:35251614. this review summarizes the current literature on the tau protein, microtubule-associated protein 2 (map2) and neurofilaments as common denominators in pathological conditions such as alzheimer's disease (ad), cerebral ischemia, and multiple sclerosis (ms). 2022-03-07 2023-08-13 Not clear
Thibaut Gauvrit, Hamza Benderradji, Luc Buée, David Blum, Didier Viea. Early-Life Environment Influence on Late-Onset Alzheimer's Disease. Frontiers in cell and developmental biology. vol 10. 2022-03-07. PMID:35252195. alzheimer disease (ad) which is the most prevalent neurodegenerative disease is mostly sporadic and primarily characterized by cognitive deficits and neuropathological lesions such as amyloid -β (aβ) plaques and neurofibrillary tangles composed of hyper- and/or abnormally phosphorylated tau protein. 2022-03-07 2023-08-13 Not clear
Wei Zhang, Nabin Kandel, Yiqun Zhou, Nathan Smith, Braulio C L B Ferreira, Miranda Perez, Matteo L Claure, Keenan J Mintz, Chunyu Wang, Roger M Leblan. Drug delivery of memantine with carbon dots for Alzheimer's disease: blood-brain barrier penetration and inhibition of tau aggregation. Journal of colloid and interface science. vol 617. 2022-03-07. PMID:35255395. drug delivery of memantine with carbon dots for alzheimer's disease: blood-brain barrier penetration and inhibition of tau aggregation. 2022-03-07 2023-08-13 zebrafish
Wei Zhang, Nabin Kandel, Yiqun Zhou, Nathan Smith, Braulio C L B Ferreira, Miranda Perez, Matteo L Claure, Keenan J Mintz, Chunyu Wang, Roger M Leblan. Drug delivery of memantine with carbon dots for Alzheimer's disease: blood-brain barrier penetration and inhibition of tau aggregation. Journal of colloid and interface science. vol 617. 2022-03-07. PMID:35255395. neurofibrillary tangle, composed of aggregated tau protein, is a pathological hallmark of alzheimer's disease (ad). 2022-03-07 2023-08-13 zebrafish
Courtney A Marshall, Jennifer D McBride, Lakshmi Changolkar, Dawn M Riddle, John Q Trojanowski, Virginia M-Y Le. Inhibition of CK2 mitigates Alzheimer's tau pathology by preventing NR2B synaptic mislocalization. Acta neuropathologica communications. vol 10. issue 1. 2022-03-05. PMID:35246269. inhibition of ck2 mitigates alzheimer's tau pathology by preventing nr2b synaptic mislocalization. 2022-03-05 2023-08-13 human
Courtney A Marshall, Jennifer D McBride, Lakshmi Changolkar, Dawn M Riddle, John Q Trojanowski, Virginia M-Y Le. Inhibition of CK2 mitigates Alzheimer's tau pathology by preventing NR2B synaptic mislocalization. Acta neuropathologica communications. vol 10. issue 1. 2022-03-05. PMID:35246269. alzheimer's disease (ad) is a neurodegenerative disorder that exhibits pathological changes in both tau and synaptic function. 2022-03-05 2023-08-13 human