| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abhishek Bhattacherjee, Emily Rodrigues, Jaesoo Jung, Matthew Luzentales-Simpson, Jhon R Enterina, Danny Galleguillos, Chris D St Laurent, Maryam Nakhaei-Nejad, Felix F Fuchsberger, Laura Streith, Qian Wang, Norihito Kawasaki, Shiteng Duan, Arjun Bains, James C Paulson, Christoph Rademacher, Fabrizio Giuliani, Simonetta Sipione, Matthew S Macaule. Repression of phagocytosis by human CD33 is not conserved with mouse CD33. Communications biology. vol 2. 2020-07-06. PMID:31815204. |
cd33 is an immunomodulatory receptor linked to alzheimer's disease (ad) susceptibility via regulation of phagocytosis in microglia. |
2020-07-06 |
2023-08-13 |
mouse |
| Mai Fujikura, Naotoshi Iwahara, Shin Hisahara, Jun Kawamata, Akihiro Matsumura, Kazuki Yokokawa, Taro Saito, Tatsuo Manabe, Takashi Matsushita, Syuuichirou Suzuki, Shun Shimoham. CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway. Journal of Alzheimer's disease : JAD. vol 68. issue 1. 2020-06-18. PMID:30775984. |
we previously demonstrated that microglia play an essential role in clearance of amyloid-β (aβ) in alzheimer's disease (ad)-like pathology. |
2020-06-18 |
2023-08-13 |
mouse |
| Carlo Sala Frigerio, Leen Wolfs, Nicola Fattorelli, Nicola Thrupp, Iryna Voytyuk, Inga Schmidt, Renzo Mancuso, Wei-Ting Chen, Maya E Woodbury, Gyan Srivastava, Thomas Möller, Eloise Hudry, Sudeshna Das, Takaomi Saido, Eric Karran, Bradley Hyman, V Hugh Perry, Mark Fiers, Bart De Stroope. The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques. Cell reports. vol 27. issue 4. 2020-06-17. PMID:31018141. |
the major risk factors for alzheimer's disease: age, sex, and genes modulate the microglia response to aβ plaques. |
2020-06-17 |
2023-08-13 |
Not clear |
| Djuna von Maydell, Mehdi Jorf. The interplay between microglial states and major risk factors in Alzheimer's disease through the eyes of single-cell RNA-sequencing: beyond black and white. Journal of neurophysiology. vol 122. issue 4. 2020-06-17. PMID:31365320. |
this spectrum spans heterogeneous populations of homeostatic and neuropathology-associated microglia in both healthy and alzheimer's disease (ad) mouse brains. |
2020-06-17 |
2023-08-13 |
mouse |
| Dafina M Angelova, David R Brow. Microglia and the aging brain: are senescent microglia the key to neurodegeneration? Journal of neurochemistry. vol 151. issue 6. 2020-06-11. PMID:31478208. |
while aged microglia have been frequently identified in neurodegenerative diseases such as alzheimer's disease, there is no conclusive evidence that proves a causal role. |
2020-06-11 |
2023-08-13 |
Not clear |
| Laufey Geirsdottir, Eyal David, Hadas Keren-Shaul, Assaf Weiner, Stefan Cornelius Bohlen, Jana Neuber, Adam Balic, Amir Giladi, Fadi Sheban, Charles-Antoine Dutertre, Christine Pfeifle, Francesca Peri, Antonella Raffo-Romero, Jacopo Vizioli, Kaspar Matiasek, Christian Scheiwe, Stephan Meckel, Kerstin Mätz-Rensing, Franziska van der Meer, Finnbogi Rutur Thormodsson, Christine Stadelmann, Noga Zilkha, Tali Kimchi, Florent Ginhoux, Igor Ulitsky, Daniel Erny, Ido Amit, Marco Prin. Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program. Cell. vol 179. issue 7. 2020-06-05. PMID:31835035. |
in addition, we observed notable differences in several gene modules of rodents compared with primate microglia, including complement, phagocytic, and susceptibility genes to neurodegeneration, such as alzheimer's and parkinson's disease. |
2020-06-05 |
2023-08-13 |
human |
| Yan Ji, Xiaowan Wang, Colin Kalicki, Blaise W Menta, Megan Baumgardner, Scott J Koppel, Ian W Weidling, Judit Perez-Ortiz, Heather M Wilkins, Russell H Swerdlo. Effects of Microglial Cytokines on Alzheimer's Disease-Related Phenomena. Journal of Alzheimer's disease : JAD. vol 67. issue 3. 2020-05-29. PMID:30714956. |
recent association studies indicate several genes highly expressed by microglia influence alzheimer's disease (ad) risk, which suggests microglial function contributes to this disease. |
2020-05-29 |
2023-08-13 |
mouse |
| Shahrnaz Kemal, Robert Vassa. Death by microglia. The Journal of experimental medicine. vol 216. issue 11. 2020-05-29. PMID:31645368. |
the roles of microglia and apoe in tauopathies, such as alzheimer's disease, remain elusive. |
2020-05-29 |
2023-08-13 |
mouse |
| T M Lancaster, M J Hill, R Sims, J William. Microglia - mediated immunity partly contributes to the genetic association between Alzheimer's disease and hippocampal volume. Brain, behavior, and immunity. vol 79. 2020-05-13. PMID:30776473. |
microglia - mediated immunity partly contributes to the genetic association between alzheimer's disease and hippocampal volume. |
2020-05-13 |
2023-08-13 |
Not clear |
| Shoutang Wang, Marco Colonn. Microglia in Alzheimer's disease: A target for immunotherapy. Journal of leukocyte biology. vol 106. issue 1. 2020-05-11. PMID:30725482. |
microglia in alzheimer's disease: a target for immunotherapy. |
2020-05-11 |
2023-08-13 |
Not clear |
| Shoutang Wang, Marco Colonn. Microglia in Alzheimer's disease: A target for immunotherapy. Journal of leukocyte biology. vol 106. issue 1. 2020-05-11. PMID:30725482. |
here, we review recent evidence implicating microglia in alzheimer's disease and discuss potential therapeutic strategies targeting microglia and their receptors in this disease. |
2020-05-11 |
2023-08-13 |
Not clear |
| Christel Claes, Johanna Van Den Daele, Ruben Boon, Sarah Schouteden, Alessio Colombo, Laura Sebastian Monasor, Mark Fiers, Laura Ordovás, FatemehArefeh Nami, Bernd Bohrmann, Sabina Tahirovic, Bart De Strooper, Catherine M Verfailli. Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 3. 2020-05-05. PMID:30442540. |
murine microglia expressing the alzheimer's disease-linked trem2 |
2020-05-05 |
2023-08-13 |
human |
| Jiae Park, Sun-Young Lee, Jeeheun Shon, Koeun Kim, Hyo Jin Lee, Kyung Ah Kim, Boo-Yong Lee, Seung-Hun Oh, Nam Keun Kim, Ok Joon Ki. Adalimumab improves cognitive impairment, exerts neuroprotective effects and attenuates neuroinflammation in an Aβ Cytotherapy. vol 21. issue 6. 2020-05-04. PMID:31076196. |
adalimumab improves cognitive impairment, exerts neuroprotective effects and attenuates neuroinflammation in an aβ the pathogenesis of alzheimer's disease (ad) is associated with an increased inflammatory response via activated microglia and astrocytes. |
2020-05-04 |
2023-08-13 |
Not clear |
| F Chris Bennett, Shane A Liddelo. Microglia Metabolic Breakdown Drives Alzheimer's Pathology. Cell metabolism. vol 30. issue 3. 2020-04-27. PMID:31484050. |
microglia metabolic breakdown drives alzheimer's pathology. |
2020-04-27 |
2023-08-13 |
Not clear |
| Julia K Götzl, Matthias Brendel, Georg Werner, Samira Parhizkar, Laura Sebastian Monasor, Gernot Kleinberger, Alessio-Vittorio Colombo, Maximilian Deussing, Matias Wagner, Juliane Winkelmann, Janine Diehl-Schmid, Johannes Levin, Katrin Fellerer, Anika Reifschneider, Sebastian Bultmann, Peter Bartenstein, Axel Rominger, Sabina Tahirovic, Scott T Smith, Charlotte Madore, Oleg Butovsky, Anja Capell, Christian Haas. Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. EMBO molecular medicine. vol 11. issue 6. 2020-04-24. PMID:31122931. |
a number of variants in genes selectively expressed in microglia are associated with an increased risk for neurodegenerative diseases such as alzheimer's disease (ad) and frontotemporal lobar degeneration (ftld). |
2020-04-24 |
2023-08-13 |
Not clear |
| Alexi Nott, Inge R Holtman, Nicole G Coufal, Johannes C M Schlachetzki, Miao Yu, Rong Hu, Claudia Z Han, Monique Pena, Jiayang Xiao, Yin Wu, Zahara Keulen, Martina P Pasillas, Carolyn O'Connor, Christian K Nickl, Simon T Schafer, Zeyang Shen, Robert A Rissman, James B Brewer, David Gosselin, David D Gonda, Michael L Levy, Michael G Rosenfeld, Graham McVicker, Fred H Gage, Bing Ren, Christopher K Glas. Brain cell type-specific enhancer-promoter interactome maps and disease Science (New York, N.Y.). vol 366. issue 6469. 2020-04-24. PMID:31727856. |
whereas psychiatric disorders were primarily associated with variants in transcriptional enhancers and promoters in neurons, sporadic alzheimer's disease (ad) variants were largely confined to microglia enhancers. |
2020-04-24 |
2023-08-13 |
human |
| T L Stephen, M Cacciottolo, D Balu, T E Morgan, M J LaDu, C E Finch, C J Pik. APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice. Acta neuropathologica communications. vol 7. issue 1. 2020-04-21. PMID:31113487. |
microglia affect alzheimer's disease (ad) pathogenesis in opposing manners, by protecting against amyloid accumulation in early phases of the disease and promoting neuropathology in advanced stages. |
2020-04-21 |
2023-08-13 |
mouse |
| Charlotte Madore, Zhuoran Yin, Jeffrey Leibowitz, Oleg Butovsk. Microglia, Lifestyle Stress, and Neurodegeneration. Immunity. vol 52. issue 2. 2020-04-21. PMID:31924476. |
in parallel, genetic association studies have identified several gene risk factors associated with alzheimer's disease that are specifically or highly expressed by microglia in the central nervous system (cns). |
2020-04-21 |
2023-08-13 |
human |
| Sijia Peng, Jingjing Jia, Jingjing Sun, Qizhi Xie, Xiaoyun Zhang, Yuanfei Deng, Li Y. LXW7 attenuates inflammation via suppressing Akt/nuclear factor kappa B and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated BV2 microglial cells. International immunopharmacology. vol 77. 2020-04-17. PMID:31732449. |
microglia activation is closely linked to ischemia, various chronic neurodegenerative diseases (e.g., alzheimer's disease, parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis), and many other central nervous system diseases. |
2020-04-17 |
2023-08-13 |
Not clear |
| Lih-Fen Lue, Thomas G Beach, Douglas G Walke. Alzheimer's Disease Research Using Human Microglia. Cells. vol 8. issue 8. 2020-04-13. PMID:31387311. |
alzheimer's disease research using human microglia. |
2020-04-13 |
2023-08-13 |
human |