| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luca Kleineidam, Vincent Chouraki, Tomasz Próchnicki, Sven J van der Lee, Laura Madrid-Márquez, Holger Wagner-Thelen, Ilker Karaca, Leonie Weinhold, Steffen Wolfsgruber, Anne Boland, Pamela V Martino Adami, Piotr Lewczuk, Julius Popp, Frederic Brosseron, Iris E Jansen, Marc Hulsman, Johannes Kornhuber, Oliver Peters, Claudine Berr, Reinhard Heun, Lutz Frölich, Christophe Tzourio, Jean-François Dartigues, Michael Hüll, Ana Espinosa, Isabel Hernández, Itziar de Rojas, Adelina Orellana, Sergi Valero, Najada Stringa, Natasja M van Schoor, Martijn Huisman, Philip Scheltens, Eckart Rüther, Jean-Francois Deleuze, Jens Wiltfang, Lluis Tarraga, Matthias Schmid, Martin Scherer, Steffi Riedel-Heller, Michael T Heneka, Philippe Amouyel, Frank Jessen, Merce Boada, Wolfgang Maier, Anja Schneider, Antonio González-Pérez, Wiesje M van der Flier, Michael Wagner, Jean-Charles Lambert, Henne Holstege, Mª Eugenia Sáez, Eicke Latz, Agustin Ruiz, Alfredo Ramire. PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment. Acta neuropathologica. vol 139. issue 6. 2021-06-08. PMID:32166339. |
a rare coding variant (rs72824905, p.p522r) conferring protection against alzheimer's disease (ad) was identified in the gene encoding the enzyme phospholipase-c-γ2 (plcg2) that is highly expressed in microglia. |
2021-06-08 |
2023-08-13 |
Not clear |
| Patrick Süß, Johannes C M Schlachetzk. Microglia in Alzheimer's Disease. Current Alzheimer research. vol 17. issue 1. 2021-06-07. PMID:32048973. |
microglia in alzheimer's disease. |
2021-06-07 |
2023-08-13 |
mouse |
| Yasuhisa Ano, Kumiko Ikado, Kazuyuki Uchida, Hiroyuki Nakayam. Amyloid β-induced Mesenteric Inflammation in an Alzheimer's Disease Transgenic Mouse Model. Current Alzheimer research. vol 17. issue 1. 2021-06-07. PMID:32048974. |
alzheimer's disease (ad) is a neurodegenerative disorder histopathologically characterized by the accumulation of amyloid β (aβ) peptides and inflammation associated with activated microglia. |
2021-06-07 |
2023-08-13 |
mouse |
| Joshua D Crapser, Elizabeth E Spangenberg, Rocio A Barahona, Miguel A Arreola, Lindsay A Hohsfield, Kim N Gree. Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain. EBioMedicine. vol 58. 2021-06-07. PMID:32745992. |
microglia facilitate loss of perineuronal nets in the alzheimer's disease brain. |
2021-06-07 |
2023-08-13 |
Not clear |
| Joshua D Crapser, Elizabeth E Spangenberg, Rocio A Barahona, Miguel A Arreola, Lindsay A Hohsfield, Kim N Gree. Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain. EBioMedicine. vol 58. 2021-06-07. PMID:32745992. |
microglia, the brain's principal immune cell, are increasingly implicated in alzheimer's disease (ad), but the molecular interfaces through which these cells contribute to amyloid beta (aβ)-related neurodegeneration are unclear. |
2021-06-07 |
2023-08-13 |
Not clear |
| Jing Jin, Jia Guo, Hongbin Cai, Chongchong Zhao, Huan Wang, Zhiyan Liu, Zhao-Ming G. M2-Like Microglia Polarization Attenuates Neuropathic Pain Associated with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 76. issue 4. 2021-06-03. PMID:32280102. |
m2-like microglia polarization attenuates neuropathic pain associated with alzheimer's disease. |
2021-06-03 |
2023-08-13 |
mouse |
| Jing Jin, Jia Guo, Hongbin Cai, Chongchong Zhao, Huan Wang, Zhiyan Liu, Zhao-Ming G. M2-Like Microglia Polarization Attenuates Neuropathic Pain Associated with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 76. issue 4. 2021-06-03. PMID:32280102. |
many alzheimer's disease (ad) patients suffer from persistent neuropathic pain (np), which is mediated, at least partially, but microglia. |
2021-06-03 |
2023-08-13 |
mouse |
| Yingying He, John Bosco Ruganzu, Quzhao Zheng, Xiangyuan Wu, Hui Jin, Xiaoqian Peng, Bo Ding, Chengheng Lin, Shengfeng Ji, Yanbing Ma, Weina Yan. Silencing of LRP1 Exacerbates Inflammatory Response Via TLR4/NF-κB/MAPKs Signaling Pathways in APP/PS1 Transgenic Mice. Molecular neurobiology. vol 57. issue 9. 2021-06-03. PMID:32572761. |
activation of glial cells (including microglia and astrocytes) appears central to the initiation and progression of neuroinflammation in alzheimer's disease (ad). |
2021-06-03 |
2023-08-13 |
mouse |
| Xinna Liu, Qi Wang, Zhengbo Shao, Shiqi Zhang, Mingying Hou, Menglu Jiang, Mengxian Du, Jing Li, Huiping Yua. Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma. Human molecular genetics. vol 30. issue 11. 2021-06-03. PMID:33856034. |
certain biological features, including amyloid deposition, rna splicing, microglia activation and reduction of crystallin production, were similar to alzheimer's disease. |
2021-06-03 |
2023-08-13 |
mouse |
| Charlotte Mezö, Nikolaos Dokalis, Omar Mossad, Ori Staszewski, Jana Neuber, Bahtiyar Yilmaz, Daniel Schnepf, Mercedes Gomez de Agüero, Stephanie C Ganal-Vonarburg, Andrew J Macpherson, Melanie Meyer-Luehmann, Peter Staeheli, Thomas Blank, Marco Prinz, Daniel Ern. Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer's disease. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32727612. |
different effects of constitutive and induced microbiota modulation on microglia in a mouse model of alzheimer's disease. |
2021-05-31 |
2023-08-13 |
mouse |
| J Michael, M S Unger, R Poupardin, P Schernthaner, H Mrowetz, J Attems, L Aigne. Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer's Disease mice. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32771067. |
microglia depletion diminishes key elements of the leukotriene pathway in the brain of alzheimer's disease mice. |
2021-05-31 |
2023-08-13 |
mouse |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32840654. |
apoe and trem2 regulate amyloid-responsive microglia in alzheimer's disease. |
2021-05-31 |
2023-08-13 |
human |
| Min Guo, Yining Hao, Yiwei Feng, Haiqing Li, Yiting Mao, Qiang Dong, Mei Cu. Microglial Exosomes in Neurodegenerative Disease. Frontiers in molecular neuroscience. vol 14. 2021-05-30. PMID:34045943. |
microglia play an important role in neurodegenerative disease [i.e., parkinson's disease (pd), alzheimer's disease (ad), and amyotrophic lateral sclerosis (als)]. |
2021-05-30 |
2023-08-13 |
Not clear |
| Yu-Ling Xu, Xiao-Yu Liu, Sai-Bo Cheng, Pei-Kun He, Mu-Keng Hong, Yu-Yao Chen, Feng-Hua Zhou, Yu-Hua Ji. Geniposide Enhances Macrophage Autophagy through Downregulation of TREM2 in Atherosclerosis. The American journal of Chinese medicine. vol 48. issue 8. 2021-05-28. PMID:33308094. |
trem2 is a key factor in the development of alzheimer's disease (ad), the deficiency of which leads to anomalous autophagy in microglia. |
2021-05-28 |
2023-08-13 |
Not clear |
| Juan Li, Xiao-Yu Cheng, Hui Yang, Li Li, Yang Niu, Jian-Qiang Yu, Wei-Qi Li, Yao Ya. Matrine ameliorates cognitive deficits via inhibition of microglia mediated neuroinflammation in an Alzheimer's disease mouse model. Die Pharmazie. vol 75. issue 7. 2021-05-27. PMID:32635978. |
matrine ameliorates cognitive deficits via inhibition of microglia mediated neuroinflammation in an alzheimer's disease mouse model. |
2021-05-27 |
2023-08-13 |
mouse |
| Anne-Laure Hemonnot-Girard, Audrey J Valverde, Jennifer Hua, Charlene Delaygue, Nathalie Linck, Tangui Maurice, François Rassendren, Helene Hirbe. Analysis of CX3CR1 haplodeficiency in male and female APP Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:33190798. |
analysis of cx3cr1 haplodeficiency in male and female app microglia, the resident immune cells of the brain, have recently emerged as key players in alzheimer disease (ad) pathogenesis, but their roles in ad remain largely elusive and require further investigation. |
2021-05-27 |
2023-08-13 |
mouse |
| Jagdeep K Sandhu, Marianna Kulk. Decoding Mast Cell-Microglia Communication in Neurodegenerative Diseases. International journal of molecular sciences. vol 22. issue 3. 2021-05-25. PMID:33499208. |
this review discusses the current understanding of the molecular conversation between mast cells and microglia in orchestrating immune responses during two of the most prevalent neurodegenerative diseases, namely alzheimer's disease and parkinson's disease. |
2021-05-25 |
2023-08-13 |
Not clear |
| Yuanyuan Liu, Boxi Zhang, Jiahe Liu, Chunyu Qiao, Nianyu Xue, Hongming Lv, Shize L. Mogroside V Alleviates Lipopolysaccharide-Induced Neuroinflammation via Inhibition of TLR4-MyD88 and Activation of AKT/AMPK-Nrf2 Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-05-22. PMID:34012471. |
as innate immune effector cells in the central nervous system (cns), microglia not only are essential for the normal development of nervous system but also act on different neurological diseases, including alzheimer's disease (ad), huntington's disease (hd), and other neuroinflammatory diseases. |
2021-05-22 |
2023-08-13 |
Not clear |
| George B Stefano, Tobias Esch, Radek Ptacek, Richard M Krea. Dysregulation of Nitric Oxide Signaling in Microglia: Multiple Points of Functional Convergence in the Complex Pathophysiology of Alzheimer Disease. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32975239. |
dysregulation of nitric oxide signaling in microglia: multiple points of functional convergence in the complex pathophysiology of alzheimer disease. |
2021-05-20 |
2023-08-13 |
Not clear |
| Paul Dembny, Andrew G Newman, Manvendra Singh, Michael Hinz, Michal Szczepek, Christina Krüger, Robert Adalbert, Omar Dzaye, Thorsten Trimbuch, Thomas Wallach, Gunnar Kleinau, Katja Derkow, Bernhard C Richard, Carola Schipke, Claus Scheidereit, Harald Stachelscheid, Douglas Golenbock, Oliver Peters, Michael Coleman, Frank L Heppner, Patrick Scheerer, Victor Tarabykin, Klemens Ruprecht, Zsuzsanna Izsvák, Jens Mayer, Seija Lehnard. Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors. JCI insight. vol 5. issue 7. 2021-05-19. PMID:32271161. |
herv-k(hml-2) rna introduced into the cerebrospinal fluid (csf) of either c57bl/6 wild-type mice or appps1 mice, a mouse model for alzheimer's disease (ad), resulted in neurodegeneration and microglia accumulation. |
2021-05-19 |
2023-08-13 |
mouse |