| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiran Hu, Yan Huang, Sanli Xing, Chuan Chen, Dingzhu Shen, Jiulin Che. Aβ promotes CD38 expression in senescent microglia in Alzheimer's disease. Biological research. vol 55. issue 1. 2022-03-04. PMID:35241173. |
in alzheimer's disease (ad), the neuroinflammatory response mediated by the activation of senescent microglia is closely related to energy dysmetabolism. |
2022-03-04 |
2023-08-13 |
Not clear |
| Tatsuhiro Akaishi, Shohei Yamamoto, Kazuho Ab. 3',4',7-Trihydroxyflavone Downregulates NO Production in LPS- or IFN-γ-Activated MG6 Microglial Cells by Attenuating the JNK-STAT1 Pathway. Biological & pharmaceutical bulletin. vol 45. issue 3. 2022-03-01. PMID:35228396. |
neuroinflammation induced by activated microglia is a key feature of neurodegenerative diseases such as alzheimer's disease. |
2022-03-01 |
2023-08-13 |
Not clear |
| Virginia Mela, Aline Sayd Gaban, Eoin O'Neill, Sibylle Bechet, Aífe Walsh, Marina A Lync. The Modulatory Effects of DMF on Microglia in Aged Mice Are Sex-Specific. Cells. vol 11. issue 4. 2022-02-25. PMID:35203379. |
marked sex-related differences in microglial number, phenotype and function have been described in late embryonic and early postnatal life in rodents and some reports suggest that sexual dimorphism extends into adulthood and age and, in models of alzheimer's disease, the changes are more profound in microglia from female, compared with male, mice. |
2022-02-25 |
2023-08-13 |
mouse |
| Ana Isabel Sánchez-Castillo, M Rosario Sepúlveda, José Luis Marín-Teva, Miguel A Cuadros, David Martín-Oliva, Elena González-Rey, Mario Delgado, Veronika E Neubran. Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases. Biomolecules. vol 12. issue 2. 2022-02-25. PMID:35204722. |
these cells induce a neuroprotective phenotype in microglia and downregulate neuroinflammation, resulting in an improvement of clinical symptoms in a variety of animal models for neurological pathologies, e.g., alzheimer's disease, traumatic brain injury and ischemic stroke. |
2022-02-25 |
2023-08-13 |
Not clear |
| Ekaterina A Rudnitskaya, Alena O Burnyasheva, Tatiana A Kozlova, Daniil A Peunov, Nataliya G Kolosova, Natalia A Stefanov. Changes in Glial Support of the Hippocampus during the Development of an Alzheimer's Disease-like Pathology and Their Correction by Mitochondria-Targeted Antioxidant SkQ1. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163053. |
astrocytes and microglia are the first cells to react to neurodegeneration, e.g., in alzheimer's disease (ad); however, the data on changes in glial support during the most common (sporadic) type of the disease are sparse. |
2022-02-15 |
2023-08-13 |
rat |
| Yuqi Ma, Peixia Fan, Rui Zhao, Yinghua Zhang, Xianwei Wang, Weigang Cu. Neuregulin-1 regulates the conversion of M1/M2 microglia phenotype via ErbB4-dependent inhibition of the NF-κB pathway. Molecular biology reports. 2022-02-15. PMID:35166983. |
the inflammatory response caused by microglia in the central nervous system plays an important role in alzheimer's disease. |
2022-02-15 |
2023-08-13 |
Not clear |
| Guy C Brown, Peter St George-Hyslo. Does Soluble TREM2 Protect Against Alzheimer's Disease? Frontiers in aging neuroscience. vol 13. 2022-02-14. PMID:35153729. |
triggering receptor expressed in myeloid cells 2 (trem2) is a pattern recognition receptor on myeloid cells, and is upregulated on microglia surrounding amyloid plaques in alzheimer's disease (ad). |
2022-02-14 |
2023-08-13 |
Not clear |
| Bhargavi Kulkarni, Natália Cruz-Martins, Dileep Kuma. Microglia in Alzheimer's Disease: An Unprecedented Opportunity as Prospective Drug Target. Molecular neurobiology. 2022-02-12. PMID:35149973. |
microglia in alzheimer's disease: an unprecedented opportunity as prospective drug target. |
2022-02-12 |
2023-08-13 |
Not clear |
| Christel Claes, Whitney E England, Emma P Danhash, Sepideh Kiani Shabestari, Amit Jairaman, Jean Paul Chadarevian, Jonathan Hasselmann, Andy P Tsai, Morgan A Coburn, Jessica Sanchez, Tau En Lim, Jorge L S Hidalgo, Christina Tu, Michael D Cahalan, Bruce T Lamb, Gary E Landreth, Robert C Spitale, Mathew Blurton-Jones, Hayk Davtya. The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-02-10. PMID:35142046. |
the p522r protective variant of plcg2 promotes the expression of antigen presentation genes by human microglia in an alzheimer's disease mouse model. |
2022-02-10 |
2023-08-13 |
mouse |
| Christel Claes, Whitney E England, Emma P Danhash, Sepideh Kiani Shabestari, Amit Jairaman, Jean Paul Chadarevian, Jonathan Hasselmann, Andy P Tsai, Morgan A Coburn, Jessica Sanchez, Tau En Lim, Jorge L S Hidalgo, Christina Tu, Michael D Cahalan, Bruce T Lamb, Gary E Landreth, Robert C Spitale, Mathew Blurton-Jones, Hayk Davtya. The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-02-10. PMID:35142046. |
the p522r variant of plcg2, expressed by microglia, is associated with reduced risk of alzheimer's disease (ad). |
2022-02-10 |
2023-08-13 |
mouse |
| Feixiong Cheng, Jielin Xu, Pengyue Zhang, Yadi Zhou, Andrew A Pieper, Jeffrey L Cummings, James B Leveren. Multimodal single-cell/nucleus RNA-sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108819. |
multimodal single-cell/nucleus rna-sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Nàdia Villacampa, Heela Sarlus, Paula Martorell, Ilya Slutzkin, Roisin M Mcmanus, Marc Beyer, Eran Segal, Michael T Henek. Proliferating microglia exhibit unique transcriptomal and functional alterations in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108841. |
proliferating microglia exhibit unique transcriptomal and functional alterations in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
mouse |
| Nàdia Villacampa, Heela Sarlus, Paula Martorell, Ilya Slutzkin, Roisin M Mcmanus, Marc Beyer, Eran Segal, Michael T Henek. Proliferating microglia exhibit unique transcriptomal and functional alterations in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108841. |
proliferation of microglia is a common process occurring in several neurodegenerative disorders including alzheimer disease (ad). |
2022-02-03 |
2023-08-13 |
mouse |
| Miguel Moutinho, Andy Po-Yi Tsai, Shweta S Puntambekar, Brad T Casali, Peter Bor-Chian Lin, Jheel Patel, Pablo Martínez, Cristian A Lasagna Reeves, Gary E Landret. The role of microglia niacin receptor (HCAR2) in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108848. |
the role of microglia niacin receptor (hcar2) in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Raz Dvir-Szternfeld, Giulia Castellani, Michal Arad, Liora Cahalon, Sara P Colaiuta, Hadas Keren-Shaul, Tommaso Croese, Tyler K Ulland, Marco Colonna, Assaf Weiner, Ido Amit, Michal Schwart. TREM2-independent neuroprotection is mediated by monocyte-derived macrophages in a mouse model of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108946. |
the relative contributions of microglia and infiltrating monocyte-derived macrophages (mdms) to containing alzheimer's disease (ad) are not fully understood. |
2022-02-03 |
2023-08-13 |
mouse |
| Andy Po-Yi Tsai, Chuanpeng Dong, Miguel Moutinho, Peter Bor-Chian Lin, Brad T Casali, Stephanie J Bissel, Adrian L Oblak, Yunlong Liu, Gary E Landreth, Bruce T Lamb, Kwangsik Nh. PLCG2 expression is associated with plaque-associated microglia in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109015. |
plcg2 expression is associated with plaque-associated microglia in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| LuLin Jian. Loss of an ER component, membralin, in astrocytes triggers neuroinflammation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109050. |
during the progression of alzheimer's disease (ad), and other neurodegenerative disorders, glial cells including astrocytes and microglia undergo morphological and physiological changes indicative of reactivity. |
2022-02-03 |
2023-08-13 |
mouse |
| Earvin Tio, Milos Milic, Philip L De Jager, Daniel Felsk. Testing a polygenic score for microglial activation against Alzheimer's disease pathology and cognition. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109079. |
neuroinflammation and activation of the brain's immune cells, microglia, are among the earliest changes in alzheimer's diseases (ad). |
2022-02-03 |
2023-08-13 |
Not clear |
| Mark Stephen Kindy, Dorothy K. GM6 attenuates Alzheimer's disease pathology through a reduction in fibrinogen levels and by regulation of Aβ, p-tau and inflammation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109082. |
alzheimer's disease (ad) is characterized by cerebral amyloid-b (ab) deposition, vascular alterations, tau pathology, microglia activation, and inflammation. |
2022-02-03 |
2023-08-13 |
Not clear |
| Oscar M Muñoz, Izumi Maezawa, Lee-Way Jin, Jacopo Di Lucente, Carlito B Lebrilla, Danielle J Harvey, Angela M Zivkovi. Activated macrophages displaying an M1 phenotype have a reduced capacity to efflux cholesterol. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109138. |
microglia, specialized phagocytic cells of the brain, likewise play a critical role in the clearance of cellular debris, particularly amyloid beta, which is involved in the pathogenesis of alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |