| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunxu Yuan, Ailikemu Aierken, Zhen Xie, Nuomin Li, Juan Zhao, Hong Qin. The age-related microglial transformation in Alzheimer's disease pathogenesis. Neurobiology of aging. vol 92. 2020-11-18. PMID:32408056. |
neuroinflammatory responses mediated by microglia, the resident immune cells of the central nervous system, have long been a subject of study in the field of alzheimer's disease (ad). |
2020-11-18 |
2023-08-13 |
human |
| Astrid M Alsema, Qiong Jiang, Laura Kracht, Emma Gerrits, Marissa L Dubbelaar, Anneke Miedema, Nieske Brouwer, Elly M Hol, Jinte Middeldorp, Roland van Dijk, Maya Woodbury, Astrid Wachter, Simon Xi, Thomas Möller, Knut P Biber, Susanne M Kooistra, Erik W G M Boddeke, Bart J L Egge. Profiling Microglia From Alzheimer's Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue. Frontiers in molecular neuroscience. vol 13. 2020-11-17. PMID:33192286. |
profiling microglia from alzheimer's disease donors and non-demented elderly in acute human postmortem cortical tissue. |
2020-11-17 |
2023-08-13 |
mouse |
| Astrid M Alsema, Qiong Jiang, Laura Kracht, Emma Gerrits, Marissa L Dubbelaar, Anneke Miedema, Nieske Brouwer, Elly M Hol, Jinte Middeldorp, Roland van Dijk, Maya Woodbury, Astrid Wachter, Simon Xi, Thomas Möller, Knut P Biber, Susanne M Kooistra, Erik W G M Boddeke, Bart J L Egge. Profiling Microglia From Alzheimer's Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue. Frontiers in molecular neuroscience. vol 13. 2020-11-17. PMID:33192286. |
recent studies based on bulk and single-cell rna sequencing in mice indicate high relevance of microglia with respect to risk genes and neuro-inflammation in alzheimer's disease (ad). |
2020-11-17 |
2023-08-13 |
mouse |
| Zhishen Xie, Jianping Zhao, Hui Wang, Yali Jiang, Qiaoling Yang, Yu Fu, Huahui Zeng, Christian Hölscher, Jiangyan Xu, Zhenqiang Zhan. Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 124. 2020-11-12. PMID:32000045. |
magnolol alleviates alzheimer's disease-like pathology in transgenic c. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of ppar-γ. |
2020-11-12 |
2023-08-13 |
caenorhabditis_elegans |
| Suzanne E Hickman, Elizabeth K Allison, Uwanda Coleman, Nathan D Kingery-Gallagher, Joseph El Khour. Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice. Frontiers in immunology. vol 10. 2020-11-10. PMID:31849963. |
heterozygous cx3cr1 deficiency in microglia restores neuronal β-amyloid clearance pathways and slows progression of alzheimer's like-disease in ps1-app mice. |
2020-11-10 |
2023-08-13 |
mouse |
| Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G Aleph Prieto, Leslie M Thompson, Joan S Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jone. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-11-09. PMID:33097708. |
gene expression and functional deficits underlie trem2-knockout microglia responses in human models of alzheimer's disease. |
2020-11-09 |
2023-08-13 |
mouse |
| Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G Aleph Prieto, Leslie M Thompson, Joan S Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jone. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-11-09. PMID:33097708. |
the discovery of trem2 as a myeloid-specific alzheimer's disease (ad) risk gene has accelerated research into the role of microglia in ad. |
2020-11-09 |
2023-08-13 |
mouse |
| Erin G Reed-Geaghan, Andrew L Croxford, Burkhard Becher, Gary E Landret. Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model. The Journal of experimental medicine. vol 217. issue 4. 2020-11-06. PMID:31967645. |
plaque-associated myeloid cells derive from resident microglia in an alzheimer's disease model. |
2020-11-06 |
2023-08-13 |
Not clear |
| Jennifer J O'Brien, James P O'Callaghan, Diane B Miller, Suman Chalgeri, Lawrence P Wennogle, Robert E Davis, Gretchen L Snyder, Joseph P Hendric. Inhibition of calcium-calmodulin-dependent phosphodiesterase (PDE1) suppresses inflammatory responses. Molecular and cellular neurosciences. vol 102. 2020-11-05. PMID:31770590. |
the ability of pde1 inhibitors to prevent or dampen excessive inflammatory responses of bv2 cells and microglia provides a basis for exploring their therapeutic utility in the treatment of neurodegenerative diseases associated with increased inflammation and microglia proliferation such as parkinson's disease and alzheimer's disease. |
2020-11-05 |
2023-08-13 |
rat |
| Benjamin J Andreone, Laralynne Przybyla, Ceyda Llapashtica, Anil Rana, Sonnet S Davis, Bettina van Lengerich, Karin Lin, Ju Shi, Yuan Mei, Giuseppe Astarita, Gilbert Di Paolo, Thomas Sandmann, Kathryn M Monroe, Joseph W Lewcoc. Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia. Nature neuroscience. vol 23. issue 8. 2020-11-05. PMID:32514138. |
human genetic data indicate that microglial dysfunction contributes to the pathology of alzheimer's disease (ad), exemplified by the identification of coding variants in triggering receptor expressed on myeloid cells 2 (trem2) and, more recently, in plcg2, a phospholipase-encoding gene expressed in microglia. |
2020-11-05 |
2023-08-13 |
mouse |
| Tim Bartels, Sebastiaan De Schepper, Soyon Hon. Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases. Science (New York, N.Y.). vol 370. issue 6512. 2020-11-04. PMID:33004513. |
microglia modulate neurodegeneration in alzheimer's and parkinson's diseases. |
2020-11-04 |
2023-08-13 |
Not clear |
| Douglas G Walker, Tiffany M Tang, Anarmaa Mendsaikhan, Ikuo Tooyama, Geidy E Serrano, Lucia I Sue, Thomas G Beach, Lih-Fen Lu. Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains. International journal of molecular sciences. vol 21. issue 2. 2020-11-02. PMID:31968618. |
patterns of expression of purinergic receptor p2ry12, a putative marker for non-activated microglia, in aged and alzheimer's disease brains. |
2020-11-02 |
2023-08-13 |
Not clear |
| Luke W Bonham, Daniel W Sirkis, Jennifer S Yokoyam. The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease. Frontiers in immunology. vol 10. 2020-10-28. PMID:31214167. |
microglia, the brain-resident myeloid cells, are strongly implicated in alzheimer's disease (ad) pathogenesis by human genetics. |
2020-10-28 |
2023-08-13 |
human |
| Nàdia Villacampa, Michael T Henek. Microglia in Alzheimer's disease: Local heroes! The Journal of experimental medicine. vol 217. issue 4. 2020-10-27. PMID:32126139. |
microglia in alzheimer's disease: local heroes! |
2020-10-27 |
2023-08-13 |
Not clear |
| Kendra L Hanslik, Tyler K Ullan. The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease. Frontiers in neurology. vol 11. 2020-10-22. PMID:33071950. |
the role of microglia and the nlrp3 inflammasome in alzheimer's disease. |
2020-10-22 |
2023-08-13 |
Not clear |
| Nassir U Al-Khishman, Qi Qi, Austyn D Roseborough, Alexander Levit, Brian L Allman, Udunna C Anazodo, Matthew S Fox, Shawn N Whitehead, Jonathan D Thiesse. TSPO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat. EJNMMI research. vol 10. issue 1. 2020-10-16. PMID:32990808. |
this study aimed to test the ability of tspo to detect activated wm microglia that are immunohistochemically positive for mhcii in rat models of prodromal alzheimer's disease and acute subcortical stroke. |
2020-10-16 |
2023-08-13 |
rat |
| Kwangmin Cho, You-Jin Jang, Se-Jong Lee, Yu-Na Jeon, Young-Lim Shim, Ji-Yong Lee, Da-Som Lim, Dong-Hou Kim, Seung-Yong Yoo. TLQP-21 mediated activation of microglial BV2 cells promotes clearance of extracellular fibril amyloid-β. Biochemical and biophysical research communications. vol 524. issue 3. 2020-10-14. PMID:32037089. |
β-amyloid (aβ) plaque in the brains of patients with alzheimer's disease (ad) is mainly caused by impaired clearance of aβ by glial cells, including microglia and astrocytes. |
2020-10-14 |
2023-08-13 |
Not clear |
| Nobutaka Sakae, Michael G Heckman, Emily R Vargas, Minerva M Carrasquillo, Melissa E Murray, Koji Kasanuki, Nilufer Ertekin-Taner, Steven G Younkin, Dennis W Dickso. Evaluation of Associations of Alzheimer's Disease Risk Variants that Are Highly Expressed in Microglia with Neuropathological Outcome Measures. Journal of Alzheimer's disease : JAD. vol 70. issue 3. 2020-10-09. PMID:31256143. |
evaluation of associations of alzheimer's disease risk variants that are highly expressed in microglia with neuropathological outcome measures. |
2020-10-09 |
2023-08-13 |
Not clear |
| Nobutaka Sakae, Michael G Heckman, Emily R Vargas, Minerva M Carrasquillo, Melissa E Murray, Koji Kasanuki, Nilufer Ertekin-Taner, Steven G Younkin, Dennis W Dickso. Evaluation of Associations of Alzheimer's Disease Risk Variants that Are Highly Expressed in Microglia with Neuropathological Outcome Measures. Journal of Alzheimer's disease : JAD. vol 70. issue 3. 2020-10-09. PMID:31256143. |
a number of alzheimer's disease (ad) susceptibility loci are expressed abundantly in microglia. |
2020-10-09 |
2023-08-13 |
Not clear |
| Kalipada Paha. A Broad Application of CRISPR Cas9 in Infectious, Inflammatory and Neurodegenerative Diseases. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 4. 2020-10-05. PMID:31782056. |
as microglial activation is a hallmark of different neurodegenerative disorders including alzheimer's disease (ad), parkinson's disease (pd), hiv-associated neurocognitive disorders (hand), amyotrophic lateral sclerosis (als), etc., selective targeting of microglial cell signaling may be a valid option to control these neurodegenerative disorders with lesser side effects. |
2020-10-05 |
2023-08-13 |
Not clear |