| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexi Nott, Inge R Holtma. Genetic insights into immune mechanisms of Alzheimer's and Parkinson's disease. Frontiers in immunology. vol 14. 2023-06-27. PMID:37359515. |
(post)-gwas studies have determined that microglia likely play an important role in the development of alzheimer's disease (ad) and parkinson's disease (pd). |
2023-06-27 |
2023-08-14 |
Not clear |
| Qianqian Huang, Chaoqing Jiang, Xue Xia, Yufan Wang, Chenxing Yan, Xiaorong Wang, Ting Lei, Xiaotong Yang, Wenqin Yang, Guo Cheng, Huile Ga. Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer's Disease. Research (Washington, D.C.). vol 6. 2023-06-27. PMID:37363131. |
inflammatory responses, manifested in excessive oxidative stress and microglia overactivation, together with metal ion-triggered amyloid-beta (aβ) deposition, are critical hallmarks of alzheimer's disease (ad). |
2023-06-27 |
2023-08-14 |
Not clear |
| George Sideris-Lampretsas, Silvia Oggero, Lynda Zeboudj, Rita Silva, Archana Bajpai, Gopuraja Dharmalingam, David A Collier, Marzia Malcangi. Galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-06-22. PMID:37349313. |
galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling alzheimer's disease. |
2023-06-22 |
2023-08-14 |
mouse |
| Simon Maksour, Lezanne Oo. Innovations advancing our understanding of microglia in Alzheimer's disease: From in vitro to in vivo models. Journal of neurochemistry. 2023-06-16. PMID:37323026. |
innovations advancing our understanding of microglia in alzheimer's disease: from in vitro to in vivo models. |
2023-06-16 |
2023-08-14 |
mouse |
| Simon Maksour, Lezanne Oo. Innovations advancing our understanding of microglia in Alzheimer's disease: From in vitro to in vivo models. Journal of neurochemistry. 2023-06-16. PMID:37323026. |
microglia have been implicated in alzheimer's disease (ad) pathogenesis through the identification of risk factor genes that are specifically or predominantly expressed in this cell type. |
2023-06-16 |
2023-08-14 |
mouse |
| Giorgia Serena Gullotta, Giuseppe Costantino, Maria Angela Sortino, Simona Federica Spampinat. Microglia and the Blood-Brain Barrier: An External Player in Acute and Chronic Neuroinflammatory Conditions. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298096. |
here, we report the specific crosstalk of microglia with all the bbb cell types focusing in particular on the involvement of microglia in the modulation of bbb function in neuroinflammatory conditions that occur in conjunction with an acute event, such as a stroke, or in a slow neurodegenerative disease, such as alzheimer's disease. |
2023-06-11 |
2023-08-14 |
Not clear |
| Xiaohui Liu, Ning Jiang, Wenxia Zho. Various Energetic Metabolism of Microglia in Response to Different Stimulations. Molecules (Basel, Switzerland). vol 28. issue 11. 2023-06-11. PMID:37298976. |
the activation of the microglia plays an important role in the neuroinflammation induced by different stimulations associated with alzheimer's disease (ad). |
2023-06-11 |
2023-08-14 |
human |
| Mahdi Yonesi, Milagros Ramos, Carmen Ramirez-Castillejo, Rocío Fernández-Serra, Fivos Panetsos, Adrián Belarra, Margarita Chevalier, Francisco J Rojo, José Pérez-Rigueiro, Gustavo V Guinea, Daniel González-Niet. Resistance to Degradation of Silk Fibroin Hydrogels Exposed to Neuroinflammatory Environments. Polymers. vol 15. issue 11. 2023-06-11. PMID:37299290. |
in this study, the stability of silk fibroin hydrogels exposed to different neuroinflammatory contexts has been explored using an in vitro microglial cell culture and two in vivo pathological models of cerebral stroke and alzheimer's disease. |
2023-06-11 |
2023-08-14 |
Not clear |
| Simon W So, Kendra M Fleming, Joshua P Nixon, Tammy A Butteric. Early Life Obesity Increases Neuroinflammation, Amyloid Beta Deposition, and Cognitive Decline in a Mouse Model of Alzheimer's Disease. Nutrients. vol 15. issue 11. 2023-06-11. PMID:37299457. |
obesity, a known risk factor of alzheimer's disease (ad), increases the activation of microglia, leading to a proinflammatory phenotype. |
2023-06-11 |
2023-08-14 |
mouse |
| Hongxia Wang, Xiaoling Li, Qi Wang, Jialiang Ma, Xiaohong Gao, Manxia Wan. TREM2, microglial and ischemic stroke. Journal of neuroimmunology. vol 381. 2023-06-11. PMID:37302170. |
currently, with the latest progress of transcriptomics analysis, different and more complex phenotypes of microglia activation have been described, such as disease-related microglia (dam) associated with alzheimer's disease (ad), white matter associated microglia (wams) in aging, and stroke-related microglia (sam) etc. |
2023-06-11 |
2023-08-14 |
Not clear |
| Yuhong Du, William J Bradshaw, Tina M Leisner, Joel K Annor-Gyamfi, Kun Qian, Frances M Bashore, Arunima Sikdar, Felix O Nwogbo, Andrey A Ivanov, Stephen V Frye, Opher Gileadi, Paul E Brennan, Allan I Levey, Alison D Axtman, Kenneth H Pearce, Haian Fu, Vittorio L Kati. Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer's disease. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37292860. |
recent genome-wide association studies have revealed genetic risk factors for alzheimer's disease (ad) that are exclusively expressed in microglia within the brain. |
2023-06-09 |
2023-08-14 |
Not clear |
| Yeonghoon Son, Hye-Jin Park, Ye Ji Jeong, Hyung-Do Choi, Nam Kim, Hae-June Le. Long-term radiofrequency electromagnetic fields exposure attenuates cognitive dysfunction in 5×FAD mice by regulating microglial function. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282482. |
we have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5×fad mice with severe late-stage alzheimer's disease reduced both amyloid-β deposition and glial activation, including microglia. |
2023-06-07 |
2023-08-14 |
mouse |
| Hans Lassman. Top ten discoveries of the year: Neuroinflammation. Free neuropathology. vol 1. 2023-06-07. PMID:37283667. |
finally, very interesting studies are discussed dealing with microglia and immune mechanisms in neurodegeneration (publication 9) and the neuropathological long-term outcome of aß vaccination in alzheimer's disease (publication 10). |
2023-06-07 |
2023-08-14 |
Not clear |
| Vera Fominykh, Alexey A Shadrin, Piotr P Jaholkowski, Shahram Bahrami, Lavinia Athanasiu, Douglas P Wightman, Emil Uffelmann, Danielle Posthuma, Geir Selbæk, Anders M Dale, Srdjan Djurovic, Oleksandr Frei, Ole A Andreasse. Shared genetic loci between Alzheimer's disease and multiple sclerosis: Crossroads between neurodegeneration and immune system. Neurobiology of disease. 2023-06-07. PMID:37286172. |
neuroinflammation is involved in the pathophysiology of alzheimer's disease (ad), including immune-linked genetic variants and molecular pathways, microglia and astrocytes. |
2023-06-07 |
2023-08-14 |
Not clear |
| Hannah Ennerfelt, Coco Holliday, Daniel A Shapiro, Kristine E Zengeler, Ashley C Bolte, Tyler K Ulland, John R Luken. CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer's disease mouse model. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 24. 2023-06-05. PMID:37276426. |
recent advances have highlighted the importance of several innate immune receptors expressed by microglia in alzheimer's disease (ad). |
2023-06-05 |
2023-08-14 |
mouse |
| Susanna R Var, Phoebe Strell, Sether T Johnson, Alex Roman, Zoey Vasilakos, Walter C Lo. Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia. Cell transplantation. vol 32. 2023-05-31. PMID:37254858. |
chronically activated and dysfunctional microglia are found in many diseases and disorders, such as alzheimer's disease, parkinson's disease, and cns-related injuries, and can accelerate or worsen the condition. |
2023-05-31 |
2023-08-14 |
Not clear |
| Katherine E Prater, Kevin J Green, Sainath Mamde, Wei Sun, Alexandra Cochoit, Carole L Smith, Kenneth L Chiou, Laura Heath, Shannon E Rose, Jesse Wiley, C Dirk Keene, Ronald Y Kwon, Noah Snyder-Mackler, Elizabeth E Blue, Benjamin Logsdon, Jessica E Young, Ali Shojaie, Gwenn A Garden, Suman Jayade. Human microglia show unique transcriptional changes in Alzheimer's disease. Nature aging. 2023-05-29. PMID:37248328. |
human microglia show unique transcriptional changes in alzheimer's disease. |
2023-05-29 |
2023-08-14 |
human |
| Katherine E Prater, Kevin J Green, Sainath Mamde, Wei Sun, Alexandra Cochoit, Carole L Smith, Kenneth L Chiou, Laura Heath, Shannon E Rose, Jesse Wiley, C Dirk Keene, Ronald Y Kwon, Noah Snyder-Mackler, Elizabeth E Blue, Benjamin Logsdon, Jessica E Young, Ali Shojaie, Gwenn A Garden, Suman Jayade. Human microglia show unique transcriptional changes in Alzheimer's disease. Nature aging. 2023-05-29. PMID:37248328. |
microglia, the innate immune cells of the brain, influence alzheimer's disease (ad) progression and are potential therapeutic targets. |
2023-05-29 |
2023-08-14 |
human |
| Megan J Lantz, Alyssa M Roberts, Donovan D Delgado, Robert A Nichol. The neuroprotective N-terminal amyloid-β core hexapeptide reverses reactive gliosis and gliotoxicity in Alzheimer's disease pathology models. Journal of neuroinflammation. vol 20. issue 1. 2023-05-27. PMID:37245024. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder characterized by accumulation of extracellular amyloid beta (aβ) and intracellular neurofibrillary tangles, leading to chronic activation of astrocytes and microglia and persistent neuroinflammation. |
2023-05-27 |
2023-08-14 |
Not clear |
| Yijun Pan, Yoshiteru Kagawa, Jiaqi Sun, Deanna S Deveson Lucas, Ryusuke Takechi, John C L Mamo, Dorothy C C Wai, Raymond S Norton, Liang Jin, Joseph A Nicolazz. Peripheral Administration of the Kv1.3-Blocking Peptide HsTX1[R14A] Improves Cognitive Performance in Senescence Accelerated SAMP8 Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023-05-24. PMID:37226029. |
increased expression of the voltage-gated potassium channel kv1.3 in activated microglia, and the subsequent release of pro-inflammatory mediators, are closely associated with the progression of alzheimer's disease (ad). |
2023-05-24 |
2023-08-14 |
mouse |