| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Thei, Jennifer Imm, Eleni Kaisis, Mark L Dallas, Talitha L Kerriga. Microglia in Alzheimer's Disease: A Role for Ion Channels. Frontiers in neuroscience. vol 12. 2020-09-29. PMID:30323735. |
a wealth of evidence indicates a pivotal role for the innate immune system, such as microglia, and inflammation in the pathology of alzheimer's disease. |
2020-09-29 |
2023-08-13 |
human |
| Laura Thei, Jennifer Imm, Eleni Kaisis, Mark L Dallas, Talitha L Kerriga. Microglia in Alzheimer's Disease: A Role for Ion Channels. Frontiers in neuroscience. vol 12. 2020-09-29. PMID:30323735. |
in this review, we discuss the evidence for an array of microglia ion channels and their importance in modulating microglial homeostasis and how this process could be disrupted in alzheimer's disease. |
2020-09-29 |
2023-08-13 |
human |
| Laura Thei, Jennifer Imm, Eleni Kaisis, Mark L Dallas, Talitha L Kerriga. Microglia in Alzheimer's Disease: A Role for Ion Channels. Frontiers in neuroscience. vol 12. 2020-09-29. PMID:30323735. |
one promising avenue for assessing the role that microglia play in the initiation and progression of alzheimer's disease is through using induced pluripotent stem cell derived microglia. |
2020-09-29 |
2023-08-13 |
human |
| Laura Thei, Jennifer Imm, Eleni Kaisis, Mark L Dallas, Talitha L Kerriga. Microglia in Alzheimer's Disease: A Role for Ion Channels. Frontiers in neuroscience. vol 12. 2020-09-29. PMID:30323735. |
here, we examine what is already understood in terms of the molecular underpinnings of inflammation in alzheimer's disease, and the utility that inducible pluripotent stem cell derived microglia may have to advance this knowledge. |
2020-09-29 |
2023-08-13 |
human |
| Jun-Ichi Satoh, Yoshihiro Kino, Motoaki Yanaizu, Tsuyoshi Ishida, Yuko Sait. Microglia express gamma-interferon-inducible lysosomal thiol reductase in the brains of Alzheimer's disease and Nasu-Hakola disease. Intractable & rare diseases research. vol 7. issue 4. 2020-09-29. PMID:30560017. |
microglia express gamma-interferon-inducible lysosomal thiol reductase in the brains of alzheimer's disease and nasu-hakola disease. |
2020-09-29 |
2023-08-13 |
human |
| Adonis Sfera, Roberto Gradini, Michael Cummings, Eddie Diaz, Amy I Price, Carolina Osori. Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease. Frontiers in neurology. vol 9. 2020-09-29. PMID:30564191. |
rusty microglia: trainers of innate immunity in alzheimer's disease. |
2020-09-29 |
2023-08-13 |
Not clear |
| Sun-Hwa Lee, Kyoungho Su. Kinase-Based Taming of Brain Microglia Toward Disease-Modifying Therapy. Frontiers in cellular neuroscience. vol 12. 2020-09-29. PMID:30568577. |
chronic neuroinflammation mediated by activated microglia is now considered to be a common characteristic shared by many neurodegenerative diseases such as parkinson's disease, alzheimer's disease, and amyotrophic lateral sclerosis, which currently pose a significant socioeconomic burden to the global healthcare system. |
2020-09-29 |
2023-08-13 |
Not clear |
| James P Bennett, Paula M Keeney, David G Brohaw. RNA Sequencing Reveals Small and Variable Contributions of Infectious Agents to Transcriptomes of Postmortem Nervous Tissues From Amyotrophic Lateral Sclerosis, Alzheimer's Disease and Parkinson's Disease Subjects, and Increased Expression of Genes From Disease-Activated Microglia. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:30983949. |
rna sequencing reveals small and variable contributions of infectious agents to transcriptomes of postmortem nervous tissues from amyotrophic lateral sclerosis, alzheimer's disease and parkinson's disease subjects, and increased expression of genes from disease-activated microglia. |
2020-09-29 |
2023-08-13 |
human |
| James P Bennett, Paula M Keeney, David G Brohaw. RNA Sequencing Reveals Small and Variable Contributions of Infectious Agents to Transcriptomes of Postmortem Nervous Tissues From Amyotrophic Lateral Sclerosis, Alzheimer's Disease and Parkinson's Disease Subjects, and Increased Expression of Genes From Disease-Activated Microglia. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:30983949. |
nervous tissues from both humans with neurodegenerative diseases (ndd) and animals with genetic models of human ndd, such as rare monogenic causes of amyotrophic lateral sclerosis (als), alzheimer's disease (ad), and parkinson's disease (pd), show activated microglia, suggesting a potential causal role for inflammation in pathogenesis of ndd. |
2020-09-29 |
2023-08-13 |
human |
| Yihe Wang, Tianrui Zhu, Min Wang, Feng Zhang, Guitao Zhang, Jing Zhao, Yuanyuan Zhang, Erxi Wu, Xiaohong L. Icariin Attenuates M1 Activation of Microglia and Aβ Plaque Accumulation in the Hippocampus and Prefrontal Cortex by Up-Regulating PPARγ in Restraint/Isolation-Stressed APP/PS1 Mice. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31001073. |
studies have shown that psychosocial stress is involved in alzheimer's disease (ad) pathogenesis; it induces m1 microglia polarization and production of pro-inflammatory cytokines, leading to neurotoxic outcomes and decreased β-amyloid (aβ) clearance. |
2020-09-29 |
2023-08-13 |
mouse |
| Kritika Mittal, Ekaterina Eremenko, Omer Berner, Yehezqel Elyahu, Itai Strominger, Daniella Apelblat, Anna Nemirovsky, Ivo Spiegel, Alon Monsoneg. CD4 T Cells Induce A Subset of MHCII-Expressing Microglia that Attenuates Alzheimer Pathology. iScience. vol 16. 2020-09-29. PMID:31203186. |
cd4 t cells induce a subset of mhcii-expressing microglia that attenuates alzheimer pathology. |
2020-09-29 |
2023-08-13 |
mouse |
| Kritika Mittal, Ekaterina Eremenko, Omer Berner, Yehezqel Elyahu, Itai Strominger, Daniella Apelblat, Anna Nemirovsky, Ivo Spiegel, Alon Monsoneg. CD4 T Cells Induce A Subset of MHCII-Expressing Microglia that Attenuates Alzheimer Pathology. iScience. vol 16. 2020-09-29. PMID:31203186. |
microglia play a key role in innate immunity in alzheimer disease (ad), but their role as antigen-presenting cells is as yet unclear. |
2020-09-29 |
2023-08-13 |
mouse |
| Jun-Ichi Satoh, Yoshihiro Kino, Motoaki Yanaizu, Tsuyoshi Ishida, Yuko Sait. Microglia express GPNMB in the brains of Alzheimer's disease and Nasu-Hakola disease. Intractable & rare diseases research. vol 8. issue 2. 2020-09-29. PMID:31218162. |
microglia express gpnmb in the brains of alzheimer's disease and nasu-hakola disease. |
2020-09-29 |
2023-08-13 |
mouse |
| Adham Fani Maleki, Serge Rives. Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer's Disease and Multiple Sclerosis. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31427930. |
innate immune cells: monocytes, monocyte-derived macrophages and microglia as therapeutic targets for alzheimer's disease and multiple sclerosis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Adham Fani Maleki, Serge Rives. Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer's Disease and Multiple Sclerosis. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31427930. |
in this review, we briefly summarize and highlight the current state of knowledge of the differential contributions of microglia and monocytes in alzheimer's disease and multiple sclerosis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Haijun Wang, Yin Shen, Haoyu Chuang, Chengdi Chiu, Youfan Ye, Lei Zha. Neuroinflammation in Alzheimer's Disease: Microglia, Molecular Participants and Therapeutic Choices. Current Alzheimer research. vol 16. issue 7. 2020-09-28. PMID:31580243. |
neuroinflammation in alzheimer's disease: microglia, molecular participants and therapeutic choices. |
2020-09-28 |
2023-08-13 |
human |
| Haijun Wang, Yin Shen, Haoyu Chuang, Chengdi Chiu, Youfan Ye, Lei Zha. Neuroinflammation in Alzheimer's Disease: Microglia, Molecular Participants and Therapeutic Choices. Current Alzheimer research. vol 16. issue 7. 2020-09-28. PMID:31580243. |
in this review, we briefly summarized the involvement of microglia in the neuroinflammatory process of alzheimer's disease. |
2020-09-28 |
2023-08-13 |
human |
| Jun-Ichi Satoh, Yoshihiro Kino, Motoaki Yanaizu, Tsuyoshi Ishida, Yuko Sait. Microglia express TMEM119 in the brains of Nasu-Hakola disease. Intractable & rare diseases research. vol 8. issue 4. 2020-09-28. PMID:31890453. |
tmem119 was expressed on microglia in nhd brains as well as in the brains of non-neurological controls (nc) and alzheimer's disease (ad) patients, although tmem119-immunolabeled areas exhibited great variability from case to case without significant differences among the study population. |
2020-09-28 |
2023-08-13 |
human |
| Sophie C Gray, Kerri J Kinghorn, Nathaniel S Woodlin. Shifting equilibriums in Alzheimer's disease: the complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis. Neural regeneration research. vol 15. issue 7. 2020-09-28. PMID:31960800. |
shifting equilibriums in alzheimer's disease: the complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sophie C Gray, Kerri J Kinghorn, Nathaniel S Woodlin. Shifting equilibriums in Alzheimer's disease: the complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis. Neural regeneration research. vol 15. issue 7. 2020-09-28. PMID:31960800. |
reflecting the well-established roles of microglia in reacting to pathogens and inflammatory stimuli, there is now a growing literature describing both protective and detrimental effects for individual cytokines and chemokines produced by microglia in alzheimer's disease. |
2020-09-28 |
2023-08-13 |
Not clear |