All Relations between Alzheimer Disease and microglial cell

Publication Sentence Publish Date Extraction Date Species
Katherine R Giordano, Charlotte R Denman, Phoebe S Dubisch, Murtaza Akhter, Jonathan Lifshit. An update on the rod microglia variant in experimental and clinical brain injury and disease. Brain communications. vol 3. issue 1. 2021-01-30. PMID:33501429. rod microglia were reported frequently in the early 1900s by neuropathologists in post-mortem cases of general paresis, alzheimer's disease and encephalitis, and then remained largely ignored for almost 100 years. 2021-01-30 2023-08-13 Not clear
Pavithra Suresh, Sarayut Phasuk, Ingrid Y Li. Modulation of microglia activation and Alzheimer's disease: CX3 chemokine ligand 1/CX3CR and P2X Tzu chi medical journal. vol 33. issue 1. 2021-01-30. PMID:33505871. modulation of microglia activation and alzheimer's disease: cx3 chemokine ligand 1/cx3cr and p2x alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by cognitive deficits. 2021-01-30 2023-08-13 Not clear
Yingying He, John Bosco Ruganzu, Hui Jin, Xiaoqian Peng, Shengfeng Ji, Yanbing Ma, Liming Zheng, Weina Yan. LRP1 knockdown aggravates Aβ Experimental cell research. vol 394. issue 2. 2021-01-27. PMID:32645395. lrp1 knockdown aggravates aβ neuroinflammation is an important pathological feature and an early event in the pathogenesis of alzheimer's disease (ad), which is characterized by activation of microglia and astrocytes. 2021-01-27 2023-08-13 Not clear
Joseph W Lewcock, Kai Schlepckow, Gilbert Di Paolo, Sabina Tahirovic, Kathryn M Monroe, Christian Haas. Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease. Neuron. vol 108. issue 5. 2021-01-27. PMID:33096024. emerging microglia biology defines novel therapeutic approaches for alzheimer's disease. 2021-01-27 2023-08-13 human
Peter Parbo, Lasse Stensvig Madsen, Rola Ismail, Henrik Zetterberg, Kaj Blennow, Simon F Eskildsen, Thomas Vorup-Jensen, David J Brook. Low plasma neurofilament light levels associated with raised cortical microglial activation suggest inflammation acts to protect prodromal Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-01-11. PMID:31898549. activated microglia, an intrinsic inflammatory response to brain lesions, are also known to be present in a majority of alzheimer or mild cognitive impaired (mci) subjects with raised β-amyloid load on their positron emission tomography (pet) imaging. 2021-01-11 2023-08-13 human
Alexander Levit, Sonny Cheng, Olivia Hough, Qingfan Liu, Yuksel Agca, Cansu Agca, Vladimir Hachinski, Shawn N Whitehea. Hypertension and Pathogenic hAPP Independently Induce White Matter Astrocytosis and Cognitive Impairment in the Rat. Frontiers in aging neuroscience. vol 12. 2021-01-10. PMID:32351378. although astrocytes and microglia play an important role in maintaining the neurovascular unit, astrocytes and microglia have been understudied in comorbid models of hypertension and alzheimer disease. 2021-01-10 2023-08-13 human
Georg Kislinger, Helmut Gnägi, Martin Kerschensteiner, Mikael Simons, Thomas Misgeld, Martina Schiffere. Multiscale ATUM-FIB Microscopy Enables Targeted Ultrastructural Analysis at Isotropic Resolution. iScience. vol 23. issue 7. 2021-01-10. PMID:32622266. we demonstrate the potential of this technique to reveal the ultrastructure of rare but pathologically important events by identifying microglia contact sites with amyloid plaques in a mouse model of familial alzheimer's disease. 2021-01-10 2023-08-13 mouse
Feng Zhang, Rujia Zhong, Song Li, Zhenfa Fu, Cheng Cheng, Huaibin Cai, Weidong L. Acute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-κB Signaling in Alzheimer's Disease Mice and Wild-Type Littermates. Frontiers in aging neuroscience. vol 9. 2021-01-09. PMID:28890695. acute hypoxia induced an imbalanced m1/m2 activation of microglia through nf-κb signaling in alzheimer's disease mice and wild-type littermates. 2021-01-09 2023-08-13 mouse
Poornima Sharma, Anjali Sharma, Faizana Fayaz, Sharad Wakode, Faheem H Potto. Biological Signatures of Alzheimer's Disease. Current topics in medicinal chemistry. vol 20. issue 9. 2021-01-08. PMID:32108008. likewise, microvascular changes, activation of microglia (immune defense system of cns), amyloid-beta aggregation, senile plaque and many more biomarkers are nearly found in all alzheimer's patients. 2021-01-08 2023-08-13 Not clear
Smita Eknath Desale, Subashchandrabose Chinnathamb. Role of dietary fatty acids in microglial polarization in Alzheimer's disease. Journal of neuroinflammation. vol 17. issue 1. 2021-01-06. PMID:32209097. we hypothesize that tuning microglia towards anti-inflammatory phenotype would reduce the propagation of tau in alzheimer's disease. 2021-01-06 2023-08-13 Not clear
Jie Pan, Nana Ma, Bo Yu, Wei Zhang, Jun Wa. Transcriptomic profiling of microglia and astrocytes throughout aging. Journal of neuroinflammation. vol 17. issue 1. 2021-01-06. PMID:32238175. activation of microglia and astrocytes, a prominent hallmark of both aging and alzheimer's disease (ad), has been suggested to contribute to aging and ad progression, but the underlying cellular and molecular mechanisms are largely unknown. 2021-01-06 2023-08-13 Not clear
Natalia Drost, Judith Houtman, Zoltán Cseresnyés, Raluca Niesner, Jan-Leo Rinnenthal, Kelly R Miller, Stefan Prokop, Frank L Heppne. The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin. Scientific reports. vol 10. issue 1. 2021-01-06. PMID:32346002. our data demonstrate that the aβ rich brain environment alters the functional characteristics of endogenous microglia as well as newly recruited peripheral myeloid cells, which has implications for the role of myeloid cells in disease and the utilization of these cells in alzheimer's disease therapy. 2021-01-06 2023-08-13 mouse
Benjamin B Tournier, Stergios Tsartsalis, Kelly Ceyzériat, Zadith Medina, Ben H Fraser, Marie-Claude Grégoire, Enikö Kövari, Philippe Mille. Fluorescence-activated cell sorting to reveal the cell origin of radioligand binding. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 6. 2021-01-05. PMID:31242048. in humans, we show that the increase in clinde binding in alzheimer's disease concerns microglia and astrocytes in the presence of a microglial expansion. 2021-01-05 2023-08-13 human
Joe C Udeochu, Jeremy M Shea, Saul A Villed. Microglia communication: Parallels between aging and Alzheimer's disease. Clinical & experimental neuroimmunology. vol 7. issue 2. 2020-12-29. PMID:27840659. microglia communication: parallels between aging and alzheimer's disease. 2020-12-29 2023-08-13 Not clear
Nicholas A Devanney, Andrew N Stewart, John C Gense. Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma. Experimental neurology. vol 329. 2020-12-24. PMID:32289316. lastly, we evaluate the evidence that metabolism regulates microglia and macrophage phenotype in vivo in models of alzheimer's disease (ad), stroke, traumatic brain injury (tbi) and spinal cord injury (sci). 2020-12-24 2023-08-13 Not clear
Sadayuki Hashioka, Ken Inoue, Haruo Takeshita, Masatoshi Inagak. Do Alzheimer's Disease Risk Gene Products Actually Act in Microglia? Frontiers in aging neuroscience. vol 12. 2020-12-22. PMID:33343331. do alzheimer's disease risk gene products actually act in microglia? 2020-12-22 2023-08-13 Not clear
Marta Olah, Vilas Menon, Naomi Habib, Mariko F Taga, Yiyi Ma, Christina J Yung, Maria Cimpean, Anthony Khairallah, Guillermo Coronas-Samano, Roman Sankowski, Dominic Grün, Alexandra A Kroshilina, Danielle Dionne, Rani A Sarkis, Garth R Cosgrove, Jeffrey Helgager, Jeffrey A Golden, Page B Pennell, Marco Prinz, Jean Paul G Vonsattel, Andrew F Teich, Julie A Schneider, David A Bennett, Aviv Regev, Wassim Elyaman, Elizabeth M Bradshaw, Philip L De Jage. Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-12-21. PMID:33257666. single cell rna sequencing of human microglia uncovers a subset associated with alzheimer's disease. 2020-12-21 2023-08-13 human
Season K Wyatt-Johnson, Randy R Brutkiewic. The Complexity of Microglial Interactions With Innate and Adaptive Immune Cells in Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2020-12-18. PMID:33328972. in alzheimer's disease (ad), there is high inflammation, reactive microglia, and astrocytes, leaky blood-brain barrier, the buildup of amyloid-beta (aβ) plaques, and neurofibrillary tangles which attract infiltrating peripheral immune cells that are interacting with the resident microglia. 2020-12-18 2023-08-13 mouse
M S Bobola, L Chen, C K Ezeokeke, T A Olmstead, C Nguyen, A Sahota, R G Williams, P D Moura. Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely and reduces Aβ load chronically, as demonstrated in vivo. Brain stimulation. vol 13. issue 4. 2020-12-04. PMID:32388044. (2016) [1] exposed 1 h of light flickering at 40 hz to awake 5xfad alzheimer's disease (ad) mouse models, generating action potentials at 40 hz, activating ∼54% of microglia to colocalize with aβ plaque, acutely, and clearing ∼ 50% of aβ plaque after seven days, but only in the visual cortex. 2020-12-04 2023-08-13 mouse
Heng-Bing Zu, Xin-Ying Liu, Kai Ya. DHCR24 overexpression modulates microglia polarization and inflammatory response via Akt/GSK3β signaling in Aβ Life sciences. vol 260. 2020-11-27. PMID:32950573. dhcr24 overexpression modulates microglia polarization and inflammatory response via akt/gsk3β signaling in aβ microglial phenotypic polarization, divided into pro-inflammatory "m1" phenotype and anti-inflammatory "m2" phenotype, played a crucial role in the pathogenesis of alzheimer's disease (ad). 2020-11-27 2023-08-13 Not clear