| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philip K-Y Chang, David Verbich, R Anne McKinne. AMPA receptors as drug targets in neurological disease--advantages, caveats, and future outlook. The European journal of neuroscience. vol 35. issue 12. 2012-11-09. PMID:22708602. |
conversely, alzheimer's disease is characterized by decreased ampa activation and synapse loss. |
2012-11-09 |
2023-08-12 |
Not clear |
| Yiwen Zheng, Sangeeta Balabhadrapatruni, Chisako Masumura, Cynthia L Darlington, Paul F Smit. Effects of the putative cognitive-enhancing ampakine, CX717, on attention and object recognition memory. Current Alzheimer research. vol 8. issue 8. 2012-09-05. PMID:22171951. |
ampakines are a class of putative nootropic drug designed to positively modulate the ampa receptor and have been investigated as a potential treatment for cognitive disorders such as alzheimer's disease. |
2012-09-05 |
2023-08-12 |
rat |
| David H Smal. Dysregulation of Ca2+ homeostasis in Alzheimer's disease: role in acetylcholinesterase production and AMPA receptor internalization. Neuro-degenerative diseases. vol 10. issue 1-4. 2012-08-29. PMID:22301681. |
dysregulation of ca2+ homeostasis in alzheimer's disease: role in acetylcholinesterase production and ampa receptor internalization. |
2012-08-29 |
2023-08-12 |
Not clear |
| Bruno Vellas, Alain Pesce, Philippe H Robert, Paul S Aisen, Sonia Ancoli-Israel, Sandrine Andrieu, Jesse Cedarbaum, Bruno Dubois, Eric Siemers, Jean-Paul Spire, Michael W Weiner, Thomas S Ma. AMPA workshop on challenges faced by investigators conducting Alzheimer's disease clinical trials. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 7. issue 4. 2011-11-23. PMID:21784343. |
ampa workshop on challenges faced by investigators conducting alzheimer's disease clinical trials. |
2011-11-23 |
2023-08-12 |
human |
| Guorui Yao, Yinong Zong, Shenyan Gu, Jie Zhou, Huaxi Xu, Irimpan I Mathews, Rongsheng Ji. Crystal structure of the glutamate receptor GluA1 N-terminal domain. The Biochemical journal. vol 438. issue 2. 2011-10-05. PMID:21639859. |
the malfunction of ampars (ampa receptors) has been implicated in many neurological diseases, including alzheimer's disease, parkinson's disease and amyotrophic lateral sclerosis. |
2011-10-05 |
2023-08-12 |
Not clear |
| Katy Bernard, Laurence Danober, Jean-Yves Thomas, Cécile Lebrun, Carmen Muñoz, Alex Cordi, Patrice Desos, Pierre Lestage, Philippe Morai. DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptors pharmacological profile of a novel cognitive enhancer. CNS neuroscience & therapeutics. vol 16. issue 5. 2011-02-28. PMID:21050420. |
positive allosteric modulators of ampa receptors could provide a therapeutic approach to the treatment of cognitive disorders resulting from aging and/or neurodegenerative diseases, such as alzheimer disease (ad). |
2011-02-28 |
2023-08-12 |
Not clear |
| B Pirotte, P Francotte, E Goffin, P Fraikin, L Danober, B Lesur, I Botez, D-H Caignard, P Lestage, P de Tulli. Ring-fused thiadiazines as core structures for the development of potent AMPA receptor potentiators. Current medicinal chemistry. vol 17. issue 30. 2011-01-26. PMID:20738245. |
this receptor subtype also represents an interesting target to develop innovative therapeutic drugs such as positive allosteric modulators (ampa receptor potentiators) since the enhancement of ampa signals is expected to be beneficial in the management of several neurological disorders such as depression, schizophrenia, parkinson's disease and learning-memory deficits linked to alzheimer's disease. |
2011-01-26 |
2023-08-12 |
Not clear |
| C Tronche, P Lestage, C Louis, I Carrie, D Béracoché. Pharmacological modulation of contextual "episodic-like" memory in aged mice. Behavioural brain research. vol 215. issue 2. 2011-01-11. PMID:20385172. |
in a third part, we showed that pharmacological reference compounds such as donepezil and memantine (mainly used in the treatment of mild to severe forms of alzheimer's diseases) reversed the age-induced memory impairments as well as emerging pharmacological compounds acting on different neurotransmitter targets (nicotinic and ampa receptors). |
2011-01-11 |
2023-08-12 |
mouse |
| Lindsay A Schwarz, Benjamin J Hall, Gentry N Patric. Activity-dependent ubiquitination of GluA1 mediates a distinct AMPA receptor endocytosis and sorting pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 49. 2011-01-07. PMID:21148011. |
the accurate trafficking of ampa receptors (ampars) to and from the synapse is a critical component of learning and memory in the brain, whereas dysfunction of ampar trafficking is hypothesized to be an underlying mechanism of alzheimer's disease. |
2011-01-07 |
2023-08-12 |
Not clear |
| Dayong Wang, G Govindaiah, Ruijie Liu, Vania De Arcangelis, Charles L Cox, Yang K Xian. Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 9. 2010-09-21. PMID:20395454. |
an in vivo study has revealed subpopulations of hyperactive neurons near abeta plaques in mutant amyloid precursor protein (app)-transgenic animal model of alzheimer's disease (ad) that can be normalized by an ampa receptor antagonist. |
2010-09-21 |
2023-08-12 |
Not clear |
| Pierre Francotte, Pascal de Tullio, Pierre Fraikin, Stéphane Counerotte, Eric Goffin, Bernard Pirott. In search of novel AMPA potentiators. Recent patents on CNS drug discovery. vol 1. issue 3. 2008-02-15. PMID:18221205. |
hence, the enhancement of ampa signals is an approach currently investigated for the management of alzheimer's disease, schizophrenia or mood disorders. |
2008-02-15 |
2023-08-12 |
Not clear |
| A S Chappell, C Gonzales, J Williams, M M Witte, R C Mohs, R Sperlin. AMPA potentiator treatment of cognitive deficits in Alzheimer disease. Neurology. vol 68. issue 13. 2007-04-25. PMID:17389305. |
ampa potentiator treatment of cognitive deficits in alzheimer disease. |
2007-04-25 |
2023-08-12 |
Not clear |
| P Murali Doraiswamy, Glen L Xion. Pharmacological strategies for the prevention of Alzheimer's disease. Expert opinion on pharmacotherapy. vol 7. issue 1. 2006-06-28. PMID:16370917. |
randomised trial data are available for antihypertensive agents (calcium channel blockers, angiotensin-converting enzyme inhibitors), pravastatin, simvastatin, conjugated oestrogen, raloxifene, rofecoxib, cx516 (ampa agonist) and cholinesterase inhibitors regarding efficacy for alzheimer's disease prevention. |
2006-06-28 |
2023-08-12 |
Not clear |
| John F Crary, Charles Y Shao, Suzanne S Mirra, A Ivan Hernandez, Todd C Sackto. Atypical protein kinase C in neurodegenerative disease I: PKMzeta aggregates with limbic neurofibrillary tangles and AMPA receptors in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 65. issue 4. 2006-06-09. PMID:16691113. |
atypical protein kinase c in neurodegenerative disease i: pkmzeta aggregates with limbic neurofibrillary tangles and ampa receptors in alzheimer disease. |
2006-06-09 |
2023-08-12 |
drosophila_melanogaster |
| Eric H Chang, Mary J Savage, Dorothy G Flood, Justin M Thomas, Robert B Levy, Veeravan Mahadomrongkul, Tomoaki Shirao, Chiye Aoki, Patricio T Huert. AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 9. 2006-04-10. PMID:16492745. |
ampa receptor downscaling at the onset of alzheimer's disease pathology in double knockin mice. |
2006-04-10 |
2023-08-12 |
mouse |
| Rongsheng Jin, Suzanne Clark, Autumn M Weeks, Joshua T Dudman, Eric Gouaux, Kathryn M Parti. Mechanism of positive allosteric modulators acting on AMPA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 39. 2006-02-21. PMID:16192394. |
small molecules that potentiate ampa receptor currents relieve cognitive deficits caused by neurodegenerative diseases such as alzheimer's disease and show promise in the treatment of depression. |
2006-02-21 |
2023-08-12 |
Not clear |
| W Danys. CX-516 (Cortex Pharmaceuticals Inc). IDrugs : the investigational drugs journal. vol 2. issue 8. 2005-10-13. PMID:16127658. |
cx-516, an ampa modulator from cortex pharmaceuticals, is in phase i/iia clinical trials for the symptomatic treatment of deficits in memory and cognition in alzheimer's disease (ad) and similar disorders [234221]. |
2005-10-13 |
2023-08-12 |
Not clear |
| Hussam Jourdi, Ted Yanagihara, Ulises Martinez, Xiaoning Bi, Gary Lynch, Michel Baudr. Effects of positive AMPA receptor modulators on calpain-mediated spectrin degradation in cultured hippocampal slices. Neurochemistry international. vol 46. issue 1. 2005-02-22. PMID:15567513. |
positive modulators of ampa receptors (ampar), also known as ampakines, are allosteric effectors of the receptors and have been extensively studied in past years due to their potential use as treatment for various diseases and ailments of the central nervous system such as mild cognitive impairment, schizophrenia, and alzheimer's disease. |
2005-02-22 |
2023-08-12 |
human |
| Michael J O'Neill, David Bleakman, Dennis M Zimmerman, Eric S Nisenbau. AMPA receptor potentiators for the treatment of CNS disorders. Current drug targets. CNS and neurological disorders. vol 3. issue 3. 2004-08-20. PMID:15180479. |
therefore, these ampa receptor potentiators offer an exciting new class of drugs with potential for treating (1) cognitive impairment associated with alzheimer's disease and schizophrenia, (2) depression, (3) slowing the progression and potentially enhancing recovery from parkinson's disease. |
2004-08-20 |
2023-08-12 |
human |
| Troy L Carter, Robert A Rissman, Amanda J Mishizen-Eberz, Barry B Wolfe, Ronald L Hamilton, Sam Gandy, David M Armstron. Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage. Experimental neurology. vol 187. issue 2. 2004-06-30. PMID:15144856. |
differential preservation of ampa receptor subunits in the hippocampi of alzheimer's disease patients according to braak stage. |
2004-06-30 |
2023-08-12 |
Not clear |