| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Petra Füger, Jasmin K Hefendehl, Karthik Veeraraghavalu, Ann-Christin Wendeln, Christine Schlosser, Ulrike Obermüller, Bettina M Wegenast-Braun, Jonas J Neher, Peter Martus, Shinichi Kohsaka, Martin Thunemann, Robert Feil, Sangram S Sisodia, Angelos Skodras, Mathias Jucke. Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging. Nature neuroscience. vol 20. issue 10. 2017-10-06. PMID:28846081. |
microglia turnover with aging and in an alzheimer's model via long-term in vivo single-cell imaging. |
2017-10-06 |
2023-08-13 |
mouse |
| Petra Füger, Jasmin K Hefendehl, Karthik Veeraraghavalu, Ann-Christin Wendeln, Christine Schlosser, Ulrike Obermüller, Bettina M Wegenast-Braun, Jonas J Neher, Peter Martus, Shinichi Kohsaka, Martin Thunemann, Robert Feil, Sangram S Sisodia, Angelos Skodras, Mathias Jucke. Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging. Nature neuroscience. vol 20. issue 10. 2017-10-06. PMID:28846081. |
while proliferation of resident neocortical microglia under homeostatic conditions was low, microglial proliferation in a mouse model of alzheimer's β-amyloidosis was increased threefold. |
2017-10-06 |
2023-08-13 |
mouse |
| Diego Mastroeni, Shobana Sekar, Jennifer Nolz, Elaine Delvaux, Katie Lunnon, Jonathan Mill, Winnie S Liang, Paul D Colema. ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity. PloS one. vol 12. issue 7. 2017-09-26. PMID:28700589. |
ank1 is up-regulated in laser captured microglia in alzheimer's brain; the importance of addressing cellular heterogeneity. |
2017-09-26 |
2023-08-13 |
Not clear |
| Rosa C Paolicelli, Ali Jawaid, Christopher M Henstridge, Andrea Valeri, Mario Merlini, John L Robinson, Edward B Lee, Jamie Rose, Stanley Appel, Virginia M-Y Lee, John Q Trojanowski, Tara Spires-Jones, Paul E Schulz, Lawrence Rajendra. TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. Neuron. vol 95. issue 2. 2017-09-14. PMID:28669544. |
mice lacking tdp-43 in microglia exhibit reduced amyloid load in a model of alzheimer's disease (ad) but at the same time display drastic synapse loss, even in the absence of amyloid. |
2017-09-14 |
2023-08-13 |
mouse |
| Marc Suárez-Calvet, Gernot Kleinberger, Miguel Ángel Araque Caballero, Matthias Brendel, Axel Rominger, Daniel Alcolea, Juan Fortea, Alberto Lleó, Rafael Blesa, Juan Domingo Gispert, Raquel Sánchez-Valle, Anna Antonell, Lorena Rami, José L Molinuevo, Frederic Brosseron, Andreas Traschütz, Michael T Heneka, Hanne Struyfs, Sebastiaan Engelborghs, Kristel Sleegers, Christine Van Broeckhoven, Henrik Zetterberg, Bengt Nellgård, Kaj Blennow, Alexander Crispin, Michael Ewers, Christian Haas. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. EMBO molecular medicine. vol 8. issue 5. 2017-09-13. PMID:26941262. |
strem2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage alzheimer's disease and associate with neuronal injury markers. |
2017-09-13 |
2023-08-13 |
Not clear |
| Francisca Cornejo, Rommy von Bernhard. Age-Dependent Changes in the Activation and Regulation of Microglia. Advances in experimental medicine and biology. vol 949. 2017-09-12. PMID:27714691. |
in addition, we will discuss the effects of aged microglia on neuronal function and their participation in the development of neurodegenerative pathologies such as parkinson's and alzheimer's diseases. |
2017-09-12 |
2023-08-13 |
Not clear |
| Risako Fujikawa, Sei Higuchi, Masato Nakatsuji, Mika Yasui, Taichi Ikedo, Manabu Nagata, Kosuke Hayashi, Masayuki Yokode, Manabu Minam. Deficiency in EP4 Receptor-Associated Protein Ameliorates Abnormal Anxiety-Like Behavior and Brain Inflammation in a Mouse Model of Alzheimer Disease. The American journal of pathology. vol 187. issue 8. 2017-09-12. PMID:28624505. |
microglia are thought to play key roles in the progression of alzheimer disease (ad). |
2017-09-12 |
2023-08-13 |
mouse |
| Jie Yin, Xiaocui Liu, Qing He, Lujun Zhou, Zengqiang Yuan, Siqi Zha. Vps35-dependent recycling of Trem2 regulates microglial function. Traffic (Copenhagen, Denmark). vol 17. issue 12. 2017-09-04. PMID:27717139. |
trem2 might be involved in the development of alzheimer's disease (ad) through regulating the inflammatory responses and phagocytosis of microglia. |
2017-09-04 |
2023-08-13 |
Not clear |
| Leah Zuroff, David Daley, Keith L Black, Maya Koronyo-Hamaou. Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes. Cellular and molecular life sciences : CMLS. vol 74. issue 12. 2017-08-28. PMID:28197669. |
clearance of cerebral aβ in alzheimer's disease: reassessing the role of microglia and monocytes. |
2017-08-28 |
2023-08-13 |
mouse |
| Felix L Yeh, Yuanyuan Wang, Irene Tom, Lino C Gonzalez, Morgan Shen. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. vol 91. issue 2. 2017-08-22. PMID:27477018. |
genetic variants of trem2, a protein expressed selectively by microglia in the brain, are associated with alzheimer's disease (ad). |
2017-08-22 |
2023-08-13 |
human |
| Debbie A E Hendrickx, Corbert G van Eden, Karianne G Schuurman, Jörg Hamann, Inge Huiting. Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology. Journal of neuroimmunology. vol 309. 2017-08-21. PMID:28601280. |
material was used from patients diagnosed with multiple sclerosis (ms) and alzheimer's disease (ad) patients and control subjects because together they contain all the microglia activation stages in an acute and a chronic inflammatory setting. |
2017-08-21 |
2023-08-13 |
human |
| Honghua Zheng, Lin Jia, Chia-Chen Liu, Zhouyi Rong, Li Zhong, Longyu Yang, Xiao-Fen Chen, John D Fryer, Xin Wang, Yun-Wu Zhang, Huaxi Xu, Guojun B. TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 7. 2017-08-18. PMID:28077724. |
triggering receptor expressed on myeloid cells 2 (trem2), which is expressed on myeloid cells including microglia in the cns, has recently been identified as a risk factor for alzheimer's disease (ad). |
2017-08-18 |
2023-08-13 |
Not clear |
| Eva Czirr, Nicholas A Castello, Kira I Mosher, Joseph M Castellano, Izumi V Hinkson, Kurt M Lucin, Bernat Baeza-Raja, Jae Kyu Ryu, Lulin Li, Sasha N Farina, Nadia P Belichenko, Frank M Longo, Katerina Akassoglou, Markus Britschgi, John R Cirrito, Tony Wyss-Cora. Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity. The Journal of experimental medicine. vol 214. issue 4. 2017-08-14. PMID:28298456. |
recent genetic evidence supports a link between microglia and the complement system in alzheimer's disease (ad). |
2017-08-14 |
2023-08-13 |
mouse |
| Kanchan Bisht, Hassan El Hajj, Julie C Savage, Maria G Sánchez, Marie-Ève Trembla. Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques. Journal of visualized experiments : JoVE. issue 112. 2017-08-11. PMID:27286292. |
a detailed protocol is provided here to identify amyloid aβ plaques in brain sections from alzheimer's disease mouse models before pre-embedding immunostaining (specifically for ionized calcium-binding adapter molecule 1 (iba1), a calcium binding protein expressed by microglia) and tissue processing for electron microscopy (em). |
2017-08-11 |
2023-08-13 |
mouse |
| Sandro Da Mesquita, Jonathan Kipni. DAMed in (Trem) 2 Steps. Cell. vol 169. issue 7. 2017-08-09. PMID:28622503. |
identify a unique population of disease-associated microglia (dam) that develop in two steps and may help to restrict damage in alzheimer and related diseases. |
2017-08-09 |
2023-08-13 |
Not clear |
| Santiago Solé-Domènech, Dana L Cruz, Estibaliz Capetillo-Zarate, Frederick R Maxfiel. The endocytic pathway in microglia during health, aging and Alzheimer's disease. Ageing research reviews. vol 32. 2017-08-04. PMID:27421577. |
the endocytic pathway in microglia during health, aging and alzheimer's disease. |
2017-08-04 |
2023-08-13 |
Not clear |
| Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendle. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. vol 90. issue 4. 2017-08-03. PMID:27196974. |
haplodeficiency of the microglia gene trem2 increases risk for late-onset alzheimer's disease (ad) but the mechanisms remain uncertain. |
2017-08-03 |
2023-08-13 |
mouse |
| Julien Muffat, Yun Li, Bingbing Yuan, Maisam Mitalipova, Attya Omer, Sean Corcoran, Grisilda Bakiasi, Li-Huei Tsai, Patrick Aubourg, Richard M Ransohoff, Rudolf Jaenisc. Efficient derivation of microglia-like cells from human pluripotent stem cells. Nature medicine. vol 22. issue 11. 2017-07-31. PMID:27668937. |
microglia, the only lifelong resident immune cells of the central nervous system (cns), are highly specialized macrophages that have been recognized to have a crucial role in neurodegenerative diseases such as alzheimer's, parkinson's and adrenoleukodystrophy (ald). |
2017-07-31 |
2023-08-13 |
mouse |
| Hadas Keren-Shaul, Amit Spinrad, Assaf Weiner, Orit Matcovitch-Natan, Raz Dvir-Szternfeld, Tyler K Ulland, Eyal David, Kuti Baruch, David Lara-Astaiso, Beata Toth, Shalev Itzkovitz, Marco Colonna, Michal Schwartz, Ido Ami. A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. Cell. vol 169. issue 7. 2017-07-24. PMID:28602351. |
a unique microglia type associated with restricting development of alzheimer's disease. |
2017-07-24 |
2023-08-13 |
mouse |
| Gunjan D Manocha, Angela M Floden, Keiko Rausch, Joshua A Kulas, Brett A McGregor, Lalida Rojanathammanee, Kelley R Puig, Kendra L Puig, Sanjib Karki, Michael R Nichols, Diane C Darland, James E Porter, Colin K Comb. APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 32. 2017-07-14. PMID:27511018. |
therefore, we hypothesized that app serves this function in microglia during alzheimer's disease. |
2017-07-14 |
2023-08-13 |
mouse |