| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feng Zhang, Rujia Zhong, Song Li, Zhenfa Fu, Cheng Cheng, Huaibin Cai, Weidong L. Acute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-κB Signaling in Alzheimer's Disease Mice and Wild-Type Littermates. Frontiers in aging neuroscience. vol 9. 2021-01-09. PMID:28890695. |
acute hypoxia induced an imbalanced m1/m2 activation of microglia through nf-κb signaling in alzheimer's disease mice and wild-type littermates. |
2021-01-09 |
2023-08-13 |
mouse |
| Poornima Sharma, Anjali Sharma, Faizana Fayaz, Sharad Wakode, Faheem H Potto. Biological Signatures of Alzheimer's Disease. Current topics in medicinal chemistry. vol 20. issue 9. 2021-01-08. PMID:32108008. |
likewise, microvascular changes, activation of microglia (immune defense system of cns), amyloid-beta aggregation, senile plaque and many more biomarkers are nearly found in all alzheimer's patients. |
2021-01-08 |
2023-08-13 |
Not clear |
| Smita Eknath Desale, Subashchandrabose Chinnathamb. Role of dietary fatty acids in microglial polarization in Alzheimer's disease. Journal of neuroinflammation. vol 17. issue 1. 2021-01-06. PMID:32209097. |
we hypothesize that tuning microglia towards anti-inflammatory phenotype would reduce the propagation of tau in alzheimer's disease. |
2021-01-06 |
2023-08-13 |
Not clear |
| Jie Pan, Nana Ma, Bo Yu, Wei Zhang, Jun Wa. Transcriptomic profiling of microglia and astrocytes throughout aging. Journal of neuroinflammation. vol 17. issue 1. 2021-01-06. PMID:32238175. |
activation of microglia and astrocytes, a prominent hallmark of both aging and alzheimer's disease (ad), has been suggested to contribute to aging and ad progression, but the underlying cellular and molecular mechanisms are largely unknown. |
2021-01-06 |
2023-08-13 |
Not clear |
| Natalia Drost, Judith Houtman, Zoltán Cseresnyés, Raluca Niesner, Jan-Leo Rinnenthal, Kelly R Miller, Stefan Prokop, Frank L Heppne. The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin. Scientific reports. vol 10. issue 1. 2021-01-06. PMID:32346002. |
our data demonstrate that the aβ rich brain environment alters the functional characteristics of endogenous microglia as well as newly recruited peripheral myeloid cells, which has implications for the role of myeloid cells in disease and the utilization of these cells in alzheimer's disease therapy. |
2021-01-06 |
2023-08-13 |
mouse |
| Benjamin B Tournier, Stergios Tsartsalis, Kelly Ceyzériat, Zadith Medina, Ben H Fraser, Marie-Claude Grégoire, Enikö Kövari, Philippe Mille. Fluorescence-activated cell sorting to reveal the cell origin of radioligand binding. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 6. 2021-01-05. PMID:31242048. |
in humans, we show that the increase in clinde binding in alzheimer's disease concerns microglia and astrocytes in the presence of a microglial expansion. |
2021-01-05 |
2023-08-13 |
human |
| Joe C Udeochu, Jeremy M Shea, Saul A Villed. Microglia communication: Parallels between aging and Alzheimer's disease. Clinical & experimental neuroimmunology. vol 7. issue 2. 2020-12-29. PMID:27840659. |
microglia communication: parallels between aging and alzheimer's disease. |
2020-12-29 |
2023-08-13 |
Not clear |
| Nicholas A Devanney, Andrew N Stewart, John C Gense. Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma. Experimental neurology. vol 329. 2020-12-24. PMID:32289316. |
lastly, we evaluate the evidence that metabolism regulates microglia and macrophage phenotype in vivo in models of alzheimer's disease (ad), stroke, traumatic brain injury (tbi) and spinal cord injury (sci). |
2020-12-24 |
2023-08-13 |
Not clear |
| Sadayuki Hashioka, Ken Inoue, Haruo Takeshita, Masatoshi Inagak. Do Alzheimer's Disease Risk Gene Products Actually Act in Microglia? Frontiers in aging neuroscience. vol 12. 2020-12-22. PMID:33343331. |
do alzheimer's disease risk gene products actually act in microglia? |
2020-12-22 |
2023-08-13 |
Not clear |
| Marta Olah, Vilas Menon, Naomi Habib, Mariko F Taga, Yiyi Ma, Christina J Yung, Maria Cimpean, Anthony Khairallah, Guillermo Coronas-Samano, Roman Sankowski, Dominic Grün, Alexandra A Kroshilina, Danielle Dionne, Rani A Sarkis, Garth R Cosgrove, Jeffrey Helgager, Jeffrey A Golden, Page B Pennell, Marco Prinz, Jean Paul G Vonsattel, Andrew F Teich, Julie A Schneider, David A Bennett, Aviv Regev, Wassim Elyaman, Elizabeth M Bradshaw, Philip L De Jage. Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-12-21. PMID:33257666. |
single cell rna sequencing of human microglia uncovers a subset associated with alzheimer's disease. |
2020-12-21 |
2023-08-13 |
human |
| Season K Wyatt-Johnson, Randy R Brutkiewic. The Complexity of Microglial Interactions With Innate and Adaptive Immune Cells in Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2020-12-18. PMID:33328972. |
in alzheimer's disease (ad), there is high inflammation, reactive microglia, and astrocytes, leaky blood-brain barrier, the buildup of amyloid-beta (aβ) plaques, and neurofibrillary tangles which attract infiltrating peripheral immune cells that are interacting with the resident microglia. |
2020-12-18 |
2023-08-13 |
mouse |
| M S Bobola, L Chen, C K Ezeokeke, T A Olmstead, C Nguyen, A Sahota, R G Williams, P D Moura. Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely and reduces Aβ load chronically, as demonstrated in vivo. Brain stimulation. vol 13. issue 4. 2020-12-04. PMID:32388044. |
(2016) [1] exposed 1 h of light flickering at 40 hz to awake 5xfad alzheimer's disease (ad) mouse models, generating action potentials at 40 hz, activating ∼54% of microglia to colocalize with aβ plaque, acutely, and clearing ∼ 50% of aβ plaque after seven days, but only in the visual cortex. |
2020-12-04 |
2023-08-13 |
mouse |
| Heng-Bing Zu, Xin-Ying Liu, Kai Ya. DHCR24 overexpression modulates microglia polarization and inflammatory response via Akt/GSK3β signaling in Aβ Life sciences. vol 260. 2020-11-27. PMID:32950573. |
dhcr24 overexpression modulates microglia polarization and inflammatory response via akt/gsk3β signaling in aβ microglial phenotypic polarization, divided into pro-inflammatory "m1" phenotype and anti-inflammatory "m2" phenotype, played a crucial role in the pathogenesis of alzheimer's disease (ad). |
2020-11-27 |
2023-08-13 |
Not clear |
| Tamotsu Tsukahara, Hisao Haniu, Takeshi Uemura, Yoshikazu Matsud. Therapeutic Potential of Porcine Liver Decomposition Product: New Insights and Perspectives for Microglia-Mediated Neuroinflammation in Neurodegenerative Diseases. Biomedicines. vol 8. issue 11. 2020-11-27. PMID:33105637. |
we also highlight some recent findings regarding bidirectional interactions between lysophospholipids and microglia and age-related neurodegenerative diseases such as dementia and alzheimer's disease. |
2020-11-27 |
2023-08-13 |
Not clear |
| Jing Li, Runtian Zhao, Yuhan Jiang, Yi Xu, Huan Zhao, Xiaoling Lyu, Tao W. Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia. Food & function. vol 11. issue 2. 2020-11-23. PMID:32003387. |
altogether, we show for the first time that ba consumption reverses alzheimer's disease-induced cognitive disfunction, decreases hippocampal neuroinflammatory responses, and induces phagocytosis of microglia to beta-amyloid protein plaques by regulating the cd33/trem2/tyrobp signaling pathway in microglia. |
2020-11-23 |
2023-08-13 |
mouse |
| Neta Lax, Nina Fainstein, Yossi Nishri, Ayal Ben-Zvi, Tamir Ben-Hu. Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer's disease mice. Journal of neuroinflammation. vol 17. issue 1. 2020-11-23. PMID:32059733. |
accumulating data suggest a central role for brain microglia in mediating cortical neuronal death in alzheimer's disease (ad), and for toll-like receptor 2 (tlr2) in their toxic activation. |
2020-11-23 |
2023-08-13 |
mouse |
| Chunxu Yuan, Ailikemu Aierken, Zhen Xie, Nuomin Li, Juan Zhao, Hong Qin. The age-related microglial transformation in Alzheimer's disease pathogenesis. Neurobiology of aging. vol 92. 2020-11-18. PMID:32408056. |
neuroinflammatory responses mediated by microglia, the resident immune cells of the central nervous system, have long been a subject of study in the field of alzheimer's disease (ad). |
2020-11-18 |
2023-08-13 |
human |
| Astrid M Alsema, Qiong Jiang, Laura Kracht, Emma Gerrits, Marissa L Dubbelaar, Anneke Miedema, Nieske Brouwer, Elly M Hol, Jinte Middeldorp, Roland van Dijk, Maya Woodbury, Astrid Wachter, Simon Xi, Thomas Möller, Knut P Biber, Susanne M Kooistra, Erik W G M Boddeke, Bart J L Egge. Profiling Microglia From Alzheimer's Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue. Frontiers in molecular neuroscience. vol 13. 2020-11-17. PMID:33192286. |
profiling microglia from alzheimer's disease donors and non-demented elderly in acute human postmortem cortical tissue. |
2020-11-17 |
2023-08-13 |
mouse |
| Astrid M Alsema, Qiong Jiang, Laura Kracht, Emma Gerrits, Marissa L Dubbelaar, Anneke Miedema, Nieske Brouwer, Elly M Hol, Jinte Middeldorp, Roland van Dijk, Maya Woodbury, Astrid Wachter, Simon Xi, Thomas Möller, Knut P Biber, Susanne M Kooistra, Erik W G M Boddeke, Bart J L Egge. Profiling Microglia From Alzheimer's Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue. Frontiers in molecular neuroscience. vol 13. 2020-11-17. PMID:33192286. |
recent studies based on bulk and single-cell rna sequencing in mice indicate high relevance of microglia with respect to risk genes and neuro-inflammation in alzheimer's disease (ad). |
2020-11-17 |
2023-08-13 |
mouse |
| Zhishen Xie, Jianping Zhao, Hui Wang, Yali Jiang, Qiaoling Yang, Yu Fu, Huahui Zeng, Christian Hölscher, Jiangyan Xu, Zhenqiang Zhan. Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 124. 2020-11-12. PMID:32000045. |
magnolol alleviates alzheimer's disease-like pathology in transgenic c. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of ppar-γ. |
2020-11-12 |
2023-08-13 |
caenorhabditis_elegans |