| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert R Butler Iii, Alena Kozlova, Hanwen Zhang, Siwei Zhang, Michael Streit, Alan R Sanders, Krzysztof Laudanski, Zhiping P Pang, Pablo V Gejman, Jubao Dua. The Genetic Relevance of Human Induced Pluripotent Stem Cell-Derived Microglia to Alzheimer's Disease and Major Neuropsychiatric Disorders. Molecular neuropsychiatry. vol 5. issue Suppl 1. 2021-04-02. PMID:32399472. |
the genetic relevance of human induced pluripotent stem cell-derived microglia to alzheimer's disease and major neuropsychiatric disorders. |
2021-04-02 |
2023-08-13 |
human |
| Robert R Butler Iii, Alena Kozlova, Hanwen Zhang, Siwei Zhang, Michael Streit, Alan R Sanders, Krzysztof Laudanski, Zhiping P Pang, Pablo V Gejman, Jubao Dua. The Genetic Relevance of Human Induced Pluripotent Stem Cell-Derived Microglia to Alzheimer's Disease and Major Neuropsychiatric Disorders. Molecular neuropsychiatry. vol 5. issue Suppl 1. 2021-04-02. PMID:32399472. |
microglia are the primary innate immune cell type in the brain that have been implicated in the pathogenesis of several neurodegenerative and neuropsychiatric disorders, most notably alzheimer's disease (ad) and schizophrenia. |
2021-04-02 |
2023-08-13 |
human |
| Smita Eknath Desale, Subashchandrabose Chinnathamb. α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia. Cell adhesion & migration. vol 15. issue 1. 2021-04-02. PMID:33724164. |
microglia, the resident immune cells, were found to be activated to inflammatory phenotype in alzheimer's disease (ad). |
2021-04-02 |
2023-08-13 |
Not clear |
| Sudha R Guttikonda, Lisa Sikkema, Jason Tchieu, Nathalie Saurat, Ryan M Walsh, Oliver Harschnitz, Gabriele Ciceri, Marjolein Sneeboer, Linas Mazutis, Manu Setty, Paul Zumbo, Doron Betel, Lot D de Witte, Dana Pe'er, Lorenz Stude. Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer's disease. Nature neuroscience. vol 24. issue 3. 2021-03-29. PMID:33558694. |
fully defined human pluripotent stem cell-derived microglia and tri-culture system model c3 production in alzheimer's disease. |
2021-03-29 |
2023-08-13 |
human |
| Ge Gao, Congcong Li, Jie Zhu, Yi Wang, Yunlong Huang, Shu Zhao, Shiyang Sheng, Yu Song, Chenhui Ji, Chunhong Li, Xiaoyu Yang, Ling Ye, Xinrui Qi, Yanyan Zhang, Xiaohuan Xia, Jialin C Zhen. Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release. Frontiers in immunology. vol 11. 2021-03-26. PMID:32117296. |
previous studies demonstrate abnormal elevation of glutaminase 1 (gls1) in microglia in chronic cns disorders including alzheimer's disease and hiv-associated neurocognitive disorders. |
2021-03-26 |
2023-08-13 |
Not clear |
| Patrick T Ronaldson, Thomas P Davi. Regulation of blood-brain barrier integrity by microglia in health and disease: A therapeutic opportunity. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 1_suppl. 2021-03-23. PMID:32928017. |
additionally, we outline the role of other nvu cell types in regulating microglial activation and highlight how microglia can be targeted for treatment of disease with a focus on ischemic stroke and alzheimer's disease. |
2021-03-23 |
2023-08-13 |
Not clear |
| Ling-Zhi Ma, Lan Tan, Yan-Lin Bi, Xue-Ning Shen, Wei Xu, Ya-Hui Ma, Hong-Qi Li, Qiang Dong, Jin-Tai Y. Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study. Molecular neurodegeneration. vol 15. issue 1. 2021-03-19. PMID:32276587. |
loss of function of triggering receptor expressed on myeloid cell 2 (trem2), a key receptor selectively expressed by microglia in the brain, contributes to the development of alzheimer's disease (ad). |
2021-03-19 |
2023-08-13 |
Not clear |
| Hazel Hall-Roberts, Elena Di Daniel, William S James, John B Davis, Sally A Cowle. In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages. Journal of visualized experiments : JoVE. issue 168. 2021-03-19. PMID:33645588. |
microglia orchestrate neuroimmune responses in several neurodegenerative diseases, including parkinson's disease and alzheimer's disease. |
2021-03-19 |
2023-08-13 |
human |
| Dervis A Salih, Sevinc Bayram, Sebastian Guelfi, Regina H Reynolds, Maryam Shoai, Mina Ryten, Jonathan W Brenton, David Zhang, Mar Matarin, Juan A Botia, Runil Shah, Keeley J Brookes, Tamar Guetta-Baranes, Kevin Morgan, Eftychia Bellou, Damian M Cummings, Valentina Escott-Price, John Hard. Genetic variability in response to amyloid beta deposition influences Alzheimer's disease risk. Brain communications. vol 1. issue 1. 2021-03-17. PMID:32274467. |
genome-wide association studies of late-onset alzheimer's disease risk have previously identified genes primarily expressed in microglia that form a transcriptional network. |
2021-03-17 |
2023-08-13 |
mouse |
| Dervis A Salih, Sevinc Bayram, Sebastian Guelfi, Regina H Reynolds, Maryam Shoai, Mina Ryten, Jonathan W Brenton, David Zhang, Mar Matarin, Juan A Botia, Runil Shah, Keeley J Brookes, Tamar Guetta-Baranes, Kevin Morgan, Eftychia Bellou, Damian M Cummings, Valentina Escott-Price, John Hard. Genetic variability in response to amyloid beta deposition influences Alzheimer's disease risk. Brain communications. vol 1. issue 1. 2021-03-17. PMID:32274467. |
in this new study, we generate an improved rna-seq-derived network that is expressed in amyloid-responsive mouse microglia and we statistically compare this with gene-level variation in previous human alzheimer's disease genome-wide association studies to predict at least four new risk genes for the disease ( |
2021-03-17 |
2023-08-13 |
mouse |
| Ivanna Ihnatovych, Barbara Birkaya, Emily Notari, Kinga Sziget. iPSC-Derived Microglia for Modeling Human-Specific DAMP and PAMP Responses in the Context of Alzheimer's Disease. International journal of molecular sciences. vol 21. issue 24. 2021-03-16. PMID:33352944. |
ipsc-derived microglia for modeling human-specific damp and pamp responses in the context of alzheimer's disease. |
2021-03-16 |
2023-08-13 |
Not clear |
| Daniele Lana, Filippo Ugolini, Maria Grazia Giovannin. Space-Dependent Glia-Neuron Interplay in the Hippocampus of Transgenic Models of β-Amyloid Deposition. International journal of molecular sciences. vol 21. issue 24. 2021-03-15. PMID:33322419. |
this review is focused on the description and discussion of the alterations of astrocytes and microglia interplay in models of alzheimer's disease (ad). |
2021-03-15 |
2023-08-13 |
Not clear |
| Tongfei Liu, Bing Zhu, Yan Liu, Xiaoming Zhang, Jun Yin, Xiaoguang Li, LuLin Jiang, Andrew P Hodges, Sara Brin Rosenthal, Lisa Zhou, Joel Yancey, Amanda McQuade, Mathew Blurton-Jones, Rudolph E Tanzi, Timothy Y Huang, Huaxi X. Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE. The Journal of experimental medicine. vol 217. issue 12. 2021-03-11. PMID:32941599. |
multi-omic comparison of alzheimer's variants in human esc-derived microglia reveals convergence at apoe. |
2021-03-11 |
2023-08-13 |
mouse |
| Tongfei Liu, Bing Zhu, Yan Liu, Xiaoming Zhang, Jun Yin, Xiaoguang Li, LuLin Jiang, Andrew P Hodges, Sara Brin Rosenthal, Lisa Zhou, Joel Yancey, Amanda McQuade, Mathew Blurton-Jones, Rudolph E Tanzi, Timothy Y Huang, Huaxi X. Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE. The Journal of experimental medicine. vol 217. issue 12. 2021-03-11. PMID:32941599. |
variations in many genes linked to sporadic alzheimer's disease (ad) show abundant expression in microglia, but relationships among these genes remain largely elusive. |
2021-03-11 |
2023-08-13 |
mouse |
| Shehata Anwar, Serge Rives. Alzheimer's disease: microglia targets and their modulation to promote amyloid phagocytosis and mitigate neuroinflammation. Expert opinion on therapeutic targets. vol 24. issue 4. 2021-03-10. PMID:32129117. |
alzheimer's disease: microglia targets and their modulation to promote amyloid phagocytosis and mitigate neuroinflammation. |
2021-03-10 |
2023-08-13 |
Not clear |
| Sujin Kim, Hyunju Chung, Han Ngoc Mai, Yunkwon Nam, Soo Jung Shin, Yong Ho Park, Mi Joo Chung, Jong Kil Lee, Hak Young Rhee, Geon-Ho Jahng, Youngkyong Kim, Yu Jin Lim, Moonkyoo Kong, Minho Moon, Weon Kuu Chun. Low-Dose Ionizing Radiation Modulates Microglia Phenotypes in the Models of Alzheimer's Disease. International journal of molecular sciences. vol 21. issue 12. 2021-03-09. PMID:32630597. |
low-dose ionizing radiation modulates microglia phenotypes in the models of alzheimer's disease. |
2021-03-09 |
2023-08-13 |
mouse |
| Lidija Radenovic, Marija Nenadic, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J Czuczwar, Pavle R Andjus, Ryszard Plut. Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival. Aging. vol 12. issue 12. 2021-03-08. PMID:32501292. |
heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of alzheimer's disease after 2 years of survival. |
2021-03-08 |
2023-08-13 |
rat |
| Nicola Fattorelli, Anna Martinez-Muriana, Leen Wolfs, Ivana Geric, Bart De Strooper, Renzo Mancus. Stem-cell-derived human microglia transplanted into mouse brain to study human disease. Nature protocols. vol 16. issue 2. 2021-03-08. PMID:33424025. |
microglia are critically involved in complex neurological disorders with a strong genetic component, such as alzheimer's disease, parkinson's disease and frontotemporal dementia. |
2021-03-08 |
2023-08-13 |
mouse |
| Walter J Lukiw, Aileen I Pogu. Vesicular Transport of Encapsulated microRNA between Glial and Neuronal Cells. International journal of molecular sciences. vol 21. issue 14. 2021-03-05. PMID:32708414. |
this communication will review our current understanding of the trafficking of mirna-containing exs and emvs from astrocytes and "activated pro-inflammatory" microglia to target neurons in neurodegenerative diseases with an emphasis on alzheimer's disease wherever possible. |
2021-03-05 |
2023-08-13 |
Not clear |
| Jun Maeda, Takeharu Minamihisamatsu, Masafumi Shimojo, Xiaoyun Zhou, Maiko Ono, Yukio Matsuba, Bin Ji, Hideki Ishii, Masanao Ogawa, Hiroyasu Akatsu, Daita Kaneda, Yoshio Hashizume, John L Robinson, Virginia M-Y Lee, Takashi Saito, Takaomi C Saido, John Q Trojanowski, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi, Naruhiko Sahar. Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor. Brain communications. vol 3. issue 1. 2021-03-03. PMID:33644757. |
recent studies with single-cell rna analysis of cns cells in alzheimer's disease and diverse other neurodegenerative conditions revealed that the transition from homeostatic microglia to disease-associated microglia was defined by changes of gene expression levels, including down-regulation of the p2y12 receptor gene ( |
2021-03-03 |
2023-08-13 |
Not clear |