| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hariharakrishnan Chidambaram, Smita Eknath Desale, Subashchandrabose Chinnathamb. Purinergic Receptor P2Y12-Mediated Tau Internalization in Microglia. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512682. |
in alzheimer's disease, microglia get over activated upon the accumulation of tau and amyloid-β species in the extracellular space, ultimately leading to neurodegeneration. |
2024-03-21 |
2024-03-24 |
Not clear |
| Heng-Cai Wang, Wei Yang, Ling Xu, Yong-Hui Han, Yi Lin, Cui-Tao Lu, Kwonseop Kim, Ying-Zheng Zhao, Xi-Chong Y. BV2 Membrane-coated PEGylated-liposomes Delivered hFGF21 to Cortical and Hippocampal Microglia for Alzheimer's Disease Therapy. Advanced healthcare materials. 2024-03-21. PMID:38513154. |
bv2 membrane-coated pegylated-liposomes delivered hfgf21 to cortical and hippocampal microglia for alzheimer's disease therapy. |
2024-03-21 |
2024-03-24 |
Not clear |
| Heng-Cai Wang, Wei Yang, Ling Xu, Yong-Hui Han, Yi Lin, Cui-Tao Lu, Kwonseop Kim, Ying-Zheng Zhao, Xi-Chong Y. BV2 Membrane-coated PEGylated-liposomes Delivered hFGF21 to Cortical and Hippocampal Microglia for Alzheimer's Disease Therapy. Advanced healthcare materials. 2024-03-21. PMID:38513154. |
microglia-mediated inflammation is involved in the pathogenesis of alzheimer's disease (ad), whereas hfgf21 has demonstrated the ability to regulate microglia activation in parkinson's disease, indicating a potential therapeutic role in ad. |
2024-03-21 |
2024-03-24 |
Not clear |
| Rosemary J Jackson, Megan S Keiser, Jonah C Meltzer, Dustin P Fykstra, Steven E Dierksmeier, Soroush Hajizadeh, Johannes Kreuzer, Robert Morris, Alexandra Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T Ranum, Ellie Carrell, YongHong Chen, Maryam A Nishtar, David M Holtzman, Wilhelm Haas, Beverly L Davidson, Bradley T Hyma. APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-03-20. PMID:38504517. |
this result suggests a promising protective effect of exogenous apoe2 and reveals a a cell non-autonomous effect of the protein on microglial activation which we go on to show is similar to plaque associated microglia in the brain of alzheimer patients who inherit apoe2. |
2024-03-20 |
2024-03-23 |
mouse |
| Hyo Jung Shin, In Soo Kim, Seung Gyu Choi, Kayoung Lee, Hyewon Park, Juhee Shin, Dayoung Kim, Jaewon Beom, Yoon Young Yi, Deepak Prasad Gupta, Gyun Jee Song, Won-Suk Chung, C Justin Lee, Dong Woon Ki. Rejuvenating aged microglia by p16 Molecular neurodegeneration. vol 19. issue 1. 2024-03-17. PMID:38493185. |
rejuvenating aged microglia by p16 age-dependent accumulation of amyloid plaques in patients with sporadic alzheimer's disease (ad) is associated with reduced amyloid clearance. |
2024-03-17 |
2024-03-19 |
mouse |
| Lun Zhang, Yongkang Gai, Yushuang Liu, Dongli Meng, Yi Zeng, Yong Luo, Huiliang Zhang, Zhuoqun Wang, Mengzhe Yang, Yunfan Li, Yi Liu, Yiwen Lai, Jiayu Yang, Gang Wu, Yu Chen, Jingtan Zhu, Shaojun Liu, Tingting Yu, Ji Zeng, Jianzhi Wang, Dan Zhu, Xiaochuan Wang, Xiaoli Lan, Rong Li. Tau induces inflammasome activation and microgliosis through acetylating NLRP3. Clinical and translational medicine. vol 14. issue 3. 2024-03-15. PMID:38488468. |
alzheimer's disease (ad) and related tauopathies are characterised by the pathologically hyperphosphorylated and aggregated microtubule-associated protein tau, which is accompanied by neuroinflammation mediated by activated microglia. |
2024-03-15 |
2024-03-17 |
Not clear |
| Dong Kyu Kim, Hyunjung Choi, Woochan Lee, Hayoung Choi, Seok Beom Hong, June-Hyun Jeong, Jihui Han, Jong Won Han, Hoon Ryu, Jong-Il Kim, Inhee Mook-Jun. Brain hypothyroidism silences the immune response of microglia in Alzheimer's disease animal model. Science advances. vol 10. issue 11. 2024-03-15. PMID:38489366. |
brain hypothyroidism silences the immune response of microglia in alzheimer's disease animal model. |
2024-03-15 |
2024-03-18 |
mouse |
| Carmen Romero-Molina, Sarah M Neuner, Marcelina Ryszawiec, Alice Pébay, Dominantly Inherited Alzheimer Network, Edoardo Marcora, Alison Goat. Autosomal Dominant Alzheimer's Disease Mutations in Human Microglia Are Not Sufficient to Trigger Amyloid Pathology in WT Mice but Might Affect Pathology in 5XFAD Mice. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473822. |
autosomal dominant alzheimer's disease mutations in human microglia are not sufficient to trigger amyloid pathology in wt mice but might affect pathology in 5xfad mice. |
2024-03-13 |
2024-03-15 |
mouse |
| Carmen Romero-Molina, Sarah M Neuner, Marcelina Ryszawiec, Alice Pébay, Dominantly Inherited Alzheimer Network, Edoardo Marcora, Alison Goat. Autosomal Dominant Alzheimer's Disease Mutations in Human Microglia Are Not Sufficient to Trigger Amyloid Pathology in WT Mice but Might Affect Pathology in 5XFAD Mice. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473822. |
several genetic variants that affect microglia function have been identified as risk factors for alzheimer's disease (ad), supporting the importance of this cell type in disease progression. |
2024-03-13 |
2024-03-15 |
mouse |
| Hugo McGurran, Victor Kumbol, Christina Krüger, Thomas Wallach, Seija Lehnard. miR-154-5p Is a Novel Endogenous Ligand for TLR7 Inducing Microglial Activation and Neuronal Injury. Cells. vol 13. issue 5. 2024-03-13. PMID:38474371. |
tlr activation in microglia, the major immune cells in the brain, can trigger the release of inflammatory molecules, which may contribute to various cns diseases including alzheimer's disease. |
2024-03-13 |
2024-03-15 |
mouse |
| Narges Rezaie, Elisabeth Rebboah, Brian A Williams, Heidi Yahan Liang, Fairlie Reese, Gabriela Balderrama-Gutierrez, Louise A Dionne, Laura Reinholdt, Diane Trout, Barbara J Wold, Ali Mortazav. Identification of robust cellular programs using reproducible LDA that impact sex-specific disease progression in different genotypes of a mouse model of AD. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38464087. |
we apply topyfic to brain single-cell and single-nucleus datasets of two 5xfad mouse models of alzheimer's disease crossed with c57bl6/j or cast/eij mice to identify distinct cell types and states in different cell types such as microglia. |
2024-03-11 |
2024-03-14 |
mouse |
| Anna Podleśny-Drabiniok, Gloriia Novikova, Yiyuan Liu, Josefine Dunst, Rose Temizer, Chiara Giannarelli, Samuele Marro, Taras Kreslavsky, Edoardo Marcora, Alison Mary Goat. BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer's disease and other disorders of lipid-rich tissues. Nature communications. vol 15. issue 1. 2024-03-06. PMID:38448474. |
bhlhe40/41 regulate microglia and peripheral macrophage responses associated with alzheimer's disease and other disorders of lipid-rich tissues. |
2024-03-06 |
2024-03-09 |
mouse |
| Anna Podleśny-Drabiniok, Gloriia Novikova, Yiyuan Liu, Josefine Dunst, Rose Temizer, Chiara Giannarelli, Samuele Marro, Taras Kreslavsky, Edoardo Marcora, Alison Mary Goat. BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer's disease and other disorders of lipid-rich tissues. Nature communications. vol 15. issue 1. 2024-03-06. PMID:38448474. |
genetic and experimental evidence suggests that alzheimer's disease (ad) risk alleles and genes may influence disease susceptibility by altering the transcriptional and cellular responses of macrophages, including microglia, to damage of lipid-rich tissues like the brain. |
2024-03-06 |
2024-03-09 |
mouse |
| Elena Rodriguez-Vieitez, Amit Kumar, Mona-Lisa Malarte, Konstantinos Ioannou, Filipa M Rocha, Konstantinos Chioti. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach. Methods in molecular biology (Clifton, N.J.). vol 2785. 2024-03-01. PMID:38427196. |
alzheimer's disease (ad) - the most common neurodegenerative disorder - is characterized by a complex neuropathology involving the deposition of extracellular amyloid-β (aβ) plaques and intracellular neurofibrillary tangles (nfts) of hyperphosphorylated tau proteins, accompanied by the activation of glial cells, i.e., astrocytes and microglia, and neuroinflammatory response, leading to neurodegeneration and cognitive dysfunction. |
2024-03-01 |
2024-03-03 |
Not clear |
| Hariharakrishnan Chidambaram, Smita Eknath Desale, Tazeen Qureshi, Subashchandrabose Chinnathamb. Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427240. |
in alzheimer's disease, microglia get activated to phagocytose damaged neurons, extracellular amyoid-β, and tau deposits. |
2024-03-01 |
2024-03-03 |
Not clear |
| Haixia Fan, Minheng Zhang, Jie Wen, Shengyuan Wang, Minghao Yuan, Houchao Sun, Liu Shu, Xu Yang, Yinshuang Pu, Zhiyou Ca. Microglia in brain aging: An overview of recent basic science and clinical research developments. Journal of biomedical research. 2024-02-25. PMID:38403286. |
in doing so, we present the current knowledge on the correlation between brain aging and the microglia, summarize recent progress of investigations about the microglia in normal aging, alzheimer's disease, parkinson's disease, huntington's disease, and amyotrophic lateral sclerosis, and then discuss the correlation between the senescent microglia and the brain, which will culminate with a presentation of the molecular complexity involved in the microglia in brain aging with suggestions for healthy aging. |
2024-02-25 |
2024-02-28 |
Not clear |
| Mai Yamakawa, Jessica E Rexac. Cell States and Interactions of CD8 T Cells and Disease-Enriched Microglia in Human Brains with Alzheimer's Disease. Biomedicines. vol 12. issue 2. 2024-02-24. PMID:38397909. |
cell states and interactions of cd8 t cells and disease-enriched microglia in human brains with alzheimer's disease. |
2024-02-24 |
2024-02-26 |
human |
| Anna Flavia Cantone, Chiara Burgaletto, Giulia Di Benedetto, Anna Pannaccione, Agnese Secondo, Carlo Maria Bellanca, Egle Augello, Antonio Munafò, Paola Tarro, Renato Bernardini, Giuseppina Cantarell. Taming Microglia in Alzheimer's Disease: Exploring Potential Implications of Choline Alphoscerate via α7 nAChR Modulation. Cells. vol 13. issue 4. 2024-02-23. PMID:38391922. |
taming microglia in alzheimer's disease: exploring potential implications of choline alphoscerate via α7 nachr modulation. |
2024-02-23 |
2024-02-25 |
Not clear |
| Anna Pumo, Samuel Legea. The dichotomous activities of microglia: A potential driver for phenotypic heterogeneity in Alzheimer's disease. Brain research. 2024-02-23. PMID:38395249. |
the dichotomous activities of microglia: a potential driver for phenotypic heterogeneity in alzheimer's disease. |
2024-02-23 |
2024-02-26 |
Not clear |
| Kazuhiro Nakas. Roles of Microglia in Neurodegenerative Diseases. Yonago acta medica. vol 67. issue 1. 2024-02-21. PMID:38380436. |
in recent years, microglia have attracted attention owing to their roles in various neurodegenerative diseases, such as alzheimer's disease, parkinson's disease, and amyotrophic lateral sclerosis. |
2024-02-21 |
2024-02-23 |
Not clear |