| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sujata Thakur, Rishika Dhapola, Phulen Sarma, Bikash Medhi, Dibbanti HariKrishna Redd. Neuroinflammation in Alzheimer's Disease: Current Progress in Molecular Signaling and Therapeutics. Inflammation. 2022-08-20. PMID:35986874. |
numerous pathways like nfκb, p38 mapk, akt/mtor, caspase, nitric oxide, and cox are involved in triggering brain immune cells like astrocytes and microglia to secrete inflammatory cytokines such as tumor necrosis factor, interleukins, and chemokines and participate in alzheimer's disease pathology. |
2022-08-20 |
2023-08-14 |
Not clear |
| Zhiyu Wang, Donald F Weave. Microglia and microglial-based receptors in the pathogenesis and treatment of Alzheimer's disease. International immunopharmacology. vol 110. 2022-08-18. PMID:35978514. |
microglia and microglial-based receptors in the pathogenesis and treatment of alzheimer's disease. |
2022-08-18 |
2023-08-14 |
human |
| Gang Zhong, Huiping Long, Tian Zhou, Yisi Liu, Jianping Zhao, Jinyu Han, Xiaohu Yang, Yin Yu, Fei Chen, Shengliang Sh. Blood-brain barrier Permeable nanoparticles for Alzheimer's disease treatment by selective mitophagy of microglia. Biomaterials. 2022-08-14. PMID:35965114. |
blood-brain barrier permeable nanoparticles for alzheimer's disease treatment by selective mitophagy of microglia. |
2022-08-14 |
2023-08-14 |
mouse |
| Ghazaleh Eskandari-Sedighi, Jaesoo Jung, Matthew S Macaule. CD33 isoforms in microglia and Alzheimer's disease: Friend and foe. Molecular aspects of medicine. 2022-08-08. PMID:35940942. |
cd33 isoforms in microglia and alzheimer's disease: friend and foe. |
2022-08-08 |
2023-08-14 |
Not clear |
| Jessica E Young, Suman Jayade. Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons. Cell stem cell. vol 29. issue 8. 2022-08-05. PMID:35931027. |
reveal that human microglia harboring the alzheimer's disease risk allele apoe4 have altered lipid metabolism and cellular activation. |
2022-08-05 |
2023-08-14 |
human |
| Aymeric Silvin, Stefan Uderhardt, Cecile Piot, Sandro Da Mesquita, Katharine Yang, Laufey Geirsdottir, Kevin Mulder, David Eyal, Zhaoyuan Liu, Cecile Bridlance, Morgane Sonia Thion, Xiao Meng Zhang, Wan Ting Kong, Marc Deloger, Vasco Fontes, Assaf Weiner, Rachel Ee, Regine Dress, Jing Wen Hang, Akhila Balachander, Svetoslav Chakarov, Benoit Malleret, Garett Dunsmore, Olivier Cexus, Jinmiao Chen, Sonia Garel, Charles Antoine Dutertre, Ido Amit, Jonathan Kipnis, Florent Ginhou. Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration. Immunity. 2022-08-05. PMID:35931085. |
we show that the previously identified disease-associated microglia (dam) population detected in murine alzheimer's disease models actually comprises two ontogenetically and functionally distinct cell lineages: embryonically derived triggering receptor expressed on myeloid cells 2 (trem2)-dependent dam expressing a neuroprotective signature and monocyte-derived trem2-expressing disease inflammatory macrophages (dims) accumulating in the brain during aging. |
2022-08-05 |
2023-08-14 |
human |
| Roman Kosoy, John F Fullard, Biao Zeng, Jaroslav Bendl, Pengfei Dong, Samir Rahman, Steven P Kleopoulos, Zhiping Shao, Kiran Girdhar, Jack Humphrey, Katia de Paiva Lopes, Alexander W Charney, Brian H Kopell, Towfique Raj, David Bennett, Christopher P Kellner, Vahram Haroutunian, Gabriel E Hoffman, Panos Rousso. Genetics of the human microglia regulome refines Alzheimer's disease risk loci. Nature genetics. vol 54. issue 8. 2022-08-05. PMID:35931864. |
genetics of the human microglia regulome refines alzheimer's disease risk loci. |
2022-08-05 |
2023-08-14 |
human |
| Roman Kosoy, John F Fullard, Biao Zeng, Jaroslav Bendl, Pengfei Dong, Samir Rahman, Steven P Kleopoulos, Zhiping Shao, Kiran Girdhar, Jack Humphrey, Katia de Paiva Lopes, Alexander W Charney, Brian H Kopell, Towfique Raj, David Bennett, Christopher P Kellner, Vahram Haroutunian, Gabriel E Hoffman, Panos Rousso. Genetics of the human microglia regulome refines Alzheimer's disease risk loci. Nature genetics. vol 54. issue 8. 2022-08-05. PMID:35931864. |
microglia are brain myeloid cells that play a critical role in neuroimmunity and the etiology of alzheimer's disease (ad), yet our understanding of how the genetic regulatory landscape controls microglial function and contributes to ad is limited. |
2022-08-05 |
2023-08-14 |
human |
| Kohei Yuyama, Yasuyuki Igarash. Linking glycosphingolipids to Alzheimer's amyloid-ß: extracellular vesicles and functional plant materials. Glycoconjugate journal. 2022-08-03. PMID:35920997. |
our studies demonstrated that exosomal gsls may be associated with the amyloid-ß (aß) peptide, a principal agent of alzheimer's disease (ad), and act to clear aß by transporting aß into brain phagocytic microglia. |
2022-08-03 |
2023-08-14 |
mouse |
| b' Juraj Javor, M\\xc3\\xa1ria Bucov\\xc3\\xa1, Vladim\\xc3\\xadra \\xc4\\x8eurmanov\\xc3\\xa1, Dominika Rado\\xc5\\xa1insk\\xc3\\xa1, Zuzana P\\xc3\\xa1rnick\\xc3\\xa1, Daniel \\xc4\\x8cierny, Egon Kur\\xc4\\x8da, Daniela \\xc4\\x8cop\\xc3\\xadkov\\xc3\\xa1-Cudr\\xc3\\xa1kov\\xc3\\xa1, Karin Gmitterov\\xc3\\xa1, Ivana Shawkatov\\xc3\\xa. Alzheimer\'s Disease Risk Variant rs3865444 in the Life (Basel, Switzerland). vol 12. issue 7. 2022-07-27. PMID:35888182.' |
alzheimer's disease risk variant rs3865444 in the polymorphisms in genes encoding receptors that modulate the activity of microglia and macrophages are attractive candidates for participation in genetic susceptibility to multiple sclerosis (ms). |
2022-07-27 |
2023-08-14 |
Not clear |
| Yuanxin Zhao, Buhan Liu, Jian Wang, Long Xu, Sihang Yu, Jiaying Fu, Xiaoyu Yan, Jing S. Aβ and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer's Disease. Biomedicines. vol 10. issue 8. 2022-07-27. PMID:35892700. |
aβ and tau regulate microglia metabolism via exosomes in alzheimer's disease. |
2022-07-27 |
2023-08-14 |
Not clear |
| Eoin O'Neill, Virginia Mela, Aline Sayd Gaban, Sibylle Bechet, Aoife McGrath, Aife Walsh, Allison McIntosh, Marina A Lync. Sex-Related Microglial Perturbation Is Related to Mitochondrial Changes in a Model of Alzheimer's Disease. Frontiers in cellular neuroscience. vol 16. 2022-07-25. PMID:35875349. |
many studies implicate microglia in the pathogenesis of alzheimer's disease (ad) but precisely how these cells make their impact has not been determined to date. |
2022-07-25 |
2023-08-14 |
mouse |
| Reiss Pal, Barry M Bradford, Neil A Mabbot. Innate Immune Tolerance in Microglia Does Not Impact on Central Nervous System Prion Disease. Frontiers in cellular neuroscience. vol 16. 2022-07-25. PMID:35875357. |
innate immune tolerance induced by consecutive systemic bacterial lipopolysaccharide (lps) treatment can induce long-term epigenetic changes in the microglia in the brain that several months later can dampen their responsiveness to subsequent lps treatment and impede the development of neuritic damage in a transgenic mouse model of alzheimer's disease-like pathology. |
2022-07-25 |
2023-08-14 |
mouse |
| Reiss Pal, Barry M Bradford, Neil A Mabbot. Innate Immune Tolerance in Microglia Does Not Impact on Central Nervous System Prion Disease. Frontiers in cellular neuroscience. vol 16. 2022-07-25. PMID:35875357. |
our data suggests innate immune tolerance in microglia does not influence the subsequent onset of prion disease-induced neuropathology in mice, despite previously published evidence of this effect in an alzheimer's disease mouse model. |
2022-07-25 |
2023-08-14 |
mouse |
| Hui-Zhi Long, Zi-Wei Zhou, Yan Cheng, Hong-Yu Luo, Feng-Jiao Li, Shuo-Guo Xu, Li-Chen Ga. The Role of Microglia in Alzheimer's Disease From the Perspective of Immune Inflammation and Iron Metabolism. Frontiers in aging neuroscience. vol 14. 2022-07-18. PMID:35847685. |
the role of microglia in alzheimer's disease from the perspective of immune inflammation and iron metabolism. |
2022-07-18 |
2023-08-14 |
Not clear |
| Anna Fracassi, Michela Marcatti, Batbayar Tumurbaatar, Randall Woltjer, Sandra Moreno, Giulio Taglialatel. TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology. Brain pathology (Zurich, Switzerland). 2022-07-11. PMID:35816404. |
trem2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with alzheimer's neuropathology. |
2022-07-11 |
2023-08-14 |
human |
| Menbere Y Wendimu, Shelley B Hook. Microglia Phenotypes in Aging and Neurodegenerative Diseases. Cells. vol 11. issue 13. 2022-07-09. PMID:35805174. |
this review provides a comprehensive overview of current research on the various microglia phenotypes and inflammatory responses in health, aging, and nds, with a special emphasis on the heterogeneous phenotypic response of microglia in acute and chronic diseases such as hemorrhagic stroke (hs), alzheimer's disease (ad), and parkinson's disease (pd). |
2022-07-09 |
2023-08-14 |
human |
| Ziyad M Althafa. Targeting Microglia in Alzheimer's Disease: From Molecular Mechanisms to Potential Therapeutic Targets for Small Molecules. Molecules (Basel, Switzerland). vol 27. issue 13. 2022-07-09. PMID:35807370. |
targeting microglia in alzheimer's disease: from molecular mechanisms to potential therapeutic targets for small molecules. |
2022-07-09 |
2023-08-14 |
Not clear |
| Mengmeng Jin, Ranjie Xu, Le Wang, Mahabub Maraj Alam, Ziyuan Ma, Sining Zhu, Alessandra C Martini, Azadeh Jadali, Matteo Bernabucci, Ping Xie, Kelvin Y Kwan, Zhiping P Pang, Elizabeth Head, Ying Liu, Ronald P Hart, Peng Jian. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease. Cell stem cell. vol 29. issue 7. 2022-07-08. PMID:35803230. |
microglia are critical in brain development and alzheimer's disease (ad) etiology. |
2022-07-08 |
2023-08-14 |
mouse |
| Jelena Stanojevic, Milorad Dragic, Ivana Stevanovic, Tihomir Ilic, Ivana Stojanovic, Milica Zeljkovic, Milica Ninkovi. Intermittent theta burst stimulation ameliorates cognitive impairment and hippocampal gliosis in the Streptozotocin-induced model of Alzheimer's disease. Behavioural brain research. 2022-07-05. PMID:35780960. |
intracerebroventricularly (icv) injected streptozotocin (stz) model of alzheimer's disease (ad) is used to explore the effect of intermittent theta burst stimulation (itbs) on astrocyte and microglia reactivity in selectively vulnerable brain regions and answer the question whether these changes are in the context of cognitive capacity. |
2022-07-05 |
2023-08-14 |
rat |