| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manuela Leri, Marzia Vasarri, Federica Carnemolla, Francesco Oriente, Serena Cabaro, Maria Stio, Donatella Degl'Innocenti, Massimo Stefani, Monica Bucciantin. EVOO Polyphenols Exert Anti-Inflammatory Effects on the Microglia Cell through TREM2 Signaling Pathway. Pharmaceuticals (Basel, Switzerland). vol 16. issue 7. 2023-07-29. PMID:37513845. |
in alzheimer's disease (ad), microglia, brain resident immune cells, become chronically inflammatory and neurotoxic. |
2023-07-29 |
2023-08-14 |
human |
| Michael-John Dolan, Martine Therrien, Saša Jereb, Tushar Kamath, Vahid Gazestani, Trevor Atkeson, Samuel E Marsh, Aleksandrina Goeva, Neal M Lojek, Sarah Murphy, Cassandra M White, Julia Joung, Bingxu Liu, Francesco Limone, Kevin Eggan, Nir Hacohen, Bradley E Bernstein, Christopher K Glass, Ville Leinonen, Mathew Blurton-Jones, Feng Zhang, Charles B Epstein, Evan Z Macosko, Beth Steven. Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro. Nature immunology. 2023-07-27. PMID:37500887. |
microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative diseases such as alzheimer's disease. |
2023-07-27 |
2023-08-14 |
human |
| Qian Zhang, Yaping Ya. The role of natural flavonoids on neuroinflammation as a therapeutic target for Alzheimer's disease: a narrative review. Neural regeneration research. vol 18. issue 12. 2023-07-14. PMID:37449593. |
the inflammatory microenvironment mainly consists of microglia, astrocytes, the complement system, chemokines, cytokines, and reactive oxygen intermediates; collectively, these factors can promote the pathological process and aggravate the severity of alzheimer's disease. |
2023-07-14 |
2023-08-14 |
Not clear |
| Mingsheng Sun, Jing Rong, Mengdi Zhou, Yi Liu, Shiqi Sun, Lu Liu, Dingjun Cai, Fanrong Liang, Ling Zha. Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine. Aging and disease. 2023-07-14. PMID:37450927. |
recently, it has been found that there may be a crosstalk phenomenon between microglia and astrocytes, which plays a crucial part in the pathology and treatment of alzheimer's disease and other central nervous system diseases closely related to inflammation, thus becoming a novel hotspot in neuroimmune research. |
2023-07-14 |
2023-08-14 |
Not clear |
| Yiyi Yang, Marta García-Cruzado, Hairuo Zeng, Lluís Camprubí-Ferrer, Bazhena Bahatyrevich-Kharitonik, Sara Bachiller, Tomas Deierbor. LPS priming before plaque deposition impedes microglial activation and restrains Aβ pathology in the 5xFAD mouse model of Alzheimer's disease. Brain, behavior, and immunity. 2023-07-12. PMID:37437821. |
microglia have an innate immunity memory (iim) with divergent functions in different animal models of neurodegenerative diseases, including alzheimer's disease (ad). |
2023-07-12 |
2023-08-14 |
mouse |
| Xia Zhao, Jinfeng Sun, Li Xiong, Lingyu She, Liwei Li, Hao Tang, Yuqing Zeng, Fan Chen, Xue Han, Shiju Ye, Wei Wang, Xu Wang, Guang Lian. β-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's disease. International journal of biological sciences. vol 19. issue 10. 2023-07-07. PMID:37416769. |
β-amyloid binds to microglia dectin-1 to induce inflammatory response in the pathogenesis of alzheimer's disease. |
2023-07-07 |
2023-08-14 |
Not clear |
| Elliot J Glotfelty, Luis B Tovar-Y-Romo, Shih-Chang Hsueh, David Tweedie, Yazhou Li, Brandon K Harvey, Barry J Hoffer, Tobias E Karlsson, Lars Olson, Nigel H Grei. The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia. Cells. vol 12. issue 10. 2023-07-06. PMID:37408199. |
using previously published data, we show that genes in the rhoa/rock signaling cascade are highly upregulated in the neurodegenerative microglia (mgnd) from app/ps-1 transgenic alzheimer's disease (ad) mice. |
2023-07-06 |
2023-08-14 |
mouse |
| Nasibeh Khayer, Nasrin Motamed, Sayed-Amir Marashi, Fatemeh Goshadro. RT-DOb, a switch gene for the gene pair {Csf1r, Milr1}, can influence the onset of Alzheimer's disease by regulating communication between mast cell and microglia. PloS one. vol 18. issue 7. 2023-07-06. PMID:37410787. |
rt-dob, a switch gene for the gene pair {csf1r, milr1}, can influence the onset of alzheimer's disease by regulating communication between mast cell and microglia. |
2023-07-06 |
2023-08-14 |
rat |
| Jifei Miao, Haixia Ma, Yang Yang, Yuanpin Liao, Cui Lin, Juanxia Zheng, Muli Yu, Jiao La. Microglia in Alzheimer's disease: pathogenesis, mechanisms, and therapeutic potentials. Frontiers in aging neuroscience. vol 15. 2023-07-03. PMID:37396657. |
microglia in alzheimer's disease: pathogenesis, mechanisms, and therapeutic potentials. |
2023-07-03 |
2023-08-14 |
Not clear |
| Tao Yin, Luciano D'Adami. BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer's disease and related dementias. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398330. |
bri2-mediated regulation of trem2 processing in microglia and its potential implications for alzheimer's disease and related dementias. |
2023-07-03 |
2023-08-14 |
Not clear |
| Dunja Mrdjen, Meelad Amouzgar, Bryan Cannon, Candace Liu, Angie Spence, Erin McCaffrey, Anusha Bharadwaj, Dmitry Tebaykin, Syed Bukhari, Felix Hartmann, Adam Kagel, Kausalia Vijayaragavan, John Paul Oliveria, Koya Yakabi, Geidy Serrano, Maria Corrada, Claudia H Kawas, Christine Fullaway, Marc Bosse, Robert Tibshirani, Thomas Beach, Michael Angelo, Thomas Montine, Sean Bendal. Spatial proteomics reveals human microglial states shaped by anatomy and neuropathology. Research square. 2023-07-03. PMID:37398389. |
microglia are implicated in aging, neurodegeneration, and alzheimer's disease (ad). |
2023-07-03 |
2023-08-14 |
human |
| Jasvinder Singh Bhatti, Satinder Kaur, Jayapriya Mishra, Harikrishnareddy Dibbanti, Arti Singh, Arubala P Reddy, Gurjit Kaur Bhatti, P Hemachandra Redd. Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-01. PMID:37392948. |
alzheimer's disease (ad) is a neurodegenerative disease that manifests its pathology through synaptic damage, mitochondrial abnormalities, microrna deregulation, hormonal imbalance, increased astrocytes & microglia, accumulation of amyloid β (aβ) and phosphorylated tau in the brains of ad patients. |
2023-07-01 |
2023-08-14 |
Not clear |
| Wael Mohamed, Jaya Kumar, Badrah S Alghamdi, Al-Hassan Soliman, Yamashita Toshihid. Neurodegeneration and inflammation crosstalk: Therapeutic targets and perspectives. IBRO neuroscience reports. vol 14. 2023-06-30. PMID:37388502. |
alzheimer's, als, parkinson's, frontotemporal dementia (ftd), and epilepsy are a few of the neurodegenerative diseases that have been linked to microglia and astroglia cells, in particular. |
2023-06-30 |
2023-08-14 |
Not clear |
| Zong-Sheng Song, Zhen Li, Yu Wang, Meng-Xing Li, Qing Liu, Ke-Jian Shi, Xiao-Wen Yao, Hui Ding, Si-Liang Li, Wei Tan. [Mechanisms of moxibustion preconditioning underlying improving learning-memory ability by regulating polarization of microglia via TLR4/NF-κB signaling pathway in AD rats]. Zhen ci yan jiu = Acupuncture research. vol 48. issue 6. 2023-06-29. PMID:37385782. |
to observe the effect of moxibustion preconditioning on learning-memory ability, toll like receptor 4(tlr4)/nuclear factor-kappa b(nf-κb) signal pathway related proteins and microglia in rats with alzheimer's disease (ad), so as to explore its possible mechanisms underlying improvement of ad. |
2023-06-29 |
2023-08-14 |
rat |
| Khoren K Epremyan, Dmitry V Mamaev, Renata A Zvyagilskay. Alzheimer's Disease: Significant Benefit from the Yeast-Based Models. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37372938. |
alzheimer's disease (ad) is an age-related, multifaceted neurological disorder associated with accumulation of aggregated proteins (amyloid aβ and hyperphosphorylated tau), loss of synapses and neurons, and alterations in microglia. |
2023-06-28 |
2023-08-14 |
Not clear |
| Oscar M Muñoz Herrera, Brian V Hong, Ulises Ruiz Mendiola, Izumi Maezawa, Lee-Way Jin, Carlito B Lebrilla, Danielle J Harvey, Angela M Zivkovi. Cholesterol, Amyloid Beta, Fructose, and LPS Influence ROS and ATP Concentrations and the Phagocytic Capacity of HMC3 Human Microglia Cell Line. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373543. |
research has found that genes specific to microglia are among the strongest risk factors for alzheimer's disease (ad) and that microglia are critically involved in the etiology of ad. |
2023-06-28 |
2023-08-14 |
human |
| Juciano Gasparotto, Nauana Somensi, Carolina Saibro Girardi, Reykla Ramon Bittencourt, Laura Martinewski de Oliveira, Laura Piloneto Hoefel, Ingrid Matsubara Scheibel, Daniel Oppermann Peixoto, José Claudio Fonseca Moreira, Tiago Fleming Outeiro, Daniel Pens Gelai. Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease. Journal of neurochemistry. 2023-06-28. PMID:37381043. |
as chronic inflammation is consistently present in neurodegenerative diseases, it was largely assumed that rage could act as a critical modulator of neuroinflammation in parkinson's disease (pd), similar to what was reported for alzheimer's disease (ad), where rage is postulated to mediate pro-inflammatory signaling in microglia by binding to amyloid-β peptide. |
2023-06-28 |
2023-08-14 |
Not clear |
| Alexi Nott, Inge R Holtma. Genetic insights into immune mechanisms of Alzheimer's and Parkinson's disease. Frontiers in immunology. vol 14. 2023-06-27. PMID:37359515. |
(post)-gwas studies have determined that microglia likely play an important role in the development of alzheimer's disease (ad) and parkinson's disease (pd). |
2023-06-27 |
2023-08-14 |
Not clear |
| Qianqian Huang, Chaoqing Jiang, Xue Xia, Yufan Wang, Chenxing Yan, Xiaorong Wang, Ting Lei, Xiaotong Yang, Wenqin Yang, Guo Cheng, Huile Ga. Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer's Disease. Research (Washington, D.C.). vol 6. 2023-06-27. PMID:37363131. |
inflammatory responses, manifested in excessive oxidative stress and microglia overactivation, together with metal ion-triggered amyloid-beta (aβ) deposition, are critical hallmarks of alzheimer's disease (ad). |
2023-06-27 |
2023-08-14 |
Not clear |
| George Sideris-Lampretsas, Silvia Oggero, Lynda Zeboudj, Rita Silva, Archana Bajpai, Gopuraja Dharmalingam, David A Collier, Marzia Malcangi. Galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-06-22. PMID:37349313. |
galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling alzheimer's disease. |
2023-06-22 |
2023-08-14 |
mouse |