| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B Wood, Jubao Duan, Gopal Thinakaran, Srikant Rangaraj. BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia. Molecular neurodegeneration. vol 17. issue 1. 2022-05-07. PMID:35526014. |
notably, bin1 protein expression and its functional roles in microglia, a cell type most relevant to alzheimer's disease, have not been examined in depth. |
2022-05-07 |
2023-08-13 |
Not clear |
| Jacinta Murray, Gregory Meloni, Etty P Cortes, Ariadna KimSilva, Michelle Jacobs, Alyssa Ramkissoon, John F Crary, Susan Morgell. Frontal lobe microglia, neurodegenerative protein accumulation, and cognitive function in people with HIV. Acta neuropathologica communications. vol 10. issue 1. 2022-05-07. PMID:35526056. |
microglia are implicated in alzheimer's disease (ad) pathogenesis. |
2022-05-07 |
2023-08-13 |
Not clear |
| Boyd Kenkhuis, Michelle van Eekeren, David A Parfitt, Yavuz Ariyurek, Poulomi Banerjee, Josef Priller, Louise van der Weerd, Willeke M C van Roon-Mo. Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia. Stem cell reports. 2022-05-06. PMID:35523178. |
iron accumulation in microglia has been observed in alzheimer's disease and other neurodegenerative disorders and is thought to contribute to disease progression through various mechanisms, including neuroinflammation. |
2022-05-06 |
2023-08-13 |
human |
| Ping Yan, Ki-Wook Kim, Qingli Xiao, Xiucui Ma, Leah R Czerniewski, Haiyan Liu, David R Rawnsley, Yan Yan, Gwendalyn J Randolph, Slava Epelman, Jin-Moo Lee, Abhinav Diwa. Peripheral monocyte-derived cells counter amyloid plaque pathogenesis in a mouse model of Alzheimer's disease. The Journal of clinical investigation. 2022-05-05. PMID:35511433. |
microglia, the parenchymal tissue macrophages in the brain, surround amyloid plaques in alzheimer's disease (ad) but are ineffective at clearing amyloid to mitigate disease progression. |
2022-05-05 |
2023-08-13 |
mouse |
| Celia Luchena, Jone Zuazo-Ibarra, Jorge Valero, Carlos Matute, Elena Alberdi, Estibaliz Capetillo-Zarat. A Neuron, Microglia, and Astrocyte Triple Co-culture Model to Study Alzheimer's Disease. Frontiers in aging neuroscience. vol 14. 2022-05-02. PMID:35493929. |
a neuron, microglia, and astrocyte triple co-culture model to study alzheimer's disease. |
2022-05-02 |
2023-08-13 |
Not clear |
| Jahirul Islam, Jung-Ah Cho, Ju-Yong Kim, Kyung-Sun Park, Young-Jae Koh, Chu Young Chung, Eun-Jae Lee, Soo Jeong Nam, Kyoungyul Lee, Seoung-Heon Kim, Sung-Hye Park, Dong Young Lee, Byeong C Kim, Kyung-Hwa Lee, Seung-Yong Seon. GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer's Disease. Frontiers in immunology. vol 13. 2022-04-25. PMID:35464490. |
gpcr19 regulates p2x7r-mediated nlrp3 inflammasomal activation of microglia by amyloid β in a mouse model of alzheimer's disease. |
2022-04-25 |
2023-08-13 |
mouse |
| Yeo Jin Park, Hye Jin Yang, Wei Li, You-Chang Oh, Younghoon G. Menthae Herba Attenuates Neuroinflammation by Regulating CREB/Nrf2/HO-1 Pathway in BV2 Microglial Cells. Antioxidants (Basel, Switzerland). vol 11. issue 4. 2022-04-23. PMID:35453334. |
chronic inflammation and oxidative stress cause microglia to be abnormally activated in the brain, resulting in neurodegenerative diseases such as alzheimer's disease (ad). |
2022-04-23 |
2023-08-13 |
Not clear |
| Dennis-Dominik Rosmus, Clemens Lange, Franziska Ludwig, Bahareh Ajami, Peter Wieghofe. The Role of Osteopontin in Microglia Biology: Current Concepts and Future Perspectives. Biomedicines. vol 10. issue 4. 2022-04-23. PMID:35453590. |
in this review, we discuss the current literature about the interaction between microglia and opn in homeostasis and several disease entities, including multiple sclerosis (ms), alzheimer's and cerebrovascular diseases (ad, cvd), amyotrophic lateral sclerosis (als), age-related macular degeneration (amd) and diabetic retinopathy (dr), in the context of the molecular pathways involved in opn signaling shaping the function of microglia. |
2022-04-23 |
2023-08-13 |
Not clear |
| Ersilia De Lorenzi, Davide Franceschini, Cecilia Contardi, Rita Maria Concetta Di Martino, Francesca Seghetti, Massimo Serra, Federica Bisceglia, Andrea Pagetta, Morena Zusso, Federica Bellut. Modulation of Amyloid β-Induced Microglia Activation and Neuronal Cell Death by Curcumin and Analogues. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457197. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder that is not restricted to the neuronal compartment but includes important interactions with immune cells, including microglia. |
2022-04-23 |
2023-08-13 |
Not clear |
| Linlin Zhang, Yanzhong Liu, Xin Wang, Dan Wang, Hao Wu, Haichun Chen, Jiaxi Chen, Yiping Li. Treadmill exercise improve recognition memory by TREM2 pathway to inhibit hippocampal microglial activation and neuroinflammation in Alzheimer's disease model. Physiology & behavior. 2022-04-22. PMID:35452628. |
however, no sufficient studies have been performed to directly observe the mechanism of exercise-related effects on microglia and neuroinflammation, in association with memory function under alzheimer's disease. |
2022-04-22 |
2023-08-13 |
Not clear |
| Linlin Zhang, Yanzhong Liu, Xin Wang, Dan Wang, Hao Wu, Haichun Chen, Jiaxi Chen, Yiping Li. Treadmill exercise improve recognition memory by TREM2 pathway to inhibit hippocampal microglial activation and neuroinflammation in Alzheimer's disease model. Physiology & behavior. 2022-04-22. PMID:35452628. |
this study aims to explore the relationship of trem2, microglia activation and neuroinflammation in the development of alzheimer's disease, followed by investigating why physical exercises improve cognition in the alzheimer's disease model by means of the adeno-associated virus (aav) injection. |
2022-04-22 |
2023-08-13 |
Not clear |
| Oualid Sbai, Mehdi Djelloul, Antonia Auletta, Alessandro Ieraci, Carlo Vascotto, L Perron. Correction to: RAGE-TXNIP axis drives inflammation in Alzheimer's by targeting Aβ to mitochondria in microglia. Cell death & disease. vol 13. issue 4. 2022-04-20. PMID:35440602. |
correction to: rage-txnip axis drives inflammation in alzheimer's by targeting aβ to mitochondria in microglia. |
2022-04-20 |
2023-08-13 |
Not clear |
| Marina A Lync. Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine. Frontiers in aging neuroscience. vol 14. 2022-04-18. PMID:35431903. |
this review will consider how age impacts on sex-related differences in microglia and ask whether the advancement of personalized medicine demands that a greater focus is placed on studying sex-related differences in microglia in alzheimer's disease, parkinson's disease and models of inflammatory stress and trauma in order to make true progress in dealing with these conditions. |
2022-04-18 |
2023-08-13 |
Not clear |
| Chao Wang, Li Fan, Rabia R Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T Grinberg, William W Seeley, Bruce L Miller, Sue-Ann Mok, Jason E Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Ga. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy. Nature communications. vol 13. issue 1. 2022-04-13. PMID:35413950. |
activation of microglia is a prominent pathological feature in tauopathies, including alzheimer's disease. |
2022-04-13 |
2023-08-13 |
mouse |
| Daniela Maftei, Tommaso Schirinzi, Nicola B Mercuri, Roberta Lattanzi, Cinzia Severin. Potential Clinical Role of Prokineticin 2 (PK2) in Neurodegenerative Diseases. Current neuropharmacology. 2022-04-12. PMID:35410604. |
the role of the immune system in neurodegenerative diseases such as alzheimer's disease (ad) and parkinson's disease (pd) has become clear in recent decades, as evidenced by the presence of activated microglia and astrocytes and numerous soluble mediators in the brain and peripheral tissues of affected patients. |
2022-04-12 |
2023-08-13 |
human |
| Sadayuki Hashioka, Ken Inoue, Koji Otsuki, Maiko Hayashida, Rei Wake, Noriyuki Kawano, Haruo Takeshita, Masatoshi Inagak. Contribution of "Genuine Microglia" to Alzheimer's Disease Pathology. Frontiers in aging neuroscience. vol 14. 2022-04-11. PMID:35401156. |
contribution of "genuine microglia" to alzheimer's disease pathology. |
2022-04-11 |
2023-08-13 |
Not clear |
| Yi-Yu Qi, Xia Heng, Zeng-Ying Yao, Shu-Yue Qu, Ping-Yuan Ge, Xin Zhao, Sai-Jia Ni, Rui Guo, Nian-Yun Yang, Qi-Chun Zhang, Hua-Xu Zh. Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer's Disease. Drug design, development and therapy. vol 16. 2022-04-08. PMID:35391788. |
involvement of huanglian jiedu decoction on microglia with abnormal sphingolipid metabolism in alzheimer's disease. |
2022-04-08 |
2023-08-13 |
Not clear |
| Oualid Sbai, Mehdi Djelloul, Antonia Auletta, Alessandro Ieraci, Carlo Vascotto, L Perron. AGE-TXNIP axis drives inflammation in Alzheimer's by targeting Aβ to mitochondria in microglia. Cell death & disease. vol 13. issue 4. 2022-04-05. PMID:35379773. |
age-txnip axis drives inflammation in alzheimer's by targeting aβ to mitochondria in microglia. |
2022-04-05 |
2023-08-13 |
mouse |
| Evgenii Gerasimov, Ekaterina Pchitskaya, Ilya Bezprozvann. TREM2 and calcium signaling in microglia - is it relevant for Alzheimer's disease? Cell calcium. vol 104. 2022-04-02. PMID:35366517. |
trem2 and calcium signaling in microglia - is it relevant for alzheimer's disease? |
2022-04-02 |
2023-08-13 |
Not clear |
| Aya Ogata, Bin Ji, Takashi Yamada, Saori Hattori, Junichiro Abe, Hiroshi Ikenuma, Masanori Ichise, Hiroko Koyama, Masaaki Suzuki, Takashi Kato, Kengo Ito, Yasuyuki Kimur. [ Bioorganic & medicinal chemistry letters. 2022-03-30. PMID:35351586. |
the receptors regulate immune responses by controlling the survival and activity of microglia and are intricately involved in the pathophysiology of alzheimer's disease. |
2022-03-30 |
2023-08-13 |
Not clear |