| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Ramón Perea, Marta Bolós, Jesús Avil. Microglia in Alzheimer's Disease in the Context of Tau Pathology. Biomolecules. vol 10. issue 10. 2021-09-07. PMID:33066368. |
however, the latest advances have revealed the complexity and importance of microglia in neurodegenerative conditions such as alzheimer's disease (ad), the most common form of dementia associated with aging. |
2021-09-07 |
2023-08-13 |
Not clear |
| Michael Fassler, Maya Saban Rappaport, Clara Benaim Cuño, Jacob Georg. Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models. Journal of neuroinflammation. vol 18. issue 1. 2021-09-07. PMID:33422057. |
engagement of trem2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in alzheimer's disease models. |
2021-09-07 |
2023-08-13 |
Not clear |
| Hongyan Qiu, Ruoqi Zhao, Guoqiang Fei, Xiaoli Pan, Shaoming Sang, Yangqi Xu, Boru Jin, Lirong Jin, Xiaoqin Cheng, Chunjiu Zhon. Dynamic Change of Intracellular Metabolism of Microglia Evaluated by Transcriptomics in an Alzheimer's Mouse Model. Journal of Alzheimer's disease : JAD. vol 81. issue 2. 2021-09-06. PMID:33814454. |
dynamic change of intracellular metabolism of microglia evaluated by transcriptomics in an alzheimer's mouse model. |
2021-09-06 |
2023-08-13 |
mouse |
| Hongyan Qiu, Ruoqi Zhao, Guoqiang Fei, Xiaoli Pan, Shaoming Sang, Yangqi Xu, Boru Jin, Lirong Jin, Xiaoqin Cheng, Chunjiu Zhon. Dynamic Change of Intracellular Metabolism of Microglia Evaluated by Transcriptomics in an Alzheimer's Mouse Model. Journal of Alzheimer's disease : JAD. vol 81. issue 2. 2021-09-06. PMID:33814454. |
microglia play diverse roles in alzheimer's disease (ad). |
2021-09-06 |
2023-08-13 |
mouse |
| Yiyi Ma, Lei Yu, Marta Olah, Rebecca Smith, Stephanie R Oatman, Mariet Allen, Ehsan Pishva, Bin Zhang, Vilas Menon, Nilüfer Ertekin-Taner, Katie Lunnon, David A Bennett, Hans-Ulrich Klein, Philip L De Jage. Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on Alzheimer's disease risk in humans. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-09-05. PMID:34482628. |
epigenomic features related to microglia are associated with attenuated effect of apoe ε4 on alzheimer's disease risk in humans. |
2021-09-05 |
2023-08-13 |
Not clear |
| Daniel T Ohm, Angela J Fought, Adam Martersteck, Christina Coventry, Jaiashre Sridhar, Tamar Gefen, Sandra Weintraub, Eileen Bigio, M-Marsel Mesulam, Emily Rogalski, Changiz Geul. Accumulation of neurofibrillary tangles and activated microglia is associated with lower neuron densities in the aphasic variant of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 31. issue 1. 2021-09-04. PMID:33010092. |
accumulation of neurofibrillary tangles and activated microglia is associated with lower neuron densities in the aphasic variant of alzheimer's disease. |
2021-09-04 |
2023-08-13 |
human |
| Hongyoon Choi, Yoori Choi, Eun Ji Lee, Hyun Kim, Youngsun Lee, Seokjun Kwon, Do Won Hwang, Dong Soo Le. Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimer's disease. Journal of neuroinflammation. vol 18. issue 1. 2021-09-04. PMID:34465358. |
hippocampal glucose uptake as a surrogate of metabolic change of microglia in alzheimer's disease. |
2021-09-04 |
2023-08-13 |
Not clear |
| Hongyoon Choi, Yoori Choi, Eun Ji Lee, Hyun Kim, Youngsun Lee, Seokjun Kwon, Do Won Hwang, Dong Soo Le. Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimer's disease. Journal of neuroinflammation. vol 18. issue 1. 2021-09-04. PMID:34465358. |
dynamically altered microglia play an important role in the progression of alzheimer's disease (ad). |
2021-09-04 |
2023-08-13 |
Not clear |
| Audrey Vautheny, Charlotte Duwat, Gwennaëlle Aurégan, Charlène Joséphine, Anne-Sophie Hérard, Caroline Jan, Julien Mitja, Pauline Gipchtein, Marie-Claude Gaillard, Luc Buée, David Blum, Philippe Hantraye, Gilles Bonvento, Emmanuel Brouillet, Karine Cambon, Alexis-Pierre Bemelman. THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency. Neurobiology of disease. vol 155. 2021-09-03. PMID:34019997. |
the role played by microglia has taken the center of the stage in the etiology of alzheimer's disease (ad). |
2021-09-03 |
2023-08-13 |
mouse |
| Md Golam Sharoar, Sarah Palko, Yingying Ge, Takaomi C Saido, Riqiang Ya. Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains. Molecular neurodegeneration. vol 16. issue 1. 2021-09-03. PMID:34215298. |
neuritic plaques in alzheimer's disease (ad) brains refer to β-amyloid (aβ) plaques surrounded by dystrophic neurites (dns), activated microglia and reactive astrocytes. |
2021-09-03 |
2023-08-13 |
Not clear |
| Hongtian Stanley Yang, Kristen D Onos, Kwangbom Choi, Kelly J Keezer, Daniel A Skelly, Gregory W Carter, Gareth R Howel. Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease. Cell reports. vol 34. issue 6. 2021-09-02. PMID:33567283. |
natural genetic variation determines microglia heterogeneity in wild-derived mouse models of alzheimer's disease. |
2021-09-02 |
2023-08-13 |
mouse |
| Hongtian Stanley Yang, Kristen D Onos, Kwangbom Choi, Kelly J Keezer, Daniel A Skelly, Gregory W Carter, Gareth R Howel. Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease. Cell reports. vol 34. issue 6. 2021-09-02. PMID:33567283. |
genetic and genome-wide association studies suggest a central role for microglia in alzheimer's disease (ad). |
2021-09-02 |
2023-08-13 |
mouse |
| Wenhui Qu, Ling L. Microglial TREM2 at the Intersection of Brain Aging and Alzheimer's Disease. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2021-09-02. PMID:34470515. |
as resident immune cells of the brain, microglia serve pivotal roles in regulating neuronal function under both physiological and pathological conditions, including aging and the most prevalent neurodegenerative disease, alzheimer's disease (ad). |
2021-09-02 |
2023-08-13 |
Not clear |
| Adrian Jorda, Juan Campos-Campos, Antonio Iradi, Martin Aldasoro, Constanza Aldasoro, Jose M Vila, Soraya L Valle. The Role of Chemokines in Alzheimer's Disease. Endocrine, metabolic & immune disorders drug targets. vol 20. issue 9. 2021-09-01. PMID:32003705. |
brain cells such as microglia and astrocytes are inflammatory cells associated with alzheimer's disease and involved in the production of inflammatory mediators, such as cytokines and chemokines. |
2021-09-01 |
2023-08-13 |
Not clear |
| Ryan K Shahidehpour, Rebecca E Higdon, Nicole G Crawford, Janna H Neltner, Eseosa T Ighodaro, Ela Patel, Douglas Price, Peter T Nelson, Adam D Bachstette. Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain. Neurobiology of aging. vol 99. 2021-09-01. PMID:33422891. |
compared with controls, the number of dystrophic microglia was greater in cases with either alzheimer's disease, dementia with lewy bodies, or limbic-predominant age-related tdp-43 encephalopathy. |
2021-09-01 |
2023-08-13 |
human |
| John Bosco Ruganzu, Quzhao Zheng, Xiangyuan Wu, Yingying He, Xiaoqian Peng, Hui Jin, Jinsong Zhou, Ruiyang Ma, Shengfeng Ji, Yanbing Ma, Yihua Qian, Yang Wang, Weina Yan. TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway. Experimental neurology. vol 336. 2021-08-30. PMID:33065077. |
overactivated microglia and neuroinflammation are considered to play a crucial role in the progression of alzheimer's disease (ad). |
2021-08-30 |
2023-08-13 |
mouse |
| Heather Woo. Astrocytic IL-3 could help microglia protect against Alzheimer disease. Nature reviews. Neurology. vol 17. issue 9. 2021-08-30. PMID:34321636. |
astrocytic il-3 could help microglia protect against alzheimer disease. |
2021-08-30 |
2023-08-13 |
Not clear |
| Nianshui Jing, Xinnan L. Dihydromyricetin Attenuates Inflammation through TLR4/NF-kappaB Pathway. Open medicine (Warsaw, Poland). vol 14. 2021-08-26. PMID:31572805. |
microglia plays a complex role in neuroinflammation, which has been implicated in neurodegenerative diseases such as alzheimer's disease and parkinson's disease. |
2021-08-26 |
2023-08-13 |
Not clear |
| Vaishnavi S Jadhav, Peter B C Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K Atwood, Shweta S Puntambekar, Stephanie J Bissel, Adrian L Oblak, Gary E Landreth, Bruce T Lam. Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice. Molecular neurodegeneration. vol 15. issue 1. 2021-08-26. PMID:33115519. |
triggering receptor expressed on myeloid cells 2 (trem2) is expressed in the brain exclusively on microglia and genetic variants are linked to neurodegenerative diseases including alzheimer's disease (ad), frontotemporal dementia (ftd) and nasu hakola disease (nhd). |
2021-08-26 |
2023-08-13 |
mouse |
| Jason Schapansky, Yelena Y Grinberg, David M Osiecki, Emily A Freeman, Stephen G Walker, Eric Karran, Sujatha M Gopalakrishnan, Robert V Talania. MEK1/2 activity modulates TREM2 cell surface recruitment. The Journal of biological chemistry. vol 296. 2021-08-25. PMID:33839686. |
rare sequence variants in the microglial cell surface receptor trem2 have been shown to increase the risk for alzheimer's disease (ad). |
2021-08-25 |
2023-08-13 |
human |