| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marie-Kim St-Pierre, Maude Bordeleau, Marie-Ève Trembla. Visualizing Dark Microglia. Methods in molecular biology (Clifton, N.J.). vol 2034. 2020-04-01. PMID:31392680. |
dark microglia, a recently described phenotype, are found in high numbers in nonhomeostatic conditions (e.g., alzheimer's disease pathology, aging, chronic stress). |
2020-04-01 |
2023-08-13 |
Not clear |
| Daisuke Kato, Ako Ikegami, Hiroshi Horiuchi, Andrew J Moorhouse, Junichi Nabekura, Hiroaki Wak. In Vivo Two-Photon Imaging of Microglial Synapse Contacts. Methods in molecular biology (Clifton, N.J.). vol 2034. 2020-04-01. PMID:31392692. |
microglia are traditionally known as immune sentinels of the brain and as key player in the pathogenesis of neurodegenerative diseases such as alzheimer's disease, parkinson disease, or amyotrophic lateral sclerosis. |
2020-04-01 |
2023-08-13 |
Not clear |
| Jonas Elias Schweig, Hailan Yao, Kyle Coppola, Chao Jin, Fiona Crawford, Michael Mullan, Daniel Pari. Spleen tyrosine kinase (SYK) blocks autophagic Tau degradation The Journal of biological chemistry. vol 294. issue 36. 2020-03-31. PMID:31324720. |
moreover, syk hyperactivation occurs in a subset of activated microglia, in dystrophic neurites surrounding aβ deposits, and in neurons affected by tau pathology both in individuals with alzheimer's disease (ad) and in ad mouse models. |
2020-03-31 |
2023-08-13 |
mouse |
| Amanda McQuade, Mathew Blurton-Jone. Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk. Journal of molecular biology. vol 431. issue 9. 2020-03-19. PMID:30738892. |
microglia in alzheimer's disease: exploring how genetics and phenotype influence risk. |
2020-03-19 |
2023-08-13 |
Not clear |
| Amanda McQuade, Mathew Blurton-Jone. Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk. Journal of molecular biology. vol 431. issue 9. 2020-03-19. PMID:30738892. |
in alzheimer's disease (ad), a majority of risk loci discovered through genome-wide association studies were found in or near genes expressed most highly in microglia leading to the hypothesis that microglia play a much larger role in disease progression than previously thought. |
2020-03-19 |
2023-08-13 |
Not clear |
| Michael R Nichols, Marie-Kim St-Pierre, Ann-Christin Wendeln, Nyasha J Makoni, Lisa K Gouwens, Evan C Garrad, Mona Sohrabi, Jonas J Neher, Marie-Eve Tremblay, Colin K Comb. Inflammatory mechanisms in neurodegeneration. Journal of neurochemistry. vol 149. issue 5. 2020-03-13. PMID:30702751. |
this review discusses the profound connection between microglia, neuroinflammation, and alzheimer's disease (ad). |
2020-03-13 |
2023-08-13 |
Not clear |
| Gabriel Chew, Enrico Petrett. Transcriptional Networks of Microglia in Alzheimer's Disease and Insights into Pathogenesis. Genes. vol 10. issue 10. 2020-02-26. PMID:31614849. |
transcriptional networks of microglia in alzheimer's disease and insights into pathogenesis. |
2020-02-26 |
2023-08-13 |
Not clear |
| Gabriel Chew, Enrico Petrett. Transcriptional Networks of Microglia in Alzheimer's Disease and Insights into Pathogenesis. Genes. vol 10. issue 10. 2020-02-26. PMID:31614849. |
microglia, the main immune cells of the central nervous system, are increasingly implicated in alzheimer's disease (ad). |
2020-02-26 |
2023-08-13 |
Not clear |
| Lee-Way Jin, Jacopo Di Lucente, Hai M Nguyen, Vikrant Singh, Latika Singh, Monique Chavez, Trevor Bushong, Heike Wulff, Izumi Maezaw. Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease. Annals of clinical and translational neurology. vol 6. issue 4. 2020-02-18. PMID:31019997. |
microglia play a pivotal role in the initiation and progression of alzheimer's disease (ad). |
2020-02-18 |
2023-08-13 |
Not clear |
| Luis Salamanca, Naguib Mechawar, Keith K Murai, Rudi Balling, David S Bouvier, Alexander Skupi. MIC-MAC: An automated pipeline for high-throughput characterization and classification of three-dimensional microglia morphologies in mouse and human postmortem brain samples. Glia. vol 67. issue 8. 2020-02-10. PMID:30983036. |
our imaging-based approach enables automatic 3d-morphology characterization and classification of thousands of individual microglia in situ and revealed species- and disease-specific morphological phenotypes in mouse aging, human alzheimer's disease, and dementia with lewy bodie's samples. |
2020-02-10 |
2023-08-13 |
mouse |
| Onanong Mee-Inta, Zi-Wei Zhao, Yu-Min Ku. Physical Exercise Inhibits Inflammation and Microglial Activation. Cells. vol 8. issue 7. 2020-02-10. PMID:31324021. |
activated microglia and several pro-inflammatory cytokines play active roles in the pathogenesis of neurodegenerative diseases, such as alzheimer's disease and parkinson's disease. |
2020-02-10 |
2023-08-13 |
Not clear |
| Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli, Leen Wolfs, Sriram Balusu, Oliver Burton, Adrian Liston, Annerieke Sierksma, Yannick Fourne, Suresh Poovathingal, Amaia Arranz-Mendiguren, Carlo Sala Frigerio, Christel Claes, Lutgarde Serneels, Tom Theys, V Hugh Perry, Catherine Verfaillie, Mark Fiers, Bart De Stroope. Stem-cell-derived human microglia transplanted in mouse brain to study human disease. Nature neuroscience. vol 22. issue 12. 2020-01-31. PMID:31659342. |
although genetics highlights the role of microglia in alzheimer's disease, one-third of putative alzheimer's disease risk genes lack adequate mouse orthologs. |
2020-01-31 |
2023-08-13 |
mouse |
| Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli, Leen Wolfs, Sriram Balusu, Oliver Burton, Adrian Liston, Annerieke Sierksma, Yannick Fourne, Suresh Poovathingal, Amaia Arranz-Mendiguren, Carlo Sala Frigerio, Christel Claes, Lutgarde Serneels, Tom Theys, V Hugh Perry, Catherine Verfaillie, Mark Fiers, Bart De Stroope. Stem-cell-derived human microglia transplanted in mouse brain to study human disease. Nature neuroscience. vol 22. issue 12. 2020-01-31. PMID:31659342. |
the cells recapitulate transcriptionally human primary microglia ex vivo and show expression of human-specific alzheimer's disease risk genes. |
2020-01-31 |
2023-08-13 |
mouse |
| E Simon, J Obst, D Gomez-Nicol. The Evolving Dialogue of Microglia and Neurons in Alzheimer's Disease: Microglia as Necessary Transducers of Pathology. Neuroscience. vol 405. 2020-01-30. PMID:29427657. |
the evolving dialogue of microglia and neurons in alzheimer's disease: microglia as necessary transducers of pathology. |
2020-01-30 |
2023-08-13 |
Not clear |
| E Simon, J Obst, D Gomez-Nicol. The Evolving Dialogue of Microglia and Neurons in Alzheimer's Disease: Microglia as Necessary Transducers of Pathology. Neuroscience. vol 405. 2020-01-30. PMID:29427657. |
in this review, we dissect the different pathways by which microglia can affect, directly or indirectly, neuronal function and dysfunction associated with diseases like alzheimer's. |
2020-01-30 |
2023-08-13 |
Not clear |
| E Simon, J Obst, D Gomez-Nicol. The Evolving Dialogue of Microglia and Neurons in Alzheimer's Disease: Microglia as Necessary Transducers of Pathology. Neuroscience. vol 405. 2020-01-30. PMID:29427657. |
we here present the rationale for proposing a model to explain the contribution of microglia to the pathophysiology of alzheimer's disease, defining microglial cells as necessary transducers of pathology and ideal targets for intervention. |
2020-01-30 |
2023-08-13 |
Not clear |
| Gemma Manich, Mireia Recasens, Tony Valente, Beatriz Almolda, Berta González, Bernardo Castellan. Role of the CD200-CD200R Axis During Homeostasis and Neuroinflammation. Neuroscience. vol 405. 2020-01-30. PMID:30367946. |
due to their essential role in the regulation of neuroinflammatory response, microglia constitute an important target for neurological diseases, such as multiple sclerosis, alzheimer's or parkinson's disease. |
2020-01-30 |
2023-08-13 |
Not clear |
| Amy F Lloyd, Veronique E Miro. The pro-remyelination properties of microglia in the central nervous system. Nature reviews. Neurology. vol 15. issue 8. 2020-01-27. PMID:31256193. |
the most prominent example of the regenerative functions is a role for microglia in supporting regeneration of myelin after injury, a process that is critical for axonal health and relevant to numerous disorders in which loss of myelin integrity is a prevalent feature, such as multiple sclerosis, alzheimer disease and motor neuron disease. |
2020-01-27 |
2023-08-13 |
Not clear |
| Milena Jović, Nataša Lončarević-Vasiljković, Sanja Ivković, Jelena Dinić, Desanka Milanović, Berislav Zlokovic, Selma Kanazi. Short-term fish oil supplementation applied in presymptomatic stage of Alzheimer's disease enhances microglial/macrophage barrier and prevents neuritic dystrophy in parietal cortex of 5xFAD mouse model. PloS one. vol 14. issue 5. 2020-01-17. PMID:31095617. |
dystrophic neurites and activated microglia are one of the main neuropathological characteristics of alzheimer's disease (ad). |
2020-01-17 |
2023-08-13 |
mouse |
| Anirudh Patir, Barbara Shih, Barry W McColl, Tom C Freema. A core transcriptional signature of human microglia: Derivation and utility in describing region-dependent alterations associated with Alzheimer's disease. Glia. vol 67. issue 7. 2020-01-16. PMID:30758077. |
a core transcriptional signature of human microglia: derivation and utility in describing region-dependent alterations associated with alzheimer's disease. |
2020-01-16 |
2023-08-13 |
mouse |