| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingde Fan, Chao Wang, Xueying Zhao, Yang Jiang, Chengwei Wan. Parthenolide alleviates microglia-mediated neuroinflammation via MAPK/TRIM31/NLRP3 signaling to ameliorate cognitive disorder. International immunopharmacology. vol 120. 2023-05-14. PMID:37182449. |
neuroinflammation, mainly mediated by microglia, is involved in the evolution of alzheimer's disease (ad). |
2023-05-14 |
2023-08-14 |
mouse |
| Xiaolan Zhou, Xingru Chen, Xiaoqing Cheng, Liting Lin, Shijian Quan, Shijun Li, Ruoting Zhan, Qingguang Wu, Sijun Li. Paeoniflorin, ferulic acid, and atractylenolide III improved LPS-induced neuroinflammation of BV2 microglia cells by enhancing autophagy. Journal of pharmacological sciences. vol 152. issue 2. 2023-05-11. PMID:37169480. |
microglia hyperactivation is an important cause of neuroinflammation in alzheimer's disease (ad). |
2023-05-11 |
2023-08-14 |
Not clear |
| Sarah E Heuer, Kelly J Keezer, Amanda A Hewes, Kristen D Onos, Kourtney C Graham, Gareth R Howell, Erik B Blos. Genetic context controls early microglia-synaptic interactions in mouse models of Alzheimer's disease. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37162819. |
common features of alzheimer's disease (ad) include amyloid pathology, microglia activation and synaptic dysfunction, however, the causal relationships amongst them remains unclear. |
2023-05-10 |
2023-08-14 |
mouse |
| Jennifer Hua, Elvira Garcia de Paco, Nathalie Linck, Tangui Maurice, Catherine Desrumaux, Bénédicte Manoury, François Rassendren, Lauriane Ulman. Microglial P2X4 receptors promote ApoE degradation and contribute to memory deficits in Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 80. issue 5. 2023-05-05. PMID:37145189. |
numerous evidences support that microglia contributes to the progression of alzheimer's disease. |
2023-05-05 |
2023-08-14 |
Not clear |
| Lu Zeng, Charles C White, David A Bennett, Hans-Ulrich Klein, Philip L De Jage. Genetic insights into the association between inflammatory bowel disease and Alzheimer's disease. medRxiv : the preprint server for health sciences. 2023-05-03. PMID:37131588. |
microglia are the resident myeloid cells of the central nervous system, and many alzheimer's disease (ad) risk loci are found in or near genes that are highly or sometimes uniquely expressed in myeloid cells. |
2023-05-03 |
2023-08-14 |
Not clear |
| Weam W Ibrahim, Krystyna Skalicka-Woźniak, Barbara Budzyńska, Nesrine S El Saye. NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via scoparone-inhibited TLR4 axis in ovariectomy/D-galactose Alzheimer's disease rat model. International immunopharmacology. vol 119. 2023-05-03. PMID:37137264. |
neuroinflammation mediated by microglia activation is a critical contributor to alzheimer's disease (ad) pathogenesis. |
2023-05-03 |
2023-08-14 |
rat |
| Si-Jia Peng, Ya Feng, Xuan Li, Xi-Xi Wang, Yu Wang, Bu-Tian Zhou, Ye Liu, Te Liu, Yun-Cheng W. Thymopentin (TP-5) prevents lipopolysaccharide-induced neuroinflammation and dopaminergic neuron injury by inhibiting the NF-κB/NLRP3 signaling pathway. International immunopharmacology. vol 119. 2023-04-30. PMID:37121113. |
neuroinflammation plays a pivotal role in neurodegenerative diseases, including parkinson's disease, alzheimer's disease, amyotrophic lateral sclerosis and stroke, and is accompanied by excessive release of inflammatory cytokines and mediators by activated microglia. |
2023-04-30 |
2023-08-14 |
mouse |
| Rosana March-Diaz, Nieves Lara-Ureña, Carmen Romero-Molina, Antonio Heras-Garvin, Clara Ortega-de San Luis, Maria I Alvarez-Vergara, Manuel A Sanchez-Garcia, Elisabeth Sanchez-Mejias, Jose C Davila, Alicia E Rosales-Nieves, Cristina Forja, Victoria Navarro, Angela Gomez-Arboledas, Maria V Sanchez-Mico, Adrian Viehweger, Almudena Gerpe, Emma J Hodson, Marisa Vizuete, Tammie Bishop, Alberto Serrano-Pozo, Jose Lopez-Barneo, Edurne Berra, Antonia Gutierrez, Javier Vitorica, Alberto Pascua. Hypoxia compromises the mitochondrial metabolism of Alzheimer's disease microglia via HIF1. Nature aging. vol 1. issue 4. 2023-04-28. PMID:37117599. |
hypoxia compromises the mitochondrial metabolism of alzheimer's disease microglia via hif1. |
2023-04-28 |
2023-08-14 |
mouse |
| Rosana March-Diaz, Nieves Lara-Ureña, Carmen Romero-Molina, Antonio Heras-Garvin, Clara Ortega-de San Luis, Maria I Alvarez-Vergara, Manuel A Sanchez-Garcia, Elisabeth Sanchez-Mejias, Jose C Davila, Alicia E Rosales-Nieves, Cristina Forja, Victoria Navarro, Angela Gomez-Arboledas, Maria V Sanchez-Mico, Adrian Viehweger, Almudena Gerpe, Emma J Hodson, Marisa Vizuete, Tammie Bishop, Alberto Serrano-Pozo, Jose Lopez-Barneo, Edurne Berra, Antonia Gutierrez, Javier Vitorica, Alberto Pascua. Hypoxia compromises the mitochondrial metabolism of Alzheimer's disease microglia via HIF1. Nature aging. vol 1. issue 4. 2023-04-28. PMID:37117599. |
genetic alzheimer's disease (ad) risk factors associate with reduced defensive amyloid β plaque-associated microglia (aβam), but the contribution of modifiable ad risk factors to microglial dysfunction is unknown. |
2023-04-28 |
2023-08-14 |
mouse |
| Raz Dvir-Szternfeld, Giulia Castellani, Michal Arad, Liora Cahalon, Sarah Phoebeluc Colaiuta, Hadas Keren-Shaul, Tommaso Croese, Chiara Burgaletto, Kuti Baruch, Tyler Ulland, Marco Colonna, Assaf Weiner, Ido Amit, Michal Schwart. Alzheimer's disease modification mediated by bone marrow-derived macrophages via a TREM2-independent pathway in mouse model of amyloidosis. Nature aging. vol 2. issue 1. 2023-04-28. PMID:37118355. |
microglia and monocyte-derived macrophages (mdm) are key players in dealing with alzheimer's disease. |
2023-04-28 |
2023-08-14 |
mouse |
| Borislav Dejanovic, Tiffany Wu, Ming-Chi Tsai, David Graykowski, Vineela D Gandham, Christopher M Rose, Corey E Bakalarski, Hai Ngu, Yuanyuan Wang, Shristi Pandey, Mitchell G Rezzonico, Brad A Friedman, Rose Edmonds, Ann De Mazière, Raphael Rakosi-Schmidt, Tarjinder Singh, Judith Klumperman, Oded Foreman, Michael C Chang, Luke Xie, Morgan Sheng, Jesse E Hanso. Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models. Nature aging. vol 2. issue 9. 2023-04-28. PMID:37118504. |
complement c1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in alzheimer's disease mouse models. |
2023-04-28 |
2023-08-14 |
mouse |
| Borislav Dejanovic, Tiffany Wu, Ming-Chi Tsai, David Graykowski, Vineela D Gandham, Christopher M Rose, Corey E Bakalarski, Hai Ngu, Yuanyuan Wang, Shristi Pandey, Mitchell G Rezzonico, Brad A Friedman, Rose Edmonds, Ann De Mazière, Raphael Rakosi-Schmidt, Tarjinder Singh, Judith Klumperman, Oded Foreman, Michael C Chang, Luke Xie, Morgan Sheng, Jesse E Hanso. Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models. Nature aging. vol 2. issue 9. 2023-04-28. PMID:37118504. |
microglia and complement can mediate neurodegeneration in alzheimer's disease (ad). |
2023-04-28 |
2023-08-14 |
mouse |
| Joana B Pereira, Shorena Janelidze, Olof Strandberg, Christopher D Whelan, Henrik Zetterberg, Kaj Blennow, Sebastian Palmqvist, Erik Stomrud, Niklas Mattsson-Carlgren, Oskar Hansso. Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer's disease pathology. Nature aging. vol 2. issue 12. 2023-04-28. PMID:37118533. |
the role of microglia in tau accumulation is currently unclear but could provide an important insight into the mechanisms underlying alzheimer's disease (ad) |
2023-04-28 |
2023-08-14 |
Not clear |
| Dongyuan Zhang, Yu Zhang, Jirong Pan, Jingjing Cao, Xiuping Sun, Xianglei Li, Ling Zhang, Chuan Qi. Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia. CNS neuroscience & therapeutics. 2023-04-19. PMID:37072933. |
degradation of nlrp3 by p62-dependent-autophagy improves cognitive function in alzheimer's disease by maintaining the phagocytic function of microglia. |
2023-04-19 |
2023-08-14 |
Not clear |
| Dongyuan Zhang, Yu Zhang, Jirong Pan, Jingjing Cao, Xiuping Sun, Xianglei Li, Ling Zhang, Chuan Qi. Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia. CNS neuroscience & therapeutics. 2023-04-19. PMID:37072933. |
activation of the nlrp3 inflammasome promotes microglia to secrete inflammatory cytokines and induce pyroptosis, leading to impaired phagocytic and clearance functions of microglia in alzheimer's disease (ad). |
2023-04-19 |
2023-08-14 |
Not clear |
| Sydney Sunna, Christine A Bowen, Christina C Ramelow, Juliet V Santiago, Prateek Kumar, Srikant Rangaraj. Advances in proteomic phenotyping of microglia in neurodegeneration. Proteomics. 2023-04-15. PMID:37060300. |
in this review, we discuss molecular insights gained from transcriptomic studies of microglia in the context of alzheimer's disease as a prototypic neurodegenerative disease, and highlight existing and emerging approaches for proteomic profiling of microglia derived from in vivo model systems and human brain. |
2023-04-15 |
2023-08-14 |
human |
| Lucia Scipioni, Daniel Tortolani, Francesca Ciaramellano, Federico Fanti, Thais Gazzi, Manuel Sergi, Marc Nazaré, Sergio Oddi, Mauro Maccarron. Aβ Chronic Exposure Promotes an Activation State of Microglia through Endocannabinoid Signalling Imbalance. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047663. |
dysfunctional phenotype of microglia, the primary brain immune cells, may aggravate alzheimer's disease (ad) pathogenesis by releasing proinflammatory factors, such as nitric oxide (no). |
2023-04-13 |
2023-08-14 |
Not clear |
| Yanhui Lu, Xiaofeng Huang, Wenping Liang, Yu Li, Mengen Xing, Wenhao Pan, Yun Zhang, Zhe Wang, Weihong Son. Regulation of TREM2 expression by transcription factor YY1 and its protective effect against Alzheimer's Disease. The Journal of biological chemistry. 2023-04-12. PMID:37044212. |
trem2 encoding the transmembrane receptor protein trem2 is a risk gene of alzheimer's disease (ad), and the impairment of trem2 functions in microglia due to mutations in trem2 may significantly increase the risk of ad by promoting ad pathologies. |
2023-04-12 |
2023-08-14 |
mouse |
| b' Siting Gan, Danilo G Macalinao, Sayyed Hamed Shahoei, Lin Tian, Xin Jin, Harihar Basnet, James T Muller, Pranita Atri, Evan Seffar, Walid Chatila, Anna-Katerina Hadjantonakis, Nikolaus Schultz, Edi Brogi, Tejus A Bale, Dana Pe\'er, Joan Massagu\\xc3\\xa. Distinct tumor architectures for metastatic colonization of the brain. bioRxiv : the preprint server for biology. 2023-04-10. PMID:37034672.' |
single-cell transcriptomic dissection reveals canonical alzheimer's disease-associated microglia (dam) responses. |
2023-04-10 |
2023-08-14 |
Not clear |
| Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomit. INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model. iScience. vol 26. issue 4. 2023-04-10. PMID:37035000. |
the genetic associations of trem2 loss-of-function variants with alzheimer disease (ad) indicate the protective roles of microglia in ad pathogenesis. |
2023-04-10 |
2023-08-14 |
mouse |