| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vicky Chou, Seeley B Fancher, Richard V Pearse, Hyo Lee, Matti Lam, Nicholas T Seyfried, David A Bennett, Phillip L De Jager, Vilas Menon, Tracy L Young-Pears. INPP5D/SHIP1 regulates inflammasome activation in human microglia. bioRxiv : the preprint server for biology. 2023-03-03. PMID:36865139. |
microglia and neuroinflammation are implicated in the development and progression of alzheimer's disease (ad). |
2023-03-03 |
2023-08-14 |
human |
| Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G Aleph Prieto, Leslie M Thompson, Joan S Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jone. Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-03-02. PMID:36864071. |
author correction: gene expression and functional deficits underlie trem2-knockout microglia responses in human models of alzheimer's disease. |
2023-03-02 |
2023-08-14 |
human |
| Clara Muñoz-Castro, Marina Mejias-Ortega, Elisabeth Sanchez-Mejias, Victoria Navarro, Laura Trujillo-Estrada, Sebastian Jimenez, Juan Antonio Garcia-Leon, Juan Jose Fernandez-Valenzuela, Maria Virtudes Sanchez-Mico, Carmen Romero-Molina, Ines Moreno-Gonzalez, David Baglietto-Vargas, Marisa Vizuete, Antonia Gutierrez, Javier Vitoric. Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer's disease hippocampus. Acta neuropathologica communications. vol 11. issue 1. 2023-03-01. PMID:36855152. |
microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the cns and the pathogenesis of alzheimer's disease (ad). |
2023-03-01 |
2023-08-14 |
human |
| Yoki Nakamur. [Microglia and innate immunity in Alzheimer's disease]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 158. issue 2. 2023-03-01. PMID:36858507. |
[microglia and innate immunity in alzheimer's disease]. |
2023-03-01 |
2023-08-14 |
Not clear |
| Miguel Moutinho, Israel Coronel, Andy P Tsai, Gonzalo Viana Di Prisco, Taylor Pennington, Brady K Atwood, Shweta S Puntambekar, Daniel C Smith, Pablo Martinez, Seonggyun Han, Younghee Lee, Cristian A Lasagna-Reeves, Bruce T Lamb, Stephanie J Bissel, Kwangsik Nho, Gary E Landret. TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation. Genome medicine. vol 15. issue 1. 2023-02-22. PMID:36805764. |
trem2 governs the response of microglia to amyloid and tau pathologies in the alzheimer's disease (ad) brain. |
2023-02-22 |
2023-08-14 |
mouse |
| Shih-Feng You, Logan Brase, Fabia Filipello, Abhirami K Iyer, Jorge Del-Aguila, June He, Ricardo D'Oliveira Albanus, John Budde, Joanne Norton, Jen Gentsch, Nina M Dräger, Sydney M Sattler, Martin Kampmann, Laura Piccio, John C Morris, Richard J Perrin, Eric McDade, Steven M Paul, Anil G Cashikar, Bruno A Benitez, Oscar Harari, Celeste M Karc. MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state. medRxiv : the preprint server for health sciences. 2023-02-17. PMID:36798226. |
ms4a4a modifies the risk of alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state. |
2023-02-17 |
2023-08-14 |
Not clear |
| Shih-Feng You, Logan Brase, Fabia Filipello, Abhirami K Iyer, Jorge Del-Aguila, June He, Ricardo D'Oliveira Albanus, John Budde, Joanne Norton, Jen Gentsch, Nina M Dräger, Sydney M Sattler, Martin Kampmann, Laura Piccio, John C Morris, Richard J Perrin, Eric McDade, Steven M Paul, Anil G Cashikar, Bruno A Benitez, Oscar Harari, Celeste M Karc. MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state. medRxiv : the preprint server for health sciences. 2023-02-17. PMID:36798226. |
genome-wide association studies (gwas) have identified many modifiers of alzheimer disease (ad) risk enriched in microglia. |
2023-02-17 |
2023-08-14 |
Not clear |
| Ya-Jing Liu, Yu Ding, Yan-Qing Yin, Hui Xiao, Gang Hu, Jia-Wei Zho. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 8. 2023-02-16. PMID:36795751. |
microglia play a critical role in the pathogenic process of neurodegenerative diseases, such as parkinson's disease (pd) and alzheimer's disease (ad). |
2023-02-16 |
2023-08-14 |
Not clear |
| Lauren H Fairley, Kei Onn Lai, Jia Hui Wong, Wei Jing Chong, Anselm Salvatore Vincent, Giuseppe D'Agostino, Xiaoting Wu, Roshan R Naik, Anusha Jayaraman, Sarah R Langley, Christiane Ruedl, Anna M Barro. Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 8. 2023-02-14. PMID:36787364. |
alzheimer's beta amyloid drastically stimulated mitochondrial hk recruitment in cultured microglia, which may contribute to microglial dysfunction in ad. |
2023-02-14 |
2023-08-14 |
mouse |
| Xiuli Zhang, Shivakumar Subbanna, Colin R O Williams, Stefanie Canals-Baker, John F Smiley, Donald A Wilson, Bhaskar C Das, Mariko Sait. Anti-inflammatory Action of BT75, a Novel RARα Agonist, in Cultured Microglia and in an Experimental Mouse Model of Alzheimer's Disease. Neurochemical research. 2023-02-13. PMID:36781685. |
anti-inflammatory action of bt75, a novel rarα agonist, in cultured microglia and in an experimental mouse model of alzheimer's disease. |
2023-02-13 |
2023-08-14 |
mouse |
| Michele Comerota, Manasee Gedam, Wen Xiong, Feng Jin, Lisheng Deng, Meng Wang, Jin Wang, Hui Zhen. Oleoylethanolamide facilitates PPARa and TFEB signaling and attenuates Ab pathology in a mouse model of Alzheimer's disease. Research square. 2023-01-30. PMID:36711875. |
emerging evidence implicates impaired microglia function and dysregulation of lipid metabolism in alzheimer's disease (ad). |
2023-01-30 |
2023-08-14 |
mouse |
| Mai M Anwar, Esra Özkan, Narges Shomalizadeh, Selin Sapancı, Ceyda Özler, Judy Kesibi, Yasemin Gürsoy-Özdemi. Assessing the role of primary healthy microglia and gap junction blocker in hindering Alzheimer's disease neuroinflammatory type: Early approaches for therapeutic intervention. Frontiers in neuroscience. vol 16. 2023-01-27. PMID:36704003. |
assessing the role of primary healthy microglia and gap junction blocker in hindering alzheimer's disease neuroinflammatory type: early approaches for therapeutic intervention. |
2023-01-27 |
2023-08-14 |
rat |
| Alejandro Lillo, Joan Serrano-Marín, Jaume Lillo, Iu Raïch, Gemma Navarro, Rafael Franc. Gene regulation in activated microglia by adenosine A Purinergic signalling. 2023-01-26. PMID:36703008. |
gene regulation in activated microglia by adenosine a most neurodegenerative disorders, including the two most common, alzheimer's disease (ad) and parkinson's disease (ad), course with activation of microglia, the resident innate immune cells of the central nervous system. |
2023-01-26 |
2023-08-14 |
Not clear |
| Lee-Way Jin, Jacopo di Lucente, Ulises Ruiz Mendiola, Xinyu Tang, Angela M Zivkovic, Carlito B Lebrilla, Izumi Maezaw. The role of FUT8-catalyzed core fucosylation in Alzheimer's amyloid-β oligomer-induced activation of human microglia. Glia. 2023-01-24. PMID:36692036. |
the role of fut8-catalyzed core fucosylation in alzheimer's amyloid-β oligomer-induced activation of human microglia. |
2023-01-24 |
2023-08-14 |
mouse |
| Lee-Way Jin, Jacopo di Lucente, Ulises Ruiz Mendiola, Xinyu Tang, Angela M Zivkovic, Carlito B Lebrilla, Izumi Maezaw. The role of FUT8-catalyzed core fucosylation in Alzheimer's amyloid-β oligomer-induced activation of human microglia. Glia. 2023-01-24. PMID:36692036. |
here we used human induced pluripotent stem cells-derived microglia (himg) as a model to study the role of fut8-catalyzed core fucosylation in amyloid-β oligomer (aβo)-induced microglial activation, in view of its significant relevance to the pathogenesis of alzheimer's disease (ad). |
2023-01-24 |
2023-08-14 |
mouse |
| Sk Chand Basha, Mekala Janaki Ramaiah, Jagannatha Rao Kosagishara. Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-01-23. PMID:36683512. |
untangling the role of trem2 in conjugation with microglia in neuronal dysfunction: a hypothesis on a novel pathway in the pathophysiology of alzheimer's disease. |
2023-01-23 |
2023-08-14 |
Not clear |
| Gerhard Leinenga, Liviu-Gabriel Bodea, Jan Schröder, Giuzhi Sun, Yichen Zhou, Jae Song, Alexandra Grubman, Jose M Polo, Jürgen Göt. Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound. Bioengineering & translational medicine. vol 8. issue 1. 2023-01-23. PMID:36684089. |
transcriptional signature in microglia isolated from an alzheimer's disease mouse model treated with scanning ultrasound. |
2023-01-23 |
2023-08-14 |
mouse |
| Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yan. TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro. Molecular neurobiology. 2023-01-20. PMID:36662361. |
triggering receptor expressed on myeloid cells-2 (trem2), a cell surface receptor mainly expressed on microglia, has been shown to play a critical role in alzheimer's disease (ad) pathogenesis and progression. |
2023-01-20 |
2023-08-14 |
mouse |
| Michael T Henek. ApoE4 makes microglia trem Neuron. vol 111. issue 2. 2023-01-19. PMID:36657395. |
apoe4 makes microglia trem the apoe-trem2 pathway links two of the most important genetic risk variants for sporadic alzheimer's disease. |
2023-01-19 |
2023-08-14 |
Not clear |
| Yingyue Zhou, Mari Tada, Zhangying Cai, Prabhakar S Andhey, Amanda Swain, Kelly R Miller, Susan Gilfillan, Maxim N Artyomov, Masaki Takao, Akiyoshi Kakita, Marco Colonn. Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia. Nature immunology. 2023-01-19. PMID:36658241. |
heterozygous hypofunctional trem2 variants impair microglia, accelerating late-onset alzheimer's disease. |
2023-01-19 |
2023-08-14 |
mouse |