| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Monika Plescher, Gerald Seifert, Jan Niklas Hansen, Peter Bedner, Christian Steinhäuser, Annett Hall. Plaque-dependent morphological and electrophysiological heterogeneity of microglia in an Alzheimer's disease mouse model. Glia. vol 66. issue 7. 2018-11-05. PMID:29493017. |
microglia, the central nervous system resident innate immune cells, cluster around aβ plaques in alzheimer's disease (ad). |
2018-11-05 |
2023-08-13 |
mouse |
| Teng Jiang, Ying-Dong Zhang, Qing Gao, Zhou Ou, Peng-Yu Gong, Jian-Quan Shi, Liang Wu, Jun-Shan Zho. TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response. Inflammation. vol 41. issue 3. 2018-10-10. PMID:29362997. |
as a recently identified susceptibility gene for alzheimer's disease (ad), triggering receptor expressed on myeloid cells 2 (trem2) encodes an immune receptor that is uniquely expressed on microglia, functioning as a modulator of microglial functions including phagocytosis and inflammatory response. |
2018-10-10 |
2023-08-13 |
mouse |
| Bingxu Huang, Dewei He, Guangxin Chen, Xin Ran, Wenjin Guo, Xingchi Kan, Wei Wang, Dianfeng Liu, Shoupeng Fu, Juxiong Li. α-Cyperone inhibits LPS-induced inflammation in BV-2 cells through activation of Akt/Nrf2/HO-1 and suppression of the NF-κB pathway. Food & function. vol 9. issue 5. 2018-10-03. PMID:29667667. |
accumulating evidence has shown that activated microglia cause inflammatory immune response, which could lead to neurodegenerative diseases such as parkinson's disease and alzheimer's disease. |
2018-10-03 |
2023-08-13 |
Not clear |
| Kazuyuki Takata, Takahide Amamiya, Hiroaki Mizoguchi, Shohei Kawanishi, Eriko Kuroda, Risa Kitamura, Aina Ito, Yuki Saito, Manami Tawa, Tomofumi Nagasawa, Haruka Okamoto, Yuko Sugino, Shigehiko Takegami, Tatsuya Kitade, Yuki Toda, William R Kem, Yoshihisa Kitamura, Shun Shimohama, Eishi Ashihar. Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 62. 2018-09-26. PMID:29175709. |
we previously demonstrated that stimulation of nicotinic acetylcholine receptors (nachrs) increases amyloid-β (aβ) phagocytosis in rat microglia and is closely associated with the decrease of brain aβ and amelioration of memory dysfunction in a transgenic mouse model of alzheimer's disease (ad). |
2018-09-26 |
2023-08-13 |
human |
| Diego Mastroeni, Jennifer Nolz, Shobana Sekar, Elaine Delvaux, Geidy Serrano, Lori Cuyugan, Winnie S Liang, Thomas G Beach, Joseph Rogers, Paul D Colema. Laser-captured microglia in the Alzheimer's and Parkinson's brain reveal unique regional expression profiles and suggest a potential role for hepatitis B in the Alzheimer's brain. Neurobiology of aging. vol 63. 2018-09-26. PMID:29207277. |
laser-captured microglia in the alzheimer's and parkinson's brain reveal unique regional expression profiles and suggest a potential role for hepatitis b in the alzheimer's brain. |
2018-09-26 |
2023-08-13 |
human |
| Tamas Halmos, Ilona Sub. [Alzheimer's disease and diabetes - the common pathogenesis]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 18. issue 1. 2018-09-14. PMID:27038867. |
as a consequence of hyperglycemia, glycation endproducts cause the development of amyloid plaques, dysruption of neurofibrilles, and activated microglia, all are typical to alzheimer's disease. |
2018-09-14 |
2023-08-13 |
human |
| Marc Fakhour. Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy. Current neuropharmacology. vol 16. issue 5. 2018-09-14. PMID:28730967. |
microglia and astrocytes in alzheimer's disease: implications for therapy. |
2018-09-14 |
2023-08-13 |
Not clear |
| Stephanie Ziegler-Waldkirch, Paolo d'Errico, Jonas-Frederic Sauer, Daniel Erny, Shakuntala Savanthrapadian, Desirée Loreth, Natalie Katzmarski, Thomas Blank, Marlene Bartos, Marco Prinz, Melanie Meyer-Luehman. Seed-induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer's disease. The EMBO journal. vol 37. issue 2. 2018-09-11. PMID:29229786. |
seed-induced aβ deposition is modulated by microglia under environmental enrichment in a mouse model of alzheimer's disease. |
2018-09-11 |
2023-08-13 |
mouse |
| Hua Bai, Bo Yang, Wenfeng Yu, Yan Xiao, Dejun Yu, Qifang Zhan. Cathepsin B links oxidative stress to the activation of NLRP3 inflammasome. Experimental cell research. vol 362. issue 1. 2018-09-07. PMID:29196167. |
oxidative stress-mediated activation of nlrp3 inflammasome in microglia is critical in the development of neurodegerative diseases such as alzheimer's disease (ad), parkinson disease (pd). |
2018-09-07 |
2023-08-13 |
Not clear |
| Namkwon Kim, Jimin Do, Jae-Sung Bae, Hee Kyung Jin, Jong-Ho Kim, Kyung-Soo Inn, Myung Sook Oh, Jong Kil Le. Piperlongumine inhibits neuroinflammation via regulating NF-κB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells. Journal of pharmacological sciences. vol 137. issue 2. 2018-09-07. PMID:29970291. |
however, the activation of abnormal microglia can be detrimental to neurons, even resulting in neurodegenerative diseases such as alzheimer's disease, parkinson's disease and huntington's disease. |
2018-09-07 |
2023-08-13 |
Not clear |
| Do Hee Kim, Hua Li, Yeong Eun Han, Ji Hye Jeong, Hwa Jin Lee, Jae-Ha Ry. Modulation of Inducible Nitric Oxide Synthase Expression in LPS-Stimulated BV-2 Microglia by Prenylated Chalcones from Cullen corylifolium (L.) Medik. through Inhibition of I-κBα Degradation. Molecules (Basel, Switzerland). vol 23. issue 1. 2018-09-03. PMID:29300354. |
the overproduction of nitric oxide (no) and prostaglandin e₂ (pge₂) by microglia may cause neurodegenerative diseases, such as alzheimer's disease and parkinson's disease. |
2018-09-03 |
2023-08-13 |
Not clear |
| Lalita Subedi, Oh Wook Kwon, Chaeho Pak, Goeun Lee, Kangwoo Lee, Hakwon Kim, Sun Yeou Ki. N,N-disubstituted azines attenuate LPS-mediated neuroinflammation in microglia and neuronal apoptosis via inhibiting MAPK signaling pathways. BMC neuroscience. vol 18. issue 1. 2018-08-13. PMID:29281977. |
activated microglia interact with astrocytes and neuronal cells to induce neuroinflammation, which can contribute to the pathogenesis and progression of alzheimer's and parkinson's disease. |
2018-08-13 |
2023-08-13 |
Not clear |
| Jiezhong Yu, Qingfang Gu, Yuqing Yan, Hongqiang Yu, Minfang Guo, Chunyun Liu, Guobin Song, Zhi Chai, Qing Wang, Baoguo Xiao, Hanting Zhang, Yuqiang Jiang, Cungen M. [Fasudil improves cognition of APP/PS1 transgenic mice via inhibiting the activation of microglia and shifting microglia phenotypes from M1 to M2]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 12. 2018-08-09. PMID:29382415. |
objective to examine the regulatory effects of rho kinase inhibitor fasudil on cognition and microglia polarization in app/ps1 transgenic (app/ps1 tg) mice, a widely used model of alzheimer's disease (ad). |
2018-08-09 |
2023-08-13 |
mouse |
| Tatsuhiro Akaishi, Kazuho Ab. CNB-001, a synthetic pyrazole derivative of curcumin, suppresses lipopolysaccharide-induced nitric oxide production through the inhibition of NF-κB and p38 MAPK pathways in microglia. European journal of pharmacology. vol 819. 2018-08-06. PMID:29221948. |
since aberrant activation of microglia is involved in the pathogenesis of alzheimer's disease, the present study was undertaken to investigate the effect of cnb-001 on microglia-mediated inflammatory responses. |
2018-08-06 |
2023-08-13 |
rat |
| Carmen Mecca, Ileana Giambanco, Rosario Donato, Cataldo Arcur. Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. International journal of molecular sciences. vol 19. issue 1. 2018-08-03. PMID:29361745. |
moreover, microglia contribute to some neurodevelopmental disorders such as nasu-hakola disease (nhd), and to aged-associated neurodegenerative diseases, such as alzheimer's disease (ad), parkinson's disease (pd), and others. |
2018-08-03 |
2023-08-13 |
human |
| Gizelle M McCarthy, Sean P Farris, Yuri A Blednov, R Adron Harris, R Dayne Mayfiel. Microglial-specific transcriptome changes following chronic alcohol consumption. Neuropharmacology. vol 128. 2018-07-17. PMID:29101021. |
alterations in steady-state cellular function and over-activation of microglia can facilitate the initiation and progression of neuropathological conditions such as alzheimer's disease, multiple sclerosis, and major depressive disorder. |
2018-07-17 |
2023-08-13 |
Not clear |
| Ashley McDonough, Richard V Lee, Jonathan R Weinstei. Microglial Interferon Signaling and White Matter. Neurochemical research. vol 42. issue 9. 2018-07-09. PMID:28540600. |
other recent studies implicate "microgliopathies" more broadly in neurological disorders including alzheimer's disease (ad) and ms, suggesting that microglia are a potential therapeutic target for disease prevention and/or treatment, with interferon signaling playing a key role in regulating the microglial phenotype. |
2018-07-09 |
2023-08-13 |
mouse |
| Nareshwaran Gnanasegaran, Vijayendran Govindasamy, Vasudevan Mani, Noor Hayaty Abu Kasi. Neuroimmunomodulatory properties of DPSCs in an in vitro model of Parkinson's disease. IUBMB life. vol 69. issue 9. 2018-06-26. PMID:28685937. |
in neurodegenerative diseases, such as alzheimer's and parkinson's, microglial cell activation is thought to contribute to their degeneration by producing neurotoxic compounds. |
2018-06-26 |
2023-08-13 |
human |
| Dimitry Ofengeim, Sonia Mazzitelli, Yasushi Ito, Judy Park DeWitt, Lauren Mifflin, Chengyu Zou, Sudeshna Das, Xian Adiconis, Hongbo Chen, Hong Zhu, Michelle A Kelliher, Joshua Z Levin, Junying Yua. RIPK1 mediates a disease-associated microglial response in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 41. 2018-06-26. PMID:28904096. |
dysfunction of microglia is known to play an important role in alzheimer's disease (ad). |
2018-06-26 |
2023-08-13 |
mouse |
| Hansruedi Mathys, Chinnakkaruppan Adaikkan, Fan Gao, Jennie Z Young, Elodie Manet, Martin Hemberg, Philip L De Jager, Richard M Ransohoff, Aviv Regev, Li-Huei Tsa. Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution. Cell reports. vol 21. issue 2. 2018-06-13. PMID:29020624. |
microglia, the tissue-resident macrophages in the brain, are damage sensors that react to nearly any perturbation, including neurodegenerative diseases such as alzheimer's disease (ad). |
2018-06-13 |
2023-08-13 |
mouse |