| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sadhana Sharma, Curtis Borski, Jessica Hanson, Micklaus A Garcia, Christopher D Link, Charles Hoeffer, Anushree Chatterjee, Prashant Nagpa. Identifying an Optimal Neuroinflammation Treatment Using a Nanoligomer Discovery Engine. ACS chemical neuroscience. 2022-11-21. PMID:36410860. |
however, chronic neuroinflammation leading to the activation of immune cells like microglia and astrocytes causes damage to the nervous tissue, and it is causally linked to a range of neurodegenerative diseases such as alzheimer's diseases (ad), multiple sclerosis (ms), parkinson's disease (pd), and many others. |
2022-11-21 |
2023-08-14 |
mouse |
| Mohsen Farhangian, Forouzan Azarafrouz, Sara Chavoshinezhad, Leila Dargah. Intranasal interferon-beta alleviates anxiety and depressive-like behaviors by modulating microglia polarization in an Alzheimer's disease model. Neuroscience letters. 2022-11-17. PMID:36396023. |
intranasal interferon-beta alleviates anxiety and depressive-like behaviors by modulating microglia polarization in an alzheimer's disease model. |
2022-11-17 |
2023-08-14 |
human |
| Sam J Washer, Marta Perez-Alcantara, Yixi Chen, Juliette Steer, William S James, Gosia Trynka, Andrew R Bassett, Sally A Cowle. Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia. Scientific reports. vol 12. issue 1. 2022-11-14. PMID:36376339. |
there is increasing genetic evidence for the role of microglia in neurodegenerative diseases, including alzheimer's, parkinson's, and motor neuron disease. |
2022-11-14 |
2023-08-14 |
human |
| José A Fernández-Albarral, Elena Salobrar-García, José A Matamoros, Cristina Fernández-Mendívil, Eric Del Sastre, Lejing Chen, Rosa de Hoz, Inés López-Cuenca, Lidia Sánchez-Puebla, José M Ramírez, Juan J Salazar, Manuela G Lopez, Ana I Ramíre. Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy. Antioxidants (Basel, Switzerland). vol 11. issue 11. 2022-11-11. PMID:36358522. |
with aging and, especially, in alzheimer's patients, the inducible enzyme heme oxygenase 1 (ho-1) progressively increases in microglia, causing iron accumulation, neuroinflammation, and neurodegeneration. |
2022-11-11 |
2023-08-14 |
mouse |
| Lukas Busch, Simone Eggert, Kristina Endres, Bernd Buf. The Hidden Role of Non-Canonical Amyloid β Isoforms in Alzheimer's Disease. Cells. vol 11. issue 21. 2022-11-11. PMID:36359817. |
recent advances have placed the pro-inflammatory activity of amyloid β (aβ) on microglia cells as the focus of research on alzheimer's disease (ad). |
2022-11-11 |
2023-08-14 |
Not clear |
| Stefania Merighi, Manuela Nigro, Alessia Travagli, Stefania Gess. Microglia and Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361780. |
microglia and alzheimer's disease. |
2022-11-11 |
2023-08-14 |
Not clear |
| Yu Chen, Fu Peng, Ziwei Xing, Junren Chen, Cheng Peng, Dan L. Beneficial effects of natural flavonoids on neuroinflammation. Frontiers in immunology. vol 13. 2022-11-10. PMID:36353622. |
neuroinflammation is the fundamental immune response against multiple factors in the central nervous system and is characterized by the production of inflammatory mediators, activated microglia and astrocytes, and the recruitment of innate and adaptive immune cells to inflammatory sites, that contributes to the pathological process of related brain diseases, such as alzheimer's disease, parkinson's disease, depression, and stroke. |
2022-11-10 |
2023-08-14 |
Not clear |
| Guodong Yang, Yufu Liu, Yonglin Liu, Yu Ma, Yiguang Li, Jie Che. Integrating network pharmacology and an experimental validation strategy elucidates the protective effect and mechanism of callicarpa nudiflora against neuroinflammation. RSC advances. vol 12. issue 48. 2022-11-09. PMID:36349022. |
abnormal activation of microglia promotes neuroinflammation (ni) in alzheimer's disease (ad). |
2022-11-09 |
2023-08-14 |
Not clear |
| Sanjeevini Babu Reddiar, Michael de Veer, Brett M Paterson, Tara Sepehrizadeh, Dorothy C C Wai, Agota Csoti, Gyorgy Panyi, Joseph A Nicolazzo, Raymond S Norto. A Biodistribution Study of the Radiolabeled Kv1.3-Blocking Peptide DOTA-HsTX1[R14A] Demonstrates Brain Uptake in a Mouse Model of Neuroinflammation. Molecular pharmaceutics. 2022-11-04. PMID:36331024. |
the voltage-gated potassium channel kv1.3 regulates the pro-inflammatory function of microglia and is highly expressed in the post-mortem brains of individuals with alzheimer's and parkinson's diseases. |
2022-11-04 |
2023-08-14 |
mouse |
| Chao-Ji Yu, Meng Wang, Rui-Yang Li, Tao Wei, Han-Chen Yang, Yun-Si Yin, Ying-Xin Mi, Qi Qin, Yi Tan. TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology. Molecular neurobiology. 2022-11-01. PMID:36318443. |
numerous studies have proven that microglia can participate in the occurrence and progression of neurodegenerative diseases (ndds), such as alzheimer's disease (ad), by regulating synaptic plasticity. |
2022-11-01 |
2023-08-14 |
Not clear |
| Shoutang Wang, Raki Sudan, Vincent Peng, Yingyue Zhou, Siling Du, Carla M Yuede, Tingting Lei, Jinchao Hou, Zhangying Cai, Marina Cella, Khai Nguyen, Pietro L Poliani, Wandy L Beatty, Yun Chen, Siyan Cao, Kent Lin, Cecilia Rodrigues, Ali H Ellebedy, Susan Gilfillan, Gordon D Brown, David M Holtzman, Simone Brioschi, Marco Colonn. TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways. Cell. vol 185. issue 22. 2022-10-28. PMID:36306735. |
genetic studies have highlighted microglia as pivotal in orchestrating alzheimer's disease (ad). |
2022-10-28 |
2023-08-14 |
human |
| Moonseok Choi, Dongsoo Kim, Young-Jin Youn, Junghwa Ryu, Yun Ha Jeon. Effect of Obesity and High-Density Lipoprotein Concentration on the Pathological Characteristics of Alzheimer's Disease in High-Fat Diet-Fed Mice. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293147. |
the typical pathological features of alzheimer's disease (ad) are the accumulation of amyloid plaques in the brain and reactivity of glial cells such as astrocytes and microglia. |
2022-10-27 |
2023-08-14 |
mouse |
| Gunel Ayyubov. Dysfunctional microglia and tau pathology in Alzheimer's disease. Reviews in the neurosciences. 2022-10-27. PMID:36302379. |
dysfunctional microglia and tau pathology in alzheimer's disease. |
2022-10-27 |
2023-08-14 |
human |
| Gunel Ayyubov. Dysfunctional microglia and tau pathology in Alzheimer's disease. Reviews in the neurosciences. 2022-10-27. PMID:36302379. |
extensive human studies and animal models show that chronic immune system stimulation involving microglia, inflammasome, complement activation, synthesis of cytokines, and reactive oxygen species exacerbates neurodegeneration in alzheimer's disease (ad) and other tauopathies. |
2022-10-27 |
2023-08-14 |
human |
| Insup Choi, George R Heaton, You-Kyung Lee, Zhenyu Yu. Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy. Science advances. vol 8. issue 43. 2022-10-26. PMID:36288297. |
in alzheimer's disease animal models, microglia play a critical role in regulating amyloid plaque formation and neurotoxicity. |
2022-10-26 |
2023-08-14 |
Not clear |
| Oliver Kann, Fadi Almouhanna, Bruno Chauss. Interferon γ: a master cytokine in microglia-mediated neural network dysfunction and neurodegeneration. Trends in neurosciences. 2022-10-25. PMID:36283867. |
pharmacological targeting of activated microglia could be beneficial during elevated ifn-γ levels, blood-brain barrier leakage, and parenchymal t lymphocyte infiltration associated with, for instance, encephalitis, multiple sclerosis, and alzheimer's disease. |
2022-10-25 |
2023-08-14 |
Not clear |
| Kyung Won Jo, Dohyun Lee, Dong Gon Cha, Eunji Oh, Yoon Ha Choi, Somi Kim, Eun Seo Park, Jong Kyoung Kim, Kyong-Tai Ki. Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ. Alzheimer's research & therapy. vol 14. issue 1. 2022-10-22. PMID:36271414. |
however, in alzheimer's disease (ad) patients, chronic exposure to aβ makes microglia to become exhausted, which reduces their phagocytic activity against aβ. |
2022-10-22 |
2023-08-14 |
Not clear |
| Jimena Monzón-Sandoval, Elena Burlacu, Devika Agarwal, Adam E Handel, Liting Wei, John Davis, Sally A Cowley, M Zameel Cader, Caleb Webbe. Lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from Alzheimer's disease mouse models. Disease models & mechanisms. vol 15. issue 10. 2022-10-18. PMID:36254682. |
lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from alzheimer's disease mouse models. |
2022-10-18 |
2023-08-14 |
mouse |
| Jimena Monzón-Sandoval, Elena Burlacu, Devika Agarwal, Adam E Handel, Liting Wei, John Davis, Sally A Cowley, M Zameel Cader, Caleb Webbe. Lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from Alzheimer's disease mouse models. Disease models & mechanisms. vol 15. issue 10. 2022-10-18. PMID:36254682. |
alzheimer's disease (ad) is the most common form of dementia, and risk-influencing genetics implicates microglia and neuroimmunity in the pathogenesis of ad. |
2022-10-18 |
2023-08-14 |
mouse |
| Yi-Ge Wu, Li-Juan Song, Li-Jun Yin, Jun-Jun Yin, Qing Wang, Jie-Zhong Yu, Bao-Guo Xiao, Cun-Gen M. The effects and potential of microglial polarization and crosstalk with other cells of the central nervous system in the treatment of Alzheimer's disease. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36254973. |
during the pathogenesis of alzheimer's disease, stimulatory factors continuously act on the microglia causing abnormal activation and unbalanced phenotypic changes; these events have become a significant and promising area of research. |
2022-10-18 |
2023-08-14 |
Not clear |