| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia Lu, Wei Zhou, Fangfang Dou, Chenfei Wang, Zhihua Y. TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease. EMBO reports. vol 22. issue 6. 2021-06-28. PMID:33998138. |
as the brain-resident innate immune cells, reactive microglia are a major pathological feature of alzheimer's disease (ad). |
2021-06-28 |
2023-08-13 |
mouse |
| Giacomo Tondo, Leonardo Iaccarino, Silvia Paola Caminiti, Luca Presotto, Roberto Santangelo, Sandro Iannaccone, Giuseppe Magnani, Daniela Peran. The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:32354345. |
the combined effects of microglia activation and brain glucose hypometabolism in early-onset alzheimer's disease. |
2021-06-24 |
2023-08-13 |
human |
| Weixi Feng, Yanli Zhang, Ze Wang, Hanrong Xu, Ting Wu, Charles Marshall, Junying Gao, Ming Xia. Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer's disease mouse model with suppression of glymphatic clearance. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:33008458. |
microglia prevent beta-amyloid plaque formation in the early stage of an alzheimer's disease mouse model with suppression of glymphatic clearance. |
2021-06-24 |
2023-08-13 |
mouse |
| Hazel Hall-Roberts, Devika Agarwal, Juliane Obst, Thomas B Smith, Jimena Monzón-Sandoval, Elena Di Daniel, Caleb Webber, William S James, Emma Mead, John B Davis, Sally A Cowle. TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:33198789. |
trem2 is a microglial cell surface receptor, with risk mutations linked to alzheimer's disease (ad), including r47h. |
2021-06-24 |
2023-08-13 |
mouse |
| Vincent Pons, Pascal Lévesque, Marie-Michèle Plante, Serge Rives. Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer's disease. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33402196. |
conditional genetic deletion of csf1 receptor in microglia ameliorates the physiopathology of alzheimer's disease. |
2021-06-24 |
2023-08-13 |
Not clear |
| Qiuju Yuan, Xiaodong Liu, Yi Zhang, Yan-Fang Xian, Juntao Zou, Xie Zhang, Pengyun Huang, You-Qiang Song, Zhi-Xiu Li. Established Beta Amyloid Pathology Is Unaffected by TREM2 Elevation in Reactive Microglia in an Alzheimer's Disease Mouse Model. Molecules (Basel, Switzerland). vol 26. issue 9. 2021-06-24. PMID:34064330. |
established beta amyloid pathology is unaffected by trem2 elevation in reactive microglia in an alzheimer's disease mouse model. |
2021-06-24 |
2023-08-13 |
mouse |
| Yanling Hu, Gemma L Fryatt, Mohammadmersad Ghorbani, Juliane Obst, David A Menassa, Maria Martin-Estebane, Tim A O Muntslag, Adrian Olmos-Alonso, Monica Guerrero-Carrasco, Daniel Thomas, Mark S Cragg, Diego Gomez-Nicol. Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology. Cell reports. vol 35. issue 10. 2021-06-24. PMID:34107254. |
the sustained proliferation of microglia is a key hallmark of alzheimer's disease (ad), accelerating its progression. |
2021-06-24 |
2023-08-13 |
human |
| Sam C Berens, Chris M Bird, Neil A Harriso. Minocycline differentially modulates human spatial memory systems. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 13. 2021-06-23. PMID:32839527. |
microglia play a critical role in many processes fundamental to learning and memory in health and are implicated in alzheimer's pathogenesis. |
2021-06-23 |
2023-08-13 |
human |
| Marvin Reich, Iñaki Paris, Martin Ebeling, Nadine Dahm, Christophe Schweitzer, Dieter Reinhardt, Roland Schmucki, Megana Prasad, Fabian Köchl, Marcel Leist, Sally A Cowley, Jitao David Zhang, Christoph Patsch, Simon Gutbier, Markus Britschg. Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia. Frontiers in immunology. vol 11. 2021-06-21. PMID:33613545. |
alzheimer's risk gene trem2 determines functional properties of new type of human ipsc-derived microglia. |
2021-06-21 |
2023-08-13 |
human |
| Marvin Reich, Iñaki Paris, Martin Ebeling, Nadine Dahm, Christophe Schweitzer, Dieter Reinhardt, Roland Schmucki, Megana Prasad, Fabian Köchl, Marcel Leist, Sally A Cowley, Jitao David Zhang, Christoph Patsch, Simon Gutbier, Markus Britschg. Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia. Frontiers in immunology. vol 11. 2021-06-21. PMID:33613545. |
microglia are key in the homeostatic well-being of the brain and microglial dysfunction has been implicated in neurodegenerative disorders such as alzheimer's disease (ad). |
2021-06-21 |
2023-08-13 |
human |
| Sejal Patel, Derek Howard, Alana Man, Deborah Schwartz, Joelle Jee, Daniel Felsky, Zdenka Pausova, Tomas Paus, Leon Frenc. Donor-Specific Transcriptomic Analysis of Alzheimer's Disease-Associated Hypometabolism Highlights a Unique Donor, Ribosomal Proteins and Microglia. eNeuro. vol 7. issue 6. 2021-06-18. PMID:33234543. |
donor-specific transcriptomic analysis of alzheimer's disease-associated hypometabolism highlights a unique donor, ribosomal proteins and microglia. |
2021-06-18 |
2023-08-13 |
mouse |
| Satoshi Muraoka, Mark P Jedrychowski, Naotoshi Iwahara, Mohammad Abdullah, Kristen D Onos, Kelly J Keezer, Jianqiao Hu, Seiko Ikezu, Gareth R Howell, Steven P Gygi, Tsuneya Ikez. Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models. Journal of proteome research. vol 20. issue 3. 2021-06-17. PMID:33534581. |
enrichment of neurodegenerative microglia signature in brain-derived extracellular vesicles isolated from alzheimer's disease mouse models. |
2021-06-17 |
2023-08-13 |
mouse |
| Maria Grazia Giovannini, Daniele Lana, Chiara Traini, Maria Giuliana Vannucch. The Microbiota-Gut-Brain Axis and Alzheimer Disease. From Dysbiosis to Neurodegeneration: Focus on the Central Nervous System Glial Cells. Journal of clinical medicine. vol 10. issue 11. 2021-06-16. PMID:34072107. |
based on this information, the role of the major microbiota products in shifting the activation profiles of astrocytes and microglia from a healthy to a diseased state will be discussed, focusing on alzheimer disease pathogenesis. |
2021-06-16 |
2023-08-13 |
Not clear |
| Nicholas F Fitz, Kyong Nyon Nam, Cody M Wolfe, Florent Letronne, Brittany E Playso, Bistra E Iordanova, Takashi D Y Kozai, Richard J Biedrzycki, Valerian E Kagan, Yulia Y Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamov. Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-06-15. PMID:34099706. |
phospholipids of apoe lipoproteins activate microglia in an isoform-specific manner in preclinical models of alzheimer's disease. |
2021-06-15 |
2023-08-13 |
mouse |
| Nicholas F Fitz, Kyong Nyon Nam, Cody M Wolfe, Florent Letronne, Brittany E Playso, Bistra E Iordanova, Takashi D Y Kozai, Richard J Biedrzycki, Valerian E Kagan, Yulia Y Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamov. Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-06-15. PMID:34099706. |
apoe and trem2 are major genetic risk factors for alzheimer's disease (ad), but how they affect microglia response to aβ remains unclear. |
2021-06-15 |
2023-08-13 |
mouse |
| Juliane Obst, Emilie Simon, Maria Martin-Estebane, Elena Pipi, Liana M Barkwill, Ivette Gonzalez-Rivera, Fergus Buchanan, Alan R Prescott, Dorte Faust, Simon Fox, Janet Brownlees, Debra Taylor, V Hugh Perry, Hugh Nuthall, Peter J Atkinson, Eric Karran, Carol Routledge, Diego Gomez-Nicol. Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration. Frontiers in immunology. vol 11. 2021-06-14. PMID:33162994. |
the proliferation and activation of microglia, the resident macrophages in the brain, is a hallmark of many neurodegenerative diseases such as alzheimer's disease (ad) and prion disease. |
2021-06-14 |
2023-08-13 |
mouse |
| Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John F Ouyang, Guizhi Sun, Nathan P Croft, Fernando J Rossello, Rebecca Simmons, Sam Buckberry, Dulce Vargas Landin, Jahnvi Pflueger, Teresa H Vandekolk, Zehra Abay, Yichen Zhou, Xiaodong Liu, Joseph Chen, Michael Larcombe, John M Haynes, Catriona McLean, Sarah Williams, Siew Yeen Chai, Trevor Wilson, Ryan Lister, Colin W Pouton, Anthony W Purcell, Owen J L Rackham, Enrico Petretto, Jose M Pol. Transcriptional signature in microglia associated with Aβ plaque phagocytosis. Nature communications. vol 12. issue 1. 2021-06-11. PMID:34021136. |
the role of microglia cells in alzheimer's disease (ad) is well recognized, however their molecular and functional diversity remain unclear. |
2021-06-11 |
2023-08-13 |
Not clear |
| Mehdi Eshraghi, Aida Adlimoghaddam, Amir Mahmoodzadeh, Farzaneh Sharifzad, Hamed Yasavoli-Sharahi, Shahrokh Lorzadeh, Benedict C Albensi, Saeid Ghavam. Alzheimer's Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia. International journal of molecular sciences. vol 22. issue 7. 2021-06-09. PMID:33805142. |
alzheimer's disease pathogenesis: role of autophagy and mitophagy focusing in microglia. |
2021-06-09 |
2023-08-13 |
Not clear |
| Luca Kleineidam, Vincent Chouraki, Tomasz Próchnicki, Sven J van der Lee, Laura Madrid-Márquez, Holger Wagner-Thelen, Ilker Karaca, Leonie Weinhold, Steffen Wolfsgruber, Anne Boland, Pamela V Martino Adami, Piotr Lewczuk, Julius Popp, Frederic Brosseron, Iris E Jansen, Marc Hulsman, Johannes Kornhuber, Oliver Peters, Claudine Berr, Reinhard Heun, Lutz Frölich, Christophe Tzourio, Jean-François Dartigues, Michael Hüll, Ana Espinosa, Isabel Hernández, Itziar de Rojas, Adelina Orellana, Sergi Valero, Najada Stringa, Natasja M van Schoor, Martijn Huisman, Philip Scheltens, Eckart Rüther, Jean-Francois Deleuze, Jens Wiltfang, Lluis Tarraga, Matthias Schmid, Martin Scherer, Steffi Riedel-Heller, Michael T Heneka, Philippe Amouyel, Frank Jessen, Merce Boada, Wolfgang Maier, Anja Schneider, Antonio González-Pérez, Wiesje M van der Flier, Michael Wagner, Jean-Charles Lambert, Henne Holstege, Mª Eugenia Sáez, Eicke Latz, Agustin Ruiz, Alfredo Ramire. PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment. Acta neuropathologica. vol 139. issue 6. 2021-06-08. PMID:32166339. |
a rare coding variant (rs72824905, p.p522r) conferring protection against alzheimer's disease (ad) was identified in the gene encoding the enzyme phospholipase-c-γ2 (plcg2) that is highly expressed in microglia. |
2021-06-08 |
2023-08-13 |
Not clear |
| Patrick Süß, Johannes C M Schlachetzk. Microglia in Alzheimer's Disease. Current Alzheimer research. vol 17. issue 1. 2021-06-07. PMID:32048973. |
microglia in alzheimer's disease. |
2021-06-07 |
2023-08-13 |
mouse |