| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aleksandra Szykowska, Yu Chen, Thomas B Smith, Charlotta Preger, Jingjing Yang, Dongming Qian, Shubhashish M Mukhopadhyay, Edvard Wigren, Stephen J Neame, Susanne Gräslund, Helena Persson, Peter J Atkinson, Elena Di Daniel, Emma Mead, John Wang, John B Davis, Nicola A Burgess-Brown, Alex N Bulloc. Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain. Structure (London, England : 1993). vol 29. issue 11. 2021-11-12. PMID:34233201. |
mutations in trem2, a receptor expressed by microglia in the brain, are associated with an increased risk of neurodegeneration, including alzheimer's disease. |
2021-11-12 |
2023-08-13 |
human |
| Manal Alaamery, Nour Albesher, Nora Aljawini, Moneera Alsuwailm, Salam Massadeh, Michael A Wheeler, Chun-Cheih Chao, Francisco J Quintan. Role of sphingolipid metabolism in neurodegeneration. Journal of neurochemistry. vol 158. issue 1. 2021-11-11. PMID:32402091. |
in this review, we discuss the role of sphingolipid metabolism in neurodegeneration, evaluating its direct roles in neuron development and health, and also in the induction of neurotoxic activities in cns-resident astrocytes and microglia in the context of neurologic diseases such as multiple sclerosis and alzheimer's disease. |
2021-11-11 |
2023-08-13 |
Not clear |
| Jielin Xu, Pengyue Zhang, Yin Huang, Yadi Zhou, Yuan Hou, Lynn M Bekris, Justin Lathia, Chien-Wei Chiang, Lang Li, Andrew A Pieper, James B Leverenz, Jeffrey Cummings, Feixiong Chen. Multimodal single-cell/nucleus RNA sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease. Genome research. vol 31. issue 10. 2021-11-11. PMID:33627474. |
multimodal single-cell/nucleus rna sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in alzheimer's disease. |
2021-11-11 |
2023-08-13 |
mouse |
| Jielin Xu, Pengyue Zhang, Yin Huang, Yadi Zhou, Yuan Hou, Lynn M Bekris, Justin Lathia, Chien-Wei Chiang, Lang Li, Andrew A Pieper, James B Leverenz, Jeffrey Cummings, Feixiong Chen. Multimodal single-cell/nucleus RNA sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease. Genome research. vol 31. issue 10. 2021-11-11. PMID:33627474. |
because disease-associated microglia (dam) and disease-associated astrocytes (daa) are involved in the pathophysiology of alzheimer's disease (ad), we systematically identified molecular networks between dam and daa to uncover novel therapeutic targets for ad. |
2021-11-11 |
2023-08-13 |
mouse |
| Antero Salminen, Kai Kaarniranta, Anu Kauppine. Hypoxia/ischemia impairs CD33 (Siglec-3)/TREM2 signaling: Potential role in Alzheimer's pathogenesis. Neurochemistry international. vol 150. 2021-11-11. PMID:34530055. |
recent genetic and molecular studies have indicated that the innate immune system, especially microglia, have a crucial role in the accumulation of β-amyloid plaques in alzheimer's disease (ad). |
2021-11-11 |
2023-08-13 |
human |
| Molly E V Swanson, Emma L Scotter, Leon C D Smyth, Helen C Murray, Brigid Ryan, Clinton Turner, Richard L M Faull, Mike Dragunow, Maurice A Curti. Identification of a dysfunctional microglial population in human Alzheimer's disease cortex using novel single-cell histology image analysis. Acta neuropathologica communications. vol 8. issue 1. 2021-11-10. PMID:33081847. |
in alzheimer's disease (ad), microglia are affected by disease processes, but may also drive pathogenesis. |
2021-11-10 |
2023-08-13 |
human |
| Jessica Cornell, Shelbi Salinas, Hou-Yuan Huang, Miou Zho. Microglia regulation of synaptic plasticity and learning and memory. Neural regeneration research. vol 17. issue 4. 2021-11-10. PMID:34472455. |
these molecules released by microglia can lead to synaptic plasticity and learning and memory deficits associated with aging, alzheimer's disease, traumatic brain injury, hiv-associated neurocognitive disorder, and other neurological or mental disorders such as autism, depression and post-traumatic stress disorder. |
2021-11-10 |
2023-08-13 |
Not clear |
| Jessica Cornell, Shelbi Salinas, Hou-Yuan Huang, Miou Zho. Microglia regulation of synaptic plasticity and learning and memory. Neural regeneration research. vol 17. issue 4. 2021-11-10. PMID:34472455. |
by summarizing the function of microglia in these processes, we aim to provide an overview of microglia regulation of synaptic plasticity and learning and memory, and to discuss the possibility of microglia manipulation as a therapeutic to ameliorate cognitive deficits associated with aging, alzheimer's disease, traumatic brain injury, hiv-associated neurocognitive disorder, and mental disorders. |
2021-11-10 |
2023-08-13 |
Not clear |
| Yuumi Okuzono, Hiroyuki Sakuma, Shuuichi Miyakawa, Masataka Ifuku, Jonghun Lee, Debashree Das, Antara Banerjee, Yang Zhao, Koji Yamamoto, Tatsuya Ando, Shuji Sat. Reduced TREM2 activation in microglia of patients with Alzheimer's disease. FEBS open bio. vol 11. issue 11. 2021-11-10. PMID:34523252. |
reduced trem2 activation in microglia of patients with alzheimer's disease. |
2021-11-10 |
2023-08-13 |
human |
| Saurav Chakraborty, Jyothsna ThimmaReddygari, Divakar Selvara. G-Lymphatic, Vascular and Immune Pathways for Aβ Clearance Cascade and Therapeutic Targets For Alzheimer's Disease. Combinatorial chemistry & high throughput screening. vol 24. issue 7. 2021-11-09. PMID:32875981. |
additionally, neuroinflammation by microglia, astrocytes, cytokines, chemokines, and the complement system also has a major role in alzheimer's disease. |
2021-11-09 |
2023-08-13 |
Not clear |
| Shady Estfanous, Kylene P Daily, Mostafa Eltobgy, Nicholas P Deems, Midhun N K Anne, Kathrin Krause, Asmaa Badr, Kaitlin Hamilton, Cierra Carafice, Ahmad Hegazi, Arwa Abu Khweek, Hesham Kelani, Shahid Nimjee, Hamdy Awad, Xiaoli Zhang, Estelle Cormet-Boyaka, Hesham Haffez, Sameh Soror, Adel Mikhail, Gerard Nuovo, Ruth M Barrientos, Mikhail A Gavrilin, Amal O Ame. Elevated Expression of MiR-17 in Microglia of Alzheimer's Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation. Frontiers in immunology. vol 12. 2021-11-08. PMID:34426734. |
elevated expression of mir-17 in microglia of alzheimer's disease patients abrogates autophagy-mediated amyloid-β degradation. |
2021-11-08 |
2023-08-13 |
mouse |
| Shady Estfanous, Kylene P Daily, Mostafa Eltobgy, Nicholas P Deems, Midhun N K Anne, Kathrin Krause, Asmaa Badr, Kaitlin Hamilton, Cierra Carafice, Ahmad Hegazi, Arwa Abu Khweek, Hesham Kelani, Shahid Nimjee, Hamdy Awad, Xiaoli Zhang, Estelle Cormet-Boyaka, Hesham Haffez, Sameh Soror, Adel Mikhail, Gerard Nuovo, Ruth M Barrientos, Mikhail A Gavrilin, Amal O Ame. Elevated Expression of MiR-17 in Microglia of Alzheimer's Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation. Frontiers in immunology. vol 12. 2021-11-08. PMID:34426734. |
autophagy is a proposed route of amyloid-β (aβ) clearance by microglia that is halted in alzheimer's disease (ad), though mechanisms underlying this dysfunction remain elusive. |
2021-11-08 |
2023-08-13 |
mouse |
| Feilun Cui, Zhipeng Xu, Yumei Lv, Jianpeng H. Role of spindle pole body component 25 in neurodegeneration. Annals of translational medicine. vol 9. issue 18. 2021-11-05. PMID:34733984. |
aberrant growth and polarization of microglia are critical for pathological initiation and progression of neurodegenerative conditions like alzheimer's disease (ad). |
2021-11-05 |
2023-08-13 |
Not clear |
| Yun-Ying Feng, Hui Che. [Nucleotide-binding Oligomerization Domain-like Receptor Family Pyrin Domain Containing 3 Inflammasome in Alzheimer's Disease]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 43. issue 5. 2021-11-04. PMID:34728041. |
alzheimer's disease(ad)is a chronic neurodegenerative disease whose cause remains unclear.the β-amyloid plaques in the brain are one of the major pathological features of ad.however,the drugs targeting extracellular β-amyloid plaques have failed to cure the disease.innate immunity and neuroinflammation play a role in the pathogenesis and progression of ad.as the macrophages existing in the central nervous system,microglia are related with extracellular β-amyloid deposition,intracellular neurofibrillary tangle formation,and neuron injury.accumulating evidence demonstrates that the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3(nlrp3)inflammasome in microglia plays a role in ad,suggesting new therapeutic target for ad in this signaling pathway.this article reviewed the studies about the activation and regulation of nlrp3 inflammasome in the pathogenesis and progression of ad as well as the development of ad therapies targeting this pathway,aiming to provide reference for further studies in this field. |
2021-11-04 |
2023-08-13 |
Not clear |
| Ping Li, Tingting Shen, Xue Luo, Ju Yang, Zhen Luo, Yulong Tan, Genlin He, Zeze Wang, Xueting Yu, Ying Wang, Xuesen Yan. Modulation of microglial phenotypes by dexmedetomidine through TREM2 reduces neuroinflammation in heatstroke. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34172807. |
trem2, whose neuro-protective function has been validated by genetic studies in alzheimer's disease and nasu-hakola disease, was significantly promoted by dex in the microglia. |
2021-11-03 |
2023-08-13 |
mouse |
| Soyoung Choi, Li Guo, Maria Francesca Cordeir. Retinal and Brain Microglia in Multiple Sclerosis and Neurodegeneration. Cells. vol 10. issue 6. 2021-11-01. PMID:34203793. |
in this review, we describe characteristics of cns microglia, including those in the retina, with a focus on their morphology, activation states and function in health, ageing, ms and other neurodegenerative diseases such as alzheimer's disease, parkinson's disease, glaucoma and retinitis pigmentosa, to highlight their activity in disease. |
2021-11-01 |
2023-08-13 |
Not clear |
| Nazanin Mirzaei, Nicola Davis, Tsz Wing Chau, Magdalena Sastr. Astrocyte Reactivity in Alzheimer's Disease: Therapeutic Opportunities to Promote Repair. Current Alzheimer research. 2021-11-01. PMID:34719372. |
astrocytes are fast climbing the ladder of importance in neurodegenerative disorders, particularly in alzheimer's disease (ad), with the prominent presence of reactive astrocytes sur- rounding amyloid β- plaques, together with activated microglia. |
2021-11-01 |
2023-08-13 |
mouse |
| Carmen Romero-Molina, Victoria Navarro, Sebastian Jimenez, Clara Muñoz-Castro, Maria V Sanchez-Mico, Antonia Gutierrez, Javier Vitorica, Marisa Vizuet. Should We Open Fire on Microglia? Depletion Models as Tools to Elucidate Microglial Role in Health and Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 18. 2021-10-28. PMID:34575898. |
microglia play a critical role in both homeostasis and disease, displaying a wide variety in terms of density, functional markers and transcriptomic profiles along the different brain regions as well as under injury or pathological conditions, such as alzheimer's disease (ad). |
2021-10-28 |
2023-08-13 |
Not clear |
| QuanQiu Wang, Pamela B Davis, Xin Qi, Shu G Chen, Mark E Gurney, George Perry, P Murali Doraiswamy, Rong X. Gut-microbiota-microglia-brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization. Alzheimer's research & therapy. vol 13. issue 1. 2021-10-28. PMID:34670619. |
interactions between the gut microbiota, microglia, and aging may modulate alzheimer's disease (ad) pathogenesis but the precise nature of such interactions is not known. |
2021-10-28 |
2023-08-13 |
Not clear |
| Kazuya Miyanishi, Arisa Sato, Nanako Kihara, Ryo Utsunomiya, Junya Tanak. Synaptic elimination by microglia and disturbed higher brain functions. Neurochemistry international. vol 142. 2021-10-27. PMID:33181238. |
in addition to the roles of microglia in normal developing and mature brains, impaired microglial phagocytosis functions also correlate with disturbances to these higher brain functions that are caused by neurological, mental, and developmental disorders; parkinson's and alzheimer's diseases, autism spectrum disorder, attention deficit/hyperactivity disorder, and schizophrenia. |
2021-10-27 |
2023-08-13 |
Not clear |