| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ari Sudwarts, Gopal Thinakara. Alzheimer's genes in microglia: a risk worth investigating. Molecular neurodegeneration. vol 18. issue 1. 2023-11-24. PMID:37986179. |
alzheimer's genes in microglia: a risk worth investigating. |
2023-11-24 |
2023-11-28 |
mouse |
| Ari Sudwarts, Gopal Thinakara. Alzheimer's genes in microglia: a risk worth investigating. Molecular neurodegeneration. vol 18. issue 1. 2023-11-24. PMID:37986179. |
despite expressing many key risk genes, the role of microglia in late-onset alzheimer's disease pathophysiology is somewhat ambiguous, with various phenotypes reported to be either harmful or protective. |
2023-11-24 |
2023-11-28 |
mouse |
| Lysosome regulation of microglia in Alzheimer's disease via TFEB-vacuolar ATPase. Nature neuroscience. 2023-11-24. PMID:38001269. |
lysosome regulation of microglia in alzheimer's disease via tfeb-vacuolar atpase. |
2023-11-24 |
2023-11-28 |
Not clear |
| Marcel S Woo, Johanna Nilsson, Joseph Therriault, Nesrine Rahmouni, Ann Brinkmalm, Andrea L Benedet, Nicholas J Ashton, Arthur C Macedo, Stijn Servaes, Yi-Ting Wang, Cécile Tissot, Jaime Fernandez Arias, Seyyed Ali Hosseini, Mira Chamoun, Firoza Z Lussier, Thomas K Karikari, Jenna Stevenson, Christina Mayer, João Pedro Ferrari-Souza, Eliane Kobayashi, Gassan Massarweh, Manuel A Friese, Tharick A Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Net. 14-3-3 [Formula: see text]-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2. Journal of neuroinflammation. vol 20. issue 1. 2023-11-24. PMID:38001539. |
synaptic loss is closely associated with tau aggregation and microglia activation in later stages of alzheimer's disease (ad). |
2023-11-24 |
2023-11-28 |
Not clear |
| Oliver Cousins, Julia J Schubert, Avinash Chandra, Mattia Veronese, Polena Valkimadi, Byron Creese, Zunera Khan, Ryan Arathimos, Adam Hampshire, Ivana Rosenzweig, Clive Ballard, Anne Corbett, Dag Aasland, Latha Velayudhan, Michael O'Neill, David Collier, Ramla Awais, Kerstin Sander, Erik Årstad, Oliver Howes, Federico Turkheimer, Angela Hodge. Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge. Journal of neuroinflammation. vol 20. issue 1. 2023-11-22. PMID:37990275. |
microglia are increasingly understood to play an important role in the pathogenesis of alzheimer's disease. |
2023-11-22 |
2023-11-29 |
Not clear |
| Baiping Wang, Heidi Martini-Stoica, Chuangye Qi, Tzu-Chiao Lu, Shuo Wang, Wen Xiong, Yanyan Qi, Yin Xu, Marco Sardiello, Hongjie Li, Hui Zhen. TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy. Nature neuroscience. 2023-11-21. PMID:37985800. |
our studies demonstrate a physiological function of tfeb-v-atpase signaling in maintaining lysosomal homeostasis and a critical role of the lysosome in mounting a microglia and immune response in tauopathy and alzheimer's disease. |
2023-11-21 |
2023-11-29 |
mouse |
| Jian Jing Siew, Hui-Mei Chen, Feng-Lan Chiu, Chia-Wei Lee, Yao-Ming Chang, Hung-Lin Chen, Thi Ngoc Anh Nguyen, Hung-Ting Liao, Mengyu Liu, Hsiao-Tien Hagar, Yung-Chen Sun, Hsing-Lin Lai, Min-Hao Kuo, David Blum, Luc Buée, Lee-Way Jin, Shih-Yu Chen, Tai-Ming Ko, Jie-Rong Huang, Hung-Chih Kuo, Fu-Tong Liu, Yijuang Cher. Galectin-3 aggravates microglial activation and tau transmission in tauopathy. The Journal of clinical investigation. 2023-11-21. PMID:37988169. |
alzheimer's disease (ad) is characterized by the accumulation of amyloid-β plaques, aggregation of hyperphosphorylated tau (ptau), and microglia activation. |
2023-11-21 |
2023-11-29 |
mouse |
| Na Li, Mengdi Li, Minfang Guo, Tao Meng, Bingtao Mu, Jingwen Yu, Jiwei Wang, Lijuan Song, Cungen Ma, Jiezhong We. [Eriodictyol improves cognitive function in 5×FAD mice of Alzheimer's disease by inhibiting the microglia NLRP3 inflammasome signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 11. 2023-11-19. PMID:37980548. |
[eriodictyol improves cognitive function in 5×fad mice of alzheimer's disease by inhibiting the microglia nlrp3 inflammasome signaling pathway]. |
2023-11-19 |
2023-11-20 |
mouse |
| Na Li, Mengdi Li, Minfang Guo, Tao Meng, Bingtao Mu, Jingwen Yu, Jiwei Wang, Lijuan Song, Cungen Ma, Jiezhong We. [Eriodictyol improves cognitive function in 5×FAD mice of Alzheimer's disease by inhibiting the microglia NLRP3 inflammasome signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 11. 2023-11-19. PMID:37980548. |
objective to investigate the therapeutic effects of eriodictyol on transgenic mice with five familial alzheimer's disease (5×fad) and the modulation of nod-like receptor-pyrin domain containing 3 (nlrp3) inflammasome in microglia. |
2023-11-19 |
2023-11-20 |
mouse |
| Nuanyi Liang, Brian A Harsch, Sitong Zhou, Alison Borkowska, Gregory C Shearer, Rima Kaddurah-Daouk, John W Newman, Kamil Borkowsk. Oxylipin transport by lipoprotein particles and its functional implications for cardiometabolic and neurological disorders. Progress in lipid research. 2023-11-18. PMID:37979798. |
however, as apoe4 is associated with alzheimer's disease-related microglia dysfunction and oxylipin dysregulation, apoe4-dependent lipoprotein oxylipin modulation in neurological pathologies is suggested. |
2023-11-18 |
2023-11-20 |
Not clear |
| Pengfei Hou, Magdalena Zielonka, Lutgarde Serneels, Anna Martinez-Muriana, Nicola Fattorelli, Leen Wolfs, Suresh Poovathingal, Dries T'Syen, Sriram Balusu, Tom Theys, Mark Fiers, Renzo Mancuso, Andrew J M Howden, Bart De Stroope. The γ-secretase substrate proteome and its role in cell signaling regulation. Molecular cell. vol 83. issue 22. 2023-11-17. PMID:37977120. |
pharmacological inhibition of γ-secretase caused substantial changes of human microglial transcriptomes, including the expression of genes related to the disease-associated microglia (dam) response described in alzheimer disease (ad). |
2023-11-17 |
2023-11-20 |
mouse |
| Jay Penney, William T Ralvenius, Anjanet Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Ping-Chieh Pao, Hannah Woolf, Li-Huei Tsa. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 2023-11-16. PMID:37969043. |
genetic findings have highlighted key roles for microglia in the pathology of neurodegenerative conditions such as alzheimer's disease (ad). |
2023-11-16 |
2023-11-20 |
mouse |
| Xiaomeng Han, Peter H Li, Shuohong Wang, Morgan Sanchez, Sneha Aggarwal, Tim Blakely, Richard Schalek, Yaron Meirovitch, Zudi Lin, Daniel Berger, Yuelong Wu, Fatima Aly, Sylvie Bay, Benoît Delatour, Pierre LaFaye, Hanspeter Pfister, Donglai Wei, Viren Jain, Hidde Ploegh, Jeff Lichtma. A large-scale volumetric correlated light and electron microscopy study localizes Alzheimer's disease-related molecules in the hippocampus. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961104. |
three molecules (ptau, aβ, and a marker for activated microglia (cd11b)) were labeled without the need for detergents by three nanobody probes in a sample of the hippocampus of the 3xtg alzheimer's disease model mouse. |
2023-11-14 |
2023-11-20 |
mouse |
| Nicola A Kearns, Artemis Iatrou, Daniel J Flood, Sashini De Tissera, Zachary M Mullaney, Jishu Xu, Chris Gaiteri, David A Bennett, Yanling Wan. Dissecting the human leptomeninges at single-cell resolution. Nature communications. vol 14. issue 1. 2023-11-04. PMID:37923721. |
we also identify distinct subtypes of border-associated macrophages (bams) that display differential gene expressions from microglia and express risk genes for alzheimer's disease (ad), as nominated by genome-wide association studies (gwas). |
2023-11-04 |
2023-11-08 |
human |
| Xin Tang, Ellen Walter, Eric Wohleb, Yanbo Fan, Chenran Wan. ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease. Autophagy. 2023-11-02. PMID:37915255. |
atg5 (autophagy related 5) in microglia controls hippocampal neurogenesis in alzheimer disease. |
2023-11-02 |
2023-11-08 |
Not clear |
| Katsura Takano-Kawabe, Tatsuhiko Izumo, Tomoki Minamihata Minamihata, Mitsuaki Moriyam. All-trans Retinoic Acid Increased Transglutaminase 2 Expressions in BV-2 Cells and Cultured Astrocytes. Current molecular pharmacology. 2023-11-02. PMID:37916634. |
activation of microglia and astrocytes has been observed in alzheimer's disease (ad). |
2023-11-02 |
2023-11-08 |
Not clear |
| Zhishen Xie, Jianping Zhao, Hui Wang, Yali Jiang, Qiaoling Yang, Yu Fu, Huahui Zeng, Christian Hölscher, Jiangyan Xu, Zhenqiang Zhan. Corrigendum to "Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ" [Biomed. Pharmacother. 124 (2020) 109886]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023-11-01. PMID:37914613. |
corrigendum to "magnolol alleviates alzheimer's disease-like pathology in transgenic c. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of ppar-γ" [biomed. |
2023-11-01 |
2023-11-08 |
caenorhabditis_elegans |
| Tingting Han, Yuxiang Xu, Lin Sun, Makoto Hashimoto, Jianshe We. Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905870. |
this review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging and chronic inflammation on the occurrence and development of neurodegenerative diseases, including alzheimer's disease, huntington's chorea, and parkinson's disease. |
2023-10-31 |
2023-11-08 |
Not clear |
| Abdollah Jafarzadeh, Abdolkarim Sheikhi, Zahra Jafarzadeh, Maryam Nemat. Differential roles of regulatory T cells in Alzheimer's disease. Cellular immunology. vol 393-394. 2023-10-31. PMID:37907046. |
extracellular amyloid-β (aβ) peptide deposition and secondary persistent inflammation due to activation of microglia, astrocytes, and infiltrated immune cells contribute to alzheimer's disease (ad)-related neurodegeneration. |
2023-10-31 |
2023-11-08 |
Not clear |
| Jianguo Liu, Joseph R Geraghty, Sarah Schram, Haley C Cropper, Justin Lei, Jeffrey A Loeb, Fei Son. Prevention of Alzheimer pathology by blocking neuregulin signaling on microglia. eNeuro. 2023-10-30. PMID:37903620. |
prevention of alzheimer pathology by blocking neuregulin signaling on microglia. |
2023-10-30 |
2023-11-08 |
mouse |