All Relations between Alzheimer Disease and \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

Publication Sentence Publish Date Extraction Date Species
Wojciech Danys. CX-516 Cortex pharmaceuticals. Current opinion in investigational drugs (London, England : 2000). vol 3. issue 7. 2003-03-12. PMID:12186271. cx-516 is one of a series of ampa modulators under development by cortex, in collaboration with shire and servier, for the potential treatment of alzheimer's disease (ad), schizophrenia and mild cognitive impairment (mci) [234221]. 2003-03-12 2023-08-12 Not clear
Jérôme Ruel, Matthieu J Guitton, Jean-Luc Puel. Negative allosteric modulation of AMPA-preferring receptors by the selective isomer GYKI 53784 (LY303070), a specific non-competitive AMPA antagonist. CNS drug reviews. vol 8. issue 3. 2002-12-09. PMID:12353057. in contrast to nmda receptor antagonists, whose favorable clinical actions are compromised by important side effects such as the impairment of memory functions, the selective ampa antagonist, gyki 53784, may be of potential clinical value, both in acute (stroke and trauma) and chronic (alzheimer's disease, epilepsy) neurological disorders. 2002-12-09 2023-08-12 Not clear
Hidetoshi Tozaki, Akira Matsumoto, Takeshi Kanno, Kaoru Nagai, Tetsu Nagata, Satoshi Yamamoto, Tomoykui Nishizak. The inhibitory and facilitatory actions of amyloid-beta peptides on nicotinic ACh receptors and AMPA receptors. Biochemical and biophysical research communications. vol 294. issue 1. 2002-07-22. PMID:12054737. amyloid-beta peptides, thus, exert their diverse actions on nicotinic ach receptors and ampa receptors, and the inhibitory actions on nicotinic ach receptors may account for the deterioration of learning and memory in alzheimer's disease. 2002-07-22 2023-08-12 xenopus_laevis
M D Ikonomovic, R Nocera, K Mizukami, D M Armstron. Age-related loss of the AMPA receptor subunits GluR2/3 in the human nucleus basalis of Meynert. Experimental neurology. vol 166. issue 2. 2001-01-04. PMID:11085901. as part of an ongoing investigation into the molecular mechanism(s) underlying neuronal vulnerability in alzheimer's disease and normal aging, we employed immunocytochemical techniques and examined the cellular localization of the alpha-amino-3-hydroxy-5-methyl-4-isoaxolepropionate (ampa) glutamate receptor subunits glur1 and glur2/3 in the basal forebrain of eight nondemented elderly human subjects (66-102 years). 2001-01-04 2023-08-12 human
K A Yamad. Therapeutic potential of positive AMPA receptor modulators in the treatment of neurological disease. Expert opinion on investigational drugs. vol 9. issue 4. 2000-12-14. PMID:11060708. thus, ampa modulators might ameliorate memory deficits that occur in dementia, such as alzheimer's disease (ad). 2000-12-14 2023-08-12 Not clear
K Wakabayashi, M Narisawa-Saito, Y Iwakura, T Arai, K Ikeda, H Takahashi, H Naw. Phenotypic down-regulation of glutamate receptor subunit GluR1 in Alzheimer's disease. Neurobiology of aging. vol 20. issue 3. 2000-01-03. PMID:10588576. we have quantitated the protein levels of alpha-amino-isoxazolepropionic acid (ampa)-type (glur1) and n-methyl-d-aspartate-type (nmdar1) glutamate receptors in postmortem brain tissues of patients with alzheimer's disease and age-matched controls using western blotting. 2000-01-03 2023-08-12 Not clear
K Wakabayashi, M Narisawa-Saito, Y Iwakura, T Arai, K Ikeda, H Takahashi, H Naw. Phenotypic down-regulation of glutamate receptor subunit GluR1 in Alzheimer's disease. Neurobiology of aging. vol 20. issue 3. 2000-01-03. PMID:10588576. these findings indicate that abnormal expressions of the ampa receptor and its interacting psd molecule are associated with alzheimer's disease and implicated in pathophysiology of this disease. 2000-01-03 2023-08-12 Not clear
S L Chan, W S Griffin, M P Mattso. Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease. Journal of neuroscience research. vol 57. issue 3. 1999-09-08. PMID:10412022. evidence for caspase-mediated cleavage of ampa receptor subunits in neuronal apoptosis and alzheimer's disease. 1999-09-08 2023-08-12 Not clear
K A Yamad. Modulating excitatory synaptic neurotransmission: potential treatment for neurological disease? Neurobiology of disease. vol 5. issue 2. 1998-12-07. PMID:9746904. thus, ampa modulators might ameliorate memory deficits that occur in dementia, such as alzheimer's disease. 1998-12-07 2023-08-12 Not clear
W Sihver, P Günther, R Schliebs, V Big. Repeated administration of tacrine to normal rats: effects on cholinergic, glutamatergic, and GABAergic receptor subtypes in rat brain using receptor autoradiography. Neurochemistry international. vol 31. issue 5. 1997-12-22. PMID:9364455. tacrine administration alters cortical ampa receptor binding in the opposite direction to that observed in patients with alzheimer's disease, suggesting that tacrine may exert a reversal in up/down-regulation of cortical glutamate receptor subtypes in alzheimer patients. 1997-12-22 2023-08-12 rat
D M Armstrong, M D Ikonomovi. AMPA-selective glutamate receptor subtype immunoreactivity in the hippocampal dentate gyrus of patients with Alzheimer disease. Evidence for hippocampal plasticity. Molecular and chemical neuropathology. vol 28. issue 1-3. 1997-01-23. PMID:8871942. immunocytochemical techniques were employed in order to examine the distribution and relative intensity of immunolabeling of the alpha-amino-3-hydroxy-5-methyl-4-isoaxolepropionate (ampa) receptor subunits glur1 and glur2/3 within the hippocampal formation of patients with alzheimer disease (ad). 1997-01-23 2023-08-12 Not clear
T P Hicks, F Cont. Amino acids as the source of considerable excitation in cerebral cortex. Canadian journal of physiology and pharmacology. vol 74. issue 4. 1996-12-18. PMID:8828881. in addition to the recent growing realisation by clinicians that the excitatory amino acids are linked critically to a number of neurological conditions, including neurodegenerative syndromes such as alzheimer's disease, cortical damage due to stroke and cerebral ischemia, epilepsy, amyotropic lateral sclerosis, and schizophrenia, the recent cloning and membrane reconstitution of specific receptors known as ampa, nmda, kainate, and metabotropic receptors and their known subunits have prompted a surge of renewed interest in this important family of synaptic transmitter molecules. 1996-12-18 2023-08-12 Not clear
M D Ikonomovic, R Sheffield, D M Armstron. AMPA-selective glutamate receptor subtype immunoreactivity in the hippocampal formation of patients with Alzheimer's disease. Hippocampus. vol 5. issue 5. 1996-09-27. PMID:8773259. immunocytochemical techniques were employed in order to examine the distribution and relative intensity of the ampa receptor subunits glur1 and glur2/3 within the hippocampal formation of normal controls and alzheimer's disease (ad) cases. 1996-09-27 2023-08-12 Not clear
S Akbarian, M A Smith, E G Jone. Editing for an AMPA receptor subunit RNA in prefrontal cortex and striatum in Alzheimer's disease, Huntington's disease and schizophrenia. Brain research. vol 699. issue 2. 1996-06-12. PMID:8616634. editing for an ampa receptor subunit rna in prefrontal cortex and striatum in alzheimer's disease, huntington's disease and schizophrenia. 1996-06-12 2023-08-12 human
U Madsen, B Ebert, P Krogsgaard-Larse. Modulation of AMPA receptor function in relation to glutamatergic abnormalities in Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 48. issue 7. 1995-03-22. PMID:7858161. modulation of ampa receptor function in relation to glutamatergic abnormalities in alzheimer's disease. 1995-03-22 2023-08-12 Not clear
D M Armstrong, M D Ikonomovic, R Sheffield, R J Wenthol. AMPA-selective glutamate receptor subtype immunoreactivity in the entorhinal cortex of non-demented elderly and patients with Alzheimer's disease. Brain research. vol 639. issue 2. 1994-07-13. PMID:8205474. the present work employed immunocytochemical techniques and examined the distribution and cytological features of the ampa receptor subunits, glur2/3 and glur1 within the entorhinal cortex of non-demented elderly (nc), patients with neuropathological and clinical verification of alzheimer's disease (ad) and patients without a clinical history of dementia yet exhibiting sufficient quantities of senile plaques to meet neuropathological criteria of alzheimer's disease (hpnd). 1994-07-13 2023-08-12 Not clear
J L Muir, K J Page, D J Sirinathsinghji, T W Robbins, B J Everit. Excitotoxic lesions of basal forebrain cholinergic neurons: effects on learning, memory and attention. Behavioural brain research. vol 57. issue 2. 1994-04-06. PMID:7509608. however, recently, with the availability of more potent cholinergic excitotoxins such as ampa, it has become apparent that nbm lesions do not provide a simple animal model of the cognitive deficits in ageing and alzheimer's disease. 1994-04-06 2023-08-12 Not clear
M D Carlson, J B Penney, A B Youn. NMDA, AMPA, and benzodiazepine binding site changes in Alzheimer's disease visual cortex. Neurobiology of aging. vol 14. issue 4. 1993-10-04. PMID:7690114. nmda, ampa, and benzodiazepine binding site changes in alzheimer's disease visual cortex. 1993-10-04 2023-08-12 human
M D Carlson, J B Penney, A B Youn. NMDA, AMPA, and benzodiazepine binding site changes in Alzheimer's disease visual cortex. Neurobiology of aging. vol 14. issue 4. 1993-10-04. PMID:7690114. quantitative receptor autoradiography was used to measure the laminar distribution of [3h]glycine and [3h]glutamate binding to the n-methyl-d-aspartate (nmda) receptor complex, [3h]d,l-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) binding to the ampa receptor, and [3h]flunitrazepam binding to the benzodiazepine (bdz) receptor in three areas of visual cortex in control and alzheimer's disease (ad) postmortem human brains (primary or striate visual cortex, visual association cortex, and higher-order visual association cortex, corresponding to brodmann areas 17, 18, and 21, respectively). 1993-10-04 2023-08-12 human
J W Geddes, J Ułas, L C Brunner, W Choe, C W Cotma. Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: non-N-methyl-D-aspartate receptors. Neuroscience. vol 50. issue 1. 1992-11-23. PMID:1328933. quantitative receptor autoradiography was used to examine the density and distribution of [3h]kainic acid and [3h]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) binding sites in the hippocampal formation and parahippocampal gyrus obtained at autopsy from 10 alzheimer's disease and eight normal control individuals. 1992-11-23 2023-08-11 human