| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Atsushi Sasak. Microglia and brain macrophages: An update. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 37. issue 5. 2018-06-11. PMID:27859676. |
activated microglia often secrete inflammatory cytokines in various diseases, including alzheimer's disease, but microglial activation is not always associated with inflammation. |
2018-06-11 |
2023-08-13 |
human |
| Wen Fu, Vlatka Vukojevic, Aarti Patel, Rania Soudy, David MacTavish, David Westaway, Kamaljit Kaur, Valeri Goncharuk, Jack Jhamanda. Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation. Journal of neuroinflammation. vol 14. issue 1. 2018-06-06. PMID:28985759. |
neuroinflammation in the brain consequent to activation of microglia is viewed as an important component of alzheimer's disease (ad) pathology. |
2018-06-06 |
2023-08-13 |
human |
| Francesca Regen, Julian Hellmann-Regen, Erica Costantini, Marcella Real. Neuroinflammation and Alzheimer's Disease: Implications for Microglial Activation. Current Alzheimer research. vol 14. issue 11. 2018-06-04. PMID:28164764. |
with growing knowledge about microglia functions in surveying the brain for alterations, microglial activation is increasingly discussed in the context of disease progression and pathogenesis of alzheimer's disease (ad). |
2018-06-04 |
2023-08-13 |
Not clear |
| Marcelo N N Vieira, Danielle Beckma. Training Microglia to Resist Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 3. 2018-05-30. PMID:28100733. |
training microglia to resist alzheimer's disease. |
2018-05-30 |
2023-08-13 |
Not clear |
| Dibyadeep Datt. APP Modulates Aβ-Induced Activation of Microglia in Mouse Model of Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 2. 2018-05-28. PMID:28077703. |
app modulates aβ-induced activation of microglia in mouse model of alzheimer's disease. |
2018-05-28 |
2023-08-13 |
mouse |
| Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F Lichtenthaler, Harald Steiner, Christian Haas. An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. EMBO molecular medicine. vol 9. issue 10. 2018-05-24. PMID:28855300. |
sequence variations occurring in the gene encoding the triggering receptor expressed on myeloid cells 2 (trem2) support an essential function of microglia and innate immunity in the pathogenesis of alzheimer's disease (ad) and other neurodegenerative disorders. |
2018-05-24 |
2023-08-13 |
Not clear |
| Soyon Hong, Beth Steven. TREM2: Keeping Microglia Fit during Good Times and Bad. Cell metabolism. vol 26. issue 4. 2018-05-22. PMID:28978423. |
microglia are the macrophages of the brain and play an important role in alzheimer's disease (ad). |
2018-05-22 |
2023-08-13 |
Not clear |
| Urte Neniskyte, Michael Fricker, Guy C Brow. Amyloid β induces microglia to phagocytose neurons via activation of protein kinase Cs and NADPH oxidase. The international journal of biochemistry & cell biology. vol 81. issue Pt B. 2018-05-15. PMID:27267660. |
thus inhibiting protein kinase cs or nadph oxidase might be beneficial in alzheimer's disease or other brain pathologies involving inflammatory neuronal loss mediated by microglia. |
2018-05-15 |
2023-08-13 |
Not clear |
| Christian Humpe. Platelets: Their Potential Contribution to the Generation of Beta-amyloid Plaques in Alzheimer's Disease. Current neurovascular research. vol 14. issue 3. 2018-05-14. PMID:28677497. |
alzheimer's disease is a severe neurodegenerative brain disorder, showing severe beta-amyloid depositions in the brain (plaques) and in vessels (cerebral amyloid angiopathy, caa), tau pathology, neurodegeneration (and loss of acetylcholine), inflammation with reactive astrocytes and microglia and cerebrovascular damage, all resulting in memory loss. |
2018-05-14 |
2023-08-13 |
Not clear |
| Yawei Hu, Ziling Zeng, Baojie Wang, Shougang Gu. Trans-caryophyllene inhibits amyloid β (Aβ) oligomer-induced neuroinflammation in BV-2 microglial cells. International immunopharmacology. vol 51. 2018-05-10. PMID:28821008. |
amyloid β (aβ) is the major component of senile plaques (sp) in the brains of alzheimer's disease (ad) patients, and serves as an inflammatory stimulus for microglia. |
2018-05-10 |
2023-08-13 |
Not clear |
| Marissa A Tafoya, Saaussan Madi, Laurel O Silleru. Superparamagnetic nanoparticle-enhanced MRI of Alzheimer's disease plaques and activated microglia in 3X transgenic mouse brains: Contrast optimization. Journal of magnetic resonance imaging : JMRI. vol 46. issue 2. 2018-05-07. PMID:27875002. |
superparamagnetic nanoparticle-enhanced mri of alzheimer's disease plaques and activated microglia in 3x transgenic mouse brains: contrast optimization. |
2018-05-07 |
2023-08-13 |
mouse |
| Marissa A Tafoya, Saaussan Madi, Laurel O Silleru. Superparamagnetic nanoparticle-enhanced MRI of Alzheimer's disease plaques and activated microglia in 3X transgenic mouse brains: Contrast optimization. Journal of magnetic resonance imaging : JMRI. vol 46. issue 2. 2018-05-07. PMID:27875002. |
to optimize magnetic resonance imaging (mri) of antibody-conjugated superparamagnetic nanoparticles for detecting amyloid-β plaques and activated microglia in a 3x transgenic mouse model of alzheimer's disease. |
2018-05-07 |
2023-08-13 |
mouse |
| Carmen Venegas, Sathish Kumar, Bernardo S Franklin, Tobias Dierkes, Rebecca Brinkschulte, Dario Tejera, Ana Vieira-Saecker, Stephanie Schwartz, Francesco Santarelli, Markus P Kummer, Angelika Griep, Ellen Gelpi, Michael Beilharz, Dietmar Riedel, Douglas T Golenbock, Matthias Geyer, Jochen Walter, Eicke Latz, Michael T Henek. Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease. Nature. vol 552. issue 7685. 2018-05-03. PMID:29293211. |
in patients with alzheimer's disease, deposition of amyloid-β is accompanied by activation of the innate immune system and involves inflammasome-dependent formation of asc specks in microglia. |
2018-05-03 |
2023-08-13 |
Not clear |
| Ricardo Taipa, Paulo Brochado, Andrew Robinson, Inês Reis, Patrício Costa, David M Mann, Manuel Melo Pires, Nuno Sous. Patterns of Microglial Cell Activation in Alzheimer Disease and Frontotemporal Lobar Degeneration. Neuro-degenerative diseases. vol 17. issue 4-5. 2018-04-25. PMID:28445885. |
patterns of microglial cell activation in alzheimer disease and frontotemporal lobar degeneration. |
2018-04-25 |
2023-08-13 |
Not clear |
| Ricardo Taipa, Paulo Brochado, Andrew Robinson, Inês Reis, Patrício Costa, David M Mann, Manuel Melo Pires, Nuno Sous. Patterns of Microglial Cell Activation in Alzheimer Disease and Frontotemporal Lobar Degeneration. Neuro-degenerative diseases. vol 17. issue 4-5. 2018-04-25. PMID:28445885. |
in this study, we sought to characterize the distribution of microglial cell activation in 2 neurodegenerative dementias with distinct protein signatures, alzheimer disease (ad) and frontotemporal lobar degeneration (ftld) of the tdp subtype, and to determine if there was an anatomical correlation with the phenotypes most commonly associated with these conditions. |
2018-04-25 |
2023-08-13 |
Not clear |
| R A Thuraisingha. Examining the Role of Microglia and Astroglia During the Pathogenesis of Alzheimer's Disease via the Puri-Li Model. Journal of molecular neuroscience : MN. vol 62. issue 3-4. 2018-04-23. PMID:28707174. |
examining the role of microglia and astroglia during the pathogenesis of alzheimer's disease via the puri-li model. |
2018-04-23 |
2023-08-13 |
Not clear |
| R A Thuraisingha. Examining the Role of Microglia and Astroglia During the Pathogenesis of Alzheimer's Disease via the Puri-Li Model. Journal of molecular neuroscience : MN. vol 62. issue 3-4. 2018-04-23. PMID:28707174. |
the puri-li kinetic model is explored here to study the contribution of microglia and astroglia during the pathogenesis of alzheimer's disease (ad). |
2018-04-23 |
2023-08-13 |
Not clear |
| Ruohe Zhao, Wanling Hu, Julia Tsai, Wei Li, Wen-Biao Ga. Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer's disease. Molecular neurodegeneration. vol 12. issue 1. 2018-04-17. PMID:28606182. |
microglia limit the expansion of β-amyloid plaques in a mouse model of alzheimer's disease. |
2018-04-17 |
2023-08-13 |
mouse |
| Ruohe Zhao, Wanling Hu, Julia Tsai, Wei Li, Wen-Biao Ga. Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer's disease. Molecular neurodegeneration. vol 12. issue 1. 2018-04-17. PMID:28606182. |
β-amyloid (aβ) plaques in the brain of alzheimer's disease (ad) are surrounded by microglia, but whether and how microglia affect the formation and maintenance of plaques remains controversial. |
2018-04-17 |
2023-08-13 |
mouse |
| Richa Hanamsagar, Mark D Alter, Carina S Block, Haley Sullivan, Jessica L Bolton, Staci D Bilb. Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity. Glia. vol 65. issue 9. 2018-04-12. PMID:28618077. |
next, a microglial developmental index (mdi) generated from gene expression patterns obtained from purified mouse microglia, was applied to human brain transcriptome datasets to test the hypothesis that variability in microglial development is associated with human diseases such as alzheimer's and autism where microglia have been suggested to play a role. |
2018-04-12 |
2023-08-13 |
mouse |