| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luke T Milham, Gary P Morris, Lyndsey M Konen, Peggy Rentsch, Nesli Avgan, Bryce Visse. Quantification of AMPA receptor subunits and RNA editing-related proteins in the J20 mouse model of Alzheimer's disease by capillary western blotting. Frontiers in molecular neuroscience. vol 16. 2024-02-01. PMID:38299128. |
quantification of ampa receptor subunits and rna editing-related proteins in the j20 mouse model of alzheimer's disease by capillary western blotting. |
2024-02-01 |
2024-02-03 |
mouse |
| Mohammad Qneibi, Sosana Bdir, Mohammad Bdair, Samia Ammar Aldwaik, Dana Sandouka, Maram Heeh, Tala Iyad Idai. AMPA receptor neurotransmission and therapeutic applications: A comprehensive review of their multifaceted modulation. European journal of medicinal chemistry. vol 266. 2024-01-18. PMID:38237342. |
this research emphasizes the potential of ampa receptor modulation as a therapy for various neurological disorders such as epilepsy and alzheimer's disease. |
2024-01-18 |
2024-01-21 |
Not clear |
| Sakiho Ueda, Akira Kuzuya, Masayoshi Kawata, Kohei Okawa, Chika Honjo, Takafumi Wada, Mizuki Matsumoto, Kazuya Goto, Masakazu Miyamoto, Atsushi Yonezawa, Yasuto Tanabe, Akio Ikeda, Ayae Kinoshita, Ryosuke Takahash. Acute inhibition of AMPA receptors by perampanel reduces amyloid β-protein levels by suppressing β-cleavage of APP in Alzheimer's disease models. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 11. 2023-10-18. PMID:37850918. |
acute inhibition of ampa receptors by perampanel reduces amyloid β-protein levels by suppressing β-cleavage of app in alzheimer's disease models. |
2023-10-18 |
2023-11-08 |
mouse |
| Amanda L Wright, Lyndsey M Konen, Bruce G Mockett, Gary P Morris, Anurag Singh, Lisseth Estefania Burbano, Luke Milham, Monica Hoang, Raphael Zinn, Rose Chesworth, Richard P Tan, Gordon A Royle, Ian Clark, Steven Petrou, Wickliffe C Abraham, Bryce Visse. The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-09-27. PMID:37759260. |
the q/r editing site of ampa receptor glua2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in alzheimer's disease. |
2023-09-27 |
2023-10-07 |
Not clear |
| Kongjie Lu, Chenyang Li, Jiao Liu, Jinpeng Wang, Yongfeng Li, Bin He, Junzhao Li, Xiaochen Zhang, Mengping Wei, Yonglu Tian, Rong Zhang, Chen Zhang, Yong Zhan. Impairments in endogenous AMPA receptor dynamics correlates with learning deficits in Alzheimer's disease model mice. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 40. 2023-09-25. PMID:37748061. |
ampa receptors (ampars) play a critical role in synaptic plasticity and learning and memory, and dysfunction or dysregulation of ampars could lead to various neurological and psychiatric disorders, such as alzheimer's disease (ad). |
2023-09-25 |
2023-10-07 |
mouse |
| Kongjie Lu, Chenyang Li, Jiao Liu, Jinpeng Wang, Yongfeng Li, Bin He, Junzhao Li, Xiaochen Zhang, Mengping Wei, Yonglu Tian, Rong Zhang, Chen Zhang, Yong Zhan. Impairments in endogenous AMPA receptor dynamics correlates with learning deficits in Alzheimer's disease model mice. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 40. 2023-09-25. PMID:37748061. |
impairments in endogenous ampa receptor dynamics correlates with learning deficits in alzheimer's disease model mice. |
2023-09-25 |
2023-10-07 |
mouse |
| Mohammad Qneibi, Hanan Jumaa, Sosana Bdir, Nawaf Al-Mahari. Electrophysiological Assessment of Newly Synthesized 2,3-Benzodiazepine Derivatives for Inhibiting the AMPA Receptor Channel. Molecules (Basel, Switzerland). vol 28. issue 16. 2023-08-26. PMID:37630319. |
abnormalities in ampa receptor trafficking and synaptic assembly are linked to cognitive decline and neurological diseases such as alzheimer's, parkinson's, and huntington's. |
2023-08-26 |
2023-09-07 |
human |
| Mohammad Qneibi, Nidal Jaradat, Nawaf Al-Maharik, Mohammed Hawash, Linda Issa, Shorooq Suboh, Leen Yahya, Adan Abu Khait, Amjaad Warasneh, Sosana Bdi. The effect of Lavandula Coronopifolia essential oil on the biophysical properties of desensitization and deactivation gating currents in ionotropic receptors. Scientific reports. vol 13. issue 1. 2023-05-24. PMID:37225859. |
the rising incidence of cancer and the lack of effective therapeutic interventions for many neurological illnesses like alzheimer's and epilepsy has prompted us to investigate the composition and effects of the lavandula coronopifolia oil from palestine on cancer cells and ampa receptor subunits in the brain due to the vast range of beneficial properties of lavandula coronopifolia essential oil (eo). |
2023-05-24 |
2023-08-14 |
Not clear |
| Eric Goffin, Pierre Fraikin, Dayana Abboud, Pascal de Tullio, Caroline Beaufour, Iuliana Botez, Julien Hanson, Laurence Danober, Pierre Francotte, Bernard Pirott. New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring. European journal of medicinal chemistry. vol 250. 2023-03-02. PMID:36863228. |
positive allosteric modulators of the ampa receptors (ampar pams) have been proposed as new drugs for the management of various neurodegenerative diseases such as alzheimer's disease, parkinson's disease, attention deficit hyperactivity disorder, depression, and schizophrenia. |
2023-03-02 |
2023-08-14 |
mouse |
| Ankita Rajput, Palvi Sharma, Nitish Kumar, Sarabjit Kaur, Saroj Aror. Neuroprotective activity of novel phenanthrene derivative from Grewia tiliaefolia by in vitro and in silico studies. Scientific reports. vol 13. issue 1. 2023-02-10. PMID:36765125. |
in silico study was conducted to predict its action on proteins playing crucial role in neurological and neurodegenerative disorders such as gamma amino butyric acid (gaba) receptor and glutamate α amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (glu ampa) receptor in epilepsy and ache enzyme in alzheimer's diseases. |
2023-02-10 |
2023-08-14 |
Not clear |
| Mohammad Qneibi, Mohammad Hawash, Nidal Jaradat, Sosana Bdi. Affecting AMPA Receptor Biophysical Gating Properties with Negative Allosteric Modulators. Molecular neurobiology. 2022-06-10. PMID:35687302. |
ampa receptor-mediated synaptic transmission abnormalities may play a role in neurologic and neurodegenerative diseases, and compounds that can modulate ampa receptor (ampar) signaling have been studied for decades as possible therapies for alzheimer's disease, parkinson's disease, depression, and epilepsy. |
2022-06-10 |
2023-08-14 |
human |
| Qi Shen, Lei Liu, Xiaotong Gu, Da Xin. Photobiomodulation suppresses JNK3 by activation of ERK/MKP7 to attenuate AMPA receptor endocytosis in Alzheimer's disease. Aging cell. vol 20. issue 1. 2021-09-02. PMID:33336891. |
photobiomodulation suppresses jnk3 by activation of erk/mkp7 to attenuate ampa receptor endocytosis in alzheimer's disease. |
2021-09-02 |
2023-08-13 |
mouse |
| Parvin Babae. NMDA and AMPA receptors dysregulation in Alzheimer's disease. European journal of pharmacology. vol 908. 2021-08-20. PMID:34265291. |
nmda and ampa receptors dysregulation in alzheimer's disease. |
2021-08-20 |
2023-08-13 |
Not clear |
| Lon S Schneider, Ronald G Thomas, Suzanne Hendrix, Robert A Rissman, James B Brewer, David P Salmon, Tilman Oltersdorf, Tomohiro Okuda, Howard H Feldma. Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial. JAMA neurology. vol 76. issue 11. 2021-05-03. PMID:31282954. |
these effects may be mediated via sigma-1 receptor activation, delivery of synaptic ampa receptors, or modulation of microglial function and may benefit patients with alzheimer disease. |
2021-05-03 |
2023-08-13 |
mouse |
| Wenrui Qu, Baoming Yuan, Jun Liu, Qianqian Liu, Xi Zhang, Ranji Cui, Wei Yang, Bingjin L. Emerging role of AMPA receptor subunit GluA1 in synaptic plasticity: Implications for Alzheimer's disease. Cell proliferation. vol 54. issue 1. 2021-01-19. PMID:33188547. |
emerging role of ampa receptor subunit glua1 in synaptic plasticity: implications for alzheimer's disease. |
2021-01-19 |
2023-08-13 |
Not clear |
| Margaret O'Connor, Yang-Ping Shentu, Guan Wang, Wen-Ting Hu, Zhen-Dong Xu, Xiao-Chuan Wang, Rong Liu, Heng-Ye Ma. Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease. iScience. vol 23. issue 9. 2021-01-10. PMID:32861999. |
acetylation of ampa receptors regulates receptor trafficking and rescues memory deficits in alzheimer's disease. |
2021-01-10 |
2023-08-13 |
mouse |
| Margaret O'Connor, Yang-Ping Shentu, Guan Wang, Wen-Ting Hu, Zhen-Dong Xu, Xiao-Chuan Wang, Rong Liu, Heng-Ye Ma. Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease. iScience. vol 23. issue 9. 2021-01-10. PMID:32861999. |
in alzheimer's disease (ad), decreases in the amount and synaptic localization of ampa receptors (ampars) result in weakened synaptic activity and dysfunction in synaptic plasticity, leading to impairments in cognitive functions. |
2021-01-10 |
2023-08-13 |
mouse |
| Alejandro Martín-Belmonte, Carolina Aguado, Rocío Alfaro-Ruíz, Makoto Itakura, Ana Esther Moreno-Martínez, Luis de la Ossa, Elek Molnár, Yugo Fukazawa, Rafael Lujá. Age-Dependent Shift of AMPA Receptors From Synapses to Intracellular Compartments in Alzheimer's Disease: Immunocytochemical Analysis of the CA1 Hippocampal Region in APP/PS1 Transgenic Mouse Model. Frontiers in aging neuroscience. vol 12. 2020-11-03. PMID:33132900. |
age-dependent shift of ampa receptors from synapses to intracellular compartments in alzheimer's disease: immunocytochemical analysis of the ca1 hippocampal region in app/ps1 transgenic mouse model. |
2020-11-03 |
2023-08-13 |
mouse |
| Katy Bernard, Sylvie Gouttefangeas, Sylvie Bretin, Stéphanie Galtier, Philippe Robert, Vjera Holthoff-Detto, Jeffrey Cummings, Maria Puey. A 24-week double-blind placebo-controlled study of the efficacy and safety of the AMPA modulator S47445 in patients with mild to moderate Alzheimer's disease and depressive symptoms. Alzheimer's & dementia (New York, N. Y.). vol 5. 2020-10-01. PMID:31297437. |
a 24-week double-blind placebo-controlled study of the efficacy and safety of the ampa modulator s47445 in patients with mild to moderate alzheimer's disease and depressive symptoms. |
2020-10-01 |
2023-08-13 |
Not clear |
| Nazanin Mozafari, Ali Shamsizadeh, Iman Fatemi, Mohammad Allahtavakoli, Amir Moghadam-Ahmadi, Elham Kaviani, Ayat Kaeid. CX691, as an AMPA receptor positive modulator, improves the learning and memory in a rat model of Alzheimer's disease. Iranian journal of basic medical sciences. vol 21. issue 7. 2020-09-30. PMID:30140412. |
cx691, as an ampa receptor positive modulator, improves the learning and memory in a rat model of alzheimer's disease. |
2020-09-30 |
2023-08-13 |
rat |