| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A N vonderEmbse, Q Hu, J C DeWit. Dysfunctional microglia:neuron interactions with significant female bias in a developmental gene x environment rodent model of Alzheimer's disease. International immunopharmacology. vol 71. 2020-01-14. PMID:30927734. |
dysfunctional microglia:neuron interactions with significant female bias in a developmental gene x environment rodent model of alzheimer's disease. |
2020-01-14 |
2023-08-13 |
mouse |
| A N vonderEmbse, Q Hu, J C DeWit. Dysfunctional microglia:neuron interactions with significant female bias in a developmental gene x environment rodent model of Alzheimer's disease. International immunopharmacology. vol 71. 2020-01-14. PMID:30927734. |
signaling between microglia and neurons is poorly characterized in the pathophysiology of alzheimer's disease (ad), particularly with regards to gene and environmental (gxe) interactions early in life. |
2020-01-14 |
2023-08-13 |
mouse |
| Darshpreet Kaur, Vivek Sharma, Rahul Deshmuk. Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer's disease. Inflammopharmacology. vol 27. issue 4. 2020-01-09. PMID:30874945. |
activation of microglia and astrocytes: a roadway to neuroinflammation and alzheimer's disease. |
2020-01-09 |
2023-08-13 |
Not clear |
| Kimberley E Stuart, Anna E King, Natalie E King, Jessica M Collins, James C Vickers, Jenna M Ziebel. Late-life environmental enrichment preserves short-term memory and may attenuate microglia in male APP/PS1 mice. Neuroscience. vol 408. 2020-01-09. PMID:30999032. |
microglia, implicated in alzheimer's disease pathology, may mediate this effect. |
2020-01-09 |
2023-08-13 |
mouse |
| Judith Houtman, Kiara Freitag, Niclas Gimber, Jan Schmoranzer, Frank L Heppner, Marina Jendrac. Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3. The EMBO journal. vol 38. issue 4. 2020-01-06. PMID:30617086. |
thus, we investigated how an impairment of autophagy mediated by becn1/beclin1 reduction, as described in alzheimer's disease patients, would influence cytokine production of microglia. |
2020-01-06 |
2023-08-13 |
Not clear |
| Takayuki Inoue, Hajime Yamakage, Masashi Tanaka, Toru Kusakabe, Akira Shimatsu, Noriko Satoh-Asahar. Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia. Cells. vol 8. issue 6. 2019-12-23. PMID:31159306. |
microglia maintain brain homeostasis and modulate neuroinflammation and are implicated in the pathogenesis of various neurological diseases such as alzheimer's disease. |
2019-12-23 |
2023-08-13 |
mouse |
| Dario Tejera, Dilek Mercan, Juan M Sanchez-Caro, Mor Hanan, David Greenberg, Hermona Soreq, Eicke Latz, Douglas Golenbock, Michael T Henek. Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome. The EMBO journal. vol 38. issue 17. 2019-12-23. PMID:31359456. |
microglia, representing the brain's major innate immune cells, play an important role during alzheimer's. |
2019-12-23 |
2023-08-13 |
mouse |
| Diana K Franco-Bocanegra, Ciaran McAuley, James A R Nicoll, Delphine Boch. Molecular Mechanisms of Microglial Motility: Changes in Ageing and Alzheimer's Disease. Cells. vol 8. issue 6. 2019-12-18. PMID:31242692. |
evidence points to microglia as accountable for some of the changes observed in the brain during ageing, and microglia have a role in the development of neurodegenerative diseases, such as alzheimer's disease. |
2019-12-18 |
2023-08-13 |
Not clear |
| Bihua Bie, Jiang Wu, Joseph F Foss, Mohamed Nagui. Activation of mGluR1 Mediates C1q-Dependent Microglial Phagocytosis of Glutamatergic Synapses in Alzheimer's Rodent Models. Molecular neurobiology. vol 56. issue 8. 2019-12-12. PMID:30652266. |
microglia and complements appear to be involved in the synaptic and cognitive deficits in alzheimer's disease (ad), though the mechanisms remain elusive. |
2019-12-12 |
2023-08-13 |
Not clear |
| Yasuhisa Ano, Yuka Yoshino, Kazuyuki Uchida, Hiroyuki Nakayam. Preventive Effects of Tryptophan-Methionine Dipeptide on Neural Inflammation and Alzheimer's Pathology. International journal of molecular sciences. vol 20. issue 13. 2019-12-03. PMID:31261895. |
previously, we identified tryptophan-tyrosine (wy) and tryptophan-methionine (wm) peptides as the suppressants of activation of the primary microglia and showed that wy peptide consumption suppresses inflammation in the brains of alzheimer's disease model mice. |
2019-12-03 |
2023-08-13 |
mouse |
| Baban S Thawkar, Ginpreet Kau. Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer's disease. Journal of neuroimmunology. vol 326. 2019-11-29. PMID:30502599. |
inhibitors of nf-κb and p2x7/nlrp3/caspase 1 pathway in microglia: novel therapeutic opportunities in neuroinflammation induced early-stage alzheimer's disease. |
2019-11-29 |
2023-08-13 |
Not clear |
| Baban S Thawkar, Ginpreet Kau. Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer's disease. Journal of neuroimmunology. vol 326. 2019-11-29. PMID:30502599. |
compelling evidence suggests that neuroinflammation stimulated by microglia, the resident macrophage-like immune cells in the brain, play a contributing role in the pathogenesis of alzheimer's disease (ad). |
2019-11-29 |
2023-08-13 |
Not clear |
| Giuseppe Caruso, Claudia G Fresta, Nicolò Musso, Mariaconcetta Giambirtone, Margherita Grasso, Simona F Spampinato, Sara Merlo, Filippo Drago, Giuseppe Lazzarino, Maria A Sortino, Susan M Lunte, Filippo Carac. Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1. Cells. vol 8. issue 1. 2019-11-27. PMID:30658430. |
microglia play a central role in the pathogenesis of alzheimer's disease, promoting neuroinflammation through the secretion of inflammatory mediators and free radicals. |
2019-11-27 |
2023-08-13 |
Not clear |
| Boris-Stephan Rauchmann, Thomas Schneider-Axmann, Panagiotis Alexopoulos, Robert Perneczk. CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum. Neurobiology of aging. vol 74. 2019-11-26. PMID:30458365. |
trem2 was suggested to be an important regulator of microglia during neurodegeneration, but previous studies report conflicting results in relation to soluble trem2 (strem2) in cerebrospinal fluid (csf) when using clinical criteria to classify alzheimer's disease (ad). |
2019-11-26 |
2023-08-13 |
human |
| Xiaoxu Zhang, Piao Ye, Dandan Wang, Yunsheng Liu, Lan Cao, Yancong Wang, Yuxia Xu, Cuiqing Zh. Involvement of RhoA/ROCK Signaling in Aβ-Induced Chemotaxis, Cytotoxicity and Inflammatory Response of Microglial BV2 Cells. Cellular and molecular neurobiology. vol 39. issue 5. 2019-11-22. PMID:30852720. |
reactive microglia clustering around amyloid plaques in brain is a histopathological feature of alzheimer's disease (ad) and reflects the contribution of neuroinflammation in ad pathogenesis. |
2019-11-22 |
2023-08-13 |
mouse |
| Irina Alafuzoff, Margit Overmyer, Seppo Helisalmi, Hilkka Soinine. Lower Counts of Astroglia and Activated Microglia in Patients with Alzheimer's Disease with Regular Use of Non-Steroidal Anti-Inflammatory Drugs. Journal of Alzheimer's disease : JAD. vol 2. issue 1. 2019-11-20. PMID:12214109. |
lower counts of astroglia and activated microglia in patients with alzheimer's disease with regular use of non-steroidal anti-inflammatory drugs. |
2019-11-20 |
2023-08-12 |
Not clear |
| Irina Alafuzoff, Margit Overmyer, Seppo Helisalmi, Hilkka Soinine. Lower Counts of Astroglia and Activated Microglia in Patients with Alzheimer's Disease with Regular Use of Non-Steroidal Anti-Inflammatory Drugs. Journal of Alzheimer's disease : JAD. vol 2. issue 1. 2019-11-20. PMID:12214109. |
epidemiological studies have indicated that non-steroidal anti-inflammatory drugs (nsaid) may have some therapeutic effect in alzheimer's disease (ad) and experimental studies have shown that microglia activation by abeta-peptide (abeta-peptide. |
2019-11-20 |
2023-08-12 |
Not clear |
| Wolfgang J Streit, Robert E Mrak, W Sue T Griffi. Microglia and neuroinflammation: a pathological perspective. Journal of neuroinflammation. vol 1. issue 1. 2019-11-20. PMID:15285801. |
specific reference is made also to their involvement in alzheimer's disease where microglial cell activation is thought to be critically important in the neurodegenerative process. |
2019-11-20 |
2023-08-12 |
Not clear |
| Ronan J Kelly, Aedín M Minogue, Anthony Lyons, Raasay S Jones, Tara C Browne, Derek A Costello, Stephanie Denieffe, Catherine O'Sullivan, Thomas J Connor, Marina A Lync. Glial Activation in AβPP/PS1 Mice is Associated with Infiltration of IFNγ-Producing Cells. Journal of Alzheimer's disease : JAD. vol 37. issue 1. 2019-11-20. PMID:23780663. |
whereas the classical histological hallmarks of alzheimer's disease (ad) are deposition of amyloid-containing plaques and development of neurofibrillary tangles, there is also clear evidence of inflammatory changes accompanied by the presence of activated microglia and astrocytosis. |
2019-11-20 |
2023-08-12 |
mouse |
| Zhijun Zhao, Gang Luo, Min Liu, Huining Guo, Mengzhou Xue, Xinchun Wang, Xin-Min Li, Jue H. Quetiapine reduces microglial number in the hippocampus of a transgenic mouse model of Alzheimer's disease. Neuroreport. vol 25. issue 11. 2019-11-20. PMID:24911389. |
previous studies have suggested that the cerebral microglia activation was associated with aβ plaques, whereas quetiapine, an atypical antipsychotic drug, decreased aβ levels in alzheimer's disease (ad) mice. |
2019-11-20 |
2023-08-13 |
mouse |